Published in Traffic on January 01, 2004
A cleavable propeptide influences Toxoplasma infection by facilitating the trafficking and secretion of the TgMIC2-M2AP invasion complex. Mol Biol Cell (2006) 1.49
Microneme proteins in apicomplexans. Subcell Biochem (2008) 1.40
Insulin granule biogenesis, trafficking and exocytosis. Vitam Horm (2009) 1.32
PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. PLoS Biol (2013) 1.31
A revised model for the secretion of tPA and cytokines from cultured endothelial cells. Blood (2010) 1.14
Differential sorting of human parathyroid hormone after transduction of mouse and rat salivary glands. Hum Gene Ther (2008) 1.04
Protease nexin-1 promotes secretory granule biogenesis by preventing granule protein degradation. Mol Biol Cell (2005) 0.98
Lumenal protein sorting to the constitutive secretory pathway of a regulated secretory cell. J Cell Sci (2006) 0.90
Sorting behavior of a transgenic erythropoietin-growth hormone fusion protein in murine salivary glands. Hum Gene Ther (2008) 0.89
Forward targeting of Toxoplasma gondii proproteins to the micronemes involves conserved aliphatic amino acids. Traffic (2011) 0.87
Tumor protein D52 controls trafficking of an apical endolysosomal secretory pathway in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol (2013) 0.87
Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells. Proc Natl Acad Sci U S A (2015) 0.86
Sorting of growth hormone-erythropoietin fusion proteins in rat salivary glands. Biochem Biophys Res Commun (2008) 0.84
Cholesterol accumulation increases insulin granule size and impairs membrane trafficking. Traffic (2012) 0.83
SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells. J Clin Invest (2014) 0.82
Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3. PLoS Genet (2013) 0.80
Preparing for an invasion: charting the pathway of adhesion proteins to Toxoplasma micronemes. Parasitol Res (2005) 0.78
Sox17 regulates insulin secretion in the normal and pathologic mouse β cell. PLoS One (2014) 0.77
The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse. Immunol Rev (2016) 0.75
Transient fusion and selective secretion of vesicle proteins in Phytophthora nicotianae zoospores. PeerJ (2013) 0.75
Macrophages and dendritic cells in islets of Langerhans in diabetic autoimmunity: a lesson on cell interactions in a mini-organ. Curr Opin Immunol (2016) 0.75
Antigen presentation events during the initiation of autoimmune diabetes in the NOD mouse. J Autoimmun (2016) 0.75
HID-1 is required for homotypic fusion of immature secretory granules during maturation. Elife (2016) 0.75
The Dense-Core Vesicle Maturation Protein CCCP-1 Binds RAB-2 and Membranes through its C-terminal Domain. Traffic (2017) 0.75
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest (2002) 5.52
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med (2011) 3.31
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem (2002) 3.08
Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse. Diabetes (2003) 2.05
Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation. J Clin Endocrinol Metab (2008) 1.91
FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication. Proc Natl Acad Sci U S A (2002) 1.72
Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex. Mol Endocrinol (2003) 1.65
Regulation of pancreatic beta-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway. J Cell Sci (2006) 1.65
Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice. Diabetes (2007) 1.64
Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets. Proc Natl Acad Sci U S A (2004) 1.60
Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome. Genome Res (2013) 1.58
Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proc Natl Acad Sci U S A (2008) 1.52
Cytokine production by islets in health and diabetes: cellular origin, regulation and function. Trends Endocrinol Metab (2010) 1.46
Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines. Endocrinology (2003) 1.40
Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes (2004) 1.31
Blockade of beta1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix. Diabetes (2006) 1.22
Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14. Diabetes (2007) 1.20
Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle. Diabetes (2011) 1.18
Activation of NF-kappaB by extracellular matrix is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells. J Biol Chem (2005) 1.17
Differential expression of E-cadherin at the surface of rat beta-cells as a marker of functional heterogeneity. J Endocrinol (2007) 1.16
Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion. J Biol Chem (2009) 1.13
Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death. Diabetes (2006) 1.12
Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion. Endocrinology (2008) 1.09
The Fas pathway is involved in pancreatic beta cell secretory function. Proc Natl Acad Sci U S A (2007) 1.08
Munc 18-1 and granuphilin collaborate during insulin granule exocytosis. Traffic (2008) 1.06
Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells. Diabetes (2008) 1.04
Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin. Diabetes (2011) 1.03
In vitro proliferation of adult human beta-cells. PLoS One (2012) 0.99
Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide. Diabetes (2004) 0.97
Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells. Endocrinology (2007) 0.97
Dynamin is functionally coupled to insulin granule exocytosis. J Biol Chem (2007) 0.96
Signaling pathways implicated in the stimulation of beta-cell proliferation by extracellular matrix. Mol Endocrinol (2009) 0.94
Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture. Diabetes (2008) 0.93
Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function. Endocrinology (2008) 0.92
Pro-survival role of gelsolin in mouse beta-cells. Diabetes (2007) 0.89
Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion. J Biol Chem (2011) 0.89
Regulation of insulin secretion by phosphatidylinositol-4,5-bisphosphate. Traffic (2010) 0.88
DIAMAP: a road map for diabetes research in Europe. J Diabetes Sci Technol (2011) 0.87
Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets. J Clin Invest (2017) 0.75
The right stuff: beta-cell channels, cycles, and sensors. Am J Physiol Endocrinol Metab (2008) 0.75
Short term exposure of beta cells to low concentrations of interleukin-1β improves insulin secretion through focal adhesion and actin remodeling and regulation of gene expression. J Biol Chem (2015) 0.75
Towards a perfect beta cell replacement. Semin Cell Dev Biol (2004) 0.75