Published in Am J Respir Crit Care Med on November 05, 2010
National Lung Screening Trial (NLST) Screening (NLST) | NCT00047385
Biomarkers and Genetic Factors Related to Emphysema | NCT00757120
Mechanistic links between COPD and lung cancer. Nat Rev Cancer (2013) 2.28
A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis. J Allergy Clin Immunol (2013) 1.16
Increased matrix metalloproteinase (MMPs) levels do not predict disease severity or progression in emphysema. PLoS One (2013) 1.00
Activation of the TLR4 signaling pathway and abnormal cholesterol efflux lead to emphysema in ApoE-deficient mice. Am J Physiol Lung Cell Mol Physiol (2012) 0.96
A novel nonhuman primate model of cigarette smoke-induced airway disease. Am J Pathol (2014) 0.95
Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation. BMC Pulm Med (2012) 0.94
Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering. Biomaterials (2013) 0.94
RAGE and tobacco smoke: insights into modeling chronic obstructive pulmonary disease. Front Physiol (2012) 0.90
Tobacco smoke induced COPD/emphysema in the animal model-are we all on the same page? Front Physiol (2013) 0.89
Delay of airway epithelial wound repair in COPD is associated with airflow obstruction severity. Respir Res (2014) 0.88
A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin. Am J Respir Crit Care Med (2016) 0.87
Novel aspects of pathogenesis and regeneration mechanisms in COPD. Int J Chron Obstruct Pulmon Dis (2015) 0.84
SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol (2013) 0.84
Increased levels of soluble interleukin-6 receptor and CCL3 in COPD sputum. Respir Res (2014) 0.83
Second hand smoke and COPD: lessons from animal studies. Front Physiol (2013) 0.83
Cigarette smoke activates the proto-oncogene c-src to promote airway inflammation and lung tissue destruction. Am J Respir Cell Mol Biol (2014) 0.81
Genetic polymorphism of matrix metalloproteinase family and chronic obstructive pulmonary disease susceptibility: a meta-analysis. Sci Rep (2013) 0.81
Accurate measurement of small airways on low-dose thoracic CT scans in smokers. Chest (2013) 0.80
Factors influencing the measurement of plasma/serum surfactant protein D levels by ELISA. PLoS One (2014) 0.80
Heterogeneity of lung mononuclear phagocytes in chronic obstructive pulmonary disease. J Innate Immun (2012) 0.79
Reactive oxygen species in peripheral blood and sputum neutrophils during bacterial and nonbacterial acute exacerbation of chronic obstructive pulmonary disease. Inflammation (2013) 0.79
Inhibition of matrix metalloproteinase-9 with low-dose doxycycline reduces acute lung injury induced by cardiopulmonary bypass. Int J Clin Exp Med (2014) 0.78
NPS2143 Inhibits MUC5AC and Proinflammatory Mediators in Cigarette Smoke Extract (CSE)-Stimulated Human Airway Epithelial Cells. Inflammation (2016) 0.76
The Role of Mitochondria and Oxidative/Antioxidative Imbalance in Pathobiology of Chronic Obstructive Pulmonary Disease. Oxid Med Cell Longev (2016) 0.76
Immune-mediated inflammation in the pathogenesis of emphysema: insights from mouse models. Cell Tissue Res (2017) 0.75
Changes in the expression and protein level of matrix metalloproteinases after exposure to waterpipe tobacco smoke. Inhal Toxicol (2015) 0.75
Relationships of MMP-9 and TIMP-1 proteins with chronic obstructive pulmonary disease risk: A systematic review and meta-analysis. J Res Med Sci (2016) 0.75
Impact of tobacco smoking on cytokine signaling via interleukin-17A in the peripheral airways. Int J Chron Obstruct Pulmon Dis (2016) 0.75
Repeated Activation of Lung Invariant NKT Cells Results in Chronic Obstructive Pulmonary Disease-Like Symptoms. PLoS One (2016) 0.75
Myeloid-specific Fos-related antigen-1 regulates cigarette smoke-induced lung inflammation, not emphysema, in mice. Am J Respir Cell Mol Biol (2015) 0.75
Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis. Proc Natl Acad Sci U S A (2016) 0.75
Pulmonary Remodeling in Equine Asthma: What Do We Know about Mediators of Inflammation in the Horse? Mediators Inflamm (2016) 0.75
Matrix Metalloproteinase-28 Is a Key Contributor to Emphysema Pathogenesis. Am J Pathol (2017) 0.75
ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med (2002) 31.79
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell (1998) 9.70
Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science (1997) 8.19
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Amplification of inflammation in emphysema and its association with latent adenoviral infection. Am J Respir Crit Care Med (2001) 4.25
The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 3.85
Matrix metalloproteinase-9 in lung remodeling. Am J Respir Cell Mol Biol (2003) 2.95
