Published in J Immunol on April 15, 2003
Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc Natl Acad Sci U S A (2004) 5.89
Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits. Nature (2008) 4.87
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol (2010) 4.07
Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens. Nat Rev Microbiol (2010) 3.45
Epithelial crosstalk at the microbiota-mucosal interface. Proc Natl Acad Sci U S A (2010) 2.26
Do symbiotic bacteria subvert host immunity? Nat Rev Microbiol (2009) 2.07
Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One (2007) 2.05
IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function. Eur J Immunol (2008) 1.97
Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria. Gastroenterology (2008) 1.89
Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli. Gut (2007) 1.85
Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2. Gut (2005) 1.84
Toll-like receptors in inflammatory bowel diseases: a decade later. Inflamm Bowel Dis (2010) 1.79
Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria. Immunology (2005) 1.75
Host-bacterial symbiosis in health and disease. Adv Immunol (2010) 1.73
Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect Immun (2004) 1.72
Sensing gram-negative bacterial lipopolysaccharides: a human disease determinant? Infect Immun (2007) 1.50
Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury. Crit Care Med (2005) 1.49
No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammation. Mol Med (2008) 1.46
Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon. PLoS One (2010) 1.45
Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation. Endocrinology (2008) 1.44
Enteroendocrine cells express functional Toll-like receptors. Am J Physiol Gastrointest Liver Physiol (2007) 1.42
Abnormal expression of Toll-like receptor 4 is associated with susceptibility to ethanol-induced gastric mucosal injury in mice. Dig Dis Sci (2013) 1.39
A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am J Physiol Gastrointest Liver Physiol (2009) 1.39
Escherichia coli strain Nissle 1917 ameliorates experimental colitis via toll-like receptor 2- and toll-like receptor 4-dependent pathways. Infect Immun (2006) 1.38
Innate immune signalling at the intestinal epithelium in homeostasis and disease. EMBO Rep (2012) 1.37
Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia. J Histochem Cytochem (2009) 1.29
Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PLoS One (2010) 1.26
Mammalian Toll-like receptors: to immunity and beyond. Clin Exp Immunol (2005) 1.23
Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-kappaB activation. World J Gastroenterol (2006) 1.21
Increased expression of 25-hydroxyvitamin D-1alpha-hydroxylase in dysgerminomas: a novel form of humoral hypercalcemia of malignancy. Am J Pathol (2004) 1.17
Selection of bifidobacteria based on adhesion and anti-inflammatory capacity in vitro for amelioration of murine colitis. Appl Environ Microbiol (2010) 1.15
Analysis of ESTs from Lutzomyia longipalpis sand flies and their contribution toward understanding the insect-parasite relationship. Genomics (2006) 1.14
NOX enzymes and Toll-like receptor signaling. Semin Immunopathol (2008) 1.13
A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin Exp Immunol (2009) 1.12
Polyunsaturated fatty acid supplementation alters proinflammatory gene expression and reduces the incidence of necrotizing enterocolitis in a neonatal rat model. Pediatr Res (2007) 1.10
Host-microbial interactions and regulation of intestinal epithelial barrier function: From physiology to pathology. World J Gastrointest Pathophysiol (2012) 1.09
Aggregating phenotype in Lactobacillus crispatus determines intestinal colonization and TLR2 and TLR4 modulation in murine colonic mucosa. Clin Vaccine Immunol (2007) 1.08
Epigenetic control of the host gene by commensal bacteria in large intestinal epithelial cells. J Biol Chem (2011) 1.06
Role of Toll-like receptors in health and diseases of gastrointestinal tract. World J Gastroenterol (2006) 1.06
Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins. Am J Physiol Gastrointest Liver Physiol (2010) 1.05
Epithelial toll-like receptor 5 is constitutively localized in the mouse cecum and exhibits distinctive down-regulation during experimental colitis. Clin Vaccine Immunol (2006) 1.04
