Published in Mol Cell on January 18, 2008
Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest (2009) 2.55
FAK in cancer: mechanistic findings and clinical applications. Nat Rev Cancer (2014) 2.46
Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell (2010) 2.38
Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus. Nat Cell Biol (2014) 2.30
The FERM domain: organizing the structure and function of FAK. Nat Rev Mol Cell Biol (2010) 2.23
Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Adv Drug Deliv Rev (2010) 2.21
Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol (2009) 1.99
Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling. J Cell Sci (2011) 1.90
The extracellular matrix modulates the hallmarks of cancer. EMBO Rep (2014) 1.88
FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol (2012) 1.87
VEGF-induced vascular permeability is mediated by FAK. Dev Cell (2012) 1.85
Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer. Am J Pathol (2008) 1.82
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79
Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J Natl Cancer Inst (2013) 1.78
Conversion of mechanical force into TGF-β-mediated biochemical signals. Curr Biol (2011) 1.74
Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis. Breast Cancer Res (2009) 1.67
Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett (2009) 1.59
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice. Nat Med (2016) 1.54
Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. J Cell Biol (2010) 1.44
FERM control of FAK function: implications for cancer therapy. Cell Cycle (2008) 1.43
TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer. Oncogene (2012) 1.43
Retracted Glabridin attenuates the migratory and invasive capacity of breast cancer cells by activating microRNA-200c. Cancer Sci (2014) 1.39
Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion. J Mammary Gland Biol Neoplasia (2011) 1.37
Focal adhesion kinase versus p53: apoptosis or survival? Sci Signal (2008) 1.36
FAK overexpression and p53 mutations are highly correlated in human breast cancer. Int J Cancer (2009) 1.35
The C terminus of talin links integrins to cell cycle progression. J Cell Biol (2011) 1.33
Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem (2010) 1.31
Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity. Cell (2015) 1.26
The dual kinase complex FAK-Src as a promising therapeutic target in cancer. Onco Targets Ther (2010) 1.22
Focal adhesion kinase and p53 signal transduction pathways in cancer. Front Biosci (Landmark Ed) (2010) 1.20
Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression. Clin Exp Metastasis (2012) 1.20
Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. J Biol Chem (2009) 1.18
The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk. Oncogene (2011) 1.17
Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2. EMBO J (2009) 1.16
HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase. Mol Cancer Res (2010) 1.16
The secret life of kinases: functions beyond catalysis. Cell Commun Signal (2011) 1.13
Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT. Oncogene (2012) 1.13
The role of focal adhesion kinase in tumor initiation and progression. Cell Adh Migr (2009) 1.11
Essential role for focal adhesion kinase in regulating stress hematopoiesis. Blood (2010) 1.11
Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo. J Biol Chem (2012) 1.10
Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem (2009) 1.10
FAK and p53 protein interactions. Anticancer Agents Med Chem (2011) 1.09
Nuclear FAK: a new mode of gene regulation from cellular adhesions. Mol Cells (2013) 1.06
Focal adhesion kinase and endothelial cell apoptosis. Microvasc Res (2011) 1.05
FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing. PLoS One (2011) 1.04
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. J Cell Biol (2012) 1.02
EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1. PLoS One (2012) 1.00
A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src. Mol Biol Cell (2011) 1.00
Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase. Mol Carcinog (2009) 0.99
Targeting FAK in human cancer: from finding to first clinical trials. Front Biosci (Landmark Ed) (2014) 0.99
Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages. PLoS Pathog (2014) 0.98
FAK nuclear export signal sequences. FEBS Lett (2008) 0.98
Regulation of focal adhesion kinase activation, breast cancer cell motility, and amoeboid invasion by the RhoA guanine nucleotide exchange factor Net1. Mol Cell Biol (2013) 0.97
Cortactin as a target for FAK in the regulation of focal adhesion dynamics. PLoS One (2012) 0.97
Role of FAK in S1P-regulated endothelial permeability. Microvasc Res (2011) 0.97
Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. J Cell Sci (2012) 0.96
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth. BMC Cancer (2013) 0.96
How focal adhesion kinase achieves regulation by linking ligand binding, localization and action. Curr Opin Struct Biol (2011) 0.96
