Published in Arch Pharm (Weinheim) on September 01, 2006
Synthesis of Two Novel 3-Amino-5-[4-chloro-2-phenoxyphenyl]-4H-1,2,4-triazoles with Anticonvulsant Activity. Iran J Pharm Res (2010) 1.02
Anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin derivatives. Eur J Pharm Sci (2002) 2.15
Synthesis and anticonvulsant activity of enaminones. 4. Investigations on isoxazole derivatives. Eur J Med Chem (2002) 1.63
Synthesis and antioxidant properties of novel N-methyl-1,3,4-thiadiazol-2-amine and 4-methyl-2H-1,2,4-triazole-3(4H)-thione derivatives of benzimidazole class. Bioorg Med Chem (2008) 1.35
Anticonvulsant activity of Schiff bases of isatin derivatives. Acta Pharm (2004) 1.27
1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti-inflammatory and antimicrobial activities. Bioorg Med Chem (2007) 1.22
Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds. Eur J Med Chem (2006) 1.21
The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones. Eur J Med Chem (2008) 1.20
Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. Epilepsy Res (2007) 1.20
Synthesis of isatin semicarbazones as novel anticonvulsants--role of hydrogen bonding. J Pharm Pharm Sci (2003) 1.18
Synthesis and structure-antituberculosis activity relationship of 1H-indole-2,3-dione derivatives. Bioorg Med Chem (2007) 1.17
Synthesis and antimicrobial activity of some 1,3,4-oxadiazole derivatives. Farmaco (2002) 1.16
Synthesis of some 3-(arylalkylthio)-4-alkyl/aryl-5-(4-aminophenyl)-4H-1,2,4-triazole derivatives and their anticonvulsant activity. Farmaco (2004) 1.15
Design, synthesis and evaluation of novel hydroxyamides as orally available anticonvulsants. Bioorg Med Chem (2004) 1.13
Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures. Nat Neurosci (2002) 1.12
Antibacterial activity of different generation dentin-bonding systems. Quintessence Int (2005) 1.08
Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies. Bioorg Med Chem (2009) 1.08
Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. J Med Chem (2009) 1.05
Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones. Eur J Med Chem (2003) 1.04
Development and characterization of novel derivatives of the antiepileptic drug lacosamide that exhibit far greater enhancement in slow inactivation of voltage-gated sodium channels. ACS Chem Neurosci (2011) 1.02
N-Aroyl-3,5-bis(benzylidene)-4-piperidones: a novel class of antimycobacterial agents. Bioorg Med Chem (2008) 1.00
Synthesis of new spiroindolinones incorporating a benzothiazole moiety as antioxidant agents. Eur J Med Chem (2009) 1.00
Cytotoxic 1,3-diarylidene-2-tetralones and related compounds. Eur J Med Chem (2002) 0.99
Activities of α-asarone in various animal seizure models and in biochemical assays might be essentially accounted for by antioxidant properties. Neurosci Res (2010) 0.99
Application of predictive QSAR models to database mining: identification and experimental validation of novel anticonvulsant compounds. J Med Chem (2004) 0.96
Prevalence of antimicrobial resistance in Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis and Streptococcus pyogenes: results of a multicentre study in Turkey. Int J Antimicrob Agents (2002) 0.96
Design & synthesis of N'-[substituted] pyridine-4-carbohydrazides as potential anticonvulsant agents. Eur J Med Chem (2010) 0.95
Design and evaluation of affinity labels of functionalized amino acid anticonvulsants. J Med Chem (2002) 0.93
Antiepileptic popular ketogenic diet: emerging twists in an ancient story. Prog Neurobiol (2005) 0.93
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia (2008) 0.92
Synthesis and evaluation of anticonvulsant and antimicrobial activities of 3-hydroxy-6-methyl-2-substituted 4h-pyran-4-one derivatives. Arch Pharm (Weinheim) (2004) 0.92
Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides. J Med Chem (2010) 0.91
Histone deacetylase inhibition activity and molecular docking of (e )-resveratrol: its therapeutic potential in spinal muscular atrophy. Chem Biol Drug Des (2009) 0.90
