Published in Prog Lipid Res on July 01, 2003
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin Microbiol Rev (2005) 3.39
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc Natl Acad Sci U S A (2007) 2.43
Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol (2010) 2.00
Crystal structure of the erythromycin polyketide synthase dehydratase. J Mol Biol (2008) 1.94
Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems. Microbiol Mol Biol Rev (2004) 1.76
Structures of the N-terminal modules imply large domain motions during catalysis by methionine synthase. Proc Natl Acad Sci U S A (2004) 1.62
Discovery of FabH/FabF inhibitors from natural products. Antimicrob Agents Chemother (2006) 1.51
Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids. Dev Cell (2014) 1.50
Crystal structures of Mycobacterium tuberculosis KasA show mode of action within cell wall biosynthesis and its inhibition by thiolactomycin. Structure (2009) 1.50
Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker. Int J Biochem Mol Biol (2010) 1.38
Transcriptome Analysis Reveals Regulation of Gene Expression for Lipid Catabolism in Young Broilers by Butyrate Glycerides. PLoS One (2016) 1.38
Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes. Proc Natl Acad Sci U S A (2010) 1.35
Structural basis of lipid biosynthesis regulation in Gram-positive bacteria. EMBO J (2006) 1.31
Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis. Biochem J (2006) 1.11
Comparative analysis of Mycobacterium and related Actinomycetes yields insight into the evolution of Mycobacterium tuberculosis pathogenesis. BMC Genomics (2012) 1.05
Direct transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesis. Proc Natl Acad Sci U S A (2008) 1.04
Phosphorylation of enoyl-acyl carrier protein reductase InhA impacts mycobacterial growth and survival. J Biol Chem (2010) 1.04
Fatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the FabY class of β-ketoacyl acyl carrier protein synthases. J Bacteriol (2012) 1.01
Insulin signalling mechanisms for triacylglycerol storage. Diabetologia (2013) 1.00
How bacterial pathogens eat host lipids: implications for the development of fatty acid synthesis therapeutics. J Biol Chem (2015) 0.99
Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents. Acta Crystallogr D Biol Crystallogr (2007) 0.98
Fatty acid synthase modulates homeostatic responses to myocardial stress. J Biol Chem (2011) 0.98
The structural biology of biosynthetic megaenzymes. Nat Chem Biol (2015) 0.96
Lipid metabolism and HCV infection. Viruses (2010) 0.96
Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates. Biochem J (2005) 0.95
The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer. Oncotarget (2014) 0.95
Direct Effect of Two Naphthalene-Sulfonyl-Indole Compounds on Toxoplasma gondii Tachyzoite. J Parasitol Res (2013) 0.94
Rv0216, a conserved hypothetical protein from Mycobacterium tuberculosis that is essential for bacterial survival during infection, has a double hotdog fold. Protein Sci (2005) 0.93
Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy. Proc Natl Acad Sci U S A (2010) 0.93
Functional characterization of an evolutionarily distinct phosphopantetheinyl transferase in the apicomplexan Cryptosporidium parvum. Eukaryot Cell (2005) 0.93
Gene-specific random mutagenesis of Escherichia coli in vivo: isolation of temperature-sensitive mutations in the acyl carrier protein of fatty acid synthesis. J Bacteriol (2006) 0.91
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB). J Mol Biol (2006) 0.91
Impact of dietary protein on lipid metabolism-related gene expression in porcine adipose tissue. Nutr Metab (Lond) (2010) 0.90
Mechanism and inhibition of the FabV enoyl-ACP reductase from Burkholderia mallei. Biochemistry (2010) 0.90
The effect of transparent TESTA2 on seed fatty acid biosynthesis and tolerance to environmental stresses during young seedling establishment in Arabidopsis. Plant Physiol (2012) 0.89
Substrate recognition by β-ketoacyl-ACP synthases. Biochemistry (2011) 0.87
