Published in Eur J Med Chem on January 01, 2003
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(2E)-3-(Dimethyl-amino)-1-(4-fluoro-phen-yl)prop-2-en-1-one. Acta Crystallogr Sect E Struct Rep Online (2012) 0.75
Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial. Lancet Oncol (2012) 2.86
Informational and energetic masking effects in the perception of multiple simultaneous talkers. J Acoust Soc Am (2001) 2.66
Anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin derivatives. Eur J Pharm Sci (2002) 2.15
Enaminones-versatile therapeutic pharmacophores. Further advances. Curr Med Chem (2000) 2.00
Daptomycin pharmacokinetics in critically ill patients receiving continuous venovenous hemodialysis. Crit Care Med (2011) 1.65
Synthesis and anticonvulsant activity of enaminones. 4. Investigations on isoxazole derivatives. Eur J Med Chem (2002) 1.63
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An HPLC method for the determination of the free cortisol/cortisone ratio in human urine. Biomed Chromatogr (2007) 1.38
Anticonvulsant activity of Schiff bases of isatin derivatives. Acta Pharm (2004) 1.27
Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds. Eur J Med Chem (2006) 1.21
The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers. Int J Pharm (2002) 1.21
The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones. Eur J Med Chem (2008) 1.20
Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. Epilepsy Res (2007) 1.20
Synthesis of isatin semicarbazones as novel anticonvulsants--role of hydrogen bonding. J Pharm Pharm Sci (2003) 1.18
Enaminones: Exploring additional therapeutic activities. J Pharm Sci (2007) 1.15
Synthesis of some 3-(arylalkylthio)-4-alkyl/aryl-5-(4-aminophenyl)-4H-1,2,4-triazole derivatives and their anticonvulsant activity. Farmaco (2004) 1.15
Design, synthesis and evaluation of novel hydroxyamides as orally available anticonvulsants. Bioorg Med Chem (2004) 1.13
Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures. Nat Neurosci (2002) 1.12
Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. J Med Chem (2009) 1.05
Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones. Eur J Med Chem (2003) 1.04
Development and characterization of novel derivatives of the antiepileptic drug lacosamide that exhibit far greater enhancement in slow inactivation of voltage-gated sodium channels. ACS Chem Neurosci (2011) 1.02
N-Aroyl-3,5-bis(benzylidene)-4-piperidones: a novel class of antimycobacterial agents. Bioorg Med Chem (2008) 1.00
Cytotoxic 1,3-diarylidene-2-tetralones and related compounds. Eur J Med Chem (2002) 0.99
Activities of α-asarone in various animal seizure models and in biochemical assays might be essentially accounted for by antioxidant properties. Neurosci Res (2010) 0.99
Dosing rationale for liraglutide in type 2 diabetes mellitus: a pharmacometric assessment. J Clin Pharmacol (2011) 0.97
Argatroban and renal replacement therapy in patients with heparin-induced thrombocytopenia. Ann Pharmacother (2005) 0.97
Application of predictive QSAR models to database mining: identification and experimental validation of novel anticonvulsant compounds. J Med Chem (2004) 0.96
Dosing in heavy-weight/obese patients with the LMWH, tinzaparin: a pharmacodynamic study. Thromb Haemost (2002) 0.96
Design & synthesis of N'-[substituted] pyridine-4-carbohydrazides as potential anticonvulsant agents. Eur J Med Chem (2010) 0.95
Antiepileptic popular ketogenic diet: emerging twists in an ancient story. Prog Neurobiol (2005) 0.93
Design and evaluation of affinity labels of functionalized amino acid anticonvulsants. J Med Chem (2002) 0.93
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The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia (2008) 0.92
Dose-response effect of a beta3-adrenergic receptor agonist, solabegron, on gastrointestinal transit, bowel function, and somatostatin levels in health. Am J Physiol Gastrointest Liver Physiol (2008) 0.92
Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides. J Med Chem (2010) 0.91