Syntaxin 6, a regulator of the protein trafficking machinery and a target of the p53 family, is required for cell adhesion and survival. J Biol Chem (2008) 0.96
Governing epidermal homeostasis by coupling cell-cell adhesion to integrin and growth factor signaling, proliferation, and apoptosis. Proc Natl Acad Sci U S A (2012) 0.95
Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells. J Cell Biol (2011) 0.95
In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking. Diabetes (2012) 0.94
FAK dimerization controls its kinase-dependent functions at focal adhesions. EMBO J (2014) 0.93
Dentin phosphoprotein (DPP) activates integrin-mediated anchorage-dependent signals in undifferentiated mesenchymal cells. J Biol Chem (2011) 0.93
FAK-heterozygous mice display enhanced tumour angiogenesis. Nat Commun (2013) 0.92
Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated. J Biol Chem (2012) 0.91
CLCA2, a target of the p53 family, negatively regulates cancer cell migration and invasion. Cancer Biol Ther (2012) 0.91
FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth. Mol Cancer Ther (2014) 0.91
Emerging roles of focal adhesion kinase in cancer. Biomed Res Int (2015) 0.90
Integrin adhesions: who's on first? What's on second? Connections between FAK and talin. Cell Adh Migr (2012) 0.90
Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol (2011) 0.90
Megakaryocytes regulate expression of Pyk2 isoforms and caspase-mediated cleavage of actin in osteoblasts. J Biol Chem (2012) 0.90
How integrins control breast biology. Curr Opin Cell Biol (2013) 0.89
Non-Smad transforming growth factor-β signaling regulated by focal adhesion kinase binding the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem (2011) 0.89
Cardiac stem cells with electrical stimulation improve ischaemic heart function through regulation of connective tissue growth factor and miR-378. Cardiovasc Res (2013) 0.89
Focal adhesion kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate. Mol Biol Cell (2011) 0.88
In oral squamous cell carcinoma, high FAK expression is correlated with low P53 expression. Virchows Arch (2012) 0.86
Supervillin-mediated suppression of p53 protein enhances cell survival. J Biol Chem (2013) 0.86
FAK interaction with MBD2: A link from cell adhesion to nuclear chromatin remodeling? Cell Adh Migr (2010) 0.86
Proteomic Profiling Identifies PTK2/FAK as a Driver of Radioresistance in HPV-negative Head and Neck Cancer. Clin Cancer Res (2016) 0.86
FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells. PLoS One (2011) 0.85
LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase. Nat Commun (2015) 0.84
Focal adhesion complex proteins in epidermis and squamous cell carcinoma. Cell Cycle (2013) 0.84
A novel curcumin analog (H-4073) enhances the therapeutic efficacy of cisplatin treatment in head and neck cancer. PLoS One (2014) 0.84
Bone marrow-induced Mef2c deficiency delays B-cell development and alters the expression of key B-cell regulatory proteins. Int Immunol (2012) 0.83
Recombinant rubistatin (r-Rub), an MVD disintegrin, inhibits cell migration and proliferation, and is a strong apoptotic inducer of the human melanoma cell line SK-Mel-28. Toxicon (2011) 0.83
FAK is required for Schwann cell spreading on immature basal lamina to coordinate the radial sorting of peripheral axons with myelination. J Neurosci (2014) 0.83
DPP in the matrix mediates cell adhesion but is not restricted to stickiness: a tale of signaling. Cell Adh Migr (2012) 0.83
FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β. Elife (2015) 0.83
Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality. Proc Natl Acad Sci U S A (2013) 0.82
FAK and Nanog cross talk with p53 in cancer stem cells. Anticancer Agents Med Chem (2013) 0.82
p53 in cell invasion, podosomes, and invadopodia. Cell Adh Migr (2014) 0.82
Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments. J Immunol (2012) 0.82
A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation. J Cell Sci (2013) 0.82
Targeting the p53 pathway. Surg Oncol Clin N Am (2013) 0.82
Focal adhesion kinase plays a role in osteoblast mechanotransduction in vitro but does not affect load-induced bone formation in vivo. PLoS One (2012) 0.82
Copper deficiency induced emphysema is associated with focal adhesion kinase inactivation. PLoS One (2012) 0.81
A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo. Anticancer Agents Med Chem (2013) 0.81
Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer. Gynecol Oncol (2014) 0.81
Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21(Cip1.). J Mol Cell Cardiol (2013) 0.81
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell (1995) 12.39
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature (1995) 11.06
The p53 pathway: positive and negative feedback loops. Oncogene (2005) 9.75
Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol (2006) 8.52
Focal adhesion kinase: the first ten years. J Cell Sci (2003) 6.83
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity. Nat Rev Cancer (2005) 5.57
Decision making by p53: life, death and cancer. Cell Death Differ (2003) 5.52
Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem (2007) 3.87
Anoikis. Cell Death Differ (2005) 3.74
Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. J Cell Biol (1998) 3.52
Structural basis for the autoinhibition of focal adhesion kinase. Cell (2007) 3.18
MDM2, an introduction. Mol Cancer Res (2003) 2.87
Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics. J Cell Biol (2007) 2.79
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol (2005) 2.75
Clinging to life: cell to matrix adhesion and cell survival. Cancer Metastasis Rev (2005) 2.73
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol (2006) 2.57
Activation of the p53 tumor suppressor protein. Biochim Biophys Acta (2002) 2.44
New concepts regarding focal adhesion kinase promotion of cell migration and proliferation. J Cell Biochem (2006) 2.42
Enhanced proliferative potential in culture of cells from p53-deficient mice. Oncogene (1993) 2.25
Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene (1995) 2.22
Focal adhesion kinase is required for blood vessel morphogenesis. Circ Res (2003) 2.18
Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis. J Clin Invest (1996) 2.10
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. J Biol Chem (2005) 1.83
Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Mol Cell Biol (2004) 1.79
Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors. Oncogene (2006) 1.71
p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain. J Biol Chem (2004) 1.48
FAK is required for axonal sorting by Schwann cells. J Cell Biol (2007) 1.43
PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation. J Biol Chem (2003) 1.32
Integrins regulate the apoptotic response to DNA damage through modulation of p53. Proc Natl Acad Sci U S A (2002) 1.29
Cell attachment to the extracellular matrix induces proteasomal degradation of p21(CIP1) via Cdc42/Rac1 signaling. Mol Cell Biol (2002) 1.23
Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/Cip1 through Skp2-dependent and -independent mechanisms. Mol Cell Biol (2006) 1.20
Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation. J Biol Chem (2004) 1.17
The focal adhesion kinase amino-terminal domain localises to nuclei and intercellular junctions in HEK 293 and MDCK cells independently of tyrosine 397 and the carboxy-terminal domain. Biochem Biophys Res Commun (2002) 1.00
Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol (2005) 11.74
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol (2009) 9.67
Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol (2006) 8.52
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. Science (2011) 4.46
Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling. Science (2004) 3.93
Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. J Cell Biol (2010) 3.56
Derivation and propagation of human embryonic stem cell lines from frozen embryos in an animal product-free environment. Nat Protoc (2012) 3.30
Differential regulation of cell motility and invasion by FAK. J Cell Biol (2003) 3.15
Human embryonic stem cell lines generated without embryo destruction. Cell Stem Cell (2008) 3.11
Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry. J Proteome Res (2010) 3.08
Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol (2002) 2.99
Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim Biophys Acta (2004) 2.98
Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest (2004) 2.95
Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol (2002) 2.84
The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res (2008) 2.53
Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science (2003) 2.40
Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance. Mol Cell Proteomics (2009) 2.39
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. J Cell Biol (2008) 2.31
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther (2010) 2.10
Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses. Mol Cell Proteomics (2009) 2.09
Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol (2009) 1.99
Strategy for the creation of clinical grade hESC line banks that HLA-match a target population. EMBO Mol Med (2012) 1.93
Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest (2006) 1.88
FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol (2012) 1.87
VEGF-induced vascular permeability is mediated by FAK. Dev Cell (2012) 1.85
Sweetening the pot: adding glycosylation to the biomarker discovery equation. Clin Chem (2009) 1.81
Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J Cell Biol (2008) 1.74
Conversion of mechanical force into TGF-β-mediated biochemical signals. Curr Biol (2011) 1.74
FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion. J Cell Biol (2005) 1.70
Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies. Am J Obstet Gynecol (2003) 1.67
Direct interaction of focal adhesion kinase with p190RhoGEF. J Biol Chem (2003) 1.67
mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.63
Differentiation potential of germ line stem cells derived from the postnatal mouse ovary. Differentiation (2010) 1.61
