Published in J Biol Chem on March 14, 2002
The HSP70 chaperone machinery: J proteins as drivers of functional specificity. Nat Rev Mol Cell Biol (2010) 5.37
Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy. Nat Genet (2012) 1.75
Genetic basis of limb-girdle muscular dystrophies: the 2014 update. Acta Myol (2014) 1.58
Heat shock proteins: cellular and molecular mechanisms in the central nervous system. Prog Neurobiol (2010) 1.37
Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy. Ann Neurol (2012) 1.35
Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone. Biochem Biophys Res Commun (2006) 1.33
The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol Cell Biol (2005) 1.25
Large isoform of MRJ (DNAJB6) reduces malignant activity of breast cancer. Breast Cancer Res (2008) 1.24
Photoreceptor IFT complexes containing chaperones, guanylyl cyclase 1 and rhodopsin. Traffic (2009) 1.16
Structural basis of defects in the sacsin HEPN domain responsible for autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). J Biol Chem (2011) 1.08
Microarray analysis of gene expression by skeletal muscle of three mouse models of Kennedy disease/spinal bulbar muscular atrophy. PLoS One (2010) 1.02
Hsp70 protein complexes as drug targets. Curr Pharm Des (2013) 1.00
The DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides. J Biol Chem (2013) 0.95
Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110. Cell Death Dis (2013) 0.94
DNAJB6 induces degradation of beta-catenin and causes partial reversal of mesenchymal phenotype. J Biol Chem (2010) 0.93
DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios. Cell Stress Chaperones (2013) 0.90
DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin. Oncogene (2012) 0.87
The large conductance, calcium-activated K+ (BK) channel is regulated by cysteine string protein. Sci Rep (2013) 0.87
A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease. J Biol Chem (2014) 0.84
J protein mutations and resulting proteostasis collapse. Front Cell Neurosci (2014) 0.84
Complete loss of the DNAJB6 G/F domain and novel missense mutations cause distal-onset DNAJB6 myopathy. Acta Neuropathol Commun (2015) 0.83
Liquid-liquid phase separation in hemoglobins: distinct aggregation mechanisms of the beta6 mutants. Biophys J (2004) 0.83
Micro-RNA-632 downregulates DNAJB6 in breast cancer. Lab Invest (2012) 0.81
Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJ. Exp Cell Res (2012) 0.79
Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer. Oncotarget (2016) 0.77
A Hsp40 chaperone protein interacts with and modulates the cellular distribution of the primase protein of human cytomegalovirus. PLoS Pathog (2012) 0.77
DNAJ Proteins in neurodegeneration: essential and protective factors. Philos Trans R Soc Lond B Biol Sci (2018) 0.76
TRNA mutations that affect decoding fidelity deregulate development and the proteostasis network in zebrafish. RNA Biol (2014) 0.76
Specific protein homeostatic functions of small heat-shock proteins increase lifespan. Aging Cell (2015) 0.76
A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene. JCI Insight (2016) 0.75
A de novo mutation of the MYH7 gene in a large Chinese family with autosomal dominant myopathy. Hum Genome Var (2015) 0.75
Meeting Report: New Directions in the Biology and Disease of Skeletal Muscle 2014. J Neuromuscul Dis (2014) 0.75
Towards a transgenic model of Huntington's disease in a non-human primate. Nature (2008) 4.47
starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res (2013) 4.33
Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication. Science (2007) 4.12
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum Mol Genet (2003) 4.07
starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res (2010) 3.99
Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly. Cell (2008) 3.96
Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection. Clin Cancer Res (2009) 3.86
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J Neurosci (2008) 3.54
Salivary proteomic and genomic biomarkers for primary Sjögren's syndrome. Arthritis Rheum (2007) 2.90
Huntingtin-protein interactions and the pathogenesis of Huntington's disease. Trends Genet (2004) 2.88
Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res (2008) 2.81
Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68
Liver-enriched transcription factors regulate microRNA-122 that targets CUTL1 during liver development. Hepatology (2010) 2.64
The SNPlex genotyping system: a flexible and scalable platform for SNP genotyping. J Biomol Tech (2005) 2.64
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature (2006) 2.61
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. J Cell Biol (2005) 2.57
Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity. J Biol Chem (2007) 2.38
Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer. Gut (2011) 2.38
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc Natl Acad Sci U S A (2003) 2.35
Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle. Circ Res (2003) 2.35
Incidence of atypical nontraumatic diaphyseal fractures of the femur. J Bone Miner Res (2012) 2.29
Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease. J Neurosci (2003) 2.20
Interaction of Huntington disease protein with transcriptional activator Sp1. Mol Cell Biol (2002) 2.19
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking. J Neurosci (2008) 2.18
A role for Gcn5 in replication-coupled nucleosome assembly. Mol Cell (2010) 2.14
Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer. Gastroenterology (2009) 2.13
Deep sequencing of human nuclear and cytoplasmic small RNAs reveals an unexpectedly complex subcellular distribution of miRNAs and tRNA 3' trailers. PLoS One (2010) 2.12
Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron (2005) 2.11
ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data. Nucleic Acids Res (2012) 2.11
Nanostructural and transcriptomic analyses of human saliva derived exosomes. PLoS One (2010) 2.11
Maladaptive role of IL-6 in ischemic acute renal failure. J Am Soc Nephrol (2005) 2.07
Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors. Nat Cell Biol (2011) 2.06
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. EMBO J (2008) 2.03
Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons. J Biol Chem (2005) 1.98
SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods. Cell (2007) 1.91
Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc Natl Acad Sci U S A (2009) 1.87
Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nat Med (2006) 1.86
Phylogeny, evolution, and biogeography of Asiatic Salamanders (Hynobiidae). Proc Natl Acad Sci U S A (2006) 1.83
The Rtt109-Vps75 histone acetyltransferase complex acetylates non-nucleosomal histone H3. J Biol Chem (2007) 1.80
Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood (2011) 1.79
deepBase: a database for deeply annotating and mining deep sequencing data. Nucleic Acids Res (2009) 1.78
Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity. J Cell Biol (2003) 1.77
MTOC translocation modulates IS formation and controls sustained T cell signaling. J Cell Biol (2008) 1.75
MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4 (PDCD4) in HeLa cervical carcinoma cells. Biochem Biophys Res Commun (2009) 1.73
snoSeeker: an advanced computational package for screening of guide and orphan snoRNA genes in the human genome. Nucleic Acids Res (2006) 1.73
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Hum Mol Genet (2008) 1.70
Electrochemical sensor for multiplex biomarkers detection. Clin Cancer Res (2009) 1.67
Transgenic rat model of Huntington's disease. Hum Mol Genet (2003) 1.66
MicroRNA patterns associated with clinical prognostic parameters and CNS relapse prediction in pediatric acute leukemia. PLoS One (2009) 1.62
Polyglutamine expansion of huntingtin impairs its nuclear export. Nat Genet (2005) 1.62
Identification of 20 microRNAs from Oryza sativa. Nucleic Acids Res (2004) 1.61
Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP. PLoS One (2009) 1.58
Adenosine A(2A) receptor mediates microglial process retraction. Nat Neurosci (2009) 1.56
Evidence that a West-East admixed population lived in the Tarim Basin as early as the early Bronze Age. BMC Biol (2010) 1.55
Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing. Proc Natl Acad Sci U S A (2005) 1.55
Injection of recombinant human type VII collagen corrects the disease phenotype in a murine model of dystrophic epidermolysis bullosa. Mol Ther (2008) 1.54
Epidemiologic study of the predisposing factors in erythema toxicum neonatorum. Dermatology (2005) 1.53
Stress-induced tRNA-derived RNAs: a novel class of small RNAs in the primitive eukaryote Giardia lamblia. Nucleic Acids Res (2008) 1.52
Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice. J Cell Biol (2008) 1.51
Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice. J Neurosci (2002) 1.48
Rice embryogenic calli express a unique set of microRNAs, suggesting regulatory roles of microRNAs in plant post-embryogenic development. FEBS Lett (2006) 1.47
Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. Nat Neurosci (2007) 1.46
Pathogenesis of carcinoma of the papilla of Vater. J Hepatobiliary Pancreat Surg (2004) 1.45
Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial. PLoS One (2011) 1.45
Extremely low genetic diversity indicating the endangered status of Ranodon sibiricus (Amphibia: Caudata) and implications for phylogeography. PLoS One (2012) 1.44
piRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells. Clin Chim Acta (2011) 1.43
Discovery and preclinical validation of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancer. PLoS One (2010) 1.43
Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons. J Neurosci (2008) 1.41
Impulse inhibition in people with Internet addiction disorder: electrophysiological evidence from a Go/NoGo study. Neurosci Lett (2010) 1.40
Mitochondrial DNA evidence for a diversified origin of workers building First Emperor of China. PLoS One (2008) 1.40
Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease. Hum Mol Genet (2005) 1.39
The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. Dev Cell (2005) 1.39
piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells. Cancer Lett (2011) 1.39
Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease. Mol Neurodegener (2007) 1.39
Exon-level expression profiling: a comprehensive transcriptome analysis of oral fluids. Clin Chem (2008) 1.38
The Relationship of Parathyroidectomy and Bisphosphonates With Fracture Risk in Primary Hyperparathyroidism: An Observational Study. Ann Intern Med (2016) 1.38
HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration. J Neurosci (2011) 1.38
A novel role for histone chaperones CAF-1 and Rtt106p in heterochromatin silencing. EMBO J (2007) 1.37
Visualizing individual nitrogen dopants in monolayer graphene. Science (2011) 1.35
Multiple pathways contribute to the pathogenesis of Huntington disease. Mol Neurodegener (2006) 1.35
Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease. J Neurosci (2003) 1.35
Systemic disease-induced salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancer. PLoS One (2009) 1.35
Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function. J Biol Chem (2002) 1.34
High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells. FEBS Lett (2010) 1.34
Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs. Hum Mol Genet (2010) 1.33
The elongator complex interacts with PCNA and modulates transcriptional silencing and sensitivity to DNA damage agents. PLoS Genet (2009) 1.32
Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. Environ Health Perspect (2011) 1.30