Published in Nat Rev Cancer on February 01, 2003
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol (2008) 11.43
Aging, cellular senescence, and cancer. Annu Rev Physiol (2012) 5.08
Tailoring to RB: tumour suppressor status and therapeutic response. Nat Rev Cancer (2008) 3.16
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol (2007) 3.10
Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci U S A (2009) 2.84
Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest (2003) 2.18
Cell type-specific effects of Rb deletion in the murine retina. Genes Dev (2004) 2.18
The RB-E2F1 pathway regulates autophagy. Cancer Res (2010) 1.90
Retinoblastoma family genes. Oncogene (2006) 1.61
Mitochondrial dysfunction in cancer. Front Oncol (2013) 1.57
MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-β1/SMAD5 signaling module. Blood (2013) 1.52
Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure. Proc Natl Acad Sci U S A (2007) 1.46
CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma. Clin Cancer Res (2015) 1.42
Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis. Mol Cell Biol (2004) 1.40
RB1, development, and cancer. Curr Top Dev Biol (2011) 1.37
The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear. Development (2005) 1.37
Human VRK1 is an early response gene and its loss causes a block in cell cycle progression. PLoS One (2008) 1.36
Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects. Proc Natl Acad Sci U S A (2009) 1.34
A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol Cell Biol (2006) 1.31
Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase. Proc Natl Acad Sci U S A (2005) 1.29
Temporal self-organization of the cyclin/Cdk network driving the mammalian cell cycle. Proc Natl Acad Sci U S A (2009) 1.28
Molecular characterization of spontaneous mesenchymal stem cell transformation. PLoS One (2008) 1.26
Saccharomyces cerevisiae as a model system to define the chromosomal instability phenotype. Mol Cell Biol (2005) 1.24
Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts? Cell Div (2007) 1.22
Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells. Mol Biol Cell (2005) 1.21
RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy. Oncotarget (2015) 1.20
Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J (2003) 1.17
SerpinB2 protection of retinoblastoma protein from calpain enhances tumor cell survival. Cancer Res (2008) 1.16
Escherichia coli Nissle 1917 distinctively modulates T-cell cycling and expansion via toll-like receptor 2 signaling. Infect Immun (2005) 1.15
Combined integrin phosphoproteomic analyses and small interfering RNA--based functional screening identify key regulators for cancer cell adhesion and migration. Cancer Res (2009) 1.13
Insights from mouse models into human retinoblastoma. Cell Div (2008) 1.13
Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis. Cancer Res (2009) 1.11
Autophagy regulation in cancer development and therapy. Am J Cancer Res (2010) 1.11
Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific. EMBO J (2004) 1.09
Protein kinase CK2 regulates cytoskeletal reorganization during ionizing radiation-induced senescence of human mesenchymal stem cells. Cancer Res (2009) 1.08
Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells. Oncol Lett (2013) 1.08
The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system. Nat Rev Cancer (2008) 1.08
Regulation of B-cell entry into the cell cycle. Immunol Rev (2008) 1.06
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis. Oncogene (2010) 1.06
Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells. Mol Endocrinol (2009) 1.00
Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation. Mol Cell Biol (2004) 1.00
Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen. Mol Biol Cell (2005) 0.99
Caspase 6 regulates B cell activation and differentiation into plasma cells. J Immunol (2008) 0.99
RhoA-mediated signaling in Notch-induced senescence-like growth arrest and endothelial barrier dysfunction. Arterioscler Thromb Vasc Biol (2011) 0.97
The multiple connections between pRB and cell metabolism. Curr Opin Cell Biol (2013) 0.95
Coordination between cell cycle progression and cell fate decision by the p53 and E2F1 pathways in response to DNA damage. J Biol Chem (2010) 0.95
Tumor promotion by caspase-resistant retinoblastoma protein. Proc Natl Acad Sci U S A (2005) 0.94
NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas. Int J Cancer (2015) 0.92
Separation of anti-proliferation and anti-apoptotic functions of retinoblastoma protein through targeted mutations of its A/B domain. PLoS One (2006) 0.91
Senescence in Human Mesenchymal Stem Cells: Functional Changes and Implications in Stem Cell-Based Therapy. Int J Mol Sci (2016) 0.91
Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization. Elife (2013) 0.90
Cooperative interactions of HER-2 and HPV-16 oncoproteins in the malignant transformation of human mammary epithelial cells. Neoplasia (2005) 0.89
Porphyromonas gingivalis invades human trophoblasts and inhibits proliferation by inducing G1 arrest and apoptosis. Cell Microbiol (2009) 0.89
Regulation of vascular smooth muscle proliferation by heparin: inhibition of cyclin-dependent kinase 2 activity by p27(kip1). J Biol Chem (2005) 0.88
Enolase-1 is a therapeutic target in endometrial carcinoma. Oncotarget (2015) 0.88
Elevated poly-(ADP-ribose)-polymerase activity sensitizes retinoblastoma-deficient cells to DNA damage-induced necrosis. Mol Cancer Res (2009) 0.88
Arsenic trioxide-mediated growth inhibition of myeloma cells is associated with an extrinsic or intrinsic signaling pathway through activation of TRAIL or TRAIL receptor 2. Cancer Biol Ther (2010) 0.86
Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors. Leukemia (2010) 0.85
Retinoblastoma protein is frequently absent or phosphorylated in anaplastic large-cell lymphoma. Am J Pathol (2004) 0.85
Essential roles of Raf/extracellular signal-regulated kinase/mitogen-activated protein kinase pathway, YY1, and Ca2+ influx in growth arrest of human vascular smooth muscle cells by bilirubin. J Biol Chem (2012) 0.85
The E2F-1 associated retinoblastoma-susceptibility gene product is modified by O-GlcNAc. Amino Acids (2010) 0.84
Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex. Am J Pathol (2007) 0.84
From quiescence to proliferation: Cdk oscillations drive the mammalian cell cycle. Front Physiol (2012) 0.83
Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate. Proc Natl Acad Sci U S A (2013) 0.83
A model of sensitivity and resistance to histone deacetylase inhibitors in diffuse large B cell lymphoma: Role of cyclin-dependent kinase inhibitors. Cancer Biol Ther (2013) 0.83
Dephosphorylation of threonine-821 of the retinoblastoma tumor suppressor protein (Rb) is required for apoptosis induced by UV and Cdk inhibition. Cell Cycle (2012) 0.82
Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity. Proc Natl Acad Sci U S A (2009) 0.82
The effect of the cyclin-dependent kinase inhibitor flavopiridol on anaplastic large cell lymphoma cells and relationship with NPM-ALK kinase expression and activity. Haematologica (2009) 0.81
Retinoblastoma protein induction by HIV viremia or CCR5 in monocytes exposed to HIV-1 mediates protection from activation-induced apoptosis: ex vivo and in vitro study. J Leukoc Biol (2012) 0.80
Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene. Genetics (2005) 0.80
Peripheral blood mononuclear cells inhibit proliferation and promote apoptosis of HeLa cells following stimulation with Bacillus Calmette-Guerin. Exp Ther Med (2012) 0.79
Epithelial-specific deletion of 11β-HSD2 hinders Apcmin/+ mouse tumorigenesis. Mol Cancer Res (2013) 0.79
Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein. J Biol Chem (2014) 0.79
Small interfering RNA survivin and GRIM-19 co-expression salmonella plasmid inhibited the growth of laryngeal cancer cells in vitro and in vivo. Int J Clin Exp Pathol (2013) 0.78
Chemical and functional aspects of posttranslational modification of proteins. Acta Naturae (2009) 0.77
A stepwise strategy for rapid and cost-effective RB1 screening in Indian retinoblastoma patients. J Hum Genet (2015) 0.77
Telomere dysfunction suppresses multiple endocrine neoplasia in mice. Genes Cancer (2014) 0.76
Stat3 and C/EBPβ synergize to induce miR-21 and miR-181b expression during sepsis. Immunol Cell Biol (2016) 0.75
Generation of a Retinoblastoma (Rb)1-inducible dominant-negative (DN) mouse model. Front Cell Neurosci (2015) 0.75
Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN-amplified retinoblastoma. Cancer Med (2017) 0.75
Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells. Sci Rep (2017) 0.75
A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1. PLoS Genet (2016) 0.75
11β-Hydroxysteroid Dehydrogenase Type II is a Potential Target for Prevention of Colorectal Tumorigenesis. J Oncobiomarkers (2013) 0.75
TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin. J Biol Chem (2016) 0.75
Inhibition of pRB Pathway Differentially Modulates Apoptosis in Esophageal Cancer Cells. Transl Oncol (2017) 0.75
Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. J Cell Sci (2003) 2.10
Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J Cell Biol (2002) 1.72
Targeting the RB-pathway in cancer therapy. Clin Cancer Res (2010) 1.54
Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics. Int J Cancer (2006) 1.53
