Published in Am J Physiol Lung Cell Mol Physiol on January 10, 2003
Expression of the reverse tetracycline-transactivator gene causes emphysema-like changes in mice. Am J Respir Cell Mol Biol (2006) 2.46
Animal models of chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol (2008) 2.18
Matrix metalloproteinases in destructive pulmonary pathology. Thorax (2005) 2.06
Molecular pathogenesis of emphysema. J Clin Invest (2008) 2.03
Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice. Am J Respir Crit Care Med (2005) 1.61
N-alpha-PGP and PGP, potential biomarkers and therapeutic targets for COPD. Respir Res (2009) 1.50
Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 1.35
Emphysema and mechanical stress-induced lung remodeling. Physiology (Bethesda) (2013) 1.32
Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs. Thorax (2007) 1.28
TLR4 protein contributes to cigarette smoke-induced matrix metalloproteinase-1 (MMP-1) expression in chronic obstructive pulmonary disease. J Biol Chem (2011) 1.18
The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema. Am J Respir Crit Care Med (2010) 1.16
Impact of the loss of Hoxa5 function on lung alveogenesis. Am J Pathol (2006) 1.12
ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Dev Cell (2011) 1.12
The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema. Am J Pathol (2010) 1.05
Structure-function relations in an elastase-induced mouse model of emphysema. Am J Respir Cell Mol Biol (2010) 1.04
Inorganic arsenic as a developmental toxicant: in utero exposure and alterations in the developing rat lungs. Mol Nutr Food Res (2009) 1.03
Emerging role of MAP kinase pathways as therapeutic targets in COPD. Int J Chron Obstruct Pulmon Dis (2006) 1.03
Increased matrix metalloproteinase (MMPs) levels do not predict disease severity or progression in emphysema. PLoS One (2013) 1.00
Attacking the multi-tiered proteolytic pathology of COPD: new insights from basic and translational studies. Pharmacol Ther (2008) 0.99
Protein phosphatase 2A regulates innate immune and proteolytic responses to cigarette smoke exposure in the lung. Toxicol Sci (2012) 0.97
Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1(+) smokers with early emphysema. J Leukoc Biol (2009) 0.94
CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke. Am J Physiol Lung Cell Mol Physiol (2014) 0.93
Emergent structure-function relations in emphysema and asthma. Crit Rev Biomed Eng (2011) 0.92
What drives the peripheral lung-remodeling process in chronic obstructive pulmonary disease? Proc Am Thorac Soc (2009) 0.92
The chemokine, CCL3, and its receptor, CCR1, mediate thoracic radiation-induced pulmonary fibrosis. Am J Respir Cell Mol Biol (2010) 0.91
Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis. PLoS One (2013) 0.90
Complex integration of matrix, oxidative stress, and apoptosis in genetic emphysema. Am J Pathol (2009) 0.89
The MMP-1/PAR-1 Axis Enhances Proliferation and Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells. Neural Plast (2015) 0.78
Functional characterization of the matrix metalloproteinase-1 cigarette smoke-responsive region and association with the lung health study. Respir Res (2012) 0.77
Collagenolytic matrix metalloproteinases in chronic obstructive lung disease and cancer. Cancers (Basel) (2015) 0.76
Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases. Respir Res (2016) 0.75
Pulmonary Remodeling in Equine Asthma: What Do We Know about Mediators of Inflammation in the Horse? Mediators Inflamm (2016) 0.75
Myeloid-specific Fos-related antigen-1 regulates cigarette smoke-induced lung inflammation, not emphysema, in mice. Am J Respir Cell Mol Biol (2015) 0.75
Effectiveness-based guidelines for the prevention of cardiovascular disease in women--2011 update: a guideline from the american heart association. Circulation (2011) 5.26
Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science (2002) 4.49
Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. Nat Med (2009) 3.32
Effectiveness-based guidelines for the prevention of cardiovascular disease in women--2011 update: a guideline from the American Heart Association. J Am Coll Cardiol (2011) 2.89
Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. FASEB J (2001) 2.79
ADAMs in cancer cell proliferation and progression. Cancer Sci (2007) 2.69
Prediction of intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease. Circulation (2006) 2.56
Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J Immunol (2007) 2.53
Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165. J Biol Chem (2002) 2.33
