Published in Gene on March 13, 2003
Chronic myeloid leukemia: mechanisms of blastic transformation. J Clin Invest (2010) 2.44
Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis. Blood (2005) 1.91
Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells. Breast Cancer Res (2013) 1.67
Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. Blood (2012) 1.61
Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals. Cancer Cell (2012) 1.52
CpG sites associated with cigarette smoking: analysis of epigenome-wide data from the Sister Study. Environ Health Perspect (2014) 1.44
The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression. Pharmacol Ther (2006) 1.27
A robust error model for iTRAQ quantification reveals divergent signaling between oncogenic FLT3 mutants in acute myeloid leukemia. Mol Cell Proteomics (2009) 1.25
Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration*. J Mol Signal (2008) 1.11
SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients. Lab Invest (2008) 1.05
Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1. Mol Pharmacol (2008) 1.02
Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells. Int J Cancer (2010) 1.01
Overexpression of PIAS3 suppresses cell growth and restores the drug sensitivity of human lung cancer cells in association with PI3-K/Akt inactivation. Neoplasia (2006) 0.99
Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation. J Cell Biochem (2011) 0.96
Different partners, opposite outcomes: a new perspective of the immunobiology of indoleamine 2,3-dioxygenase. Mol Med (2012) 0.95
PTP1B suppresses prolactin activation of Stat5 in breast cancer cells. Am J Pathol (2010) 0.95
Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling. J Biol Chem (2006) 0.95
5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization. Mol Cancer Res (2010) 0.93
Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia. Leukemia (2014) 0.93
Role of protein tyrosine phosphatases in cancer. Prog Nucleic Acid Res Mol Biol (2006) 0.92
Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis. Cancer Prev Res (Phila) (2011) 0.91
MHC class II transactivator (CIITA) expression is upregulated in multiple myeloma cells by IFN-gamma. Mol Immunol (2007) 0.91
SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma. Neoplasia (2014) 0.90
Mechanisms of SHP-1 P2 promoter regulation in hematopoietic cells and its silencing in HTLV-1-transformed T cells. J Leukoc Biol (2008) 0.89
Comprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation Sequencing. PLoS One (2015) 0.88
SHP-1 is a target of regorafenib in colorectal cancer. Oncotarget (2014) 0.88
Lack of TNFalpha expression protects anaplastic lymphoma kinase-positive T-cell lymphoma (ALK+ TCL) cells from apoptosis. Proc Natl Acad Sci U S A (2009) 0.88
Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling. J Cell Mol Med (2009) 0.88
Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells. BMC Cancer (2012) 0.88
Pharmacological Targeting SHP-1-STAT3 Signaling Is a Promising Therapeutic Approach for the Treatment of Colorectal Cancer. Neoplasia (2015) 0.87
Deep-sequencing analysis of the mouse transcriptome response to infection with Brucella melitensis strains of differing virulence. PLoS One (2011) 0.87
Promoter-specific induction of the phosphatase SHP-1 by viral infection and cytokines in CNS glia. J Neurochem (2008) 0.87
Expression and Localization of TRK-Fused Gene Products in the Rat Brain and Retina. Acta Histochem Cytochem (2011) 0.86
Differential methylation pattern of ID4, SFRP1, and SHP1 between acute myeloid leukemia and chronic myeloid leukemia. J Korean Med Sci (2009) 0.86
The impact of non-tumor-derived circulating nucleic acids implicates the prognosis of non-small cell lung cancer. J Cancer Res Clin Oncol (2012) 0.85
Redox balance dynamically regulates vascular growth and remodeling. Semin Cell Dev Biol (2012) 0.85
Significance of SHP-1 and SHP-2 expression in human papillomavirus infected Condyloma acuminatum and cervical cancer. Pathol Oncol Res (2008) 0.85