Correlations between cytotoxicity and topography of some 2-arylidenebenzocycloalkanones determined by X-ray crystallography. J Med Chem (2002) 0.90
Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors. J Med Chem (2009) 0.89
Design, synthesis and potential 6 Hz psychomotor seizure test activity of some novel 2-(substituted)-3-{[substituted]amino}quinazolin-4(3H)-one. Eur J Med Chem (2011) 0.89
Influence of multidrug resistance (MDR) proteins at the blood-brain barrier on the transport and brain distribution of enaminone anticonvulsants. J Pharm Sci (2001) 0.89
The effects of production and presentation level on the auditory distance perception of speech. J Acoust Soc Am (2001) 0.88
Profile of anticonvulsant activity and minimal toxicity of methyl 4-[(p-chlorophenyl)amino]-6-methyl-2-oxo-cyclohex-3-en-1-oate and some prototype antiepileptic drugs in mice and rats. Epilepsia (1994) 0.88
The role of P-glycoprotein in drug resistance in multiple myeloma. Leuk Lymphoma (2014) 0.88
A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage. Epilepsia (2011) 0.88
Synthesis and anticonvulsant activities of N-benzyl (2R)-2-acetamido-3-oxysubstituted propionamide derivatives. Bioorg Med Chem (2008) 0.87
Pharmacokinetic and pharmacodynamic basis for effective argatroban dosing in pediatrics. J Clin Pharmacol (2010) 0.87
GBR12909 possesses anticonvulsant activity in zebrafish and rodent models of generalized epilepsy but cardiac ion channel effects limit its clinical utility. Pharmacology (2007) 0.87
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells. Eur J Med Chem (2007) 0.87
Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities. J Med Chem (2010) 0.87
E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: a topographical study of some novel potent cytotoxins. Bioorg Med Chem (2007) 0.86
Trametinib, a first-in-class oral MEK inhibitor mass balance study with limited enrollment of two male subjects with advanced cancers. Xenobiotica (2013) 0.86
Synthesis of some oxime ether derivatives of 1-(2-naphthyl)-2-(1,2,4-triazol-1-yl)ethanone and their anticonvulsant and antimicrobial activities. Arch Pharm (Weinheim) (2006) 0.85
Synthesis and anticonvulsant activity of some substituted 1,2,4-thiadiazoles. Eur J Med Chem (2008) 0.85
Enhancing the permeation of marker compounds and enaminone anticonvulsants across Caco-2 monolayers by modulating tight junctions using zonula occludens toxin. Eur J Pharm Biopharm (2001) 0.84
Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds. Eur J Med Chem (2002) 0.84
N-Substituted amino acid N'-benzylamides: synthesis, anticonvulsant, and metabolic activities. Bioorg Med Chem (2004) 0.84
Enaminones 10. Molecular modeling aspects of the 5-methylcyclohexenone derivatives. Bioorg Med Chem (2009) 0.84
Enhanced permeability of molecular weight markers and poorly bioavailable compounds across Caco-2 cell monolayers using the absorption enhancer, zonula occludens toxin. Pharm Res (2002) 0.84
Functionalized amido ketones: new anticonvulsant agents. Bioorg Med Chem (2003) 0.83
Anticonvulsant activity of 2,4(1H)-diarylimidazoles in mice and rats acute seizure models. Bioorg Med Chem (2010) 0.83
Cytostatic activity of novel 4'-aminochalcone-based imides. Bioorg Med Chem Lett (2007) 0.82
Proteomic searches comparing two (R)-lacosamide affinity baits: An electrophilic arylisothiocyanate and a photoactivated arylazide group. Org Biomol Chem (2010) 0.82
Intravenous and subcutaneous weight-based dosing of the low molecular weight heparin tinzaparin (Innohep) in end-stage renal disease patients undergoing chronic hemodialysis. Am J Kidney Dis (2002) 0.82
Characterization of total plasma glycosaminoglycan levels in healthy volunteers following oral administration of a novel antithrombotic odiparcil with aspirin or enoxaparin. J Clin Pharmacol (2008) 0.82
Design and synthesis of semicarbazones and their bio-isosteric analogues as potent anticonvulsants: the role of hydrogen bonding. Acta Pharm (2003) 0.81
The PPARgamma agonist FMOC-L-leucine protects both mature and immature brain. Biomed Pharmacother (2007) 0.81
Anti-narcoleptic agent modafinil and its sulfone: a novel facile synthesis and potential anti-epileptic activity. Neurochem Res (2004) 0.81