Structure-assisted discovery of an aminothiazole derivative as a lead molecule for inhibition of bacterial fatty-acid synthesis. Acta Crystallogr D Biol Crystallogr (2007) 0.86
Genomic regions associated with bovine milk fatty acids in both summer and winter milk samples. BMC Genet (2012) 0.85
Structural analysis of protein-protein interactions in type I polyketide synthases. Crit Rev Biochem Mol Biol (2012) 0.85
Polyketide synthesis genes associated with toxin production in two species of Gambierdiscus (Dinophyceae). BMC Genomics (2015) 0.85
Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium. J Lipid Res (2014) 0.84
Liraglutide prevents hypoadiponectinemia-induced insulin resistance and alterations of gene expression involved in glucose and lipid metabolism. Mol Med (2011) 0.83
Mammalian fatty acid synthase activity from crude tissue lysates tracing ¹³C-labeled substrates using gas chromatography-mass spectrometry. Anal Biochem (2012) 0.81
Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase: Enoyl Reductase and β-Ketoacyl Reductase Catalytic Domains. Genomics Inform (2015) 0.80
Antimycobacterial Activity and Mechanism of Action of NAS-91. Antimicrob Agents Chemother (2007) 0.79
Probing intra- versus interchain kinetic preferences of L-Thr acylation on dimeric VibF with mass spectrometry. Biophys J (2006) 0.79
Sunflower (Helianthus annuus) fatty acid synthase complex: enoyl-[acyl carrier protein]-reductase genes. Planta (2014) 0.78
Characterization of key triacylglycerol biosynthesis processes in rhodococci. Sci Rep (2016) 0.78
Depletion of Myostatin b Promotes Somatic Growth and Lipid Metabolism in Zebrafish. Front Endocrinol (Lausanne) (2016) 0.78
Deletion of the β-acetoacetyl synthase FabY in Pseudomonas aeruginosa induces hypoacylation of lipopolysaccharide and increases antimicrobial susceptibility. Antimicrob Agents Chemother (2013) 0.78
Crystallization and preliminary X-ray crystallographic analysis of β-ketoacyl-ACP synthase I (XoFabB) from Xanthomonas oryzae pv. oryzae. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.78
Estrogens and selective estrogen receptor modulators regulate gene and protein expression in the mesenteric arteries. Vascul Pharmacol (2011) 0.78
Ontogenetic development of adipose tissue in grass carp (Ctenopharyngodon idellus). Fish Physiol Biochem (2015) 0.77
Immunohistochemical expressions of fatty acid synthase and phosphorylated c-Met in thyroid carcinomas of follicular origin. Int J Clin Exp Pathol (2011) 0.77
The potential of ¹¹C-acetate PET for monitoring the Fatty acid synthesis pathway in Tumors. Curr Pharm Biotechnol (2013) 0.77
Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria. Acta Crystallogr D Biol Crystallogr (2012) 0.77
PDIA3 Knockdown Exacerbates Free Fatty Acid-Induced Hepatocyte Steatosis and Apoptosis. PLoS One (2015) 0.77
A novel role for an ECF sigma factor in fatty acid biosynthesis and membrane fluidity in Pseudomonas aeruginosa. PLoS One (2013) 0.77
Nutrigenomics and Beef Quality: A Review about Lipogenesis. Int J Mol Sci (2016) 0.76
Effect of Dietary Restriction and Subsequent Re-Alimentation on the Transcriptional Profile of Bovine Skeletal Muscle. PLoS One (2016) 0.76
Sunflower (Helianthus annuus) fatty acid synthase complex: β-hydroxyacyl-[acyl carrier protein] dehydratase genes. Planta (2015) 0.76
Validation of the Antidiabetic and Hypolipidemic Effects of Hawthorn by Assessment of Gluconeogenesis and Lipogenesis Related Genes and AMP-Activated Protein Kinase Phosphorylation. Evid Based Complement Alternat Med (2013) 0.76
Unexpected link between polyketide synthase and calcium carbonate biomineralization. Zoological Lett (2015) 0.75
Analysis of miRNAs and their target genes associated with lipid metabolism in duck liver. Sci Rep (2016) 0.75
Constitutive expression of microRNA-150 in mammary epithelium suppresses secretory activation and impairs de novo lipogenesis. Development (2016) 0.75
Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis. Cell Res (2016) 0.75
