Published in J Cell Sci on April 15, 2003
Non-muscle myosin II takes centre stage in cell adhesion and migration. Nat Rev Mol Cell Biol (2009) 7.77
Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol (2010) 7.27
Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Cancer Metastasis Rev (2009) 4.36
Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A (2003) 4.03
Paxillin comes of age. J Cell Sci (2008) 3.57
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell (2008) 3.31
Structural basis for the autoinhibition of focal adhesion kinase. Cell (2007) 3.18
ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. Cell (2008) 2.94
FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron (2003) 2.86
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol (2005) 2.75
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol (2006) 2.57
Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest (2009) 2.55
FAK in cancer: mechanistic findings and clinical applications. Nat Rev Cancer (2014) 2.46
Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction. Nat Neurosci (2004) 2.41
Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Adv Drug Deliv Rev (2010) 2.21
Compartmentalization of redox signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal (2009) 2.17
RAS Interaction with PI3K: More Than Just Another Effector Pathway. Genes Cancer (2011) 2.12
Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res (2009) 2.04
Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harb Perspect Med (2012) 1.99
Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. Biochem J (2007) 1.95
Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J Cell Biol (2007) 1.93
Growth control by intracellular tension and extracellular stiffness. Trends Cell Biol (2008) 1.93
Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Nat Med (2011) 1.86
Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity. J Neurosci (2009) 1.83
A push-pull mechanism for regulating integrin function. Proc Natl Acad Sci U S A (2005) 1.82
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79
Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion. Mol Cell Biol (2006) 1.76
Modeling HER2 effects on cell behavior from mass spectrometry phosphotyrosine data. PLoS Comput Biol (2006) 1.74
Control of axonal branching and synapse formation by focal adhesion kinase. Nat Neurosci (2004) 1.74
Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood (2012) 1.72
Focal adhesion kinase as a regulator of cell tension in the progression of cancer. Semin Cancer Biol (2007) 1.64
Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J Clin Invest (2005) 1.61
Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Mol Cancer Ther (2011) 1.61
Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett (2009) 1.59
Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling. Blood (2011) 1.59
Growth cone travel in space and time: the cellular ensemble of cytoskeleton, adhesion, and membrane. Neuron (2012) 1.58
Cellular responses to substrate topography: role of myosin II and focal adhesion kinase. Biophys J (2006) 1.58
Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530. Oncogene (2008) 1.57
MicroRNA-205 inhibits Src-mediated oncogenic pathways in renal cancer. Cancer Res (2011) 1.57
Forcing stem cells to behave: a biophysical perspective of the cellular microenvironment. Annu Rev Biophys (2012) 1.55
Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout. Blood (2007) 1.54
Inhibition of Src family kinases with dasatinib blocks migration and invasion of human melanoma cells. Mol Cancer Res (2008) 1.52
Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling. Blood (2007) 1.52
Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility. Oncogene (2007) 1.51
Focal adhesion kinase is essential for cardiac looping and multichamber heart formation. Genesis (2010) 1.51
Nonreceptor tyrosine kinases in prostate cancer. Neoplasia (2007) 1.50
Src-dependent phosphorylation of ASAP1 regulates podosomes. Mol Cell Biol (2007) 1.48
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proc Natl Acad Sci U S A (2008) 1.48
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell (2009) 1.47
Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. J Cell Biol (2010) 1.44
Exploring the control circuit of cell migration by mathematical modeling. Biophys J (2008) 1.44
FERM control of FAK function: implications for cancer therapy. Cell Cycle (2008) 1.43
Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA. Mol Cell Biol (2006) 1.43
Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner. J Biol Chem (2008) 1.42
Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response. J Exp Med (2010) 1.41
Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions. Mol Cell Biol (2006) 1.41
Endothelial focal adhesions and barrier function. J Physiol (2005) 1.36
Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites. J Cell Sci (2008) 1.34
Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy. Circ Res (2006) 1.34
Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle. J Cardiovasc Pharmacol Ther (2008) 1.34
Proximal, selective, and dynamic interactions between integrin alphaIIbbeta3 and protein tyrosine kinases in living cells. J Cell Biol (2004) 1.33
Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system. J Cell Biol (2009) 1.33
Disordered purinergic signaling inhibits pathological angiogenesis in cd39/Entpd1-null mice. Am J Pathol (2007) 1.32
Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem (2010) 1.31
Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Mol Cell Biol (2005) 1.30
Rheostatic signaling by CD44 and hyaluronan. Cell Signal (2009) 1.30
FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas. J Cell Sci (2009) 1.29
An occludin-focal adhesion kinase protein complex at the blood-testis barrier: a study using the cadmium model. Endocrinology (2009) 1.28
Focal adhesion kinase is a blood-testis barrier regulator. Proc Natl Acad Sci U S A (2009) 1.26
Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts. J Bone Miner Res (2009) 1.26
The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. J Cell Biol (2005) 1.26
Stretch of beta 1 integrin activates an outwardly rectifying chloride current via FAK and Src in rabbit ventricular myocytes. J Gen Physiol (2003) 1.23
Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration. Biochem J (2005) 1.23
Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling. J Neurosci (2011) 1.23
Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection. J Biol Chem (2008) 1.23
FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion. Mol Biol Cell (2011) 1.22
Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK. Oncogene (2006) 1.22
Focal adhesion kinase and p53 signal transduction pathways in cancer. Front Biosci (Landmark Ed) (2010) 1.20
FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype. Mol Biol Cell (2007) 1.19
Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment. Mol Cell Biol (2007) 1.18
Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. J Biol Chem (2009) 1.18
Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines. Mol Cancer (2009) 1.18
Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase. J Biol Chem (2008) 1.17
Disruption of laminin-integrin-CD151-focal adhesion kinase axis sensitizes breast cancer cells to ErbB2 antagonists. Cancer Res (2010) 1.17
Angiotensin II (AT1) receptors and NADPH oxidase regulate Cl- current elicited by beta1 integrin stretch in rabbit ventricular myocytes. J Gen Physiol (2004) 1.16
Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2. EMBO J (2009) 1.16
Integrin signaling, cell survival, and anoikis: distinctions, differences, and differentiation. J Signal Transduct (2011) 1.14
Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines. J Transl Med (2008) 1.13
Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis. Neoplasia (2008) 1.13
Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT. Oncogene (2012) 1.13
Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer. IUBMB Life (2010) 1.12
FAK is a critical regulator of neuroblastoma liver metastasis. Oncotarget (2012) 1.12
Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. PLoS One (2008) 1.11
Specific induction of pp125 focal adhesion kinase in human breast cancer. Br J Cancer (2005) 1.11
FAK regulates cardiomyocyte survival following ischemia/reperfusion. J Mol Cell Cardiol (2008) 1.11
Essential role for focal adhesion kinase in regulating stress hematopoiesis. Blood (2010) 1.11
The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways. Oncogene (2011) 1.11
CNTO 95, a fully human anti alphav integrin antibody, inhibits cell signaling, migration, invasion, and spontaneous metastasis of human breast cancer cells. Clin Exp Metastasis (2007) 1.10
Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo. J Biol Chem (2012) 1.10