Published in J Biol Chem on February 26, 2003
A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet (2005) 2.85
FSH signaling pathways in immature granulosa cells that regulate target gene expression: branching out from protein kinase A. Cell Signal (2006) 2.12
Molecular mechanisms of neutrophil dysfunction in glycogen storage disease type Ib. Blood (2014) 1.52
Cobalt Chloride Upregulates Impaired HIF-1α Expression to Restore Sevoflurane Post-conditioning-Dependent Myocardial Protection in Diabetic Rats. Front Physiol (2017) 1.39
Transcription activator-like effector hybrids for conditional control and rewiring of chromosomal transgene expression. Sci Rep (2012) 1.37
Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do! Ann Rheum Dis (2005) 1.35
A versatile valve-enabled microfluidic cell co-culture platform and demonstration of its applications to neurobiology and cancer biology. Biomed Microdevices (2011) 1.27
STAT3 negatively regulates thyroid tumorigenesis. Proc Natl Acad Sci U S A (2012) 1.23
Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress. Neurochem Res (2007) 1.22
Copper regulation of hypoxia-inducible factor-1 activity. Mol Pharmacol (2008) 1.12
Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene (2014) 1.09
Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxia-inducible factor-1α transcription factor and its target genes in mice. Antioxid Redox Signal (2011) 1.08
Role of oxygen availability in CFTR expression and function. Am J Respir Cell Mol Biol (2008) 1.05
Functional role of gangliotetraosylceramide in epithelial-to-mesenchymal transition process induced by hypoxia and by TGF-{beta}. FASEB J (2010) 1.05
Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. PLoS One (2011) 1.05
Hypoxia inducible factor 1 (HIF-1) and cardioprotection. Acta Pharmacol Sin (2010) 1.04
The importance of the stem cell marker prominin-1/CD133 in the uptake of transferrin and in iron metabolism in human colon cancer Caco-2 cells. PLoS One (2011) 1.02
Signaling by hypoxia-inducible factors is critical for ovulation in mice. Endocrinology (2009) 1.02
The hypoxic testicle: physiology and pathophysiology. Oxid Med Cell Longev (2012) 1.01
Transcription and splicing regulation in human umbilical vein endothelial cells under hypoxic stress conditions by exon array. BMC Genomics (2009) 0.97
Deferroxamine preconditioning promotes long-lasting retinal ischemic tolerance. J Ocul Pharmacol Ther (2008) 0.96
The induction of HIF-1 reduces astrocyte activation by amyloid beta peptide. Eur J Neurosci (2009) 0.94
Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes. Toxicol Appl Pharmacol (2006) 0.93
Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes. BMC Genomics (2010) 0.93
Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway. J Neurochem (2012) 0.90
The anti-angiogenic factor PEDF is present in the human heart and is regulated by anoxia in cardiac myocytes and fibroblasts. J Cell Mol Med (2010) 0.90
Stem cells, redox signaling, and stem cell aging. Antioxid Redox Signal (2014) 0.89
Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells. BMC Complement Altern Med (2012) 0.89
Regression of pathological cardiac hypertrophy: signaling pathways and therapeutic targets. Pharmacol Ther (2012) 0.88
Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha. J Biol Chem (2008) 0.87
Inhibition of oxygen-induced hypoxia-inducible factor-1alpha degradation unmasks estradiol induction of vascular endothelial growth factor expression in ECC-1 cancer cells in vitro. Endocrinology (2009) 0.86
Analysis of hypoxia and hypoxia-like states through metabolite profiling. PLoS One (2011) 0.86
Hypoxia-inducible factor-1alpha suppresses the expression of macrophage scavenger receptor 1. Pflugers Arch (2009) 0.85
Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2α. Mol Vis (2012) 0.85
Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia. J Biol Chem (2013) 0.85
Hypoxia-inducible factor 2 alpha is essential for hepatic outgrowth and functions via the regulation of leg1 transcription in the zebrafish embryo. PLoS One (2014) 0.85
Preferential transcription of rabbit Aldh1a1 in the cornea: implication of hypoxia-related pathways. Mol Cell Biol (2004) 0.84
Upregulated copper transporters in hypoxia-induced pulmonary hypertension. PLoS One (2014) 0.84
Hypoxia and PGE(2) regulate MiTF-CX during cervical ripening. Mol Endocrinol (2012) 0.83
Galectin-3 up-regulation in hypoxic and nutrient deprived microenvironments promotes cell survival. PLoS One (2014) 0.82