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol (2003) 2.66
Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release. Am J Respir Crit Care Med (2003) 2.64
Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest (2002) 2.52
Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Thorax (2003) 2.47
An animal model of autoimmune emphysema. Am J Respir Crit Care Med (2004) 2.40
Gene expression profiling of human lung tissue from smokers with severe emphysema. Am J Respir Cell Mol Biol (2004) 2.33
Evaluation of serum CC-16 as a biomarker for COPD in the ECLIPSE cohort. Thorax (2008) 2.25
Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest (2009) 2.17
Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease. J Immunol (2009) 2.05
Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2002) 2.00
Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema. Lab Invest (1998) 1.97
Genetic determinants of emphysema distribution in the national emphysema treatment trial. Am J Respir Crit Care Med (2007) 1.94
Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2008) 1.83
Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema. Am J Respir Crit Care Med (1999) 1.69
Association between markers of emphysema and more severe chronic obstructive pulmonary disease. Thorax (2006) 1.60
Gender differences in the severity of CT emphysema in COPD. Chest (2007) 1.59
Doxycycline in patients with abdominal aortic aneurysms and in mice: comparison of serum levels and effect on aneurysm growth in mice. J Vasc Surg (2002) 1.57
Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD. Eur Respir J (2009) 1.56
Matrix metalloproteinase-9 promoter polymorphism associated with upper lung dominant emphysema. Am J Respir Crit Care Med (2005) 1.52
Chronic LPS inhalation causes emphysema-like changes in mouse lung that are associated with apoptosis. Am J Respir Cell Mol Biol (2008) 1.51
Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Regulation by interleukin-10. Am J Respir Crit Care Med (2000) 1.44
MMP inhibition in abdominal aortic aneurysms. Rationale for a prospective randomized clinical trial. Ann N Y Acad Sci (1999) 1.44
Causal relationship between indium compound inhalation and effects on the lungs. J Occup Health (2009) 1.44
Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin. Am J Physiol Lung Cell Mol Physiol (2008) 1.43
Progressive adult-onset emphysema in transgenic mice expressing human MMP-1 in the lung. Am J Physiol Lung Cell Mol Physiol (2003) 1.42
Exploring the role of CT densitometry: a randomised study of augmentation therapy in alpha1-antitrypsin deficiency. Eur Respir J (2009) 1.41
A site on laminin alpha 5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis. J Immunol (2003) 1.38
Membrane-type 1 matrix metalloproteinase is required for normal alveolar development. Dev Dyn (2005) 1.32
Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease. Respir Med (2009) 1.26
Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study. BMC Pulm Med (2007) 1.21
Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide. Am J Physiol Lung Cell Mol Physiol (2008) 1.17
Matrix metalloproteinases -8, -9 and -12 in smokers and patients with stage 0 COPD. Int J Chron Obstruct Pulmon Dis (2007) 1.15
Oxidative damage to nucleic acids in severe emphysema. Chest (2008) 1.10
Effects of cigarette smoke exposure and cessation on inflammatory cells and matrix metalloproteinase activity in mice. Exp Lung Res (2004) 1.09
Genetic polymorphism in matrix metalloproteinase-9 and pulmonary emphysema. Biochem Biophys Res Commun (2001) 1.08
Isolation of human monocyte populations. Curr Protoc Immunol (2006) 1.06
Elastin expression in very severe human COPD. Eur Respir J (2009) 1.06
Chemokines in bronchiolar epithelium in the development of chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2004) 1.05
Involvement of MMP-12 and phosphodiesterase type 4 in cigarette smoke-induced inflammation in mice. Eur Respir J (2006) 1.02
All-trans retinoic acid modulates the balance of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with emphysema. Chest (2003) 0.94
Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin deficiency. Respir Res (2009) 0.91
Plasma surfactant D in patients following acute paraquat intoxication. Clin Toxicol (Phila) (2007) 0.89
Use of proteomic patterns of serum biomarkers in patients with chronic obstructive pulmonary disease: correlation with clinical parameters. Proc Am Thorac Soc (2006) 0.88
Roles of serum clara cell protein 16 and surfactant protein-D in the early diagnosis and progression of silicosis. J Occup Environ Med (2007) 0.86
