Published in Nature on April 29, 1976
The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction. Psychopharmacology (Berl) (2012) 1.96
Isolation, primary structure, and synthesis of alpha-endorphin and gamma-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity. Proc Natl Acad Sci U S A (1976) 1.80
Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary. Proc Natl Acad Sci U S A (1977) 1.74
Mu opioids and their receptors: evolution of a concept. Pharmacol Rev (2013) 1.66
A brief history of opiates, opioid peptides, and opioid receptors. Proc Natl Acad Sci U S A (1993) 1.46
Endogenous opioids and pain: a review. J R Soc Med (1981) 1.38
Opioid peptides. Br Med J (Clin Res Ed) (1984) 1.38
Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study. Proc Natl Acad Sci U S A (1977) 1.36
Morphinomimetic activity of synthetic fragments of beta-lipotropin and analogs. Proc Natl Acad Sci U S A (1976) 1.22
C-fragment of lipotropin--an endogenous potent analgesic peptide. Br J Pharmacol (1977) 1.09
Presence of immunoreactive beta-endorphin in normal human plasma: a concomitant release of beta-endorphin with adrenocorticotropin after metyrapone administration. J Clin Invest (1978) 1.02
Isolation of the C-fragment and C'-fragment of lipotropin from pig pituitary and C-fragment from brain. Biochem J (1978) 0.94
Properties and localization of beta-endorphin receptor in rat brain. Proc Natl Acad Sci U S A (1979) 0.93
In vitro biosynthesis of beta-endorphin, gamma-lipoprotein, and beta-lipotropin by the pars intermedia of beef pituitary glands. Proc Natl Acad Sci U S A (1977) 0.93
Isolation and structure of pro-methionine-enkephalin: Potential enkephalin precursor from porcine hypothalamus. Proc Natl Acad Sci U S A (1979) 0.93
In vitro biosynthesis of beta-endorphin in pituitary glands. Proc Natl Acad Sci U S A (1977) 0.91
Tolerance and dependence evoked by an endogenous opiate peptide. Proc Natl Acad Sci U S A (1976) 0.89
Beta-endorphin: stimulation of growth hormone release in vivo. Proc Natl Acad Sci U S A (1977) 0.89
Partial characterization of the mRNA that codes for enkephalins in bovine adrenal medulla and human pheochromocytoma. Proc Natl Acad Sci U S A (1982) 0.87
Search of the human proteome for endomorphin-1 and endomorphin-2 precursor proteins. Life Sci (2007) 0.85
Influence of N-terminal acetylation and C-terminal proteolysis on the analgesic activity of beta-endorphin. Biochem J (1980) 0.85
The effects of endomorphin-1 and endomorphin-2 in CHO cells expressing recombinant mu-opioid receptors and SH-SY5Y cells. Br J Pharmacol (1999) 0.85
beta-Endorphin: cross tolerance to and cross physical dependence on morphine. Proc Natl Acad Sci U S A (1976) 0.83
Distribution of beta-endorphin-related peptides in rat pituitary and brain. Biochem J (1982) 0.83
beta-Endorphin: formation of alpha-helix in lipid solutions. Proc Natl Acad Sci U S A (1979) 0.83
Effects of acute ethanol on corticotropin-releasing hormone and β-endorphin systems at the level of the rat central amygdala. Psychopharmacology (Berl) (2011) 0.81
Beta endorphin selectively stimulates aldosterone secretion in hypophysectomized, nephrectomized dogs. J Clin Invest (1983) 0.81
Enhancement of a nociceptive reaction by opioid antagonists in mice. Br J Pharmacol (1978) 0.80
Pituitary somatotrophs contain [Met]enkephalin-like immunoreactivity. Proc Natl Acad Sci U S A (1978) 0.80
Interactions of peptides derived from the C-fragment of beta-lipotropin with brain opiate receptors [proceedings]. Br J Pharmacol (1976) 0.79
The transcriptional regulation of the preproenkephalin gene. Biochem J (1995) 0.78
beta-Endorphin-induced analgesia is inhibited by synthetic analogs of beta-endorphin. Proc Natl Acad Sci U S A (1984) 0.77
Induction of the acrosome reaction in guinea-pig spermatozoa in vitro by the Ca ionophore A23187 [proceedings]. J Physiol (1976) 0.77
Pharmacological Profiles of Oligomerized μ-Opioid Receptors. Cells (2013) 0.77
Human beta-endorphin: the real opium of the people? Br Med J (1978) 0.75
Effects of peptides of pituitary origin on the formation of C21 steroid by fetal calf adrenal cells in culture. Biochem Biophys Res Commun (1977) 0.75
Exercise induced asthma and endogenous opioids. Thorax (1986) 0.75
beta-Endorphin: demonstration of a tertiary structure in aqueous solution. Proc Natl Acad Sci U S A (1981) 0.75
Post-natal ultrastructural development of the cat myocardium [proceedings]. J Physiol (1977) 0.75
Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature (1980) 5.39
International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev (1998) 5.34
Muscarinic receptor subtypes. Annu Rev Pharmacol Toxicol (1990) 3.64
The binding of agonists to brain muscarinic receptors. Mol Pharmacol (1978) 3.17
Reconstitution of a calcium pump using defined membrane components. Proc Natl Acad Sci U S A (1974) 3.11
The binding of antagonists to brain muscarinic receptors. Mol Pharmacol (1978) 2.35
Cholesterol is excluded from the phospholipid annulus surrounding an active calcium transport protein. Nature (1975) 2.30
Annular lipids determine the ATPase activity of a calcium transport protein complexed with dipalmitoyllecithin. Biochemistry (1976) 2.06
Biochemical studies on muscarinic acetylcholine receptors. J Neurochem (1976) 1.88
13 C nuclear magnetic resonance relaxation measurements of synthetic lecithins and the effect of spin-labeled lipids. Biochemistry (1972) 1.83
Reversible lipid titrations of the activity of pure adenosine triphosphatase-lipid complexes. Biochemistry (1974) 1.73
Modification of the binding properties of muscarinic receptors by gallamine. Mol Pharmacol (1983) 1.73
The character of the muscarinic receptors in different regions of the rat brain. Proc R Soc Lond B Biol Sci (1980) 1.68
Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors. Mol Pharmacol (1995) 1.64
Clusters in lipid bilayers and the interpretation of thermal effects in biological membranes. Biochemistry (1974) 1.50
Binding of agonists and antagonists to muscarinic receptors. J Supramol Struct (1976) 1.50
The interaction of paramagnetic ions and spin labels with lecithin bilayers. Biochim Biophys Acta (1973) 1.49
Effects of contamination on radioligand binding parameters. Trends Pharmacol Sci (2000) 1.49
Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng-Prusoff equations. Br J Pharmacol (1993) 1.49
Guanine nucleotides modulate muscarinic receptor binding in the heart. Biochem Biophys Res Commun (1979) 1.42
The functional topography of transmembrane domain 3 of the M1 muscarinic acetylcholine receptor, revealed by scanning mutagenesis. J Biol Chem (1999) 1.37
Pharmacological characterization of acetylcholine-stimulated [35S]-GTP gamma S binding mediated by human muscarinic m1-m4 receptors: antagonist studies. Br J Pharmacol (1993) 1.33
Pharmacological characterization of guanine nucleotide exchange reactions in membranes from CHO cells stably transfected with human muscarinic receptors m1-m4. Life Sci (1993) 1.26
13 C and 1 H nuclear magnetic resonance relaxation measurements of the lipids of sarcoplasmic reticulum membranes. Biochemistry (1972) 1.23
ERKI/II regulation by the muscarinic acetylcholine receptors in neurons. J Neurosci (2000) 1.23
Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation. J Biol Chem (1990) 1.22
A study of the muscarinic receptor by gel electrophoresis. Br J Pharmacol (1979) 1.19
Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis. Mol Pharmacol (1995) 1.19
Temperature coefficients of affinity constants for the binding of antagonists to muscarinic receptors in the rat cerebral cortex. Br J Pharmacol (1979) 1.18
A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart. J Gen Physiol (1982) 1.17
Propylbenzilylcholine mustard labels an acidic residue in transmembrane helix 3 of the muscarinic receptor. J Biol Chem (1989) 1.15
Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies. Mol Pharmacol (1998) 1.15
Two populations of binding sites for muscarinic antagonists in the rat heart. Eur J Pharmacol (1981) 1.14
High resolution proton relaxation studies of lecithins. Biochim Biophys Acta (1972) 1.13
The effects of ions on the binding of agonists and antagonists to muscarinic receptors. Br J Pharmacol (1979) 1.10
Enzymic synthesis, characterisation and nuclear-magnetic-resonance spectra of pppA2'p5'A2'p5'A and related oligonucleotides: comparison with chemically synthesised material. Eur J Biochem (1979) 1.09
Occupancy of muscarinic acetylcholine receptors stimulates a guanylate cyclase in neuroblastoma cells. Biochem Soc Trans (1977) 1.09
Ligand-binding propeties of the muscarinic acetylcholine receptor in mouse neuroblastoma cells. Biochem J (1978) 1.07
The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart. Br J Pharmacol (1983) 1.06