Levels of aqueous humor trace elements in patients with non-exsudative age-related macular degeneration: a case-control study. PLoS One (2013) 0.82
HIF-1α inhibition reduces nasal inflammation in a murine allergic rhinitis model. PLoS One (2012) 0.82
NEU3 sialidase is activated under hypoxia and protects skeletal muscle cells from apoptosis through the activation of the epidermal growth factor receptor signaling pathway and the hypoxia-inducible factor (HIF)-1α. J Biol Chem (2012) 0.82
Hypoxia-induced retinal neovascularization in zebrafish embryos: a potential model of retinopathy of prematurity. PLoS One (2015) 0.81
The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines. PLoS One (2014) 0.81
The effects of CoCl2 on HIF-1α protein under experimental conditions of autoprogressive hypoxia using mouse models. Int J Mol Sci (2014) 0.81
Distinct regulatory mechanisms of the human ferritin gene by hypoxia and hypoxia mimetic cobalt chloride at the transcriptional and post-transcriptional levels. Cell Signal (2014) 0.81
A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level. EMBO J (2015) 0.80
In vitro expansion of human glioblastoma cells at non-physiological oxygen tension irreversibly alters subsequent in vivo aggressiveness and AC133 expression. Int J Oncol (2011) 0.80
Hypoxia-inducible factor-1α (HIF-1α) protein diminishes sodium glucose transport 1 (SGLT1) and SGLT2 protein expression in renal epithelial tubular cells (LLC-PK1) under hypoxia. J Biol Chem (2013) 0.80
RhoC GTPase Is a Potent Regulator of Glutamine Metabolism and N-Acetylaspartate Production in Inflammatory Breast Cancer Cells. J Biol Chem (2016) 0.80
Manganese-mediated acceleration of age-related hearing loss in mice. Sci Rep (2016) 0.79
Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway. Bioorg Med Chem Lett (2011) 0.79
Treatment of mouse limb ischemia with an integrative hypoxia-responsive vector expressing the vascular endothelial growth factor gene. PLoS One (2012) 0.79
Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer. Breast Cancer Res (2014) 0.79
Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer. PLoS Comput Biol (2015) 0.79
Development of a novel neuroprotective strategy: combined treatment with hypothermia and valproic acid improves survival in hypoxic hippocampal cells. Surgery (2014) 0.79
The hypoxia-mimetic agent CoCl2 induces chemotherapy resistance in LOVO colorectal cancer cells. Mol Med Rep (2016) 0.79
The effect of 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) on cell viability under hypoxia. Mol Vis (2013) 0.79
Effects of CoCl2 on multi-lineage differentiation of C3H/10T1/2 mesenchymal stem cells. Korean J Physiol Pharmacol (2015) 0.78
A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein. Nucleic Acids Res (2007) 0.78
Iron, hepcidin, and the metal connection. Front Pharmacol (2014) 0.78
Methods to study the tumor microenvironment under controlled oxygen conditions. Trends Biotechnol (2014) 0.78
A breath of fresh air for diabetic nephropathy. J Am Soc Nephrol (2014) 0.78
Hypoxia-inducible factor-1α and Wnt/β-catenin signaling pathways promote the invasion of hypoxic gastric cancer cells. Mol Med Rep (2015) 0.77
Mechanisms of Hypoxic Up-Regulation of Versican Gene Expression in Macrophages. PLoS One (2015) 0.77
Attenuation of choroidal neovascularization by histone deacetylase inhibitor. PLoS One (2015) 0.77
Chylomicron-bound LPS selectively inhibits the hepatocellular response to proinflammatory cytokines. J Surg Res (2007) 0.77
Development path and current status of the NANIVID: a new device for cancer cell studies. J Micro Nanolithogr MEMS MOEMS (2012) 0.76
Artemin is hypoxia responsive and promotes oncogenicity and increased tumor initiating capacity in hepatocellular carcinoma. Oncotarget (2016) 0.76
Stabilization of hypoxia-inducible factor-1α in buffer containing cobalt chloride for Western blot analysis. Anal Biochem (2011) 0.76
Driving the Hypoxia-Inducible Pathway in Human Pericytes Promotes Vascular Density in an Exosome-Dependent Manner. Microcirculation (2015) 0.76
The endoplasmic reticulum stress and the HIF-1 signalling pathways are involved in the neuronal damage caused by chemical hypoxia. Br J Pharmacol (2015) 0.76
Hypoxia inducible factor-stabilizing bioactive glasses for directing mesenchymal stem cell behavior. Tissue Eng Part A (2014) 0.76
Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts. Mediators Inflamm (2015) 0.76
Role of reactive oxygen species in the neural and hormonal regulation of the PNMT gene in PC12 cells. Oxid Med Cell Longev (2011) 0.75
