Published in J Lipid Res on December 01, 2002
Omega-3 Fatty Acid Supplementation to Prevent Preterm Birth in High Risk Pregnancies | NCT00135902
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell (2010) 8.69
Dietary fats and prevention of type 2 diabetes. Prog Lipid Res (2008) 3.01
Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab (2012) 2.96
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest (2011) 2.68
Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. J Biol Chem (2009) 2.33
Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome. Curr Opin Lipidol (2009) 1.87
A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med (2014) 1.83
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Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice. Diabetologia (2008) 1.47
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Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. Am J Physiol Endocrinol Metab (2010) 1.45
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The aetiology of bacterial vaginosis. J Appl Microbiol (2011) 1.22
Omega-3 fatty acid supplementation and cardiovascular disease. J Lipid Res (2012) 1.22
Saturated long-chain fatty acids activate inflammatory signaling in astrocytes. J Neurochem (2012) 1.21
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Lipidomics analysis of essential fatty acids in macrophages. Prostaglandins Leukot Essent Fatty Acids (2008) 1.10
Polyunsaturated fatty acid supplementation alters proinflammatory gene expression and reduces the incidence of necrotizing enterocolitis in a neonatal rat model. Pediatr Res (2007) 1.10
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Inhibition of cytokine signaling in human retinal endothelial cells through modification of caveolae/lipid rafts by docosahexaenoic acid. Invest Ophthalmol Vis Sci (2007) 1.07
Docosahexaenoic acid pretreatment confers neuroprotection in a rat model of perinatal cerebral hypoxia-ischemia. Am J Obstet Gynecol (2009) 1.06
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Polyunsaturated fatty acid metabolism in prostate cancer. Cancer Metastasis Rev (2011) 1.04
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Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. PLoS One (2012) 1.01
Fatty acid-regulated transcription factors in the liver. Annu Rev Nutr (2013) 1.00
The role of inflammation in the pathology of acne. J Clin Aesthet Dermatol (2013) 0.99
Effect of marine n-3 fatty acids on circulating inflammatory markers in healthy subjects and subjects with cardiovascular risk factors. Inflamm Res (2011) 0.98
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Maternal docosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed newborn mice. J Nutr (2010) 0.97
Lipids derived from virulent Francisella tularensis broadly inhibit pulmonary inflammation via toll-like receptor 2 and peroxisome proliferator-activated receptor α. Clin Vaccine Immunol (2013) 0.97
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Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol (2009) 0.94
Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity. Genes Dev (2012) 0.94
The relationship between dietary fatty acids and inflammatory genes on the obese phenotype and serum lipids. Nutrients (2013) 0.93
Fatty acids regulate endothelial lipase and inflammatory markers in macrophages and in mouse aorta: a role for PPARγ. Arterioscler Thromb Vasc Biol (2012) 0.93
Macrophage recruitment in obese adipose tissue. Obes Rev (2015) 0.92
Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells. J Biol Chem (2011) 0.92
Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice. J Inflamm (Lond) (2011) 0.92
Insulin signaling and life span. Pflugers Arch (2009) 0.90
Regulation of chemokine and chemokine receptor expression by PPARγ in adipocytes and macrophages. PLoS One (2012) 0.90
High throughput screening of small molecule libraries for modifiers of radiation responses. Int J Radiat Biol (2011) 0.90
Plasma fatty acid ratios affect blood gene expression profiles--a cross-sectional study of the Norwegian Women and Cancer Post-Genome Cohort. PLoS One (2013) 0.90
Fast food fever: reviewing the impacts of the Western diet on immunity. Nutr J (2014) 0.89
TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells. Biosci Rep (2012) 0.89
n-3 polyunsaturated fatty acids and autoimmune-mediated glomerulonephritis. Prostaglandins Leukot Essent Fatty Acids (2010) 0.89
Western diet enhances hepatic inflammation in mice exposed to cecal ligation and puncture. BMC Physiol (2010) 0.88
n-3 Fatty acids uniquely affect anti-microbial resistance and immune cell plasma membrane organization. Chem Phys Lipids (2011) 0.88
EPA and DHA exposure alters the inflammatory response but not the surface expression of Toll-like receptor 4 in macrophages. Lipids (2014) 0.88
A sustained increase in plasma NEFA upregulates the Toll-like receptor network in human muscle. Diabetologia (2013) 0.88
Developing dendritic cells become 'lacy' cells packed with fat and glycogen. Immunology (2005) 0.88