A multicenter prospective randomized trial of corticosteroids in primary therapy for Kawasaki disease: clinical course and coronary artery outcome. J Pediatr (2006) 2.13
Tuberous sclerosis-associated lesions of the kidney, brain, and skin are angiogenic neoplasms. J Am Acad Dermatol (2002) 2.05
Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. Nat Med (2006) 2.03
Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice. J Clin Invest (2005) 1.94
Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology (2006) 1.81
MMP-1 drives immunopathology in human tuberculosis and transgenic mice. J Clin Invest (2011) 1.77
Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor. J Natl Cancer Inst (2012) 1.76
Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 induction by cigarette smoke. J Biol Chem (2004) 1.75
Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol. J Biol Chem (2002) 1.73
Transgenic overexpression of matrix metalloproteinase-9 in macrophages attenuates the inflammatory response and improves left ventricular function post-myocardial infarction. J Mol Cell Cardiol (2012) 1.69
HMGA2 is a driver of tumor metastasis. Cancer Res (2013) 1.66
The impact of angiotensin-converting enzyme inhibitor therapy on the extracellular collagen matrix during left ventricular assist device support in patients with end-stage heart failure. J Am Coll Cardiol (2007) 1.63
Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice. Am J Respir Crit Care Med (2005) 1.61
Matrix metalloproteinases in development and disease. Birth Defects Res C Embryo Today (2006) 1.61
Joint diseases and matrix metalloproteinases: a role for MMP-13. Curr Pharm Biotechnol (2008) 1.60
Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells. Am J Pathol (2007) 1.54
Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling. Circulation (2012) 1.54
MT1-MMP and MMP-7 in invasion and metastasis of human cancers. Cancer Metastasis Rev (2003) 1.48
Structural emphysema does not correlate with lung compliance: lessons from the mouse smoking model. Exp Lung Res (2005) 1.48
Altered lymphocyte trafficking and diminished airway reactivity in transgenic mice expressing human MMP-9 in a mouse model of asthma. Am J Physiol Lung Cell Mol Physiol (2009) 1.48
Prognostic role of KiSS-1 and possibility of therapeutic modality of metastin, the final peptide of the KiSS-1 gene, in urothelial carcinoma. Mol Cancer Ther (2012) 1.47
Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh. Environ Health Perspect (2008) 1.44
Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin. Am J Physiol Lung Cell Mol Physiol (2008) 1.43
Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents. J Clin Invest (2010) 1.42
Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage. Am J Pathol (2003) 1.42
MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing. Am J Pathol (2009) 1.40
Prevalence of Patent Foramen Ovale in the Japanese Population- Autopsy Study. Circ J (2015) 1.39
Misexpression of full-length HMGA2 induces benign mesenchymal tumors in mice. Cancer Res (2006) 1.35
Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents. J Clin Invest (2010) 1.33
The role of matrix metalloproteinases in glioma invasion. Front Biosci (2003) 1.33
Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells. J Immunol (2003) 1.31
Detection of von Willebrand factor-cleaving protease (ADAMTS-13) in human platelets. Biochem Biophys Res Commun (2004) 1.29
Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases. Pathol Int (2010) 1.29
Expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic cartilage. Pathol Int (2007) 1.23
KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization. Proc Natl Acad Sci U S A (2013) 1.23
Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma. Clin Cancer Res (2010) 1.22
Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice. Cancer Res (2007) 1.21
ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor. Am J Pathol (2004) 1.21
Increased RANKL expression is related to tumour migration and metastasis of renal cell carcinomas. J Pathol (2009) 1.20
Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection. Circulation (2012) 1.18
Increased medial degradation with pseudo-aneurysm formation in apolipoprotein E-knockout mice deficient in tissue inhibitor of metalloproteinases-1. Circulation (2003) 1.18
Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice. Biochem Biophys Res Commun (2007) 1.18
TLR4 protein contributes to cigarette smoke-induced matrix metalloproteinase-1 (MMP-1) expression in chronic obstructive pulmonary disease. J Biol Chem (2011) 1.18
Human glioblastomas overexpress ADAMTS-5 that degrades brevican. Acta Neuropathol (2005) 1.17
Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases. Oncogene (2003) 1.17
Constitutive and induced CD44 shedding by ADAM-like proteases and membrane-type 1 matrix metalloproteinase. Cancer Res (2004) 1.17
Overexpression of MMP9 in macrophages attenuates pulmonary fibrosis induced by bleomycin. Int J Biochem Cell Biol (2007) 1.16
Functional expression of the GABAB receptor in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2006) 1.14
Mechanical unloading during left ventricular assist device support increases left ventricular collagen cross-linking and myocardial stiffness. Circulation (2005) 1.14
Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis. Lab Invest (2011) 1.12
ADAM-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage. Arthritis Rheum (2008) 1.10
Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci (2003) 1.09
Mechanisms of heat-induced antigen retrieval: analyses in vitro employing SDS-PAGE and immunohistochemistry. J Histochem Cytochem (2005) 1.09
Expression of snail in upper urinary tract urothelial carcinoma: prognostic significance and implications for tumor invasion. Clin Cancer Res (2010) 1.09
Bioactive depsides and anthocyanins from jaboticaba (Myrciaria cauliflora). J Nat Prod (2006) 1.07
ADAM28 is overexpressed in human breast carcinomas: implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3. Cancer Res (2006) 1.07
Establishment of a real-time, quantitative, and reproducible mouse model of Staphylococcus osteomyelitis using bioluminescence imaging. Infect Immun (2011) 1.06
Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors. J Biol Chem (2004) 1.06
Invasive lobular carcinoma arising in phyllodes tumor of the breast. Virchows Arch (2003) 1.05
The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema. Am J Pathol (2010) 1.05
Blockade of receptor for advanced glycation end product attenuates pulmonary reperfusion injury in mice. J Thorac Cardiovasc Surg (2008) 1.04
Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis. Circulation (2008) 1.03
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan. J Biol Chem (2004) 1.02
Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm. Cardiovasc Res (2011) 1.01
Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF. J Immunol (2009) 1.01
Expression of TNF-α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and resistance to the sunitinib treatment in clear cell renal cell carcinomas. Int J Cancer (2014) 1.01
Emphysematous changes are caused by degradation of type III collagen in transgenic mice expressing MMP-1. Exp Lung Res (2003) 0.99
Regulation of monocyte chemoattractant protein-1 through angiotensin II type 1 receptor in prostate cancer. Am J Pathol (2012) 0.98
Neuromuscular and vascular hamartoma of the cecum. Virchows Arch (2001) 0.98
Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation. Cancer Sci (2009) 0.98
Activation of the aryl hydrocarbon receptor pathway enhances cancer cell invasion by upregulating the MMP expression and is associated with poor prognosis in upper urinary tract urothelial cancer. Carcinogenesis (2009) 0.98
Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization. Atherosclerosis (2011) 0.97
Production and activation of matrix metalloproteinase 7 (matrilysin 1) in the lungs of patients with idiopathic pulmonary fibrosis. Arch Pathol Lab Med (2010) 0.96
Cigarette smoke components induce matrix metalloproteinase-1 in aortic endothelial cells through inhibition of mTOR signaling. Toxicol Sci (2011) 0.96
Activation of the TLR4 signaling pathway and abnormal cholesterol efflux lead to emphysema in ApoE-deficient mice. Am J Physiol Lung Cell Mol Physiol (2012) 0.96
Malignant transformation of sialadenoma papilliferum of the palate: a case report. Virchows Arch (2004) 0.96
Leaky ryanodine receptors in β-sarcoglycan deficient mice: a potential common defect in muscular dystrophy. Skelet Muscle (2012) 0.95
Primary invasive micropapillary carcinoma of the stomach. Pathol Int (2008) 0.95
Mice with cardiac overexpression of peroxisome proliferator-activated receptor γ have impaired repolarization and spontaneous fatal ventricular arrhythmias. Circulation (2011) 0.95
Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization. FEBS Open Bio (2013) 0.95
Systemic overexpression of TNFα-converting enzyme does not lead to enhanced shedding activity in vivo. PLoS One (2013) 0.94
Pericellular activation of proMMP-7 (promatrilysin-1) through interaction with CD151. Lab Invest (2005) 0.94
Embryonic expression profile of chicken CHD7, the ortholog of the causative gene for CHARGE syndrome. Birth Defects Res A Clin Mol Teratol (2007) 0.94