Downregulation of signal transducer and activator of transcription 3 by sorafenib: a novel mechanism for hepatocellular carcinoma therapy. World J Gastroenterol (2014) 0.85
Epigenetic regulation of signal transducer and activator of transcription 3 in acute myeloid leukemia. Leuk Res (2008) 0.84
Immunohistochemical Mapping of TRK-Fused Gene Products in the Rat Brainstem. Acta Histochem Cytochem (2012) 0.84
Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice. PLoS One (2012) 0.84
Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: implications for epigenetic therapy. Leukemia (2013) 0.84
Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1. Clin Immunol (2009) 0.83
Tumoral prostate shows different expression pattern of somatostatin receptor 2 (SSTR2) and phosphotyrosine phosphatase SHP-1 (PTPN6) according to tumor progression. Adv Urol (2009) 0.83
SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma. Oncogene (2015) 0.83
Negative regulation of the SH2-homology containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein. Blood (2007) 0.83
Methylation profiling of SOCS1, SOCS2, SOCS3, CISH and SHP1 in Philadelphia-negative myeloproliferative neoplasm. J Cell Mol Med (2013) 0.81
SHP-1 and IL-1α conspire to provoke neutrophilic dermatoses. Rare Dis (2014) 0.80
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts. Nat Commun (2015) 0.78
The tyrosine 343 residue of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions. J Biol Chem (2010) 0.78
Hepatitis B virus X protein inhibits extracellular IFN-α-mediated signal transduction by downregulation of type I IFN receptor. Int J Mol Med (2012) 0.78
Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1. Cell Death Dis (2017) 0.78
SHP-1 regulation of mast cell function in allergic inflammation and anaphylaxis. PLoS One (2013) 0.78
Commentary: IL-4 and IL-13 receptors and signaling. Cytokine (2015) 0.77
Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition. Cell Death Dis (2016) 0.76
Suppression of SHP-1 promotes corticospinal tract sprouting and functional recovery after brain injury. Cell Death Dis (2013) 0.76
Enhancing SHP-1 expression with 5-azacytidine may inhibit STAT3 activation and confer sensitivity in lestaurtinib (CEP-701)-resistant FLT3-ITD positive acute myeloid leukemia. BMC Cancer (2015) 0.76
Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma. Oncotarget (2015) 0.76
Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain. PLoS One (2014) 0.76
A missense methionine mutation augments catalytic activity but reduces thermal stability in two protein tyrosine phosphatases. Biochem Biophys Res Commun (2016) 0.75
Expression of SHP-1 and SOCS6 in patients with acute leukemia and their clinical implication. Onco Targets Ther (2017) 0.75
An epigenetic modifier induces production of (10'S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla. Bioorg Med Chem (2017) 0.75
Increased SHP-1 expression results in radioresistance, inhibition of cellular senescence, and cell cycle redistribution in nasopharyngeal carcinoma cells. Radiat Oncol (2015) 0.75
Protein tyrosine phosphatase SHP-1 sensitizes EGFR/HER-2 positive breast cancer cells to trastuzumab through modulating phosphorylation of EGFR and HER-2. Onco Targets Ther (2015) 0.75
The immunomodulating roles of glycoproteins in epithelial ovarian cancer. Front Biosci (Elite Ed) (2012) 0.75
SMIP-016 in action: CD37 as a death receptor. Cancer Cell (2012) 0.75
Role and mechanism of decitabine combined with tyrosine kinase inhibitors in advanced chronic myeloid leukemia cells. Oncol Lett (2017) 0.75
Sequential combination of docetaxel with a SHP-1 agonist enhanced suppression of p-STAT3 signaling and apoptosis in triple negative breast cancer cells. J Mol Med (Berl) (2017) 0.75
CEACAM1 as a multi-purpose target for cancer immunotherapy. Oncoimmunology (2017) 0.75
Shp1 function in myeloid cells. J Leukoc Biol (2017) 0.75
Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol (2004) 6.99