A myogenic differentiation checkpoint activated by genotoxic stress. Nat Genet (2002) 1.53
Double-strand DNA breaks recruit the centromeric histone CENP-A. Proc Natl Acad Sci U S A (2009) 1.47
Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. Proc Natl Acad Sci U S A (2003) 1.47
Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol (2006) 1.45
BCR-ABL-transformed GMP as myeloid leukemic stem cells. Proc Natl Acad Sci U S A (2008) 1.34
c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. J Cell Biol (2004) 1.26
Selection of mammalian cells based on their cell-cycle phase using dielectrophoresis. Proc Natl Acad Sci U S A (2007) 1.23
Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb. Nat Cell Biol (2002) 1.22
RB restricts DNA damage-initiated tumorigenesis through an LXCXE-dependent mechanism of transcriptional control. Mol Cell (2011) 1.16
Induction of cell retraction by the combined actions of Abl-CrkII and Rho-ROCK1 signaling. J Cell Biol (2008) 1.13
Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl. Proc Natl Acad Sci U S A (2003) 1.12
The CML stem cell: evolution of the progenitor. Cell Cycle (2009) 1.10
Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation. Mol Cell Biol (2004) 1.00
Abl tyrosine kinase promotes dorsal ruffles but restrains lamellipodia extension during cell spreading on fibronectin. Mol Biol Cell (2007) 1.00
Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy. Int J Hematol (2008) 1.00
cAMP-mediated inhibition of DNA replication and S phase progression: involvement of Rb, p21Cip1, and PCNA. Mol Biol Cell (2005) 0.97
A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development. Mol Cell Biol (2009) 0.97
Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage. Biochem J (2002) 0.96
Tumor promotion by caspase-resistant retinoblastoma protein. Proc Natl Acad Sci U S A (2005) 0.94
Blockade of tumor necrosis factor-induced Bid cleavage by caspase-resistant Rb. J Biol Chem (2007) 0.93
Death by Abl: a matter of location. Curr Top Dev Biol (2004) 0.92
An evolutionarily acquired genotoxic response discriminates MyoD from Myf5, and differentially regulates hypaxial and epaxial myogenesis. EMBO Rep (2011) 0.92
DNA damage-induced cell death: lessons from the central nervous system. Cell Res (2008) 0.91
Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells. J Biol Chem (2009) 0.91
Separation of anti-proliferation and anti-apoptotic functions of retinoblastoma protein through targeted mutations of its A/B domain. PLoS One (2006) 0.91
Exclusion of c-Abl from the nucleus restrains the p73 tumor suppression function. J Biol Chem (2003) 0.91
Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR-ABL. PLoS One (2011) 0.90
Radiation dose-dependent maintenance of G(2) arrest requires retinoblastoma protein. Cell Cycle (2002) 0.89
Modulation of human checkpoint kinase Chk1 by the regulatory beta-subunit of protein kinase CK2. Oncogene (2003) 0.87
Apoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20Q. Proc Natl Acad Sci U S A (2008) 0.87
Trp53 deficiency protects against acute intestinal inflammation. J Immunol (2013) 0.86
Murine xenograft model for human uterine fibroids: an in vivo imaging approach. Reprod Sci (2009) 0.85
Systems analysis of quantitative shRNA-library screens identifies regulators of cell adhesion. BMC Syst Biol (2008) 0.84
Uracil DNA N-glycosylase promotes assembly of human centromere protein A. PLoS One (2011) 0.84
Eph tumour suppression: the dark side of Gleevec. Nat Cell Biol (2006) 0.83
Platelet-derived growth factor C is upregulated in human uterine fibroids and regulates uterine smooth muscle cell growth. Biol Reprod (2009) 0.83
Nuclear expression of β-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells. Mol Cancer Res (2013) 0.83
Exploiting the promiscuity of imatinib. J Biol (2009) 0.82
Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition. J Biol Chem (2005) 0.82
Persistent inhibition of ABL tyrosine kinase causes enhanced apoptotic response to TRAIL and disrupts the pro-apoptotic effect of chloroquine. PLoS One (2013) 0.81
Ectopic expression of p73alpha, but not p73beta, suppresses myogenic differentiation. J Biol Chem (2004) 0.81
β-Catenin-dependent lysosomal targeting of internalized tumor necrosis factor-α suppresses caspase-8 activation in apoptosis-resistant colon cancer cells. Mol Biol Cell (2012) 0.81
Reduced focal adhesion kinase and paxillin phosphorylation in BCR-ABL-transfected cells. Cancer (2002) 0.80
Expression profiling of protein tyrosine kinases and their ligand activators in leiomyoma uteri. Syst Biol Reprod Med (2010) 0.79
Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73. BMC Biol (2009) 0.75