Published in EMBO J on August 24, 2006
Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors. Proc Natl Acad Sci U S A (2011) 1.72
Bacterial lipids: metabolism and membrane homeostasis. Prog Lipid Res (2013) 1.42
Comprehensive analysis of temporal alterations in cellular proteome of Bacillus subtilis under curcumin treatment. PLoS One (2015) 1.39
Transcriptional regulation in bacterial membrane lipid synthesis. J Lipid Res (2008) 1.21
Inference of the transcriptional regulatory network in Staphylococcus aureus by integration of experimental and genomics-based evidence. J Bacteriol (2011) 1.15
Improving fatty acids production by engineering dynamic pathway regulation and metabolic control. Proc Natl Acad Sci U S A (2014) 1.14
Fatty acid biosynthesis in actinomycetes. FEMS Microbiol Rev (2011) 1.13
Transcriptional regulation of membrane lipid homeostasis in Escherichia coli. J Biol Chem (2009) 1.10
Acyl-Acyl carrier protein regulates transcription of fatty acid biosynthetic genes via the FabT repressor in Streptococcus pneumoniae. J Biol Chem (2009) 1.10
Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252. Antimicrob Agents Chemother (2013) 1.06
Analysis of proteins with the 'hot dog' fold: prediction of function and identification of catalytic residues of hypothetical proteins. BMC Struct Biol (2009) 1.03
A σW-dependent stress response in Bacillus subtilis that reduces membrane fluidity. Mol Microbiol (2011) 0.98
Structure of a sigma28-regulated nonflagellar virulence protein from Campylobacter jejuni. J Mol Biol (2008) 0.90
Biochemical characterization of the transcriptional regulator BzdR from Azoarcus sp. CIB. J Biol Chem (2010) 0.89
Active site comparisons and catalytic mechanisms of the hot dog superfamily. Chem Rev (2012) 0.89
Global transcriptome response in Lactobacillus sakei during growth on ribose. BMC Microbiol (2011) 0.87
Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus. PLoS Pathog (2013) 0.86
A Sense of Balance: Experimental Investigation and Modeling of a Malonyl-CoA Sensor in Escherichia coli. Front Bioeng Biotechnol (2015) 0.85
Intramolecular signal transmission in a tetrameric repressor of the IclR family. Proc Natl Acad Sci U S A (2011) 0.84
A rainbow coalition of lipid transcriptional regulators. Mol Microbiol (2010) 0.82
Transcriptional regulation of fatty acid biosynthesis in mycobacteria. Mol Microbiol (2013) 0.82
A genetically encoded metabolite sensor for malonyl-CoA. Chem Biol (2012) 0.79
Phosphatidylglycerol homeostasis in glycerol-phosphate auxotrophs of Staphylococcus aureus. BMC Microbiol (2013) 0.79
Effects of different carbon sources on the growth, fatty acids production, and expression of three desaturase genes of Mortierella alpina ATCC 16266. Curr Microbiol (2011) 0.79
Function-biased choice of additives for optimization of protein crystallization - the case of the putative thioesterase PA5185 from Pseudomonas aeruginosa PAO1. Cryst Growth Des (2008) 0.77
De novo synthesis of fatty acids is regulated by FapR protein in Exiguobacterium antarcticum B7, a psychrotrophic bacterium isolated from Antarctica. BMC Res Notes (2016) 0.76
Cerulenin inhibits unsaturated fatty acids synthesis in Bacillus subtilis by modifying the input signal of DesK thermosensor. Microbiologyopen (2014) 0.76
Mutations upstream of fabI in triclosan resistant Staphylococcus aureus strains are associated with elevated fabI gene expression. BMC Genomics (2015) 0.76
Crystal structure and functional insight of HP0420-homolog from Helicobacter felis. Biochem Biophys Res Commun (2010) 0.75
FapR: From Control of Membrane Lipid Homeostasis to a Biotechnological Tool. Front Mol Biosci (2016) 0.75
Suppression of microbial metabolic pathways inhibits the generation of the human body odor component diacetyl by Staphylococcus spp. PLoS One (2014) 0.75
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene (1989) 60.30
Macromolecular TLS refinement in REFMAC at moderate resolutions. Methods Enzymol (2003) 9.69
Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0. Acta Crystallogr D Biol Crystallogr (2003) 7.82
Plasmids for ectopic integration in Bacillus subtilis. Gene (1996) 5.87
Fatty acid degradation in Escherichia coli. An inducible acyl-CoA synthetase, the mapping of old-mutations, and the isolation of regulatory mutants. Eur J Biochem (1969) 5.58
Crystal structure of lac repressor core tetramer and its implications for DNA looping. Science (1995) 4.08
Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system. Nat Struct Biol (2000) 3.90
The many faces of the helix-turn-helix domain: transcription regulation and beyond. FEMS Microbiol Rev (2005) 3.87
The structural biology of type II fatty acid biosynthesis. Annu Rev Biochem (2005) 3.69
Molecular basis of thermosensing: a two-component signal transduction thermometer in Bacillus subtilis. EMBO J (2001) 2.65
Alteration of the Bacillus subtilis glutamine synthetase results in overproduction of the enzyme. J Bacteriol (1977) 2.49
FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis. Dev Cell (2003) 2.22
A new mechanism of transcriptional regulation: release of an activator triggered by small molecule binding. Cell (1992) 2.21
The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases. BMC Bioinformatics (2004) 2.16
Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site. Structure (1996) 2.14
Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res (2003) 2.08
Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the fadB promoter is prevented by long chain fatty acyl coenzyme A. J Biol Chem (1992) 1.99
The structural basis of acyl coenzyme A-dependent regulation of the transcription factor FadR. EMBO J (2001) 1.95
The FadR.DNA complex. Transcriptional control of fatty acid metabolism in Escherichia coli. J Biol Chem (2001) 1.76
Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold. EMBO J (2000) 1.69
FadR, transcriptional co-ordination of metabolic expediency. Mol Microbiol (1998) 1.63
Bacillus subtilis acyl carrier protein is encoded in a cluster of lipid biosynthesis genes. J Bacteriol (1996) 1.60
The three-dimensional structure of 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. Strain CBS-3. J Biol Chem (1998) 1.58
Escherichia coli transcription factor that both activates fatty acid synthesis and represses fatty acid degradation. J Mol Biol (1991) 1.58
Product diversity and regulation of type II fatty acid synthases. Biochem Cell Biol (2004) 1.49
Cloning and characterization of a gene (fadR) involved in regulation of fatty acid metabolism in Escherichia coli. J Bacteriol (1985) 1.46
Crystal structure of the Escherichia coli thioesterase II, a homolog of the human Nef binding enzyme. Nat Struct Biol (2000) 1.45
The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli. J Biol Chem (2002) 1.44
The structure of 4-hydroxybenzoyl-CoA thioesterase from arthrobacter sp. strain SU. J Biol Chem (2003) 1.40
Structure of the arginine repressor from Bacillus stearothermophilus. Nat Struct Biol (1999) 1.31
X-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesterase. J Biol Chem (2002) 1.30
Organization of genes for tetrapyrrole biosynthesis in gram--positive bacteria. Microbiology (1999) 1.26
A secondary RNA polymerase sigma factor from Streptococcus pyogenes. Mol Microbiol (2001) 1.24
Response of Bacillus subtilis to cerulenin and acquisition of resistance. J Bacteriol (2001) 1.23
Monitoring energy balance: metabolites of fatty acid synthesis as hypothalamic sensors. Annu Rev Biochem (2005) 1.20
Duplicated dockerin subdomains of Clostridium thermocellum endoglucanase CelD bind to a cohesin domain of the scaffolding protein CipA with distinct thermodynamic parameters and a negative cooperativity. Biochemistry (2002) 1.20
Analysis of acyl coenzyme A binding to the transcription factor FadR and identification of amino acid residues in the carboxyl terminus required for ligand binding. J Biol Chem (1995) 1.15
Fatty acyl-CoA binding domain of the transcription factor FadR. Characterization by deletion, affinity labeling, and isothermal titration calorimetry. J Biol Chem (1998) 1.08
Three-dimensional structure of MecI. Molecular basis for transcriptional regulation of staphylococcal methicillin resistance. J Biol Chem (2003) 1.07
Transcriptional control of membrane lipid synthesis in bacteria. Curr Opin Microbiol (2005) 0.99
Metallo-beta-lactamases: novel weaponry for antibiotic resistance in bacteria. Acc Chem Res (2006) 2.46
FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis. Dev Cell (2003) 2.22
Membrane thickness cue for cold sensing in a bacterium. Curr Biol (2010) 2.01
Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol (2009) 2.00
Evidence that the essential response regulator YycF in Streptococcus pneumoniae modulates expression of fatty acid biosynthesis genes and alters membrane composition. J Bacteriol (2005) 1.76