Binding of Src to Na+/K+-ATPase forms a functional signaling complex. Mol Biol Cell (2005) 1.92
Lessons from the lysozyme of phage T4. Protein Sci (2010) 1.85
Identification of a pool of non-pumping Na/K-ATPase. J Biol Chem (2007) 1.69
Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat Chem Biol (2010) 1.59
mtDNA lineage expansions in Sherpa population suggest adaptive evolution in Tibetan highlands. Mol Biol Evol (2013) 1.57
Triage of pediatric injuries after the 2008 Wen-Chuan earthquake in China. J Pediatr Surg (2009) 1.50
Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics. Circ Res (2013) 1.48
Activities of fructan- and sucrose-metabolizing enzymes in wheat stems subjected to water stress during grain filling. Planta (2004) 1.46
Retracted Pathological dislocation of the hip due to coxotuberculosis in children: a 29-case report. J Orthop Surg Res (2014) 1.38
Digitalis-induced signaling by Na+/K+-ATPase in human breast cancer cells. Mol Pharmacol (2004) 1.36
Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples. Biochem Biophys Res Commun (2009) 1.35
The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides. J Biol Chem (2001) 1.34
Crystal structure of human protein-tyrosine phosphatase SHP-1. J Biol Chem (2002) 1.30
Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase. J Cell Biol (2008) 1.22
Prediction of outcomes in crescentic IgA nephropathy in a multicenter cohort study. J Am Soc Nephrol (2013) 1.20
Ouabain-induced endocytosis of the plasmalemmal Na/K-ATPase in LLC-PK1 cells requires caveolin-1. Kidney Int (2005) 1.19
Involvement of polyamines in the drought resistance of rice. J Exp Bot (2007) 1.19
Changes in sodium pump expression dictate the effects of ouabain on cell growth. J Biol Chem (2009) 1.16
Correlation of cytokinin levels in the endosperms and roots with cell number and cell division activity during endosperm development in rice. Ann Bot (2002) 1.12
Expression of myopodin induces suppression of tumor growth and metastasis. Am J Pathol (2004) 1.10
A novel missense mutation of the EDA gene in a Mongolian family with congenital hypodontia. J Hum Genet (2006) 1.10
Synthesis, antibacterial activity and quantum-chemical studies of novel 2-arylidenehydrazinyl-4-arylthiazole analogues. Chem Pharm Bull (Tokyo) (2011) 1.09
Abscisic acid and ethylene interact in wheat grains in response to soil drying during grain filling. New Phytol (2006) 1.08
Positive inotropic effect of ouabain on isolated heart is accompanied by activation of signal pathways that link Na+/K+-ATPase to ERK1/2. J Cardiovasc Pharmacol (2003) 1.07
A review about nothing: are apolar cavities in proteins really empty? Protein Sci (2009) 1.06
NaKtide, a Na/K-ATPase-derived peptide Src inhibitor, antagonizes ouabain-activated signal transduction in cultured cells. J Biol Chem (2009) 1.04
SHP-1 suppresses cancer cell growth by promoting degradation of JAK kinases. J Cell Biochem (2003) 1.04
Protein expression profiling of breast cancer cells by dissociable antibody microarray (DAMA) staining. Mol Cell Proteomics (2007) 1.02
Augmented rififylin is a risk factor linked to aberrant cardiomyocyte function, short-QT interval and hypertension. Hypertension (2011) 0.99
Impairment of Na/K-ATPase signaling in renal proximal tubule contributes to Dahl salt-sensitive hypertension. J Biol Chem (2011) 0.98
Reprogramming of trophoblast stem cells into pluripotent stem cells by Oct4. Stem Cells (2011) 0.98
Electrical image of passive mantle upwelling beneath the northern East Pacific Rise. Nature (2013) 0.98
Focal brain ischemia in rat: acute changes in brain tissue T1 reflect acute increase in brain tissue water content. NMR Biomed (2005) 0.98
Homogeneous photosensitization of complex TiO₂ nanostructures for efficient solar energy conversion. Sci Rep (2012) 0.98
Quantum-dot-sensitized TiO2 inverse opals for photoelectrochemical hydrogen generation. Small (2011) 0.97
Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation. J Cell Biochem (2011) 0.96
