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1
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Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors.
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Bioorg Med Chem
|
2010
|
0.95
|
|
2
|
Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1.
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J Med Chem
|
2009
|
0.92
|
|
3
|
Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors.
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Bioorg Med Chem
|
2007
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0.83
|
|
4
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New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites.
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J Med Chem
|
2013
|
0.82
|
|
5
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Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: role played by PLC-γ, IP3 receptors.
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Brain Res
|
2011
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0.81
|
|
6
|
Synthesis of enantiomerically pure milnacipran analogs and inhibition of dopamine, serotonin, and norepinephrine transporters.
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Bioorg Med Chem Lett
|
2007
|
0.80
|
|
7
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Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists.
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Neurochem Int
|
2003
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0.80
|
|
8
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Correlating the metabolic stability of psychedelic 5-HT₂A agonists with anecdotal reports of human oral bioavailability.
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Neurochem Res
|
2014
|
0.80
|
|
9
|
Discovery of benzamide analogues as a novel class of 5-HT₃ receptor agonists.
|
ChemMedChem
|
2011
|
0.79
|
|
10
|
4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships.
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J Med Chem
|
2007
|
0.77
|
|
11
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Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid.
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Org Biomol Chem
|
2007
|
0.76
|
|
12
|
Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as γ-aminobutyric acid(a) receptor agonists.
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J Med Chem
|
2013
|
0.75
|
|
13
|
Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands.
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J Med Chem
|
2014
|
0.75
|
|
14
|
Identification of a new series of non-peptidic NK3 receptor antagonists.
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Bioorg Med Chem Lett
|
2011
|
0.75
|
|
15
|
N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors.
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Bioorg Med Chem
|
2013
|
0.75
|
|
16
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Molecular hybridization of potent and selective γ-Hydroxybutyric Acid (GHB) ligands; Design, synthesis, binding studies, and molecular modelling of novel 3-hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-hydroxycrotonic acid (T-HCA) Analogs.
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J Med Chem
|
2017
|
0.75
|