Published in Neuron on March 27, 2003
The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A (2008) 7.41
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A (2006) 5.78
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A (2008) 4.97
Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proc Natl Acad Sci U S A (2005) 3.40
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem (2009) 2.64
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci U S A (2005) 2.58
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. EMBO J (2012) 2.36
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem (2005) 2.07
The role of parkin in familial and sporadic Parkinson's disease. Mov Disord (2010) 1.90
Neurodegeneration and neuroprotection in Parkinson disease. NeuroRx (2004) 1.77
Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 1.70
Drosophila models of neurodegenerative diseases. Annu Rev Pathol (2009) 1.67
How does parkin ligate ubiquitin to Parkinson's disease? EMBO Rep (2004) 1.54
Effects of gender on nigral gene expression and parkinson disease. Neurobiol Dis (2007) 1.53
Neuroinflammation, Oxidative Stress and the Pathogenesis of Parkinson's Disease. Clin Neurosci Res (2006) 1.50
Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila. Proc Natl Acad Sci U S A (2005) 1.48
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. J Clin Invest (2009) 1.35
Drosophila melanogaster in the study of human neurodegeneration. CNS Neurol Disord Drug Targets (2010) 1.33
Pruning and loss of excitatory synapses by the parkin ubiquitin ligase. Proc Natl Acad Sci U S A (2008) 1.23
Parkin promotes intracellular Abeta1-42 clearance. Hum Mol Genet (2009) 1.18
Cellular and molecular mechanisms of Parkinson's disease: neurotoxins, causative genes, and inflammatory cytokines. Cell Mol Neurobiol (2006) 1.17
Parkinson's disease: gene therapies. Cold Spring Harb Perspect Med (2012) 1.13
Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6. Cell Death Differ (2010) 1.13
Parkin counteracts symptoms in a Drosophila model of Parkinson's disease. BMC Neurosci (2004) 1.12
Drosophila models of neurodegenerative disease. NeuroRx (2005) 1.12
Chasing genes in Alzheimer's and Parkinson's disease. Hum Genet (2004) 1.11
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution. Front Mol Neurosci (2014) 1.10
MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity. Neurobiol Dis (2007) 1.09
Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease. BMC Neurosci (2009) 1.08
GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs. Proc Natl Acad Sci U S A (2007) 1.03
A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease. Biochim Biophys Acta (2009) 1.02
Neurodegenerative models in Drosophila: polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis. Neurobiol Dis (2010) 1.02
Food experience-induced taste desensitization modulated by the Drosophila TRPL channel. Nat Neurosci (2013) 1.01
GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc Natl Acad Sci U S A (2013) 0.99
Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. PLoS One (2009) 0.95
Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model. Mol Neurodegener (2010) 0.95
Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. PLoS One (2012) 0.95
Programmed cell death and new discoveries in the genetics of parkinsonism. J Neurochem (2007) 0.94
The protective role of prosaposin and its receptors in the nervous system. Brain Res (2014) 0.94
Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1. Mol Cell Biol (2013) 0.93
α-Synuclein and neuronal cell death. Mol Neurobiol (2012) 0.92
Altered dopamine signaling and MPTP resistance in mice lacking the Parkinson's disease-associated GPR37/parkin-associated endothelin-like receptor. Proc Natl Acad Sci U S A (2004) 0.91
Role of the ubiquitin proteasome system in Parkinson's disease. BMC Biochem (2007) 0.91
Models for LRRK2-Linked Parkinsonism. Parkinsons Dis (2011) 0.91
α-Synuclein and mitochondrial dysfunction in Parkinson's disease. Mol Neurobiol (2013) 0.91
An optimized method for histological detection of dopaminergic neurons in Drosophila melanogaster. J Histochem Cytochem (2008) 0.90
Genetic factors and manganese-induced neurotoxicity. Front Genet (2014) 0.90
Drosophila melanogaster as a model organism of brain diseases. Int J Mol Sci (2009) 0.90
Drosophila models of Parkinson's disease: discovering relevant pathways and novel therapeutic strategies. Parkinsons Dis (2011) 0.89
Recent advances in using Drosophila to model neurodegenerative diseases. Apoptosis (2009) 0.86
GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions. Biochemistry (2009) 0.86
Parkin promotes degradation of the mitochondrial pro-apoptotic ARTS protein. PLoS One (2012) 0.85
α-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies. Parkinsons Dis (2010) 0.84
Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model. Neurosci Lett (2006) 0.84
Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand. Br J Pharmacol (2014) 0.82
Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling. PLoS Genet (2013) 0.81
Molecular aspects of dopaminergic neurodegeneration: gene-environment interaction in parkin dysfunction. Int J Environ Res Public Health (2011) 0.81
KF-1 Ubiquitin Ligase: An Anxiety Suppressor. Front Neurosci (2009) 0.81
Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1. Front Pharmacol (2015) 0.79
Overexpression of parkin in the rat nigrostriatal dopamine system protects against methamphetamine neurotoxicity. Exp Neurol (2013) 0.79
RNA metabolism in the pathogenesis of Parkinson׳s disease. Brain Res (2014) 0.79
Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biol (2017) 0.77
Drosophila as a tool for personalized medicine: a primer. Per Med (2010) 0.77
Transcriptome Profiling Following Neuronal and Glial Expression of ALS-Linked SOD1 in Drosophila. G3 (Bethesda) (2013) 0.76
Antioxidants put Parkinson flies back in the PINK. Proc Natl Acad Sci U S A (2006) 0.76
Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome. J Neurosci (2015) 0.76
Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice. BMC Neurosci (2013) 0.76
Mechanisms of Parkinson's disease-related proteins in mediating secondary brain damage after cerebral ischemia. J Cereb Blood Flow Metab (2017) 0.76
The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors. Elife (2017) 0.75
Molecules that cause or prevent Parkinson's disease. PLoS Biol (2004) 0.75
Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration. Mol Neurodegener (2015) 0.75
Genetics of Parkinson's disease. Dialogues Clin Neurosci (2004) 0.75
Differential effects of phytotherapic preparations in the hSOD1 Drosophila melanogaster model of ALS. Sci Rep (2017) 0.75
Understanding and treating neurodegeneration: insights from the flies. Age (Dordr) (2005) 0.75
Drosophila clueless is involved in Parkin-dependent mitophagy by promoting VCP-mediated Marf degradation. Hum Mol Genet (2016) 0.75
Parkin deficiency exacerbate ethanol-induced dopaminergic neurodegeneration by P38 pathway dependent inhibition of autophagy and mitochondrial function. Redox Biol (2016) 0.75
Cell-permeable parkin proteins suppress Parkinson disease-associated phenotypes in cultured cells and animals. PLoS One (2014) 0.75
Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination. Neuroscience (2017) 0.75
GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant. Neurobiol Dis (2017) 0.75
Gene therapy targeting mitochondrial pathway in Parkinson's disease. J Neural Transm (Vienna) (2016) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci (2008) 5.89
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A (2006) 5.78
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A (2008) 4.97
Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat Neurosci (2005) 3.69
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J (2008) 3.51
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature (2010) 3.41
Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med (2012) 2.80
PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila. Cell (2004) 2.78
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Sci Rep (2012) 2.60
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci U S A (2005) 2.58
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol Cell (2002) 2.53
Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. Cell Stem Cell (2013) 2.32
Stretchable batteries with self-similar serpentine interconnects and integrated wireless recharging systems. Nat Commun (2013) 2.02
Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. PLoS Genet (2012) 2.01
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem Biophys Res Commun (2003) 1.96
Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2. J Neurosci (2010) 1.91
Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon. Nature (2007) 1.83
Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell (2007) 1.82
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells. Proc Natl Acad Sci U S A (2012) 1.78
Conformal piezoelectric energy harvesting and storage from motions of the heart, lung, and diaphragm. Proc Natl Acad Sci U S A (2014) 1.76
HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites. FASEB J (2006) 1.75
In vivo evidence of CHIP up-regulation attenuating tau aggregation. J Neurochem (2005) 1.66
Atypical cadherins Dachsous and Fat control dynamics of noncentrosomal microtubules in planar cell polarity. Dev Cell (2010) 1.63
Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis. J Neurochem (2002) 1.57
Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway. Genes Dev (2013) 1.54
CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70. J Neurochem (2004) 1.50
Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice. J Neurochem (2015) 1.48
Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Hum Mol Genet (2009) 1.47
Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model. Neurobiol Aging (2013) 1.46