The effects of p-chloromercuribenzoate on muscarinic receptors in the cerebral cortex. Br J Pharmacol (1983) 1.06
Measurement of fast lateral diffusion of lipids in vesicles and in biological membranes by 1 H nuclear magnetic resonance. Biochemistry (1973) 1.06
Transmembrane domains 4 and 7 of the M(1) muscarinic acetylcholine receptor are critical for ligand binding and the receptor activation switch. J Biol Chem (2001) 1.05
Alanine-scanning mutagenesis of transmembrane domain 6 of the M(1) muscarinic acetylcholine receptor suggests that Tyr381 plays key roles in receptor function. Mol Pharmacol (1999) 1.02
The effect of p-chloromercuribenzoate on structure-binding relationships of muscarinic receptors in the rat cerebral cortex. Br J Pharmacol (1983) 1.02
Acetylcholine mustard labels the binding site aspartate in muscarinic acetylcholine receptors. J Biol Chem (1994) 1.00
Modulation of the structure-binding relationships of antagonists for muscarinic acetylcholine receptor subtypes. Br J Pharmacol (1991) 0.99
Lipid phase transitions control beta-hydroxybutyrate dehydrogenase activity in defined-lipid protein complexes. FEBS Lett (1975) 0.99
Regulation of muscarinic agonist binding by cations and guanine nucleotides. Eur J Pharmacol (1983) 0.99
13C-enriched phosphatidylethanolamines from Escherichia coli. Biochim Biophys Acta (1975) 0.96
A determination of the mobility gradient in lipid bilayers by 13C nuclear magnetic resonance. Proc R Soc Lond B Biol Sci (1976) 0.95
Nicotinic and muscarinic cholinergic receptor binding in the human hippocampal formation during development and aging. Brain Res Dev Brain Res (1997) 0.93
Modulation of the binding properties of muscarinic receptors: evidence for receptor-effector coupling. Adv Biochem Psychopharmacol (1980) 0.93
Hydrodynamic properties of muscarinic acetylcholine receptors solubilized from rat forebrain. Br J Pharmacol (1984) 0.93
Complete control of the lipid environment of membrane-bound proteins: application to a calcium transport system. FEBS Lett (1974) 0.92
Estimation of antagonist Kb from inhibition curves in functional experiments: alternatives to the Cheng-Prusoff equation. Trends Pharmacol Sci (1993) 0.92
The functional role of the binding site aspartate in muscarinic acetylcholine receptors, probed by site-directed mutagenesis. Eur J Pharmacol (1995) 0.90
Muscarinic receptors in the central nervous system of the rat. II. Distribution of binding of [3H]propylbenzilylcholine mustard in the midbrain and hindbrain. Brain Res (1979) 0.90
The role of the aspartate-arginine-tyrosine triad in the m1 muscarinic receptor: mutations of aspartate 122 and tyrosine 124 decrease receptor expression but do not abolish signaling. Mol Pharmacol (1997) 0.90
Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site. Mol Pharmacol (2000) 0.89
Solubilization and characterization of guanine nucleotide-sensitive muscarinic agonist binding sites from rat myocardium. Br J Pharmacol (1984) 0.89
Peptide mapping studies on muscarinic receptors: receptor structure and location of the ligand binding site. Trends Pharmacol Sci (1988) 0.89
The function of a highly-conserved arginine residue in activation of the muscarinic M1 receptor. Eur J Pharmacol (1995) 0.89
Solubilisation and molecular characterisation of muscarinic acetylcholine receptors. J Recept Res (1983) 0.88
The affinity, selectivity and biological activity of telenzepine enantiomers. Eur J Pharmacol (1989) 0.88
The effects of saponin on the binding and functional properties of the human adenosine A1 receptor. Br J Pharmacol (1996) 0.88
19 F NMR of monofluorostearic acids in lecithin vesicles. Biochim Biophys Acta (1971) 0.87
The existence of stable enantiomers of telenzepine and their stereoselective interaction with muscarinic receptor subtypes. Mol Pharmacol (1989) 0.87
Competitive binding studies with multiple sites. Effects arising from depletion of the free radioligand. Biochim Biophys Acta (1980) 0.87
The binding of pirenzepine to digitonin-solubilized muscarinic acetylcholine receptors from the rat myocardium. Br J Pharmacol (1986) 0.86
13 C NMR spectra of lecithin vesicles and erythrocyte membranes. Nature (1971) 0.86
The modes of binding of ligands to cardiac muscarinic receptors. Trends Pharmacol Sci (1989) 0.86
A network of conserved intramolecular contacts defines the off-state of the transmembrane switch mechanism in a seven-transmembrane receptor. J Biol Chem (2000) 0.86