Published in Endocrinology on April 01, 2003
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. Proc Natl Acad Sci U S A (2005) 1.88
Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. Diabetes (2008) 1.85
Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells. Diabetes (2010) 1.80
Changes in microRNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD mice. Diabetes (2012) 1.32
Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2. Biochem J (2005) 1.21
MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity. J Clin Invest (2012) 1.17
Rfx6 maintains the functional identity of adult pancreatic β cells. Cell Rep (2014) 1.05
Concise review: in search of unlimited sources of functional human pancreatic beta cells. Stem Cells Transl Med (2012) 0.97
HDLs protect pancreatic β-cells against ER stress by restoring protein folding and trafficking. Diabetes (2012) 0.93
Microencapsulation of islets within alginate/poly(ethylene glycol) gels cross-linked via Staudinger ligation. Acta Biomater (2010) 0.92
Transcriptional response of pancreatic beta cells to metabolic stimulation: large scale identification of immediate-early and secondary response genes. BMC Mol Biol (2007) 0.92
Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival. Endocrinology (2010) 0.91
Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion. J Biol Chem (2011) 0.89
Mechanisms of transcriptional regulation underlying temporal integration of signals. Nucleic Acids Res (2006) 0.88
Regulation of insulin secretion by phosphatidylinositol-4,5-bisphosphate. Traffic (2010) 0.88
Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells. Cell Commun Signal (2015) 0.86
High passage MIN6 cells have impaired insulin secretion with impaired glucose and lipid oxidation. PLoS One (2012) 0.85
The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner. Endocrinology (2009) 0.85
The GTPase Rab37 Participates in the Control of Insulin Exocytosis. PLoS One (2013) 0.85
Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets. J Cell Mol Med (2015) 0.84
Hepatitis C virus induced a novel apoptosis-like death of pancreatic beta cells through a caspase 3-dependent pathway. PLoS One (2012) 0.84
Microarray analysis of novel candidate genes responsible for glucose-stimulated insulin secretion in mouse pancreatic β cell line MIN6. PLoS One (2013) 0.83
The class I histone deacetylase inhibitor MS-275 prevents pancreatic beta cell death induced by palmitate. J Diabetes Res (2014) 0.82
The GTPase RalA regulates different steps of the secretory process in pancreatic beta-cells. PLoS One (2009) 0.81
Analysis of synaptic-like microvesicle exocytosis of B-cells using a live imaging technique. PLoS One (2014) 0.81
Reduction of connexin36 content by ICER-1 contributes to insulin-secreting cells apoptosis induced by oxidized LDL particles. PLoS One (2013) 0.80
Clic4, a novel protein that sensitizes β-cells to apoptosis. Mol Metab (2015) 0.80
Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells. Am J Physiol Regul Integr Comp Physiol (2015) 0.79
Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells. Cell Mol Life Sci (2011) 0.79
Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice. Diabetes (2013) 0.78
Functional Analysis of Novel Candidate Regulators of Insulin Secretion in the MIN6 Mouse Pancreatic β Cell Line. PLoS One (2016) 0.78
Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic β-cells and disrupts glucose homeostasis. Endocrinology (2014) 0.77
Label-free detection of insulin and glucagon within human islets of Langerhans using Raman spectroscopy. PLoS One (2013) 0.77
Cholecystokinin expression in the β-cell leads to increased β-cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis. Am J Physiol Endocrinol Metab (2015) 0.76
Covalent layer-by-layer assembly of hyperbranched polymers on alginate microcapsulesto impart stability and permselectivity. J Mater Chem B Mater Biol Med (2014) 0.75
Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity. J Diabetes Res (2015) 0.75
The neuronal K(+)Cl(-) co-transporter 2 (Slc12a5) modulates insulin secretion. Sci Rep (2017) 0.75
A low-protein diet during pregnancy prevents modifications in intercellular communication proteins in rat islets. Biol Res (2015) 0.75
Aldosterone induces clonal β-cell failure through glucocorticoid receptor. Sci Rep (2015) 0.75
Involvement of heparan sulfate 3-O-sulfotransferase isoform-1 in the insulin secretion pathway. J Diabetes Investig (2012) 0.75
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest (2002) 5.52
Insulin gene mutations as a cause of permanent neonatal diabetes. Proc Natl Acad Sci U S A (2007) 3.77
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med (2011) 3.31
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem (2002) 3.08
How insulin engages its primary binding site on the insulin receptor. Nature (2013) 2.52
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc Natl Acad Sci U S A (2002) 2.19
Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes. Diabetes (2008) 2.15
Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse. Diabetes (2003) 2.05
Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation. J Clin Endocrinol Metab (2008) 1.91
Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3. Proc Natl Acad Sci U S A (2002) 1.73
FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication. Proc Natl Acad Sci U S A (2002) 1.72
Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex. Mol Endocrinol (2003) 1.65
Regulation of pancreatic beta-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway. J Cell Sci (2006) 1.65
Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice. Diabetes (2007) 1.64
Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets. Proc Natl Acad Sci U S A (2004) 1.60
Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome. Genome Res (2013) 1.58
Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proc Natl Acad Sci U S A (2008) 1.52
Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat. Diabetes (2006) 1.49
Cytokine production by islets in health and diabetes: cellular origin, regulation and function. Trends Endocrinol Metab (2010) 1.46
Glucagon replacement via micro-osmotic pump corrects hypoglycemia and alpha-cell hyperplasia in prohormone convertase 2 knockout mice. Diabetes (2002) 1.42
Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists. Proc Natl Acad Sci U S A (2010) 1.36
Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132: interaction between AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3. Endocrinology (2005) 1.31
Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes (2004) 1.31
On the processing of proghrelin to ghrelin. J Biol Chem (2006) 1.27
No mantle formation in rodent islets -- the prototype of islet revisited. Diabetes Res Clin Pract (2009) 1.22
Blockade of beta1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix. Diabetes (2006) 1.22
Mg(2+)-dependent gating of bacterial MgtE channel underlies Mg(2+) homeostasis. EMBO J (2009) 1.20
Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14. Diabetes (2007) 1.20
Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of ß-cell regeneration. Islets (2010) 1.19
The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study. J Neurochem (2006) 1.19
Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle. Diabetes (2011) 1.18
Activation of NF-kappaB by extracellular matrix is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells. J Biol Chem (2005) 1.17
Differential expression of E-cadherin at the surface of rat beta-cells as a marker of functional heterogeneity. J Endocrinol (2007) 1.16
Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics. J Neurochem (2010) 1.15
Sorting ourselves out: seeking consensus on trafficking in the beta-cell. Traffic (2004) 1.14
Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion. Proc Natl Acad Sci U S A (2004) 1.14
Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion. J Biol Chem (2009) 1.13
Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death. Diabetes (2006) 1.12
Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted. Biochem Biophys Res Commun (2009) 1.11
Neuropeptide processing profile in mice lacking prohormone convertase-1. Biochemistry (2005) 1.09
Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion. Endocrinology (2008) 1.09
Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene. Rev Endocr Metab Disord (2010) 1.08
The Fas pathway is involved in pancreatic beta cell secretory function. Proc Natl Acad Sci U S A (2007) 1.08
Munc 18-1 and granuphilin collaborate during insulin granule exocytosis. Traffic (2008) 1.06
Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis. J Neurochem (2009) 1.04
Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells. Diabetes (2008) 1.04
Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin. Diabetes (2011) 1.03
Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors. FASEB J (2006) 1.02
Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival. Proc Natl Acad Sci U S A (2006) 1.01
In vitro proliferation of adult human beta-cells. PLoS One (2012) 0.99
Insulin secretion: movement at all levels. Diabetes (2002) 0.99
Regulation of proglucagon transcription by activated transcription factor (ATF) 3 and a novel isoform, ATF3b, through the cAMP-response element/ATF site of the proglucagon gene promoter. J Biol Chem (2003) 0.98
Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3. J Biol Chem (2003) 0.98
Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide. Diabetes (2004) 0.97
Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells. Endocrinology (2007) 0.97
Dynamin is functionally coupled to insulin granule exocytosis. J Biol Chem (2007) 0.96
Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat. PLoS One (2009) 0.96
Contrasting patterns of expression of transcription factors in pancreatic alpha and beta cells. Proc Natl Acad Sci U S A (2003) 0.95
Signaling pathways implicated in the stimulation of beta-cell proliferation by extracellular matrix. Mol Endocrinol (2009) 0.94
Pancreatic beta-cell mass or beta-cell function? That is the question! Diabetes Obes Metab (2008) 0.93
The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice. J Biol Chem (2007) 0.93
Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture. Diabetes (2008) 0.93
Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function. Endocrinology (2008) 0.92
Complementation analysis demonstrates that insulin cross-links both alpha subunits in a truncated insulin receptor dimer. J Biol Chem (2007) 0.90
Strain-dependent influences on the hypothalamo-pituitary-adrenal axis profoundly affect the 7B2 and PC2 null phenotypes. Endocrinology (2005) 0.90
Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion. J Biol Chem (2011) 0.89
Pro-survival role of gelsolin in mouse beta-cells. Diabetes (2007) 0.89
Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1. Endocrinology (2003) 0.89
Regulation of insulin secretion by phosphatidylinositol-4,5-bisphosphate. Traffic (2010) 0.88
Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion. J Biol Chem (2012) 0.88
DIAMAP: a road map for diabetes research in Europe. J Diabetes Sci Technol (2011) 0.87
Economic evaluation of HIV screening in pregnant women attending antenatal clinics in India. Health Policy (2005) 0.87
Altered proglucagon processing in an alpha-cell line derived from prohormone convertase 2 null mouse islets. J Biol Chem (2004) 0.87
Molecular and functional characterization of a new X-linked chronic granulomatous disease variant (X91+) case with a double missense mutation in the cytosolic gp91phox C-terminal tail. Biochim Biophys Acta (2002) 0.86
Identification of genetic loci involved in diabetes using a rat model of depression. Mamm Genome (2009) 0.86
Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor. J Biol Chem (2006) 0.86
Nestin expression in pancreatic endocrine and exocrine cells of mice lacking glucagon signaling. Dev Dyn (2007) 0.86
Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1). Proc Natl Acad Sci U S A (2003) 0.85
Autoimmunity against INS-IGF2 protein expressed in human pancreatic islets. J Biol Chem (2013) 0.83
The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6. Endocrinology (2007) 0.82
Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin. Genetics (2013) 0.82
GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1). Islets (2011) 0.82
Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon. Endocrinology (2004) 0.81
Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry. J Mol Endocrinol (2005) 0.81
Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone. Endocrinology (2003) 0.81
Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains. J Cereb Blood Flow Metab (2009) 0.81