Published in Biochem Biophys Res Commun on December 26, 2003
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc Natl Acad Sci U S A (2004) 4.76
"Sleeping beauty": quiescence in Saccharomyces cerevisiae. Microbiol Mol Biol Rev (2004) 4.23
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci U S A (2006) 3.41
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci U S A (2005) 2.58
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem (2005) 2.07
Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism. PLoS Biol (2004) 2.02
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proc Natl Acad Sci U S A (2005) 1.91
Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging. Proc Natl Acad Sci U S A (2006) 1.88
The role of oxidative stress in Parkinson's disease. J Parkinsons Dis (2013) 1.86
The genetics of Parkinson disease. J Geriatr Psychiatry Neurol (2010) 1.69
Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. J Neurosci Res (2009) 1.68
Quantitative proteomic analysis of single pancreatic islets. Proc Natl Acad Sci U S A (2009) 1.62
DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE). PLoS One (2013) 1.49
DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. Proc Natl Acad Sci U S A (2010) 1.38
Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. J Neurochem (2009) 1.34
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease. PLoS One (2009) 1.30
Oxidative and nitrative protein modifications in Parkinson's disease. Free Radic Biol Med (2008) 1.25
Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Mol Neurodegener (2007) 1.24
Genetic mouse models of parkinsonism: strengths and limitations. NeuroRx (2005) 1.22
Mitochondrial dysfunction and oxidative stress in Parkinson's disease. Prog Neurobiol (2013) 1.20
Neuroprotective function of DJ-1 in Parkinson's disease. Oxid Med Cell Longev (2013) 1.12
Targets for neuroprotection in Parkinson's disease. Biochim Biophys Acta (2008) 1.08
Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease. BMC Neurosci (2009) 1.08
Genetic findings in Parkinson's disease and translation into treatment: a leading role for mitochondria? Genes Brain Behav (2007) 1.07
Toxin-induced and genetic animal models of Parkinson's disease. Parkinsons Dis (2010) 1.04
Programmed cell death in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.04
A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease. Biochim Biophys Acta (2009) 1.02
Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening. PLoS One (2012) 1.02
Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. J Comp Neurol (2007) 0.99
Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis. PLoS One (2012) 0.94
Programmed cell death and new discoveries in the genetics of parkinsonism. J Neurochem (2007) 0.94
Cross Talk between Two Antioxidant Systems, Thioredoxin and DJ-1: Consequences for Cancer. Oncoscience (2014) 0.94
Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL. J Biol Chem (2011) 0.93
Animal models of Parkinson's disease: a gateway to therapeutics? Neurotherapeutics (2014) 0.93
Progress in the pathogenesis and genetics of Parkinson's disease. Philos Trans R Soc Lond B Biol Sci (2008) 0.91
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J Biol Chem (2010) 0.90
Mitochondrial dysfunction in genetic animal models of Parkinson's disease. Antioxid Redox Signal (2011) 0.90
Neurodegenerative disorders: Parkinson's disease and Huntington's disease. J Neurol Neurosurg Psychiatry (2005) 0.87
Human DJ-1-specific transcriptional activation of tyrosine hydroxylase gene. J Biol Chem (2010) 0.86
The role of DJ-1 in the pathogenesis of endometriosis. PLoS One (2011) 0.85
Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease. Neurobiol Dis (2013) 0.84
DJ-1 upregulates breast cancer cell invasion by repressing KLF17 expression. Br J Cancer (2014) 0.84
DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity. Hum Mol Genet (2010) 0.83
Identification of a novel functional deletion variant in the 5'-UTR of the DJ-1 gene. BMC Med Genet (2009) 0.83
Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis. Cell Res (2015) 0.82
Identification of an artificial peptide motif that binds and stabilizes reduced human DJ-1. J Struct Biol (2011) 0.82
DJ-1 can inhibit microtubule associated protein 1 B formed aggregates. Mol Neurodegener (2011) 0.82
Redox Regulation of Protein Function via Cysteine S-Nitrosylation and Its Relevance to Neurodegenerative Diseases. Int J Cell Biol (2012) 0.82
The E163K DJ-1 mutant shows specific antioxidant deficiency. Brain Res (2008) 0.82
Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione. PLoS One (2011) 0.81
Brain mitochondria from DJ-1 knockout mice show increased respiration-dependent hydrogen peroxide consumption. Redox Biol (2014) 0.81
L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments. J Neurosci Res (2010) 0.81
Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats. Mol Neurodegener (2011) 0.81
Metabolic role for yeast DJ-1 superfamily proteins. Proc Natl Acad Sci U S A (2014) 0.80
A proteomic analysis of mushroom polysaccharide-treated HepG2 cells. Sci Rep (2016) 0.80
Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes. Toxicol Lett (2008) 0.80
New insights on Parkinson's disease genes: the link between mitochondria impairment and neuroinflammation. J Neural Transm (Vienna) (2015) 0.80
Proteome analysis reveals roles of L-DOPA in response to oxidative stress in neurons. BMC Neurosci (2014) 0.79
Neuroproteomics as a promising tool in Parkinson's disease research. J Neural Transm (Vienna) (2008) 0.79