Correlations between cytotoxicity and topography of some 2-arylidenebenzocycloalkanones determined by X-ray crystallography. J Med Chem (2002) 0.90
Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors. J Med Chem (2009) 0.89
Design, synthesis and potential 6 Hz psychomotor seizure test activity of some novel 2-(substituted)-3-{[substituted]amino}quinazolin-4(3H)-one. Eur J Med Chem (2011) 0.89
Direct formation of nanospheres from amphiphilic beta-cyclodextrin inclusion complexes. Pharm Res (2003) 0.89
Synthesis and antimicrobial evaluation of some new substituted purine derivatives. Bioorg Med Chem (2008) 0.88
A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage. Epilepsia (2011) 0.88
Synthesis and anticonvulsant activities of N-benzyl (2R)-2-acetamido-3-oxysubstituted propionamide derivatives. Bioorg Med Chem (2008) 0.87
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells. Eur J Med Chem (2007) 0.87
GBR12909 possesses anticonvulsant activity in zebrafish and rodent models of generalized epilepsy but cardiac ion channel effects limit its clinical utility. Pharmacology (2007) 0.87
Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities. J Med Chem (2010) 0.87
E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: a topographical study of some novel potent cytotoxins. Bioorg Med Chem (2007) 0.86
Synthesis and anticonvulsant activity of some substituted 1,2,4-thiadiazoles. Eur J Med Chem (2008) 0.85
N-Substituted amino acid N'-benzylamides: synthesis, anticonvulsant, and metabolic activities. Bioorg Med Chem (2004) 0.84
Carboxylic acid derivatives of histone deacetylase inhibitors induce full length SMN2 transcripts: a promising target for spinal muscular atrophy therapeutics. Arch Med Sci (2011) 0.84
Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds. Eur J Med Chem (2002) 0.84
Anticonvulsant activity of 2,4(1H)-diarylimidazoles in mice and rats acute seizure models. Bioorg Med Chem (2010) 0.83
Functionalized amido ketones: new anticonvulsant agents. Bioorg Med Chem (2003) 0.83
Cytostatic activity of novel 4'-aminochalcone-based imides. Bioorg Med Chem Lett (2007) 0.82
Proteomic searches comparing two (R)-lacosamide affinity baits: An electrophilic arylisothiocyanate and a photoactivated arylazide group. Org Biomol Chem (2010) 0.82
Synthesis of 3-(4-substituted benzoylmethyl)-2-benzoxazolinones and screening antimicrobial activities. Farmaco (2002) 0.82
Design and synthesis of semicarbazones and their bio-isosteric analogues as potent anticonvulsants: the role of hydrogen bonding. Acta Pharm (2003) 0.81
Design, synthesis, and development of novel caprolactam anticonvulsants. Bioorg Med Chem (2003) 0.81
Anti-narcoleptic agent modafinil and its sulfone: a novel facile synthesis and potential anti-epileptic activity. Neurochem Res (2004) 0.81
An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine. Pharmacol Biochem Behav (2003) 0.81
Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents. Bioorg Med Chem Lett (2009) 0.81
Comparison of the antibacterial activity of different self-etching primers and adhesives. J Contemp Dent Pract (2008) 0.81
The PPARgamma agonist FMOC-L-leucine protects both mature and immature brain. Biomed Pharmacother (2007) 0.81
Synthesis, anticonvulsant and antimicrobial activities of some new 2-acetylnaphthalene derivatives. Bioorg Med Chem (2010) 0.80
Synthesis and anticonvulsant activity of 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues. J Enzyme Inhib Med Chem (2012) 0.80
Design, synthesis and anticonvulsant evaluation of novel N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothio amides. Eur J Med Chem (2011) 0.80
A new class of anticonvulsants possessing 6 Hz activity: 3,4-dialkyloxy thiophene bishydrazones. Eur J Med Chem (2009) 0.80
Enaminones 12. An explanation of anticonvulsant activity and toxicity per Linus Pauling's clathrate hypothesis. Eur J Med Chem (2012) 0.79
Psychomotor seizure test, neurotoxicity and in vitro neuroprotection assay of some semicarbazone analogues. Cent Nerv Syst Agents Med Chem (2013) 0.79
