Published in J Virol on May 01, 2003
Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses. J Virol (2006) 5.48
NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase. J Virol (2009) 2.39
Orthobunyaviruses: recent genetic and structural insights. Nat Rev Microbiol (2014) 1.81
PKR-dependent and -independent mechanisms are involved in translational shutoff during Sindbis virus infection. J Virol (2004) 1.81
Efficient cDNA-based rescue of La Crosse bunyaviruses expressing or lacking the nonstructural protein NSs. J Virol (2005) 1.68
Bunyamwera virus nonstructural protein NSs counteracts interferon regulatory factor 3-mediated induction of early cell death. J Virol (2003) 1.67
Interaction of Bunyamwera Orthobunyavirus NSs protein with mediator protein MED8: a mechanism for inhibiting the interferon response. J Virol (2006) 1.36
La Crosse virus nonstructural protein NSs counteracts the effects of short interfering RNA. J Virol (2005) 1.31
Requirement of the N-terminal region of orthobunyavirus nonstructural protein NSm for virus assembly and morphogenesis. J Virol (2006) 1.26
Minigenomes, transcription and replication competent virus-like particles and beyond: reverse genetics systems for filoviruses and other negative stranded hemorrhagic fever viruses. Antiviral Res (2011) 1.24
Epidemiology, molecular virology and diagnostics of Schmallenberg virus, an emerging orthobunyavirus in Europe. Vet Res (2013) 1.20
Mutational analysis of the Bunyamwera orthobunyavirus nucleocapsid protein gene. J Virol (2009) 1.19
Suppression of the interferon and NF-κB responses by severe fever with thrombocytopenia syndrome virus. J Virol (2012) 1.17
Discovery of a unique novel clade of mosquito-associated bunyaviruses. J Virol (2013) 1.17
Activation of the Antiviral Kinase PKR and Viral Countermeasures. Viruses (2009) 1.05
Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR. PLoS Pathog (2009) 1.03
Role of N-linked glycans on bunyamwera virus glycoproteins in intracellular trafficking, protein folding, and virus infectivity. J Virol (2005) 1.02
Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication. Virology (2011) 1.02
Viperin, MTAP44, and protein kinase R contribute to the interferon-induced inhibition of Bunyamwera Orthobunyavirus replication. J Virol (2012) 0.97
Bunyaviruses and the type I interferon system. Viruses (2009) 0.96
Antiviral responses in mouse embryonic stem cells: differential development of cellular mechanisms in type I interferon production and response. J Biol Chem (2014) 0.96
Mouse embryonic stem cells are deficient in type I interferon expression in response to viral infections and double-stranded RNA. J Biol Chem (2013) 0.95
Role of Bunyamwera Orthobunyavirus NSs protein in infection of mosquito cells. PLoS Negl Trop Dis (2012) 0.94
The role of interferon antagonist, non-structural proteins in the pathogenesis and emergence of arboviruses. Viruses (2011) 0.90
Non-structural proteins of arthropod-borne bunyaviruses: roles and functions. Viruses (2013) 0.85
Systems to establish bunyavirus genome replication in the absence of transcription. J Virol (2013) 0.84
Generation of Recombinant Oropouche Viruses Lacking the Nonstructural Protein NSm or NSs. J Virol (2015) 0.78
Translational control by negative-strand RNA viruses: methods for the study of a crucial virus/host interaction. Methods (2012) 0.75
Severe fever with thrombocytopenia syndrome virus inhibits exogenous Type I IFN signaling pathway through its NSs invitro. PLoS One (2017) 0.75
How cells respond to interferons. Annu Rev Biochem (1998) 24.27
Functional role of type I and type II interferons in antiviral defense. Science (1994) 18.92
Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. J Gen Virol (2000) 7.00
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
PKR; a sentinel kinase for cellular stress. Oncogene (1999) 5.29
The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase. Proc Natl Acad Sci U S A (1992) 4.74
Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L. EMBO J (1997) 4.53
Rescue of a segmented negative-strand RNA virus entirely from cloned complementary DNAs. Proc Natl Acad Sci U S A (1996) 3.80
Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication. J Virol (2000) 3.77
Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses. Virology (2001) 3.76
Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines. Proc Natl Acad Sci U S A (1988) 3.67
Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection. Immunity (2000) 3.07
Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis. Proc Natl Acad Sci U S A (2001) 2.63
Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon. J Virol (2002) 2.50
Mx proteins: mediators of innate resistance to RNA viruses. Rev Sci Tech (1998) 2.40
Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus. J Virol (2002) 2.37
The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus. J Virol (2000) 2.08
Emerging viruses: the Bunyaviridae. Mol Med (1997) 1.87
Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein. J Virol (1996) 1.76
Synthesis of bunyavirus-specific proteins in a continuous cell line (XTC-2) derived from Xenopus laevis. J Gen Virol (1985) 1.68
Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections. J Virol (1999) 1.62
Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes. Proc Natl Acad Sci U S A (2002) 1.34
Fascination with 2-5A-dependent RNase: a unique enzyme that functions in interferon action. J Interferon Res (1994) 1.17
Inhibition of puumala and tula hantaviruses in Vero cells by MxA protein. Virology (1996) 1.16
Mouse Mx2 protein inhibits hantavirus but not influenza virus replication. Arch Virol (2001) 0.96
Interferon-induced rat Mx proteins confer resistance to Rift Valley fever virus and other arthropod-borne viruses. J Interferon Cytokine Res (2001) 0.87
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science (2006) 16.00
The interferon response circuit: induction and suppression by pathogenic viruses. Virology (2006) 4.56
IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nat Immunol (2011) 4.18
Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses. Cell Host Microbe (2007) 4.14
NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription. J Virol (2004) 3.52
Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon. Blood (2006) 2.53
Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon. J Virol (2002) 2.50
Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction. PLoS One (2008) 2.45
NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase. J Virol (2009) 2.39
Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence. J Virol (2006) 2.14
Neurons produce type I interferon during viral encephalitis. Proc Natl Acad Sci U S A (2006) 2.02
Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3. J Virol (2005) 1.96
Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome activate RIG-I and antiviral signaling. Cell Host Microbe (2013) 1.95
La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts. J Virol (2007) 1.90
Viral immune modulators perturb the human molecular network by common and unique strategies. Nature (2012) 1.86
Efficient bunyavirus rescue from cloned cDNA. Virology (2004) 1.82
Coronavirus non-structural protein 1 is a major pathogenicity factor: implications for the rational design of coronavirus vaccines. PLoS Pathog (2007) 1.78
Inhibition of RNA polymerase II phosphorylation by a viral interferon antagonist. J Biol Chem (2004) 1.75
Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription. PLoS Pathog (2010) 1.73
Phenoloxidase activity acts as a mosquito innate immune response against infection with Semliki Forest virus. PLoS Pathog (2012) 1.69
Efficient cDNA-based rescue of La Crosse bunyaviruses expressing or lacking the nonstructural protein NSs. J Virol (2005) 1.68
Bunyamwera virus nonstructural protein NSs counteracts interferon regulatory factor 3-mediated induction of early cell death. J Virol (2003) 1.67
Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner. J Virol (2005) 1.66
RNA polymerase I-mediated expression of viral RNA for the rescue of infectious virulent and avirulent Rift Valley fever viruses. Virology (2008) 1.61
Interferon, Mx, and viral countermeasures. Cytokine Growth Factor Rev (2007) 1.54
The intracellular sites of early replication and budding of SARS-coronavirus. Virology (2007) 1.53
Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus. J Virol (2013) 1.52
T7 RNA polymerase-dependent and -independent systems for cDNA-based rescue of Rift Valley fever virus. J Gen Virol (2008) 1.50
Functional L polymerase of La Crosse virus allows in vivo reconstitution of recombinant nucleocapsids. J Gen Virol (2003) 1.42
Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist. J Virol (2013) 1.40
Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection. PLoS Pathog (2010) 1.39
Advances in dissecting mosquito innate immune responses to arbovirus infection. J Gen Virol (2009) 1.39
Segment-specific terminal sequences of Bunyamwera bunyavirus regulate genome replication. Virology (2003) 1.38
Interaction of Bunyamwera Orthobunyavirus NSs protein with mediator protein MED8: a mechanism for inhibiting the interferon response. J Virol (2006) 1.36
Role of the cytoplasmic tail domains of Bunyamwera orthobunyavirus glycoproteins Gn and Gc in virus assembly and morphogenesis. J Virol (2007) 1.33
Complementarity, sequence and structural elements within the 3' and 5' non-coding regions of the Bunyamwera orthobunyavirus S segment determine promoter strength. J Gen Virol (2004) 1.33
Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter. J Med Virol (2007) 1.32
Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. Mol Biol Cell (2003) 1.32
Genetic elements regulating packaging of the Bunyamwera orthobunyavirus genome. J Gen Virol (2006) 1.31
Interferon and cytokine responses to SARS-coronavirus infection. Cytokine Growth Factor Rev (2008) 1.28
Tick-borne encephalitis virus delays interferon induction and hides its double-stranded RNA in intracellular membrane vesicles. J Virol (2010) 1.27
CDK/ERK-mediated phosphorylation of the human influenza A virus NS1 protein at threonine-215. Virology (2008) 1.26
Requirement of the N-terminal region of orthobunyavirus nonstructural protein NSm for virus assembly and morphogenesis. J Virol (2006) 1.26
