Published in Proc Natl Acad Sci U S A on February 23, 2009
Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy. Neuron (2010) 1.75
Drosophila melanogaster in the study of human neurodegeneration. CNS Neurol Disord Drug Targets (2010) 1.33
Flightless flies: Drosophila models of neuromuscular disease. Ann N Y Acad Sci (2010) 1.28
Mechanisms mediating spinal and bulbar muscular atrophy: investigations into polyglutamine-expanded androgen receptor function and dysfunction. Front Neurol (2013) 1.05
Androgens selectively protect against apoptosis in hippocampal neurones. J Neuroendocrinol (2010) 0.96
Mediator subunit18 controls flowering time and floral organ identity in Arabidopsis. PLoS One (2013) 0.88
Pathogenic mechanisms and therapeutic strategies in spinobulbar muscular atrophy. CNS Neurol Disord Drug Targets (2013) 0.80
Endocrine disrupters: the new players able to affect the epigenome. Front Cell Dev Biol (2015) 0.79
Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy. Elife (2015) 0.75
The regulation of E2F by pRB-family proteins. Genes Dev (1998) 12.77
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature (1991) 9.89
Trinucleotide repeat disorders. Annu Rev Neurosci (2007) 9.45
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature (2007) 7.74
Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev (2006) 6.32
Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature (2008) 3.68
Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait. Neurology (1968) 3.48
ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology. Cell (2006) 3.39
The E2F family: specific functions and overlapping interests. EMBO J (2004) 3.33
Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol (2002) 3.00
Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Neuron (2002) 2.98
RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev (1996) 2.92
Molecular mechanisms of E2F-dependent activation and pRB-mediated repression. J Cell Sci (2004) 2.89
Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol (2000) 2.84
RNA toxicity is a component of ataxin-3 degeneration in Drosophila. Nature (2008) 2.74
Retinoblastoma protein partners. Adv Cancer Res (2001) 2.53
Coordinated regulation of life and death by RB. Nat Rev Cancer (2003) 2.39
Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance. Mol Cell (2004) 2.38
Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila. Neuron (2002) 2.15
Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev (1996) 2.06
TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr Biol (2006) 1.88
ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nat Med (2007) 1.87
The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc Natl Acad Sci U S A (2007) 1.78
Suppressive function of androgen receptor in bone resorption. Proc Natl Acad Sci U S A (2003) 1.72
Polyglutamine neurodegenerative diseases and regulation of transcription: assembling the puzzle. Genes Dev (2006) 1.65
Re-evaluating cell-cycle regulation by E2Fs. Cell (2006) 1.46
Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length. Hum Mol Genet (2000) 1.41
Distinctions in the specificity of E2F function revealed by gene expression signatures. Proc Natl Acad Sci U S A (2005) 1.34
Neuronal apoptosis at the G1/S cell cycle checkpoint. Cell Tissue Res (2001) 1.33
Retinoblastoma, a tumor suppressor, is a coactivator for the androgen receptor in human prostate cancer DU145 cells. Biochem Biophys Res Commun (1998) 1.18
Differential regulation of androgen and glucocorticoid receptors by retinoblastoma protein. J Biol Chem (1998) 0.96
Large-scale pattern growth of graphene films for stretchable transparent electrodes. Nature (2009) 11.18
Modulation of microRNA processing by p53. Nature (2009) 7.88
The Arabidopsis GNOM ARF-GEF mediates endosomal recycling, auxin transport, and auxin-dependent plant growth. Cell (2003) 6.95
Identifying genetic determinants needed to establish a human gut symbiont in its habitat. Cell Host Microbe (2009) 6.67
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell (2007) 4.71
Retracted DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nat Cell Biol (2007) 4.45
Variation in use of blood transfusion in coronary artery bypass graft surgery. JAMA (2010) 4.13
Retracted A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol (2007) 3.97
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Mol Cell (2008) 3.60
Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature (2007) 3.59
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature (2003) 3.49
Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. Nat Med (2012) 3.46
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science (2008) 3.38
Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes. Diabetes Care (2012) 3.28
Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J (2002) 3.16
Systematic analysis of SNARE molecules in Arabidopsis: dissection of the post-Golgi network in plant cells. Cell Struct Funct (2004) 3.13
Retracted GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. Nature (2009) 3.10
Odorant-binding proteins OBP57d and OBP57e affect taste perception and host-plant preference in Drosophila sechellia. PLoS Biol (2007) 3.03
Retracted DNA demethylation in hormone-induced transcriptional derepression. Nature (2009) 2.90
Arabidopsis sterol endocytosis involves actin-mediated trafficking via ARA6-positive early endosomes. Curr Biol (2003) 2.84
MicroRNA-214 suppresses osteogenic differentiation of C2C12 myoblast cells by targeting Osterix. Bone (2013) 2.79