Leucine-rich repeat kinase 2: a new player with a familiar theme for Parkinson's disease pathogenesis. Proc Natl Acad Sci U S A (2005) 0.79
Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers. J Neurochem (2014) 0.79
Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection. Pharmacol Ther (2015) 0.78
6-OHDA-Induced Changes in Parkinson`s Disease-Related Gene Expression are not Affected by the Overexpression of PGAM5 in In Vitro Differentiated Embryonic Mesencephalic Cells. Cell Mol Neurobiol (2015) 0.78
Mitochondrial control of cell bioenergetics in Parkinson's disease. Free Radic Biol Med (2016) 0.78
Transduced Tat-DJ-1 protein inhibits cytokines-induced pancreatic RINm5F cell death. BMB Rep (2016) 0.77
Parkinson's Disease: The Mitochondria-Iron Link. Parkinsons Dis (2016) 0.76
Microglia-Derived Cytokines/Chemokines Are Involved in the Enhancement of LPS-Induced Loss of Nigrostriatal Dopaminergic Neurons in DJ-1 Knockout Mice. PLoS One (2016) 0.76
Mechanisms of Parkinson's disease-related proteins in mediating secondary brain damage after cerebral ischemia. J Cereb Blood Flow Metab (2017) 0.76
Understanding and treating neurodegeneration: insights from the flies. Age (Dordr) (2005) 0.75
Parkinson's disease: genetics and beyond. Curr Neuropharmacol (2007) 0.75
Molecules that cause or prevent Parkinson's disease. PLoS Biol (2004) 0.75
Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation. Int J Biol Sci (2016) 0.75
Targeting urate to reduce oxidative stress in Parkinson disease. Exp Neurol (2017) 0.75
Cytoprotective mechanisms of DJ-1 against oxidative stress through modulating ERK1/2 and ASK1 signal transduction. Redox Biol (2017) 0.75
Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro. Sci Rep (2017) 0.75
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci (2008) 5.89
Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nat Med (2011) 3.95
DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep (2004) 3.84
Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat Neurosci (2005) 3.69
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J (2008) 3.51
Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med (2012) 2.80
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci U S A (2005) 2.58
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol Cell (2002) 2.53
Prospective 10-year surveillance of human prion diseases in Japan. Brain (2010) 2.41
Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol (2010) 2.33
Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. Cell Stem Cell (2013) 2.32
Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells. Biochem Biophys Res Commun (2004) 2.31
Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs. EMBO Rep (2003) 2.16
Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila. Neuron (2003) 2.12
Posterior cerebral artery laterality on magnetic resonance angiography predicts long-term functional outcome in middle cerebral artery occlusion. Stroke (2012) 2.05
Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. PLoS Genet (2012) 2.01
Spinocerebellar ataxia type 31 is associated with "inserted" penta-nucleotide repeats containing (TGGAA)n. Am J Hum Genet (2009) 1.96
Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2. J Neurosci (2010) 1.91
Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts. Am J Hum Genet (2012) 1.90
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. J Biol Chem (2001) 1.86
Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell (2007) 1.82
The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease. J Biol Chem (2003) 1.78
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells. Proc Natl Acad Sci U S A (2012) 1.78
Biochemical characterization of the core structure of alpha-synuclein filaments. J Biol Chem (2002) 1.77
123I-MIBG myocardial scintigraphy for differentiating Parkinson's disease from other neurodegenerative parkinsonism: a systematic review and meta-analysis. Parkinsonism Relat Disord (2012) 1.72
In vivo evidence of CHIP up-regulation attenuating tau aggregation. J Neurochem (2005) 1.66
Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherol. Mol Ther (2008) 1.59
Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis. J Neurochem (2002) 1.57
Spreading of amyotrophic lateral sclerosis lesions--multifocal hits and local propagation? J Neurol Neurosurg Psychiatry (2013) 1.57
Blood-brain barrier destruction determines Fisher/Bickerstaff clinical phenotypes: an in vitro study. J Neurol Neurosurg Psychiatry (2013) 1.53
DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Mol Cancer Res (2003) 1.53
Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients. Biochem Biophys Res Commun (2004) 1.53
Lithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model. PLoS Med (2007) 1.52
Validation of cardiac (123)I-MIBG scintigraphy in patients with Parkinson's disease who were diagnosed with dopamine PET. Eur J Nucl Med Mol Imaging (2010) 1.51
Profound cardiac sympathetic denervation occurs in Parkinson disease. Brain Pathol (2005) 1.51
CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70. J Neurochem (2004) 1.50
Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice. J Neurochem (2015) 1.48
PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. Neurobiol Dis (2006) 1.47
Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model. Neurobiol Aging (2013) 1.46
R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. Biochim Biophys Acta (2004) 1.46
Bereitschaftspotential augmentation by neuro-feedback training in Parkinson's disease. Clin Neurophysiol (2013) 1.41
