PubRank

Xiao-Jiang Li

Author PubWeight™ 100.03‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Towards a transgenic model of Huntington's disease in a non-human primate. Nature 2008 4.47
2 Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum Mol Genet 2003 4.07
3 Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J Neurosci 2008 3.54
4 Huntingtin-protein interactions and the pathogenesis of Huntington's disease. Trends Genet 2004 2.88
5 Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. J Cell Biol 2005 2.57
6 Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc Natl Acad Sci U S A 2003 2.35
7 Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease. J Neurosci 2003 2.20
8 Interaction of Huntington disease protein with transcriptional activator Sp1. Mol Cell Biol 2002 2.19
9 N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking. J Neurosci 2008 2.18
10 Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron 2005 2.11
11 Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. EMBO J 2008 2.03
12 Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons. J Biol Chem 2005 1.98
13 Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc Natl Acad Sci U S A 2009 1.87
14 Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nat Med 2006 1.86
15 Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity. J Cell Biol 2003 1.77
16 Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Hum Mol Genet 2008 1.70
17 Transgenic rat model of Huntington's disease. Hum Mol Genet 2003 1.66
18 Polyglutamine expansion of huntingtin impairs its nuclear export. Nat Genet 2005 1.62
19 Adenosine A(2A) receptor mediates microglial process retraction. Nat Neurosci 2009 1.56
20 Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice. J Cell Biol 2008 1.51
21 Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice. J Neurosci 2002 1.48
22 Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. Nat Neurosci 2007 1.46
23 Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons. J Neurosci 2008 1.41
24 Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease. Hum Mol Genet 2005 1.39
25 Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease. Mol Neurodegener 2007 1.39
26 Multiple pathways contribute to the pathogenesis of Huntington disease. Mol Neurodegener 2006 1.35
27 Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease. J Neurosci 2003 1.35
28 Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs. Hum Mol Genet 2010 1.33
29 Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently. J Biol Chem 2002 1.29
30 Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice. J Biol Chem 2010 1.25
31 Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth. J Neurosci 2006 1.23
32 Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease. Hum Mol Genet 2008 1.23
33 Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin. J Cell Biol 2008 1.22
34 Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH. Proc Natl Acad Sci U S A 2006 1.20
35 Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. J Clin Invest 2008 1.19
36 Huntingtin and its role in neuronal degeneration. Neuroscientist 2004 1.16
37 Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice. Hum Mol Genet 2002 1.14
38 Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release. Hum Mol Genet 2003 1.11
39 TWEAK-Fn14 pathway inhibition protects the integrity of the neurovascular unit during cerebral ischemia. J Cereb Blood Flow Metab 2006 1.10
40 Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments. Hum Mol Genet 2010 1.08
41 Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor. Brain 2011 1.03
42 Regulation of intracellular HAP1 trafficking. J Neurosci Res 2007 0.99
43 Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity. J Biol Chem 2008 0.98
44 Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. J Biol Chem 2009 0.96
45 Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases. Brain Res Rev 2008 0.96
46 Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation. Hum Mol Genet 2011 0.96
47 Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates. Mol Ther 2007 0.94
48 AHI-1 interacts with BCR-ABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells. J Exp Med 2008 0.94
49 Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. Proc Natl Acad Sci U S A 2010 0.92
50 Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice. J Biol Chem 2008 0.92
51 Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A. Proc Natl Acad Sci U S A 2014 0.91
52 Activation of gene transcription by heat shock protein 27 may contribute to its neuronal protection. J Biol Chem 2009 0.90
53 Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice. J Biol Chem 2010 0.88
54 Immunohistochemical localization of huntingtin-associated protein 1 in endocrine system of the rat. J Histochem Cytochem 2005 0.87
55 Context-dependent dysregulation of transcription by mutant huntingtin. J Biol Chem 2006 0.86
56 Polyglutamine toxicity in non-neuronal cells. Cell Res 2010 0.86
57 Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms. J Cell Biol 2013 0.86
58 Nuclear accumulation of polyglutamine disease proteins and neuropathology. Mol Brain 2009 0.85
59 Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17. Hum Mol Genet 2009 0.85
60 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking. J Biol Chem 2006 0.85
61 Impaired alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and function by mutant huntingtin. J Biol Chem 2011 0.84
62 Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington's disease monkeys. BMC Neurosci 2013 0.84
63 Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation. J Neurosci 2013 0.82
64 Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting. J Clin Invest 2013 0.81
65 Brainstem Hap1-Ahi1 is involved in insulin-mediated feeding control. FEBS Lett 2010 0.80
66 Clearance of mutant huntingtin. Autophagy 2010 0.79
67 Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells. Cell Mol Life Sci 2011 0.79
68 [Clinical efficacy analysis of treating advanced prostate cancer by yiqi jiedu quyu recipe combined endocrine therapy]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2013 0.79
69 Hypothalamic Ahi1 mediates feeding behavior through interaction with 5-HT2C receptor. J Biol Chem 2011 0.79
70 Beyond mice: genetically modifying larger animals to model human diseases. J Genet Genomics 2012 0.77
71 Recent advances in basic neurosciences and brain disease: from synapses to behavior. Mol Pain 2006 0.76
72 TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain. Hum Mol Genet 2013 0.76
73 Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice. Mol Brain 2010 0.76
74 Welcome to molecular brain. Mol Brain 2008 0.75
75 A huntingtin-HAP1-PCM1 pathway in ciliogenesis. Expert Rev Proteomics 2012 0.75
76 [Correlation between the vascular endothelial growth factor C expression and lymph node metastasis in human nasopharyngeal carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008 0.75
77 [Diagnosis and reoperation for thyroid carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2005 0.75
78 [Clinical observation of airening suppository in treatment of 30 patients with carcinoma fever]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008 0.75
79 In vitro expression systems for the Huntington protein. Methods Mol Biol 2003 0.75
80 [Achieve single-stage autotrophic biological nitrogen removal process by controlling the concentration of free ammonia]. Huan Jing Ke Xue 2011 0.75
81 Thermal decomposition and kinetics studies on 1,4-dinitropiperazine (DNP). J Hazard Mater 2007 0.75
82 [Mechanism study on leptin resistance in lung cancer cachexia rats treated by Xiaoyan Decoction]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2014 0.75