Role of matrix metalloproteinases in the inflammatory response in human airway cell-based assays and in rodent models of airway disease. J Pharmacol Exp Ther (2006) 0.85
Associations between environmental exposures and serum concentrations of Clara cell protein among elderly men in Oslo, Norway. Environ Res (2008) 0.80
Lung epithelium injury biomarkers in workers exposed to sulphur dioxide in a non-ferrous smelter. Biomarkers (2009) 0.78
Surfactant protein D (SP-D) and systemic scleroderma (SSc). J Dermatol (2001) 0.77
Results of initial low-dose computed tomographic screening for lung cancer. N Engl J Med (2013) 5.92
MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell (2002) 4.93
Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N Engl J Med (2011) 4.16
Elastin fragments drive disease progression in a murine model of emphysema. J Clin Invest (2006) 3.11
Airflow limitation and airway dimensions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 3.09
Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI. Proc Natl Acad Sci U S A (2002) 2.96
Matrix metalloproteinase-9 in lung remodeling. Am J Respir Cell Mol Biol (2003) 2.95
Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 2.81
Results of the two incidence screenings in the National Lung Screening Trial. N Engl J Med (2013) 2.66
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol (2003) 2.66
Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis. J Clin Invest (2002) 2.56
Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest (2002) 2.52
Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol (2007) 2.08
A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD (2012) 2.07
Quantification of lung microstructure with hyperpolarized 3He diffusion MRI. J Appl Physiol (1985) (2009) 2.01
Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood (2004) 2.01
Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling. Circ Res (2002) 1.98
Fragments of extracellular matrix as mediators of inflammation. Int J Biochem Cell Biol (2007) 1.89
Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2008) 1.83
Obesity and risk of cancer in Japan. Int J Cancer (2005) 1.79
Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration. J Biol Chem (2001) 1.74
Maintenance of glomerular filtration barrier integrity requires laminin alpha5. J Am Soc Nephrol (2010) 1.73
Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro. J Leukoc Biol (2002) 1.62
Characterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease. Thorax (2007) 1.61
National Lung Screening Trial findings by age: Medicare-eligible versus under-65 population. Ann Intern Med (2014) 1.56
Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease. Am J Physiol Lung Cell Mol Physiol (2004) 1.56
Predictors of osteoporosis and vertebral fractures in patients presenting with moderate-to-severe chronic obstructive lung disease. COPD (2012) 1.55
Ablation of matrix metalloproteinase-9 increases severity of viral myocarditis in mice. Circulation (2008) 1.54
Accelerated enlargement of experimental abdominal aortic aneurysms in a mouse model of chronic cigarette smoke exposure. J Am Coll Surg (2004) 1.53
A prospective evaluation of lung volume reduction surgery in 200 consecutive patients. Chest (2003) 1.51
Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation. J Immunol (2004) 1.49
Matrix metalloproteinases 9 and 2 are necessary for the migration of Langerhans cells and dermal dendritic cells from human and murine skin. J Immunol (2002) 1.49
MRI of piriformis syndrome. AJR Am J Roentgenol (2004) 1.48
Role of collateral paths in long-range diffusion in lungs. J Appl Physiol (1985) (2008) 1.47
Automated matching of pulmonary nodules: evaluation in serial screening chest CT. AJR Am J Roentgenol (2009) 1.44
Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. J Clin Invest (2013) 1.42
Combination therapy of 15-epi-lipoxin A4 with antibiotics protects mice from Escherichia coli-induced sepsis*. Crit Care Med (2014) 1.42
Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases. Cancer Res (2006) 1.41
Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9. J Leukoc Biol (2009) 1.41
Activation of the FGF2-FGFR1 autocrine pathway: a novel mechanism of acquired resistance to gefitinib in NSCLC. Mol Cancer Res (2013) 1.40
Mice that lack matrix metalloproteinase-9 display delayed wound healing associated with delayed reepithelization and disordered collagen fibrillogenesis. Matrix Biol (2009) 1.40
Image quality assurance in the prostate, lung, colorectal, and ovarian cancer screening trial network of the National Lung Screening Trial. J Digit Imaging (2005) 1.39
A site on laminin alpha 5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis. J Immunol (2003) 1.38