Secretory phospholipase A2 induces dendritic cell maturation. Eur J Immunol (2004) 0.88
Poly(anhydride) nanoparticles act as active Th1 adjuvants through Toll-like receptor exploitation. Clin Vaccine Immunol (2010) 0.88
Human serum-derived hydroxy long-chain fatty acids exhibit anti-inflammatory and anti-proliferative activity. J Exp Clin Cancer Res (2011) 0.88
Dietary oil composition differentially modulates intestinal endotoxin transport and postprandial endotoxemia. Nutr Metab (Lond) (2013) 0.87
Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process. Cardiovasc Diabetol (2015) 0.86
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Docosahexaenoic acid decreases pro-inflammatory mediators in an in vitro murine adipocyte macrophage co-culture model. PLoS One (2014) 0.86
Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors. Cancer Metastasis Rev (2011) 0.85
Impact of new-generation lipid emulsions on cellular mechanisms of parenteral nutrition-associated liver disease. Adv Nutr (2014) 0.85
The potential interactions between polyunsaturated fatty acids and colonic inflammatory processes. Clin Exp Immunol (2005) 0.84
Docosahexaenoic acid confers neuroprotection in a rat model of perinatal hypoxia-ischemia potentiated by Escherichia coli lipopolysaccharide-induced systemic inflammation. Am J Obstet Gynecol (2010) 0.84
The fatty acid oxidation product 15-A3t-isoprostane is a potent inhibitor of NFκB transcription and macrophage transformation. J Neurochem (2011) 0.84
Fatty acids from Plasmodium falciparum down-regulate the toxic activity of malaria glycosylphosphatidylinositols. Infect Immun (2006) 0.84
Fatty acids isolated from Toxoplasma gondii reduce glycosylphosphatidylinositol-induced tumor necrosis factor alpha production through inhibition of the NF-kappaB signaling pathway. Infect Immun (2007) 0.83
Omega-3 fatty acids and cognitive function in women. Womens Health (Lond Engl) (2010) 0.83
New generation lipid emulsions prevent PNALD in chronic parenterally fed preterm pigs. J Lipid Res (2014) 0.83
Fish oil supplementation induces expression of genes related to cell cycle, endoplasmic reticulum stress and apoptosis in peripheral blood mononuclear cells: a transcriptomic approach. J Intern Med (2014) 0.83
Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease. Front Immunol (2016) 0.82
The lipopolysaccharide-induced pro-inflammatory response in RAW264.7 cells is attenuated by an unsaturated fatty acid-bovine serum albumin complex and enhanced by a saturated fatty acid-bovine serum albumin complex. Inflamm Res (2011) 0.82
Bioactive products generated by group V sPLA(2) hydrolysis of LDL activate macrophages to secrete pro-inflammatory cytokines. Cytokine (2010) 0.82
Greater expression of TLR2, TLR4, and IL6 due to negative energy balance is associated with lower expression of HLA-DRA and HLA-A in bovine blood neutrophils after intramammary mastitis challenge with Streptococcus uberis. Funct Integr Genomics (2010) 0.82
Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis. Biochim Biophys Acta (2009) 0.81
Biomarkers of primary open-angle glaucoma. Expert Rev Ophthalmol (2010) 0.81
Oral administration of alkylglycerols differentially modulates high-fat diet-induced obesity and insulin resistance in mice. Evid Based Complement Alternat Med (2013) 0.80
Docosahexaenoic acid differentially affects TNFα and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages. Prostaglandins Leukot Essent Fatty Acids (2015) 0.80
Anti-inflammatory nutrition as a pharmacological approach to treat obesity. J Obes (2010) 0.80
N-3 (omega-3) polyunsaturated Fatty acids in the pathophysiology and treatment of depression: pre-clinical evidence. CNS Neurol Disord Drug Targets (2013) 0.80
Impact of maternal obesity on fetal programming of cardiovascular disease. Physiology (Bethesda) (2015) 0.80
Neutrophil generation of inflammatory precursors is not modulated by docosahexaenoic acid. Inflamm Res (2009) 0.80
Cholesterol, Inflammasomes, and Atherogenesis. Curr Cardiovasc Risk Rep (2012) 0.80
DHA Suppresses Primary Macrophage Inflammatory Responses via Notch 1/ Jagged 1 Signaling. Sci Rep (2016) 0.80
Toll-like receptor 4-induced endoplasmic reticulum stress contributes to impairment of vasodilator action of insulin. Am J Physiol Endocrinol Metab (2015) 0.80
Lipids induce expression of serum-responsive transmembrane kinase EhTMKB1-9 in an early branching eukaryote Entamoeba histolytica. Sci Rep (2012) 0.79
Serum amyloid A impairs the antiinflammatory properties of HDL. J Clin Invest (2015) 0.78
Marine n-3 Fatty Acids and Gene Expression in Peripheral Blood Mononuclear Cells. Curr Cardiovasc Risk Rep (2014) 0.78
Fish oil supplementation inhibits NNK-induced lung carcinogenesis in the A/J mouse. Nutr Cancer (2009) 0.78
Role of toll-like receptor 4 in colorectal carcinogenesis: a meta-analysis. PLoS One (2014) 0.77
LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice. J Lipid Res (2013) 0.77
Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner. Biochim Biophys Acta (2013) 0.77
Omega-3 fatty acid intervention suppresses lipopolysaccharide-induced inflammation and weight loss in mice. Mar Drugs (2015) 0.76
Interaction of differentiated human adipocytes with macrophages leads to trogocytosis and selective IL-6 secretion. Cell Death Dis (2015) 0.76
Baseline characteristics of the randomised cohort from the Look AHEAD (Action for Health in Diabetes) study. Diab Vasc Dis Res (2006) 4.30
Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. J Biol Chem (2003) 3.20
Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J Biol Chem (2004) 2.36
Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. J Biol Chem (2009) 2.33
High glucose induces toll-like receptor expression in human monocytes: mechanism of activation. Diabetes (2008) 2.23
Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell Metab (2006) 2.02
Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways. J Lipid Res (2012) 1.79
Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4. J Immunol (2005) 1.70
P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis. EMBO J (2002) 1.48
Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex. J Immunol (2005) 1.47
Genome-wide identification of peroxisome proliferator response elements using integrated computational genomics. J Lipid Res (2006) 1.44
The modulation of inflammatory gene expression by lipids: mediation through Toll-like receptors. Mol Cells (2006) 1.39
Differential modulation of Nods signaling pathways by fatty acids in human colonic epithelial HCT116 cells. J Biol Chem (2007) 1.37
Snagger: a user-friendly program for incorporating additional information for tagSNP selection. BMC Bioinformatics (2008) 1.35
Lower total adipocyte number but no evidence for small adipocyte depletion in patients with type 2 diabetes. Diabetes Care (2009) 1.19
Inhibition of homodimerization of Toll-like receptor 4 by curcumin. Biochem Pharmacol (2006) 1.11
Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner. J Immunol (2009) 1.08
Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochem Pharmacol (2007) 1.07
Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids. J Immunol (2013) 1.07
Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry. Cancer Epidemiol Biomarkers Prev (2010) 1.07
Modulation of pattern recognition receptor-mediated inflammation and risk of chronic diseases by dietary fatty acids. Nutr Rev (2010) 1.05
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. Nutr Rev (2011) 1.00
Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin. Biochem Pharmacol (2009) 1.00
Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol (2016) 0.98
The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochem Pharmacol (2005) 0.97
The phosphatidylinositol 3-kinase/Akt pathway negatively regulates Nod2-mediated NF-kappaB pathway. Biochem Pharmacol (2008) 0.96
Suppression of MyD88- and TRIF-dependent signaling pathways of Toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea. Biochem Pharmacol (2006) 0.96
Genes involved with folate uptake and distribution and their association with colorectal cancer risk. Cancer Causes Control (2009) 0.92
PPARδ deficiency disrupts hypoxia-mediated tumorigenic potential of colon cancer cells. Mol Carcinog (2014) 0.92
Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line. Biochem Biophys Res Commun (2002) 0.89
Use of a computerized tracking system to monitor and provide feedback on dietary goals for calorie-restricted diets: the POUNDS LOST study. J Diabetes Sci Technol (2012) 0.88
Protective effects of genistein on proinflammatory pathways in human brain microvascular endothelial cells. J Nutr Biochem (2008) 0.86
Auranofin, as an anti-rheumatic gold compound, suppresses LPS-induced homodimerization of TLR4. Biochem Biophys Res Commun (2006) 0.85
Effect of NPY5R antagonist MK-0557 on weight regain after very-low-calorie diet-induced weight loss. Obesity (Silver Spring) (2007) 0.85
Inhibition of Nod2 signaling and target gene expression by curcumin. Mol Pharmacol (2008) 0.84
Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men. J Nutr Biochem (2011) 0.84
Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin. Am J Physiol Endocrinol Metab (2013) 0.84
Bromocriptine increased operant responding for high fat food but decreased chow intake in both obesity-prone and resistant rats. Behav Brain Res (2010) 0.80
Acrolein with an alpha, beta-unsaturated carbonyl group inhibits LPS-induced homodimerization of toll-like receptor 4. Mol Cells (2008) 0.78
Dietary strawberries increase the proliferative response of CD3/CD28-activated CD8⁺ T cells and the production of TNF-α in lipopolysaccharide-stimulated monocytes from obese human subjects. Br J Nutr (2013) 0.75
Editor's Note: Suppression of Tumor Cell Growth Both in Nude Mice and in Culture by n-3 Polyunsaturated Fatty Acids: Mediation through Cyclooxygenase-Independent Pathways. Cancer Res (2019) 0.75
Cardiometabolic risk modification: current trends and emerging therapies. JAAPA (2006) 0.75