Pattern recognition via the toll-like receptor system in the human female genital tract. Mediators Inflamm (2010) 1.01
Innate immune signaling in defense against intestinal microbes. Immunol Rev (2012) 1.00
Regulation of intestinal barrier function by signal transducer and activator of transcription 5b. Gut (2008) 0.99
Macrophage migration inhibitory factor contributes to the development of acute dextran sulphate sodium-induced colitis in Toll-like receptor 4 knockout mice. Clin Exp Immunol (2005) 0.98
Role of toll-like receptor 4 in the proinflammatory response to Vibrio cholerae O1 El tor strains deficient in production of cholera toxin and accessory toxins. Infect Immun (2005) 0.94
LPS induces translocation of TLR4 in amniotic epithelium. Placenta (2006) 0.94
Eubacterium limosum ameliorates experimental colitis and metabolite of microbe attenuates colonic inflammatory action with increase of mucosal integrity. World J Gastroenterol (2006) 0.94
How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology. J Immunol Res (2015) 0.94
Immunological alteration and changes of gut microbiota after dextran sulfate sodium (DSS) administration in mice. Clin Exp Med (2014) 0.93
A commensal Helicobacter sp. of the rodent intestinal flora activates TLR2 and NOD1 responses in epithelial cells. PLoS One (2009) 0.91
Tissue expression of Toll-like receptors 2 and 4 in sporadic human colorectal cancer. Cancer Immunol Immunother (2011) 0.91
Animal models of intestinal inflammation: ineffective communication between coalition members. Springer Semin Immunopathol (2005) 0.91
Toll-like receptor signaling and regulation of intestinal immunity. Virulence (2013) 0.91
Down-regulation of single immunoglobulin interleukin-1R-related molecule (SIGIRR)/TIR8 expression in intestinal epithelial cells during inflammation. Clin Exp Immunol (2010) 0.90
Corticotropin releasing factor in the rat colon: expression, localization and upregulation by endotoxin. Peptides (2009) 0.90
Rectal administration of Lactobacillus casei DG modifies flora composition and Toll-like receptor expression in colonic mucosa of patients with mild ulcerative colitis. Dig Dis Sci (2010) 0.89
Respiratory tract epithelial cells express retinaldehyde dehydrogenase ALDH1A and enhance IgA production by stimulated B cells in the presence of vitamin A. PLoS One (2014) 0.89
The "polarizing-tolerizing" mechanism of intestinal epithelium: its relevance to colonic homeostasis. Semin Immunopathol (2007) 0.88
Regulation of Toll-like receptor 4 expression in mouse colon by macrophage migration inhibitory factor. Histochem Cell Biol (2005) 0.88
Effects of alanyl-glutamine dipeptide on the expression of colon-inflammatory mediators during the recovery phase of colitis induced by dextran sulfate sodium. Eur J Nutr (2012) 0.87
Lactobacillus casei prevents the development of dextran sulphate sodium-induced colitis in Toll-like receptor 4 mutant mice. Clin Exp Immunol (2007) 0.86
Pattern recognition receptors in the gut: analysis of their expression along the intestinal tract and the crypt/villus axis. Physiol Rep (2015) 0.85
Expression of Toll-like receptors 2 and 9 in cells of dog jejunum and colon naturally infected with Leishmania infantum. BMC Immunol (2013) 0.84
Gut microbial colonization orchestrates TLR2 expression, signaling and epithelial proliferation in the small intestinal mucosa. PLoS One (2014) 0.82
NOD-like receptors in intestinal homeostasis and epithelial tissue repair. Int J Mol Sci (2014) 0.82
Potential association between TLR4 and chitinase 3-like 1 (CHI3L1/YKL-40) signaling on colonic epithelial cells in inflammatory bowel disease and colitis-associated cancer. Curr Mol Med (2013) 0.81
Association of TLR5 sequence variants and mRNA level with cytokine transcription in pigs. Immunogenetics (2012) 0.81
Chromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4α during colitis. Mol Cell Biol (2014) 0.80
Lipopolysaccharide induces CD25-positive, IL-10-producing lymphocytes without secretion of proinflammatory cytokines in the human colon: low MD-2 mRNA expression in colonic macrophages. J Clin Immunol (2004) 0.80
Immune-directed support of rich microbial communities in the gut has ancient roots. Dev Comp Immunol (2014) 0.80
Clostridium butyricum TO-A culture supernatant downregulates TLR4 in human colonic epithelial cells. Dig Dis Sci (2007) 0.79