The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum Mol Genet (2011) 1.44
Bereitschaftspotential augmentation by neuro-feedback training in Parkinson's disease. Clin Neurophysiol (2013) 1.41
The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. PLoS Genet (2010) 1.41
LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. J Neurosci (2010) 1.35
Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. Acta Neuropathol (2011) 1.34
Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion. Stroke (2007) 1.34
PAR-1 kinase phosphorylates Dlg and regulates its postsynaptic targeting at the Drosophila neuromuscular junction. Neuron (2007) 1.31
Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins. J Neurosci (2006) 1.30
Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia. J Biol Chem (2002) 1.29
Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease. Antioxid Redox Signal (2007) 1.28
Efficient targeted mutagenesis in medaka using custom-designed transcription activator-like effector nucleases. Genetics (2013) 1.26
A rotarod test for evaluation of motor skill learning. J Neurosci Methods (2010) 1.26
Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents. Stroke (2006) 1.26
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission. Proc Natl Acad Sci U S A (2011) 1.24
Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells. J Biol Chem (2004) 1.21
Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1. J Neurosci (2007) 1.21
Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity. J Biol Chem (2004) 1.20
Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila. Hum Mol Genet (2010) 1.19
Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. J Biol Chem (2012) 1.15
Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster. PLoS Genet (2010) 1.14
Proteomic pattern analysis discriminates among multiple sclerosis-related disorders. Ann Neurol (2012) 1.14
L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner. Neurosci Res (2008) 1.13
Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic mice. Brain Res (2009) 1.13
Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model. Hum Mol Genet (2004) 1.12
Pael-R is accumulated in Lewy bodies of Parkinson's disease. Ann Neurol (2004) 1.12
Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival. J Neurosci (2005) 1.11
Early protective effect of bone marrow mononuclear cells against ischemic white matter damage through augmentation of cerebral blood flow. Stroke (2010) 1.11
Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementia. Neuroreport (2009) 1.11
A mouse model characterizing features of vascular dementia with hippocampal atrophy. Stroke (2010) 1.11
A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines. Hum Mol Genet (2011) 1.10
The endoplasmic reticulum stress sensor, ATF6α, protects against neurotoxin-induced dopaminergic neuronal death. J Biol Chem (2010) 1.09
Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila. Genes Dev (2011) 1.08
Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1. J Neurosci (2011) 1.08
Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease. BMC Neurosci (2009) 1.08
A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats. Brain (2013) 1.07
Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Hum Mol Genet (2006) 1.06
Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models. J Neurosci Res (2009) 1.05
Selective white matter abnormalities in a novel rat model of vascular dementia. Neurobiol Aging (2011) 1.05
Loss of TDP-43 causes age-dependent progressive motor neuron degeneration. Brain (2013) 1.05
The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model. EMBO J (2003) 1.04
Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3. Hum Mol Genet (2008) 1.04
A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. J Neurochem (2006) 1.03
U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy. J Neurochem (2004) 1.03
Parkin and endoplasmic reticulum stress. Ann N Y Acad Sci (2003) 1.03
Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals. Neurobiol Dis (2006) 1.01
Recovery of upper-limb function due to enhanced use-dependent plasticity in chronic stroke patients. Brain (2010) 1.01
Induction of protective immunity by vaccination with wild-type apo superoxide dismutase 1 in mutant SOD1 transgenic mice. J Neuropathol Exp Neurol (2010) 1.00
VAChT-Cre. Fast and VAChT-Cre.Slow: postnatal expression of Cre recombinase in somatomotor neurons with different onset. Genesis (2003) 0.99
Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase. Genes Cells (2008) 0.99
Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1. PLoS Genet (2012) 0.99
Negative motor seizure arising from the negative motor area: is it ictal apraxia? Epilepsia (2009) 0.98
A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. J Biol Chem (2003) 0.98
Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila. Biochem Biophys Res Commun (2007) 0.97