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest (2007) 2.73
Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo. J Biol Chem (2004) 2.72
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A (2006) 2.60
Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice. Nat Med (2005) 2.59
Quantitative analysis demonstrates most transcription factors require only simple models of specificity. Nat Biotechnol (2011) 2.58
Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. J Bone Miner Res (2012) 2.53
Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis. Nat Rev Rheumatol (2009) 2.50
Retracted Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell (2009) 2.48
Retracted Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions. Nature (2008) 2.42
Determining the specificity of protein-DNA interactions. Nat Rev Genet (2010) 2.38
Evaluation of methods for modeling transcription factor sequence specificity. Nat Biotechnol (2013) 2.34
Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans. Development (2003) 2.18
Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila. Neuron (2002) 2.15
Tuning the graphene work function by electric field effect. Nano Lett (2009) 2.14
GETDB, a database compiling expression patterns and molecular locations of a collection of Gal4 enhancer traps. Genesis (2002) 2.14
GlcNAcylation of histone H2B facilitates its monoubiquitination. Nature (2011) 2.14
Grazoprevir-Elbasvir Combination Therapy for Treatment-Naive Cirrhotic and Noncirrhotic Patients With Chronic Hepatitis C Virus Genotype 1, 4, or 6 Infection: A Randomized Trial. Ann Intern Med (2015) 2.13
Glutathione depletion prevents diet-induced obesity and enhances insulin sensitivity. Obesity (Silver Spring) (2011) 2.12
Long-term calcium supplementation may have adverse effects on serum cholesterol and carotid intima-media thickness in postmenopausal women: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr (2013) 2.11
Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology (2003) 2.10
Retracted Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. Nat Cell Biol (2003) 2.08
Vitamin E decreases bone mass by stimulating osteoclast fusion. Nat Med (2012) 2.04
Long-term outcome of hand-assisted laparoscopic radical nephrectomy for T1 renal cell carcinoma. Int J Urol (2014) 2.03
Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study. Acta Diabetol (2010) 2.01
A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling. Biochem J (2003) 2.00
Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development (2002) 1.99
Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proc Natl Acad Sci U S A (2002) 1.99
Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation. Proc Natl Acad Sci U S A (2013) 1.97
Dally regulates Dpp morphogen gradient formation in the Drosophila wing. Development (2003) 1.94
Alternative trans-splicing: a novel mode of pre-mRNA processing. Biol Cell (2006) 1.92
Retracted The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. Cell (2003) 1.88
Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation. Curr Biol (2004) 1.87
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol Cell (2009) 1.84
Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis. Crit Care Med (2008) 1.84
FGF10 maintains stem cell compartment in developing mouse incisors. Development (2002) 1.84
Limited internal radiation exposure associated with resettlements to a radiation-contaminated homeland after the Fukushima Daiichi nuclear disaster. PLoS One (2013) 1.81
Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors. J Clin Invest (2002) 1.81
Surgical repair of ventricular septal defect after myocardial infarction: outcomes from the Society of Thoracic Surgeons National Database. Ann Thorac Surg (2012) 1.80
A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing. EMBO Rep (2011) 1.79
Requirements for FGF3 and FGF10 during inner ear formation. Development (2003) 1.76
Retracted Nuclear receptor function requires a TFTC-type histone acetyl transferase complex. Mol Cell (2002) 1.75
A complex and mobile structure forms a distinct subregion within the continuous vacuolar membrane in young cotyledons of Arabidopsis. Plant J (2002) 1.74
Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes. Proc Natl Acad Sci U S A (2008) 1.74
Suppressive function of androgen receptor in bone resorption. Proc Natl Acad Sci U S A (2003) 1.72
Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages. Arterioscler Thromb Vasc Biol (2010) 1.70
Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation. J Clin Invest (2013) 1.70
The Arabidopsis AAA ATPase SKD1 is involved in multivesicular endosome function and interacts with its positive regulator LYST-INTERACTING PROTEIN5. Plant Cell (2007) 1.70
HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. Proc Natl Acad Sci U S A (2013) 1.67
STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor. J Biol Chem (2008) 1.64
Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proc Natl Acad Sci U S A (2009) 1.63
Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. Proc Natl Acad Sci U S A (2012) 1.61
Wnt/beta-catenin and estrogen signaling converge in vivo. J Biol Chem (2004) 1.60
An unconventional myosin in Drosophila reverses the default handedness in visceral organs. Nature (2006) 1.60
The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. J Exp Med (2010) 1.59
Significant increase of serum high-mobility group box chromosomal protein 1 levels in patients with severe acute pancreatitis. Pancreas (2006) 1.58