Rectal administration of lipopolysaccharide and ovalbumin ameliorates acute murine colitis. Dig Dis Sci (2011) 0.79
Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase. Inflamm Bowel Dis (2010) 0.79
Compartmentalizing intestinal epithelial cell toll-like receptors for immune surveillance. Cell Mol Life Sci (2015) 0.78
Toll-like receptor 4 contributes to the inhibitory effect of morphine on colonic motility in vitro and in vivo. Sci Rep (2015) 0.77
β-2 microglobulin is unsuitable as an internal reference gene for the analysis of gene expression in human colorectal cancer. Biomed Rep (2013) 0.77
Effects of corticosterone and dietary energy on immune function of broiler chickens. PLoS One (2015) 0.76
Specific messenger RNA expression for signal transduction molecules by lipopolysaccharide in intestinal macrophages. Clin Exp Immunol (2006) 0.75
Homeostasis of the Gut Barrier and Potential Biomarkers. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
Impact of Novel Sorghum Bran Diets on DSS-Induced Colitis. Nutrients (2017) 0.75
Upregulation of Toll-like receptor 2 and nuclear factor-kappa B expression in experimental colonic schistosomiasis. J Adv Res (2014) 0.75
Toll-like receptor 4 signaling integrates intestinal inflammation with tumorigenesis: lessons from the murine model of colitis-associated cancer. Cancers (Basel) (2011) 0.75
Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway. Cell Death Differ (2017) 0.75
NSAID-induced antral ulcers are associated with distinct changes in mucosal gene expression. Aliment Pharmacol Ther (2009) 0.75
CD14 and IL18 gene polymorphisms associated with colorectal cancer subsite risks among atomic bomb survivors. Hum Genome Var (2015) 0.75
IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice. PLoS One (2015) 0.75
Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster. EMBO J (2009) 2.56
Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment. Dig Endosc (2013) 2.30
Evidence-based clinical practice guidelines for irritable bowel syndrome. J Gastroenterol (2014) 2.30
Systematic review on epidemiology of gastroesophageal reflux disease in Asia. Clin Gastroenterol Hepatol (2006) 1.79
Which landmark results in a more consistent diagnosis of Barrett's esophagus, the gastric folds or the palisade vessels? Gastrointest Endosc (2006) 1.70
Prevalence of endoscopically negative and positive gastroesophageal reflux disease in the Japanese. Scand J Gastroenterol (2005) 1.57
Reg protein is overexpressed in gastric cancer cells, where it activates a signal transduction pathway that converges on ERK1/2 to stimulate growth. FEBS Lett (2002) 1.56
Nocturnal gastric acid breakthrough during the administration of rabeprazole and ranitidine in Helicobacter pylori-negative subjects: effects of different regimens. J Gastroenterol (2003) 1.54
Inflammatory bowel disease: review from the aspect of genetics. J Gastroenterol (2009) 1.51
Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization. J Clin Invest (2005) 1.49
Radially asymmetric gastroesophageal acid reflux in the distal esophagus: examinations with novel pH sensor catheter equipped with 8 pH sensors. J Gastroenterol (2012) 1.49
Clinical significance of the highly sensitive fucosylated fraction of α-fetoprotein in patients with chronic liver disease. J Gastroenterol Hepatol (2011) 1.47
Growth inhibition of esophageal squamous carcinoma cells by peroxisome proliferator-activated receptor-gamma ligands. J Lab Clin Med (2002) 1.46
Usefulness of catheterless radiotelemetry pH monitoring system to examine the relationship between duodenal acidity and upper gastrointestinal symptoms. J Gastroenterol Hepatol (2011) 1.44
Is a computerized bowel sound auscultation system useful for the detection of increased bowel motility? Am J Gastroenterol (2002) 1.41
MFG-E8 attenuates intestinal inflammation in murine experimental colitis by modulating osteopontin-dependent alphavbeta3 integrin signaling. J Immunol (2009) 1.38
Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis. J Immunol (2004) 1.33
Difference in localization of esophageal mucosal breaks among grades of esophagitis. J Gastroenterol Hepatol (2006) 1.24
Localization of early-stage dysplastic Barrett's lesions in patients with short-segment Barrett's esophagus. Am J Gastroenterol (2006) 1.21
Consumption of uncooked deer meat as a risk factor for hepatitis E virus infection: an age- and sex-matched case-control study. J Med Virol (2004) 1.20