The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. PLoS Genet (2010) 1.41
Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation. EMBO Rep (2008) 1.40
DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3. Int J Oncol (2005) 1.39
Trypsinogen hL expressed in the human lung is a new member of the trypsinogen family. Biol Pharm Bull (2003) 1.37
Pure sensory infarct in the territories of anterior cerebral artery. Neurology (2010) 1.37
NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora. Am J Pathol (2008) 1.35
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone. J Neurochem (2007) 1.34
Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. Acta Neuropathol (2011) 1.34
Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels. Proc Natl Acad Sci U S A (2008) 1.34
Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion. Stroke (2007) 1.34
The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytes. Mol Cell Biol (2003) 1.32
A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus. J Biol Chem (2008) 1.32
Plasma globotriaosylsphingosine as a biomarker of Fabry disease. Mol Genet Metab (2010) 1.31
Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils. J Neurosci Res (2004) 1.30
Early detection of abnormal prion protein in genetic human prion diseases now possible using real-time QUIC assay. PLoS One (2013) 1.30
A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells. Proc Natl Acad Sci U S A (2006) 1.30
Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia. J Biol Chem (2002) 1.29
Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease. Antioxid Redox Signal (2007) 1.28
Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress. Free Radic Res (2005) 1.27
Efficient targeted mutagenesis in medaka using custom-designed transcription activator-like effector nucleases. Genetics (2013) 1.26
A rotarod test for evaluation of motor skill learning. J Neurosci Methods (2010) 1.26
Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents. Stroke (2006) 1.26
Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity. J Biol Chem (2004) 1.20
Intensity of chronic cerebral hypoperfusion determines white/gray matter injury and cognitive/motor dysfunction in mice. J Neurosci Res (2009) 1.18
Secretion of DJ-1 into the serum of patients with Parkinson's disease. Neurosci Lett (2007) 1.15
PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor. Exp Cell Res (2004) 1.15
Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts. J Clin Invest (2009) 1.15
Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. J Biol Chem (2012) 1.15
Regional analysis of age-related decline in dopamine transporters and dopamine D2-like receptors in human striatum. Synapse (2009) 1.15
Proteomic pattern analysis discriminates among multiple sclerosis-related disorders. Ann Neurol (2012) 1.14
L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner. Neurosci Res (2008) 1.13
Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic mice. Brain Res (2009) 1.13
Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model. Hum Mol Genet (2004) 1.12
Pael-R is accumulated in Lewy bodies of Parkinson's disease. Ann Neurol (2004) 1.12
Cognitive status correlates with white matter alteration in Parkinson's disease. Hum Brain Mapp (2011) 1.12
Early protective effect of bone marrow mononuclear cells against ischemic white matter damage through augmentation of cerebral blood flow. Stroke (2010) 1.11
Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementia. Neuroreport (2009) 1.11
A mouse model characterizing features of vascular dementia with hippocampal atrophy. Stroke (2010) 1.11
Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1. Biochem Biophys Res Commun (2005) 1.10
Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN. Int J Oncol (2009) 1.10
DJ-1 binds to mitochondrial complex I and maintains its activity. Biochem Biophys Res Commun (2009) 1.10
Modulation of collagen fibrillogenesis by tenascin-X and type VI collagen. Exp Cell Res (2004) 1.09
The endoplasmic reticulum stress sensor, ATF6α, protects against neurotoxin-induced dopaminergic neuronal death. J Biol Chem (2010) 1.09
Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43. Brain (2012) 1.09
A conditionally dispensable chromosome controls host-specific pathogenicity in the fungal plant pathogen Alternaria alternata. Genetics (2002) 1.07
A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats. Brain (2013) 1.07
Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Hum Mol Genet (2006) 1.06
Distinct effects of caudalizing factors on regional specification of embryonic stem cell-derived neural precursors. Brain Res Dev Brain Res (2005) 1.06
Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circ Res (2017) 1.06
Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models. J Neurosci Res (2009) 1.05
Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke. Exp Neurol (2007) 1.05
Selective white matter abnormalities in a novel rat model of vascular dementia. Neurobiol Aging (2011) 1.05
Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1. Toxicol Sci (2005) 1.05
DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. J Cereb Blood Flow Metab (2007) 1.05
Loss of TDP-43 causes age-dependent progressive motor neuron degeneration. Brain (2013) 1.05
Dura mater graft-associated Creutzfeldt-Jakob disease in Japan: clinicopathological and molecular characterization of the two distinct subtypes. Neuropathology (2009) 1.05
Redefining the disease locus of 16q22.1-linked autosomal dominant cerebellar ataxia. J Hum Genet (2007) 1.05