How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function. Proc Natl Acad Sci U S A (2013) 1.75
PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis. Mol Microbiol (2003) 1.69
Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nat Struct Mol Biol (2009) 1.64
Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation. EMBO J (2004) 1.58
Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria. J Biol Chem (2007) 1.53
Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis. J Biol Chem (2003) 1.52
Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons. Free Radic Biol Med (2006) 1.50
Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential. Biochim Biophys Acta (2007) 1.49
Regulation of glutamate metabolism by protein kinases in mycobacteria. Mol Microbiol (2008) 1.48
Structural plasticity and catalysis regulation of a thermosensor histidine kinase. Proc Natl Acad Sci U S A (2009) 1.45
Mechanism of membrane fluidity optimization: isothermal control of the Bacillus subtilis acyl-lipid desaturase. Mol Microbiol (2002) 1.43
The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis. Mol Cell (2002) 1.42
Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase. Structure (2004) 1.42
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds. EMBO J (2006) 1.37
The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol (2002) 1.36
Control of membrane lipid fluidity by molecular thermosensors. J Bacteriol (2004) 1.33
Coupling of fatty acid and phospholipid synthesis in Bacillus subtilis. J Bacteriol (2007) 1.32
Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase. Proc Natl Acad Sci U S A (2006) 1.30
Sensitive EDTA-based microbiological assays for detection of metallo-{beta}-lactamases in nonfermentative gram-negative bacteria. J Clin Microbiol (2005) 1.28
The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth. J Bacteriol (2006) 1.27
Trapping and characterization of a reaction intermediate in carbapenem hydrolysis by B. cereus metallo-beta-lactamase. J Am Chem Soc (2008) 1.26
Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility. Proc Natl Acad Sci U S A (2008) 1.25
Rising standards for tuberculosis drug development. Trends Pharmacol Sci (2008) 1.25
Control of fatty acid desaturation: a mechanism conserved from bacteria to humans. Mol Microbiol (2006) 1.24
The membrane fluidity sensor DesK of Bacillus subtilis controls the signal decay of its cognate response regulator. J Bacteriol (2004) 1.24
The crystal structure and catalytic mechanism of cellobiohydrolase CelS, the major enzymatic component of the Clostridium thermocellum Cellulosome. J Mol Biol (2002) 1.23
The metallo-beta-lactamase GOB is a mono-Zn(II) enzyme with a novel active site. J Biol Chem (2007) 1.23
Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases. Biochem Biophys Res Commun (2005) 1.22
Induction of protective immunity by synthetic Vibrio cholerae hexasaccharide derived from V. cholerae O1 Ogawa lipopolysaccharide bound to a protein carrier. J Infect Dis (2002) 1.22
Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall. J Am Chem Soc (2013) 1.21
A convenient microbiological assay employing cell-free extracts for the rapid characterization of Gram-negative carbapenemase producers. J Antimicrob Chemother (2008) 1.21
Bacillus subtilis DesR functions as a phosphorylation-activated switch to control membrane lipid fluidity. J Biol Chem (2004) 1.21
Duplicated dockerin subdomains of Clostridium thermocellum endoglucanase CelD bind to a cohesin domain of the scaffolding protein CipA with distinct thermodynamic parameters and a negative cooperativity. Biochemistry (2002) 1.20
Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress. J Biol Chem (2005) 1.19
Microbiology. TB--a new target, a new drug. Science (2005) 1.18
Mechanism of Cu(A) assembly. Nat Chem Biol (2008) 1.17
Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1. Acta Crystallogr D Biol Crystallogr (2007) 1.17
Membrane topology of the acyl-lipid desaturase from Bacillus subtilis. J Biol Chem (2002) 1.16
Mimicking natural evolution in metallo-beta-lactamases through second-shell ligand mutations. Proc Natl Acad Sci U S A (2005) 1.16
The Bacillus subtilis acyl lipid desaturase is a delta5 desaturase. J Bacteriol (2003) 1.14
Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria. J Biol Chem (2010) 1.14