The placenta: transcriptional, epigenetic, and physiological integration during development. J Clin Invest (2010) 1.61
Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term. Endocrinology (2006) 1.58
The focal adhesion kinase--a regulator of cell migration and invasion. IUBMB Life (2002) 1.55
FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth. EMBO J (2002) 1.55
A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J Cell Sci (2009) 1.55
Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway. Cancer Res (2006) 1.55
Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. Endocrinology (2008) 1.47
Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis. Cancer Res (2009) 1.44
Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development (2005) 1.44
FERM control of FAK function: implications for cancer therapy. Cell Cycle (2008) 1.43
Trophoblast stem cells. Biol Reprod (2010) 1.42
Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. Cancer Biol Ther (2010) 1.41
Binding of the streptococcal surface glycoproteins GspB and Hsa to human salivary proteins. Infect Immun (2006) 1.40
Serum-free derivation of human embryonic stem cell lines on human placental fibroblast feeders. Fertil Steril (2005) 1.39
Syndecan-2 mediates adhesion and proliferation of colon carcinoma cells. J Biol Chem (2002) 1.36
Listeriosis in the pregnant guinea pig: a model of vertical transmission. Infect Immun (2004) 1.35
v-Src SH3-enhanced interaction with focal adhesion kinase at beta 1 integrin-containing invadopodia promotes cell invasion. J Biol Chem (2002) 1.31
Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem (2010) 1.31
Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Mol Cell Biol (2005) 1.30
Disruption of apical-basal polarity of human embryonic stem cells enhances hematoendothelial differentiation. Stem Cells (2007) 1.30
Generation of multipotent cell lines from a distinct population of male germ line stem cells. Reproduction (2008) 1.29
FAK promotes organization of fibronectin matrix and fibrillar adhesions. J Cell Sci (2003) 1.28
Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype. Dev Biol (2005) 1.25
Human cytotrophoblasts promote endothelial survival and vascular remodeling through secretion of Ang2, PlGF, and VEGF-C. Dev Biol (2003) 1.24
Identification and characterization of repopulating spermatogonial stem cells from the adult human testis. Hum Reprod (2011) 1.23
Toward defining the human parotid gland salivary proteome and peptidome: identification and characterization using 2D SDS-PAGE, ultrafiltration, HPLC, and mass spectrometry. Biochemistry (2005) 1.22
Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression. Clin Exp Metastasis (2012) 1.20
Assessing the effects of diurnal variation on the composition of human parotid saliva: quantitative analysis of native peptides using iTRAQ reagents. Anal Chem (2005) 1.18
Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. J Biol Chem (2009) 1.18
Transcriptomic signature of trophoblast differentiation in a human embryonic stem cell model. Biol Reprod (2011) 1.16
Human cytomegalovirus chemokine receptor US28-induced smooth muscle cell migration is mediated by focal adhesion kinase and Src. J Biol Chem (2003) 1.15
A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia. Development (2011) 1.15
Focal adhesion kinase mediates cell survival via NF-kappaB and ERK signaling pathways. Am J Physiol Cell Physiol (2006) 1.15
Establishment of human trophoblast progenitor cell lines from the chorion. Stem Cells (2011) 1.15
EPHB4 regulates chemokine-evoked trophoblast responses: a mechanism for incorporating the human placenta into the maternal circulation. Development (2005) 1.10
Analytical validation of protein-based multiplex assays: a workshop report by the NCI-FDA interagency oncology task force on molecular diagnostics. Clin Chem (2009) 1.10
Tumor necrosis factor-alpha stimulates focal adhesion kinase activity required for mitogen-activated kinase-associated interleukin 6 expression. J Biol Chem (2007) 1.08
Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. J Cell Biol (2014) 1.07
Derivation of human embryonic stem cell lines from biopsied blastomeres on human feeders with minimal exposure to xenomaterials. Stem Cells Dev (2009) 1.07
Protein-based multiplex assays: mock presubmissions to the US Food and Drug Administration. Clin Chem (2009) 1.07
Abnormal placentation and the syndrome of preeclampsia. Semin Nephrol (2004) 1.06
Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nat Commun (2011) 1.06
Syndecan-4 regulates localization, activity and stability of protein kinase C-alpha. Biochem J (2004) 1.03
Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia. J Clin Invest (2013) 1.03
The human placenta remodels the uterus by using a combination of molecules that govern vasculogenesis or leukocyte extravasation. Ann N Y Acad Sci (2003) 1.02
Acid-catalyzed oxygen-18 labeling of peptides. Anal Chem (2009) 1.02
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. J Cell Biol (2012) 1.02
Safety paradigm: genetic evaluation of therapeutic grade human embryonic stem cells. J R Soc Interface (2010) 1.02