Overexpression of Stat3C in pulmonary epithelium protects against hyperoxic lung injury. J Immunol (2005) 1.37
Laminin isoforms and lung development: all isoforms are not equal. Dev Biol (2006) 1.37
Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo. Am J Pathol (2005) 1.36
Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 1.35
Laparoscopic gastric resection for gastrointestinal stromal tumors. Surg Endosc (2008) 1.34
Mouse strain modulates the role of the ciliated cell in acute tracheobronchial airway injury-distal airways. Am J Pathol (2002) 1.34
Clinical research in chronic obstructive pulmonary disease: needs and opportunities. Am J Respir Crit Care Med (2003) 1.32
Membrane-type 1 matrix metalloproteinase is required for normal alveolar development. Dev Dyn (2005) 1.32
Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment. J Infect Dis (2005) 1.31
Role of macrophage migration inhibitory factor in bleomycin-induced lung injury and fibrosis in mice. Am J Physiol Lung Cell Mol Physiol (2002) 1.29
Laparoscopic Dor versus Toupet fundoplication following Heller myotomy for achalasia: results of a multicenter, prospective, randomized-controlled trial. Surg Endosc (2011) 1.27
Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems. J Biol Chem (2008) 1.26
The role of the lung microbiome in health and disease. A National Heart, Lung, and Blood Institute workshop report. Am J Respir Crit Care Med (2013) 1.26
Effects of CT section thickness and reconstruction kernel on emphysema quantification relationship to the magnitude of the CT emphysema index. Acad Radiol (2010) 1.26
Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells. Am J Respir Cell Mol Biol (2008) 1.25
Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. J Clin Invest (2005) 1.25
Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia. J Immunol (2009) 1.25
In vivo lung morphometry with hyperpolarized 3He diffusion MRI in canines with induced emphysema: disease progression and comparison with computed tomography. J Appl Physiol (1985) (2006) 1.21
Characterization of mouse alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol (2009) 1.20
Hyperpolarized 3He MR imaging: physiologic monitoring observations and safety considerations in 100 consecutive subjects. Radiology (2008) 1.19
The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein. Blood (2003) 1.18
Collecting 48,000 CT exams for the lung screening study of the National Lung Screening Trial. J Digit Imaging (2008) 1.17
Performance of Lung-RADS in the National Lung Screening Trial: a retrospective assessment. Ann Intern Med (2015) 1.17
Epithelial laminin alpha5 is necessary for distal epithelial cell maturation, VEGF production, and alveolization in the developing murine lung. Dev Biol (2005) 1.15
Clara cells impact the pulmonary innate immune response to LPS. Am J Physiol Lung Cell Mol Physiol (2007) 1.14
Needle biopsy of incidentally discovered adrenal masses is rarely informative and potentially hazardous. Surgery (2007) 1.13
Hyperpolarized (3)He MRI of mouse lung. Magn Reson Med (2004) 1.12
Molecular and functional properties of lung SP cells. Am J Physiol Lung Cell Mol Physiol (2006) 1.12
Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung. Dev Biol (2002) 1.12
In vivo detection of acinar microstructural changes in early emphysema with (3)He lung morphometry. Radiology (2011) 1.11
3He diffusion MRI of the lung. Acad Radiol (2005) 1.11
Lung imaging in asthmatic patients: the picture is clearer. J Allergy Clin Immunol (2011) 1.10
Oxidative damage to nucleic acids in severe emphysema. Chest (2008) 1.10
Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation. Nat Commun (2013) 1.09
Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils. J Biol Chem (2008) 1.08
Neutrophil elastase mediates innate host protection against Pseudomonas aeruginosa. J Immunol (2008) 1.07
Imbalance between cysteine proteases and inhibitors in a baboon model of bronchopulmonary dysplasia. Am J Respir Crit Care Med (2005) 1.07
Evaluation of reader variability in the interpretation of follow-up CT scans at lung cancer screening. Radiology (2011) 1.06
Analysis of comorbid factors that increase the COPD assessment test scores. Respir Res (2014) 1.06
Decreased airway expression of vascular endothelial growth factor in cigarette smoke-induced emphysema in mice and COPD patients. Inhal Toxicol (2008) 1.06
Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice. Br J Pharmacol (2012) 1.06
Chemosensory functions for pulmonary neuroendocrine cells. Am J Respir Cell Mol Biol (2014) 1.06
Chemokines in bronchiolar epithelium in the development of chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2004) 1.05