Electron cryo-microscopy and single-particle averaging of Rift Valley fever virus: evidence for GN-GC glycoprotein heterodimers. J Virol (2009) 1.25
A single amino acid change in the nuclear localization sequence of the nsP2 protein affects the neurovirulence of Semliki Forest virus. J Virol (2002) 1.23
In response to pathogens, glial cells dynamically and differentially regulate Toll-like receptor gene expression. J Neuroimmunol (2005) 1.23
Efficient production of Rift Valley fever virus-like particles: The antiviral protein MxA can inhibit primary transcription of bunyaviruses. Virology (2009) 1.23
A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B. J Virol (2008) 1.22
Gene expression profiling of the preclinical scrapie-infected hippocampus. Biochem Biophys Res Commun (2005) 1.21
The unique architecture of Bunyamwera virus factories around the Golgi complex. Cell Microbiol (2008) 1.20
Structural basis for encapsidation of genomic RNA by La Crosse Orthobunyavirus nucleoprotein. Proc Natl Acad Sci U S A (2013) 1.19
Thogoto virus ML protein suppresses IRF3 function. Virology (2005) 1.19
A target on the move: innate and adaptive immune escape strategies of hepatitis C virus. Antiviral Res (2006) 1.19
Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice. J Virol (2013) 1.19
Analysis of N-linked glycosylation of hantaan virus glycoproteins and the role of oligosaccharide side chains in protein folding and intracellular trafficking. J Virol (2004) 1.19
Mutational analysis of the Bunyamwera orthobunyavirus nucleocapsid protein gene. J Virol (2009) 1.19
Bunyamwera orthobunyavirus S-segment untranslated regions mediate poly(A) tail-independent translation. J Virol (2009) 1.18
Induction of DNA damage signaling upon Rift Valley fever virus infection results in cell cycle arrest and increased viral replication. J Biol Chem (2012) 1.18
PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response. J Gen Virol (2009) 1.18
Interferon antagonist NSs of La Crosse virus triggers a DNA damage response-like degradation of transcribing RNA polymerase II. J Biol Chem (2010) 1.17
Knockdown of piRNA pathway proteins results in enhanced Semliki Forest virus production in mosquito cells. J Gen Virol (2013) 1.17
Mapping the Golgi targeting and retention signal of Bunyamwera virus glycoproteins. J Virol (2004) 1.16
Structure of Crimean-Congo hemorrhagic fever virus nucleoprotein: superhelical homo-oligomers and the role of caspase-3 cleavage. J Virol (2012) 1.16
Attenuation of bunyavirus replication by rearrangement of viral coding and noncoding sequences. J Virol (2005) 1.16
A bunyamwera virus minireplicon system in mosquito cells. J Virol (2004) 1.16
The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors. PLoS Pathog (2011) 1.14
Polymorphism and structural maturation of bunyamwera virus in Golgi and post-Golgi compartments. J Virol (2003) 1.13
RNA interference targets arbovirus replication in Culicoides cells. J Virol (2012) 1.13
Vaccination with virus-like particles protects mice from lethal infection of Rift Valley Fever Virus. Virology (2009) 1.13
Viruses in the Anopheles A, Anopheles B, and Tete serogroups in the Orthobunyavirus genus (family Bunyaviridae) do not encode an NSs protein. J Virol (2009) 1.09
Insertion of EGFP into the replicase gene of Semliki Forest virus results in a novel, genetically stable marker virus. J Gen Virol (2007) 1.09
Homotypic interaction of Bunyamwera virus nucleocapsid protein. J Virol (2005) 1.09
Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization. Nucleic Acids Res (2013) 1.09
Creation of a recombinant Rift Valley fever virus with a two-segmented genome. J Virol (2011) 1.08
Golgi localization of Hantaan virus glycoproteins requires coexpression of G1 and G2. Virology (2002) 1.08
Mutational analyses of the nonconserved sequences in the Bunyamwera Orthobunyavirus S segment untranslated regions. J Virol (2005) 1.07
Crimean-Congo hemorrhagic fever virus delays activation of the innate immune response. J Med Virol (2008) 1.07
Novel gene product of Thogoto virus segment 6 codes for an interferon antagonist. J Virol (2003) 1.07
Semliki forest virus-induced endoplasmic reticulum stress accelerates apoptotic death of mammalian cells. J Virol (2010) 1.07
Key Golgi factors for structural and functional maturation of bunyamwera virus. J Virol (2005) 1.06
Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity. J Virol (2008) 1.06
Cell-to-cell spread of the RNA interference response suppresses Semliki Forest virus (SFV) infection of mosquito cell cultures and cannot be antagonized by SFV. J Virol (2009) 1.04
Detection and identification of putative bacterial endosymbionts and endogenous viruses in tick cell lines. Ticks Tick Borne Dis (2012) 1.03
Characterization of Maguari orthobunyavirus mutants suggests the nonstructural protein NSm is not essential for growth in tissue culture. Virology (2006) 1.03
Interaction of severe acute respiratory syndrome-associated coronavirus with dendritic cells. J Gen Virol (2006) 1.03
Role of N-linked glycans on bunyamwera virus glycoproteins in intracellular trafficking, protein folding, and virus infectivity. J Virol (2005) 1.02
Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus. Virol J (2006) 1.01