Ouabain- and marinobufagenin-induced proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5. Circulation (2003) 0.96
RACK1 promotes the proliferation, migration and invasion capacity of mouse hepatocellular carcinoma cell line in vitro probably by PI3K/Rac1 signaling pathway. Biomed Pharmacother (2013) 0.96
Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. J Biol Chem (2012) 0.95
Gene expression analysis of human soft tissue leiomyosarcomas. Hum Pathol (2003) 0.95
p47(phox) PX domain of NADPH oxidase targets cell membrane via moesin-mediated association with the actin cytoskeleton. J Cell Biochem (2004) 0.95
Cell signaling associated with Na(+)/K(+)-ATPase: activation of phosphatidylinositide 3-kinase IA/Akt by ouabain is independent of Src. Biochemistry (2013) 0.94
Different roles of the cardiac Na+/Ca2+-exchanger in ouabain-induced inotropy, cell signaling, and hypertrophy. Am J Physiol Heart Circ Physiol (2012) 0.93
Involvement of polyamines in the post-anthesis development of inferior and superior spikelets in rice. Planta (2008) 0.92
Identification of a potential receptor that couples ion transport to protein kinase activity. J Biol Chem (2010) 0.90
Alterations of Na+/K+-ATPase function in caveolin-1 knockout cardiac fibroblasts. J Mol Cell Cardiol (2010) 0.90
Synergistic effect of mesangial cell-induced CXCL1 and TGF-β1 in promoting podocyte loss in IgA nephropathy. PLoS One (2013) 0.90
Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese. Nephrol Dial Transplant (2011) 0.90
Involvement of reactive oxygen species in a feed-forward mechanism of Na/K-ATPase-mediated signaling transduction. J Biol Chem (2013) 0.89
Experimental study of nano-HA artificial bone with different pore sizes for repairing the radial defect. Int Orthop (2008) 0.89
In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes. Cell Res (2011) 0.89
Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation. Circulation (2013) 0.87
Increased plasma sVCAM-1 is associated with severity in IgA nephropathy. BMC Nephrol (2013) 0.87
Elevated expression of iASPP in head and neck squamous cell carcinoma and its clinical significance. Med Oncol (2012) 0.87
Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation. J Clin Invest (2014) 0.86
Enoyl coenzyme A hydratase 1 is an important factor in the lymphatic metastasis of tumors. Biomed Pharmacother (2011) 0.86
Retracted Transgenic ramie [Boehmeria nivea (L.) Gaud.]: factors affecting the efficiency of Agrobacterium tumefaciens-mediated transformation and regeneration. Plant Cell Rep (2009) 0.85
Identification of a PKCepsilon-dependent regulation of myocardial contraction by epicatechin-3-gallate. Am J Physiol Heart Circ Physiol (2007) 0.85
[Diagnosis and treatment of unilateral gluteal muscle contracture]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2011) 0.85
Convergence analysis of three classes of split-complex gradient algorithms for complex-valued recurrent neural networks. Neural Comput (2010) 0.84
Caveolin-1 knockdown is associated with the metastasis and proliferation of human lung cancer cell line NCI-H460. Biomed Pharmacother (2012) 0.84
Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha. J Biol Chem (2005) 0.84
Transcriptome profiling using pyrosequencing shows genes associated with bast fiber development in ramie (Boehmeria nivea L.). BMC Genomics (2014) 0.84
Detection and analysis of reactive oxygen species (ROS) generated by nano-sized TiO2 powder under ultrasonic irradiation and application in sonocatalytic degradation of organic dyes. Ultrason Sonochem (2010) 0.84
Agrobacterium-mediated genetic transformation and regeneration of transgenic plants using leaf midribs as explants in ramie [Boehmeria nivea (L.) Gaud]. Mol Biol Rep (2014) 0.83
Photon upconversion in hetero-nanostructured photoanodes for enhanced near-infrared light harvesting. Adv Mater (2013) 0.83
Metabonomics study of urine from Sprague-Dawley rats exposed to Huang-yao-zi using (1)H NMR spectroscopy. J Pharm Biomed Anal (2009) 0.83