Control of the heart rate of rat embryos during the organogenic period. Hypoxia (Auckl) (2016) 0.75
High homocysteine levels prevent via H2 S the CoCl2 -induced alteration of lymphocyte viability. J Cell Mol Med (2016) 0.75
Analysis of a Nitroreductase-Based Hypoxia Sensor in Primary Neuronal Cultures. ACS Chem Neurosci (2016) 0.75
Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells. Oncotarget (2016) 0.75
Retinal Cell Degeneration in Animal Models. Int J Mol Sci (2016) 0.75
Amplified centrosomes and mitotic index display poor concordance between patient tumors and cultured cancer cells. Sci Rep (2017) 0.75
Subchronic inhalation of soluble manganese induces expression of hypoxia-associated angiogenic genes in adult mouse lungs. Toxicol Appl Pharmacol (2007) 0.75
CD133 Modulate HIF-1α Expression under Hypoxia in EMT Phenotype Pancreatic Cancer Stem-Like Cells. Int J Mol Sci (2016) 0.75
Hypoxia-Inducible Factor-1α Mediates Increased Sympathoexcitation via Glutamatergic N-Methyl-d-Aspartate Receptors in the Paraventricular Nucleus of Rats With Chronic Heart Failure. Circ Heart Fail (2016) 0.75
Radioprotective effect on HepG2 cells of low concentrations of cobalt chloride: induction of hypoxia-inducible factor-1 alpha and clearance of reactive oxygen species. J Radiat Res (2012) 0.75
Ornithine Aminotransferase, an Important Glutamate-Metabolizing Enzyme at the Crossroads of Multiple Metabolic Pathways. Biology (Basel) (2017) 0.75
Hypoxia-inducible factor 1 mediates hypoxia-enhanced synthesis of progesterone during luteinization of granulosa cells. J Reprod Dev (2016) 0.75
Effects of Ranibizumab and Aflibercept on Human Müller Cells and Photoreceptors under Stress Conditions. Int J Mol Sci (2017) 0.75
Oxygen Availability for Porphyrin Biosynthesis Enzymes Determines the Production of Protoporphyrin IX (PpIX) during Hypoxia. PLoS One (2015) 0.75
Mechanism Governing Human Kappa-Opioid Receptor Expression under Desferrioxamine-Induced Hypoxic Mimic Condition in Neuronal NMB Cells. Int J Mol Sci (2017) 0.75
Human activated macrophages and hypoxia: a comprehensive review of the literature. Iran J Basic Med Sci (2014) 0.75
Molecular Mechanism Underlying the Action of Substituted Pro-Gly Dipeptide Noopept. Acta Naturae (2016) 0.75
Induction of hypoxia-inducible factor-1α inhibits drug-induced apoptosis in the human leukemic cell line HL-60. Korean J Hematol (2010) 0.75
Identification of Iron Homeostasis Genes Dysregulation Potentially Involved in Retinopathy of Prematurity Pathogenicity by Microarray Analysis. J Ophthalmol (2015) 0.75
HIF Stabilization Weakens Primary Cilia. PLoS One (2016) 0.75
Effects of Cobalt Chloride, a Hypoxia-Mimetic Agent, on Autophagy and Atrophy in Skeletal C2C12 Myotubes. Biomed Res Int (2017) 0.75
Hypoxia triggers IFN-I production in muscle: Implications in dermatomyositis. Sci Rep (2017) 0.75
Bcl-2/adenovirus E1B 19 kDa interacting protein-3 knockdown enables growth of breast cancer metastases in the lung, liver, and bone. Cancer Res (2005) 1.30
In vivo evidence for interferon-gamma-mediated homeostatic mechanisms in small intestine of the NHE3 Na+/H+ exchanger knockout model of congenital diarrhea. J Biol Chem (2002) 1.04
The role of calcium in hypoxia-induced signal transduction and gene expression. Cell Calcium (2004) 0.99
Functional importance of the carboxyl-terminal region of striated muscle tropomyosin. J Biol Chem (2003) 0.96
Drosophila Ube3a regulates monoamine synthesis by increasing GTP cyclohydrolase I activity via a non-ubiquitin ligase mechanism. Neurobiol Dis (2010) 0.88
Functional genomics approach to hypoxia signaling. J Appl Physiol (1985) (2004) 0.88
Microsomal prostaglandin E2 synthase-1 is induced by conditional expression of RET/PTC in thyroid PCCL3 cells through the activation of the MEK-ERK pathway. J Biol Chem (2003) 0.85
A potential molecular link between aerobic glycolysis and cancer. Cell Cycle (2006) 0.83
Calcium-dependent activation of Pyk2 by hypoxia. Cell Signal (2002) 0.79
Genomic and physiological analysis of oxygen sensitivity and hypoxia tolerance in PC12 cells. Ann N Y Acad Sci (2002) 0.79
Oxygen sensing in neuroendocrine cells and other cell types: pheochromocytoma (PC12) cells as an experimental model. Endocr Pathol (2003) 0.79
Discovery of oxygen-responsive genes in pheochromocytoma cells. Methods Enzymol (2004) 0.78
Novel role for cyclin-dependent kinase 2 in neuregulin-induced acetylcholine receptor epsilon subunit expression in differentiated myotubes. J Biol Chem (2005) 0.77
Down-regulation of interleukin 7 mRNA by hypoxia is calcium dependent. Neurol Res (2008) 0.75