Published in Neurochem Int on June 01, 2003
Novel, potent, and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. J Pharmacol Exp Ther (2008) 1.02
2-Aminoethyl methylphosphonate, a potent and rapidly acting antagonist of GABA(A)-ρ1 receptors. Mol Pharmacol (2011) 0.79
GABA-ρ receptors: distinctive functions and molecular pharmacology. Br J Pharmacol (2017) 0.75
Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors. Bioorg Med Chem (2005) 3.38
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. J Med Chem (2005) 2.94
Central nervous system depressant action of flavonoid glycosides. Eur J Pharmacol (2006) 1.26
(+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinant alpha1beta2gamma2L GABA(A) receptors. Biochem Pharmacol (2005) 1.22
Alpha9 nicotinic acetylcholine receptors and the treatment of pain. Biochem Pharmacol (2009) 1.11
GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic. Biochem Pharmacol (2004) 1.10
Flavonoid modulation of GABA(A) receptors. Br J Pharmacol (2011) 1.09
Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorg Med Chem (2009) 1.07
Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. Br J Pharmacol (2011) 1.07
GABA(C) receptors as drug targets. Curr Drug Targets CNS Neurol Disord (2003) 1.05
Activation of single heteromeric GABA(A) receptor ion channels by full and partial agonists. J Physiol (2004) 1.05
The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor. J Neurochem (2007) 1.03
Novel, potent, and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. J Pharmacol Exp Ther (2008) 1.02
Modulation of ionotropic GABA receptors by natural products of plant origin. Adv Pharmacol (2006) 1.00
α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). Proc Natl Acad Sci U S A (2012) 0.99
Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: characterization of conditions for affinity and transport experiments in Caco-2 cells. Eur J Pharm Sci (2008) 0.99
Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem (2002) 0.97
The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. Biochem Pharmacol (2004) 0.97
Structure-activity relationships of selective GABA uptake inhibitors. Curr Top Med Chem (2006) 0.97
Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors. Eur J Pharmacol (2003) 0.96
Stress and GABA receptors. J Neurochem (2009) 0.96
Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs. J Neurochem (2009) 0.95
A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chem Biol Drug Des (2008) 0.95
Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors. Bioorg Med Chem (2010) 0.95
Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors. Mol Pharmacol (2003) 0.94
Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors. Chirality (2003) 0.92
Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1. J Med Chem (2009) 0.92
(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction. J Med Chem (2011) 0.91
Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability. J Biol Chem (2004) 0.91
Novel oral drug administration in an animal model of neuroleptic therapy. J Neurosci Methods (2005) 0.91
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2. J Pharmacol Exp Ther (2004) 0.90
Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues. Bioorg Med Chem (2005) 0.90
Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology (2008) 0.90
Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors. Eur J Pharmacol (2004) 0.89
Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships. J Med Chem (2008) 0.88
Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review. Amino Acids (2013) 0.87
A tetrazolyl-substituted subtype-selective AMPA receptor agonist. J Med Chem (2007) 0.87
Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors. Eur J Pharmacol (2004) 0.87
Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain. J Pharmacol Exp Ther (2005) 0.86
3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes. Biochem Pharmacol (2011) 0.86
Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site. Neuropharmacology (2010) 0.86
Guanidino acids act as rho1 GABA(C) receptor antagonists. Neurochem Res (2009) 0.86
Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors. Biochem Pharmacol (2012) 0.86
A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS. Neurochem Int (2006) 0.86
Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated analogs. J Pharmacol Exp Ther (2002) 0.86
Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol. J Pharmacol Exp Ther (2011) 0.85
Double-Mannich annulation of cyclic ketones using N,N-Bis(ethoxymethyl)alkylamine reagents. Org Lett (2006) 0.85
Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an alpha-conotoxin containing a nonreducible cystine analogue. J Med Chem (2009) 0.84
Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. J Med Chem (2006) 0.84
Structure-activity relationship and pharmacology of gamma-aminobutyric acid (GABA) transport inhibitors. Adv Pharmacol (2006) 0.84
(3-Aminocyclopentyl)methylphosphinic acids: novel GABA(C) receptor antagonists. Neuropharmacology (2006) 0.84
GABA(A) receptor ligands and their therapeutic potentials. Curr Top Med Chem (2002) 0.83
GABA transporters GAT-1 and GAT-3 in the human dorsolateral prefrontal cortex in schizophrenia. Neuropsychobiology (2004) 0.83
Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors. Bioorg Med Chem (2007) 0.83
6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. Eur J Pharmacol (2005) 0.83
Mutations of the 2' proline in the M2 domain of the human GABAC rho1 subunit alter agonist responses. Neuropharmacology (2004) 0.83
Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. Bioorg Med Chem Lett (2007) 0.83
Specific GABA(A) agonists and partial agonists. Chem Rec (2002) 0.83
Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors. Mol Pharmacol (2003) 0.83
Medicinal chemistry of ρ GABAC receptors. Future Med Chem (2011) 0.82
Flavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptors. Br J Pharmacol (2012) 0.82
2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. Br J Pharmacol (2012) 0.82
GABAergic control of arteriolar diameter in the rat retina. Invest Ophthalmol Vis Sci (2013) 0.82
New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites. J Med Chem (2013) 0.82
Aza-THIP and related analogues of THIP as GABA C antagonists. Bioorg Med Chem (2003) 0.82
Relative impact of residues at the intracellular and extracellular ends of the human GABAC rho1 receptor M2 domain on picrotoxinin activity. Eur J Pharmacol (2007) 0.82