A new water instillation method for colonoscopy without sedation as performed by endoscopists-in-training. Gastrointest Endosc (2002) 1.17
Barrett's esophagus in Japanese patients: its prevalence, form, and elongation. J Gastroenterol (2008) 1.17
A Japanese case of eosinophilic esophagitis. J Gastroenterol (2006) 1.13
Predictors for squamous re-epithelialization of Barrett's esophagus after endoscopic biopsy. J Gastroenterol Hepatol (2007) 1.12
Angiolipoma of the colon diagnosed after endoscopic resection. Gastrointest Endosc (2002) 1.11
Evidence-based clinical practice guidelines for functional dyspepsia. J Gastroenterol (2015) 1.08
Ror2 is required for midgut elongation during mouse development. Dev Dyn (2010) 1.06
Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology (2006) 1.06
Epithelial toll-like receptor 5 is constitutively localized in the mouse cecum and exhibits distinctive down-regulation during experimental colitis. Clin Vaccine Immunol (2006) 1.04
Upper gastrointestinal complications associated with gemcitabine-concurrent proton radiotherapy for inoperable pancreatic cancer. J Gastroenterol (2013) 1.03
Transgenic overexpression of Reg protein caused gastric cell proliferation and differentiation along parietal cell and chief cell lineages. Oncogene (2004) 1.02
A randomized, placebo-controlled, double-blind clinical trial of rikkunshito for patients with non-erosive reflux disease refractory to proton-pump inhibitor: the G-PRIDE study. J Gastroenterol (2014) 1.01
Double-balloon endoscopy for treatment of small bowel penetration by fish bone. Dig Endosc (2012) 1.00
Expression of cytoplasmic TFF2 is a marker of tumor metastasis and negative prognostic factor in gastric cancer. Lab Invest (2003) 0.99
Gastric ulcer associated with cytomegalovirus in an immunocompetent patient: method for diagnosis. Case Rep Gastroenterol (2012) 0.99
Psychometric validation of the Japanese translation of the Quality of Life in Reflux and Dyspepsia questionnaire in patients with heartburn. J Gastroenterol (2007) 0.98
Tolerance to famotidine and ranitidine treatment after 14 days of administration in healthy subjects without Helicobacter pylori infection. J Gastroenterol Hepatol (2003) 0.98
Clinical characteristics of Japanese patients with eosinophilic esophagitis and eosinophilic gastroenteritis. J Gastroenterol (2012) 0.98
BRAF and K-ras gene mutations in human pancreatic cancers. Cancer Lett (2003) 0.97
Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture. Lab Invest (2007) 0.97
Effects of mosapride on esophageal functions and gastroesophageal reflux. J Gastroenterol Hepatol (2010) 0.96
Half-solidification of nutrient does not decrease gastro-esophageal reflux events in patients fed via percutaneous endoscopic gastrostomy. Clin Nutr (2009) 0.95
Unsedated transnasal small-caliber esophagogastroduodenoscopy in elderly and bedridden patients. World J Gastroenterol (2009) 0.94
Influence of acid suppressants on gastric emptying: cross-over analysis in healthy volunteers. J Gastroenterol Hepatol (2006) 0.94
Expression of regenerating gene I in gastric adenocarcinomas: correlation with tumor differentiation status and patient survival. Cancer (2004) 0.92
Prevalence of and risk factors for Barrett's esophagus with intestinal predominant mucin phenotype. Scand J Gastroenterol (2006) 0.92
A 2008 questionnaire-based survey of gastroesophageal reflux disease and related diseases by physicians in East Asian countries. Digestion (2009) 0.92
Efficacy of prokinetic agents in improving bowel preparation for colonoscopy. Digestion (2008) 0.91
Rare case of Takayasu's arteritis associated with Crohn's disease. Intern Med (2011) 0.91
Reg protein is a unique growth factor of gastric mucosal cells. J Gastroenterol (2004) 0.90
Lifestyle factors and efficacy of lifestyle interventions in gastroesophageal reflux disease patients with functional dyspepsia: primary care perspectives from the LEGEND study. Intern Med (2015) 0.90
Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs. BMC Gastroenterol (2013) 0.90
Maternal factors in a model of type 1 diabetes differentially affect the development of insulitis and overt diabetes in offspring. Diabetes (2005) 0.90
Interleukin-8 regulates expression of Reg protein in Helicobacter pylori-infected gastric mucosa. Am J Gastroenterol (2005) 0.89