Acid-inducible transcription of the operon encoding the citrate lyase complex of Lactococcus lactis Biovar diacetylactis CRL264. J Bacteriol (2004) 1.14
Evidence for a dinuclear active site in the metallo-beta-lactamase BcII with substoichiometric Co(II). A new model for metal uptake. J Biol Chem (2007) 1.13
Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance. Mol Microbiol (2010) 1.12
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases. Chem Biol Drug Des (2009) 1.11
Characterization and reconstitution of a 4Fe-4S adenylyl sulfate/phosphoadenylyl sulfate reductase from Bacillus subtilis. J Biol Chem (2003) 1.11
Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase. J Biol Chem (2005) 1.11
Atomic (0.94 A) resolution structure of an inverting glycosidase in complex with substrate. J Mol Biol (2002) 1.10
Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity. J Am Chem Soc (2014) 1.10
The Bacillus subtilis desaturase: a model to understand phospholipid modification and temperature sensing. Arch Microbiol (2005) 1.09
Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases. J Mol Biol (2007) 1.09
Metal content and localization during turnover in B. cereus metallo-beta-lactamase. J Am Chem Soc (2008) 1.07
Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile. J Am Chem Soc (2003) 1.06
Identification of the critical residues involved in peptidoglycan detection by Nod1. J Biol Chem (2005) 1.05
Exploring the role and the binding affinity of a second zinc equivalent in B. cereus metallo-beta-lactamase. Biochemistry (2002) 1.05
Structural determinants of substrate binding to Bacillus cereus metallo-beta-lactamase. J Biol Chem (2004) 1.04
Effect of pH on the active site of an Arg121Cys mutant of the metallo-beta-lactamase from Bacillus cereus: implications for the enzyme mechanism. Biochemistry (2005) 1.04
Structural and enzymatic insights into the ATP binding and autophosphorylation mechanism of a sensor histidine kinase. J Biol Chem (2010) 1.03
The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase. J Mol Biol (2003) 1.03
Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket. Chem Biol (2011) 1.03
Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis. Mol Microbiol (2009) 1.03
Radiologic progression of pulmonary infiltrates predicts a worse prognosis in severe community-acquired pneumonia than bacteremia. Chest (2008) 1.03
Isolation and characterization of unsaturated fatty acid auxotrophs of Streptococcus pneumoniae and Streptococcus mutans. J Bacteriol (2007) 1.02
Identification of a soluble diacylglycerol kinase required for lipoteichoic acid production in Bacillus subtilis. J Biol Chem (2007) 1.02
The trans-sialidase from the african trypanosome Trypanosoma brucei. Eur J Biochem (2002) 1.01
Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis. Biochemistry (2008) 1.01
Remodeling a DNA-binding protein as a specific in vivo inhibitor of bacterial secretin PulD. Proc Natl Acad Sci U S A (2007) 1.01
Brucella abortus synthesizes phosphatidylcholine from choline provided by the host. J Bacteriol (2006) 1.01
The FHA-containing protein GarA acts as a phosphorylation-dependent molecular switch in mycobacterial signaling. FEBS Lett (2008) 1.00
Insights into the catalytic mechanism of PPM Ser/Thr phosphatases from the atomic resolution structures of a mycobacterial enzyme. Structure (2007) 1.00
Transcriptional control of membrane lipid synthesis in bacteria. Curr Opin Microbiol (2005) 0.99
The Zn2 position in metallo-beta-lactamases is critical for activity: a study on chimeric metal sites on a conserved protein scaffold. J Mol Biol (2007) 0.99
Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis. J Biol Chem (2007) 0.99
Asp-120 locates Zn2 for optimal metallo-beta-lactamase activity. J Biol Chem (2007) 0.98
Metallo-β-lactamases withstand low Zn(II) conditions by tuning metal-ligand interactions. Nat Chem Biol (2012) 0.98
A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis. Mol Microbiol (2011) 0.97
Functional plasticity and allosteric regulation of α-ketoglutarate decarboxylase in central mycobacterial metabolism. Chem Biol (2011) 0.97
The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria. FEBS Lett (2006) 0.97
Biochemical and structural characterization of Salmonella typhimurium glyoxalase II: new insights into metal ion selectivity. Biochemistry (2007) 0.97