An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine. Pharmacol Biochem Behav (2003) 0.81
Daptomycin pharmacokinetics and pharmacodynamics in a pooled sample of patients receiving thrice-weekly hemodialysis. Antimicrob Agents Chemother (2012) 0.81
Enaminones 8: CoMFA and CoMSIA studies on some anticonvulsant enaminones. Bioorg Med Chem (2008) 0.81
Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents. Bioorg Med Chem Lett (2009) 0.81
Design, synthesis, and development of novel caprolactam anticonvulsants. Bioorg Med Chem (2003) 0.81
Synthesis, anticonvulsant and antimicrobial activities of some new 2-acetylnaphthalene derivatives. Bioorg Med Chem (2010) 0.80
Synthesis and anticonvulsant activity of 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues. J Enzyme Inhib Med Chem (2012) 0.80
Design, synthesis and anticonvulsant evaluation of novel N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothio amides. Eur J Med Chem (2011) 0.80
Orbital infections in patients with human immunodeficiency virus infection. Ophthalmology (1996) 0.80
A new class of anticonvulsants possessing 6 Hz activity: 3,4-dialkyloxy thiophene bishydrazones. Eur J Med Chem (2009) 0.80
In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity. Pharmacol Biochem Behav (2008) 0.79
Psychomotor seizure test, neurotoxicity and in vitro neuroprotection assay of some semicarbazone analogues. Cent Nerv Syst Agents Med Chem (2013) 0.79
Potent mammalian cerebroprotection and neuronal cell death inhibition are afforded by a synthetic antioxidant analogue of marine invertebrate cell protectant ovothiols. Eur J Neurosci (2003) 0.79
Enaminones 12. An explanation of anticonvulsant activity and toxicity per Linus Pauling's clathrate hypothesis. Eur J Med Chem (2012) 0.79
Cytotoxic and anticonvulsant aryloxyaryl Mannich bases and related compounds. Eur J Med Chem (2004) 0.79
Preclinical evaluation of the pharmacokinetics, brain uptake and metabolism of E121, an antiepileptic enaminone ester, in rats. Biopharm Drug Dispos (2003) 0.79
Enaminones 11. An examination of some ethyl ester enaminone derivatives as anticonvulsant agents. Bioorg Med Chem (2013) 0.79
LC/MS determination of the enaminones E139, DM5 and DM27 in rat serum. J Pharm Biomed Anal (2002) 0.78
Multidrug resistance and anticonvulsants: new studies with some enaminones. Curr Med Chem (2004) 0.78
A base-catalyzed solution-phase parallel synthesis of substituted vinylic benzamides from 3-amino-2-cyclohexanones. J Comb Chem (2004) 0.78
Investigation into new anticonvulsant derivatives of alpha-substituted N-benzylamides of gamma-hydroxy- and gamma-acetoxybutyric acid. Part 5: search for new anticonvulsant compounds. Bioorg Med Chem (2004) 0.78
1,2-ethane bis-1-amino-4-benzamidine is active against several brain insult and seizure challenges through anti-NMDA mechanisms targeting the 3H-TCP binding site and antioxidant action. Eur J Med Chem (2010) 0.78
QSAR of the anticonvulsant enaminones; molecular modeling aspects and other assessments. Med Chem (2005) 0.78
Synthesis, characterization, and anticonvulsant activity of enaminones. Part 5: investigations on 3-carboalkoxy-2-methyl-2,3-dihydro-1H-phenothizin-4[10H]-one derivatives. Bioorg Med Chem (1998) 0.78
Modulation of sodium channel inactivation gating by a novel lactam: implications for seizure suppression in chronic limbic epilepsy. J Pharmacol Exp Ther (2008) 0.78
Enaminones 9. Further studies on the anticonvulsant activity and potential type IV phosphodiesterase inhibitory activity of substituted vinylic benzamides. Bioorg Med Chem (2005) 0.77
Synthesis and anticonvulsant activity of imidooxy derivatives. J Med Chem (1991) 0.77
Determination of endogenous glycosaminoglycans derived disaccharides in human plasma by HPLC: validation and application in a clinical study. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 0.77
Bone loss in the oestrogen-depleted rat is not exacerbated by sitagliptin, either alone or in combination with a thiazolidinedione. Diabetes Obes Metab (2013) 0.77