Cytotoxic and anticonvulsant aryloxyaryl Mannich bases and related compounds. Eur J Med Chem (2004) 0.79
In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity. Pharmacol Biochem Behav (2008) 0.79
Potent mammalian cerebroprotection and neuronal cell death inhibition are afforded by a synthetic antioxidant analogue of marine invertebrate cell protectant ovothiols. Eur J Neurosci (2003) 0.79
1,2-ethane bis-1-amino-4-benzamidine is active against several brain insult and seizure challenges through anti-NMDA mechanisms targeting the 3H-TCP binding site and antioxidant action. Eur J Med Chem (2010) 0.78
Modulation of sodium channel inactivation gating by a novel lactam: implications for seizure suppression in chronic limbic epilepsy. J Pharmacol Exp Ther (2008) 0.78
Investigation into new anticonvulsant derivatives of alpha-substituted N-benzylamides of gamma-hydroxy- and gamma-acetoxybutyric acid. Part 5: search for new anticonvulsant compounds. Bioorg Med Chem (2004) 0.78
Gamma-irradiated liposome/noisome and lipogelosome/niogelosome formulations for the treatment of rheumatoid arthritis. Interv Med Appl Sci (2013) 0.77
Mechanisms of action of CHF3381 in the forebrain. Br J Pharmacol (2003) 0.77
Defining the structural parameters that confer anticonvulsant activity by the site-by-site modification of (R)-N'-benzyl 2-amino-3-methylbutanamide. J Med Chem (2011) 0.77
POMA analyses as new efficient bioinformatics' platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues. Bioorg Med Chem Lett (2012) 0.77
The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide. J Med Chem (2010) 0.76
Amido-3-hydroxypyridin-4-ones as iron(III) ligands. Chemistry (2010) 0.76
Search for anticonvulsant and analgesic active derivatives of dihydrofuran-2(3H)-one. Bioorg Med Chem (2012) 0.76
Novel chlorhexidine releasing system developed from thermosensitive vinyl ether-based hydrogels. J Biomed Mater Res B Appl Biomater (2007) 0.76
An investigation of the bactericidal effect of certain antiseptics and disinfectants on some hospital isolates of gram-negative bacteria. Infect Control Hosp Epidemiol (2003) 0.75
Cytotoxic 2-benzylidene-6-(nitrobenzylidene)cyclohexanones which display substantially greater toxicity for neoplasms than non-malignant cells. Bioorg Med Chem (2010) 0.75
The effects of gamma irradiation on diclofenac sodium, liposome and niosome ingredients for rheumatoid arthritis. Interv Med Appl Sci (2013) 0.75
Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore. Bioorg Med Chem Lett (2010) 0.75
1,3-diaryl-2-propenones and 2-benzylidene-1,3-indandiones: a quest for compounds displaying greater toxicity to neoplasms than normal cells. Arch Pharm (Weinheim) (2010) 0.75
Synthesis, antioxidant and radical scavenging activities of novel benzimidazoles. J Enzyme Inhib Med Chem (2005) 0.75
Synthesis of some novel 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime ester derivatives and evaluation of their anticonvulsant activity. Eur J Med Chem (2012) 0.75
Anticonvulsant activity of benzylamides of some amino acids and heterocyclic acids. Protein Pept Lett (2003) 0.75
Synthesis and research of benzylamides of some isocyclic and heterocyclic acids as potential anticonvulsants. Acta Pol Pharm (2013) 0.75
Crystal structure of 2,3-diaza-1,3-diphenylpropene. Anal Sci (2003) 0.75
The two-dimensional coordination polymer poly[[bis(3-methylpyridine)cadmium(II)]-tetra-mu-cyano-nickel(II)]. Acta Crystallogr C (2005) 0.75
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity. Bioorg Med Chem Lett (2009) 0.75
Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones. Eur J Med Chem (2002) 0.75
Anticonvulsant and sedative-hypnotic activities of N-substituted isatin semicarbazones. Arch Pharm (Weinheim) (2002) 0.75
Synthesis and anticonvulsant activity of some new bishydrazones derived from 3,4-dipropyloxythiophene. Eur J Med Chem (2009) 0.75
Synthesis and anticonvulsant activities of 4-N-substituted arylsemicarbazones. Pol J Pharmacol (2003) 0.75
Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds. Eur J Med Chem (2002) 0.75