Cloning, overexpression, purification, crystallization and preliminary X-ray diffraction analysis of Rv0241c (HtdX) from Mycobacterium tuberculosis H37Rv. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.75
Phytosphingosine degradation pathway includes fatty acid α-oxidation reactions in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2017) 0.75
Insights into Sexual Precocity of Female Oriental River Prawn Macrobrachium nipponense through Transcriptome Analysis. PLoS One (2016) 0.75
Chemotherapy can induce weight normalization of morbidly obese mice despite undiminished ingestion of high fat diet. Oncotarget (2017) 0.75
Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases. Sci Rep (2016) 0.75
Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism. Spermatogenesis (2015) 0.75
Construction of Global Acyl Lipid Metabolic Map by Comparative Genomics and Subcellular Localization Analysis in the Red Alga Cyanidioschyzon merolae. Front Plant Sci (2016) 0.75
Ketoacylsynthase Domains of a Polyunsaturated Fatty Acid Synthase in Thraustochytrium sp. Strain ATCC 26185 Can Effectively Function as Stand-Alone Enzymes in Escherichia coli. Appl Environ Microbiol (2017) 0.75
Discovery and Characterization of the 3-Hydroxyacyl-ACP Dehydratase Component of the Plant Mitochondrial Fatty Acid Synthase System. Plant Physiol (2017) 0.75
Evaluation of SCD and FASN Gene Expression in Baluchi, Iran-Black, and Arman Sheep. Rep Biochem Mol Biol (2016) 0.75
Fatty acid synthase 2 contributes to diapause preparation in a beetle by regulating lipid accumulation and stress tolerance genes expression. Sci Rep (2017) 0.75
Anti-Tumorigenic Potential of a Novel Orlistat-AICAR Combination in Prostate Cancer Cells. J Cell Biochem (2017) 0.75
Full-length sequencing and identification of novel polymorphisms in the ACACA gene of Valle del Belice sheep breed. J Genet (2017) 0.75
Leukemia/lymphoma-related factor (LRF) exhibits stage- and context-dependent transcriptional controls in the oligodendrocyte lineage and modulates remyelination. J Neurosci Res (2017) 0.75
Head-to-head coiled arrangement of the subunits of the animal fatty acid synthase. Chem Biol (2004) 1.57
Structure and molecular organization of mammalian fatty acid synthase. Nat Struct Mol Biol (2005) 1.48
Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein. J Biol Chem (2003) 1.24
Down-regulation of mitochondrial acyl carrier protein in mammalian cells compromises protein lipoylation and respiratory complex I and results in cell death. J Biol Chem (2009) 1.13
Mechanism of the beta-ketoacyl synthase reaction catalyzed by the animal fatty acid synthase. Biochemistry (2002) 1.09
Coupling of the de novo fatty acid biosynthesis and lipoylation pathways in mammalian mitochondria. J Biol Chem (2007) 1.06
Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain. J Biol Chem (2005) 1.04
Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. PLoS One (2012) 1.00
Characterization of the beta-carbon processing reactions of the mammalian cytosolic fatty acid synthase: role of the central core. Biochemistry (2004) 0.99
Effect of modification of the length and flexibility of the acyl carrier protein-thioesterase interdomain linker on functionality of the animal fatty acid synthase. Biochemistry (2005) 0.93
Catalytic residues are shared between two pseudosubunits of the dehydratase domain of the animal fatty acid synthase. Chem Biol (2007) 0.91
Engineering of an active animal fatty acid synthase dimer with only one competent subunit. Chem Biol (2003) 0.86
Echoes from the past: a healthy Baltic Sea requires more effort. Ambio (2014) 0.80
Lysozyme-like activity in eggs and in some tissues of land snails Helix aspersa maxima and Achatina achatina. Folia Biol (Krakow) (2004) 0.78
In silico analysis of candidate genes associated with humoral innate immune response in chicken. BMC Proc (2011) 0.75
Changes in Quail Blastodermal Cell Status as a Result of Selection. Folia Biol (Krakow) (2015) 0.75