The miR-7 identified from collagen biomaterial-based three-dimensional cultured cells regulates neural stem cell differentiation. Stem Cells Dev (2013) 0.82
Elevated expression of histone demethylase PHF8 associates with adverse prognosis in patients of laryngeal and hypopharyngeal squamous cell carcinoma. Epigenomics (2014) 0.82
Spectroscopic investigation on assisted sonocatalytic damage of bovine serum albumin (BSA) by metronidazole (MTZ) under ultrasonic irradiation combined with nano-sized ZnO. Spectrochim Acta A Mol Biomol Spectrosc (2010) 0.81
Ultrasensitive detection of thrombin using surface plasmon resonance and quartz crystal microbalance sensors by aptamer-based rolling circle amplification and nanoparticle signal enhancement. Chem Commun (Camb) (2014) 0.81
One-step construction of reagentless biosensor based on chitosan-carbon nanotubes-nile blue-horseradish peroxidase biocomposite formed by electrodeposition. Talanta (2009) 0.81
Genetic polymorphisms of pharmacogenomic VIP variants in the Kyrgyz population from northwest China. Gene (2013) 0.80
The novel responses of ethambutol against Mycobacterium smegmatis mc²155 Revealed by proteomics analysis. Curr Microbiol (2010) 0.80
EGF-stimulation activates the nuclear localization signal of SHP-1. J Cell Biochem (2005) 0.80
Roles of conserved basic amino acid residues and activation mechanism of the hyperthermophilic aspartate racemase at high temperature. Proteins (2006) 0.80
Reduction of hexavalent chromium by Pannonibacter phragmitetus LSSE-09 stimulated with external electron donors under alkaline conditions. J Hazard Mater (2010) 0.79
Nail fold capillary observation in replanted severed fingers. Microsurgery (2008) 0.79
Induction of differentiation-specific miRNAs in TPA-induced myeloid leukemia cells through MEK/ERK activation. Int J Mol Med (2012) 0.79
Progression of IgA nephropathy under current therapy regimen in a Chinese population. Clin J Am Soc Nephrol (2014) 0.79
Rat hippocampal proteomic alterations following intrahippocampal injection of amyloid beta peptide (1-40). Neurosci Lett (2011) 0.78
Ouabain-induced alterations of the apical junctional complex involve α1 and β1 Na,K-ATPase downregulation and ERK1/2 activation independent of caveolae in colorectal cancer cells. J Membr Biol (2013) 0.77
Substrate specificity of protein tyrosine phosphatase: differential behavior of SHP-1 and SHP-2 towards signal regulation protein SIRPalpha1. J Cell Biochem (2002) 0.77
Subcellular proteomics: determination of specific location and expression levels of lymphatic metastasis associated proteins in hepatocellular carcinoma by subcellular fractionation. Biomed Pharmacother (2011) 0.77
[Diagnosis and treatment of deltoid contracture in children]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2006) 0.77
A novel photoanode with three-dimensionally, hierarchically ordered nanobushes for highly efficient photoelectrochemical cells. Adv Mater (2012) 0.77
One-step construction of biosensor based on chitosan-ionic liquid-horseradish peroxidase biocomposite formed by electrodeposition. Biosens Bioelectron (2008) 0.77
Protein subcellular localization profiling of breast cancer cells by dissociable antibody microarray staining. Proteomics (2010) 0.77
Evaluation of experimental design and computational parameter choices affecting analyses of ChIP-seq and RNA-seq data in undomesticated poplar trees. BMC Genomics (2014) 0.76
Spectroscopic study on interaction of bovine serum albumin with sodium magnesium chlorophyllin and its sonodynamic damage under ultrasonic irradiation. Spectrochim Acta A Mol Biomol Spectrosc (2009) 0.76
Ech1 is a potent suppressor of lymphatic metastasis in hepatocarcinoma. Biomed Pharmacother (2013) 0.76
Interaction of atrial natriuretic peptide and ouabain in the myocardium. Can J Physiol Pharmacol (2012) 0.75
catena-Poly[triethyl-ammonium [[triphenyl-tin(IV)]-μ-3,3'-dihydroxy-4,4'-methyl-ene-di-2-naphtho-ato]]. Acta Crystallogr Sect E Struct Rep Online (2010) 0.75