Published in Bioorg Med Chem Lett on May 05, 2003
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Completion of a Programmable DNA-Binding Small Molecule Library. Tetrahedron (2007) 1.58
Improved nuclear localization of DNA-binding polyamides. Nucleic Acids Res (2006) 1.55
Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities. Nucleic Acids Res (2003) 1.48
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element. J Am Chem Soc (2009) 1.21
Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding. J Am Chem Soc (2010) 1.15
HPV episome levels are potently decreased by pyrrole-imidazole polyamides. Antiviral Res (2011) 1.11
Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells. Bioorg Med Chem Lett (2008) 1.08
Minor groove to major groove, an unusual DNA sequence-dependent change in bend directionality by a distamycin dimer. Biochemistry (2011) 0.94
Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns. Nucleic Acids Res (2011) 0.93
Programmable DNA-binding small molecules. Bioorg Med Chem (2013) 0.89
Binding studies of a large antiviral polyamide to a natural HPV sequence. Biochimie (2014) 0.89
Solution-phase synthesis of pyrrole-imidazole polyamides. J Am Chem Soc (2009) 0.89
Fluorescence assay of polyamide-DNA interactions. Anal Biochem (2012) 0.85
Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture. J Med Chem (2009) 0.85
Structure-based DNA-targeting strategies with small molecule ligands for drug discovery. Med Res Rev (2013) 0.84
DNA Binding Polyamides and the Importance of DNA Recognition in their use as Gene-Specific and Antiviral Agents. Med Chem (Los Angeles) (2014) 0.83
Cost, effectiveness and environmental relevance of multidrug transporters in sea urchin embryos. J Exp Biol (2013) 0.79
Oligomerization route to Py-Im polyamide macrocycles. Org Lett (2009) 0.77
DNA microstructure influences selective binding of small molecules designed to target mixed-site DNA sequences. Nucleic Acids Res (2017) 0.75
Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA. Nature (2002) 3.45
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SCMTR: a chloride-selective, membrane-anchored peptide channel that exhibits voltage gating. J Am Chem Soc (2002) 1.30
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DNA damage repair genes controlling human papillomavirus (HPV) episome levels under conditions of stability and extreme instability. PLoS One (2013) 0.94
Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors. J Biol Chem (2009) 0.90
Novel insights into the cellular mechanisms of the anti-inflammatory effects of NF-kappaB essential modulator binding domain peptides. J Biol Chem (2010) 0.89
Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain. Bioorg Med Chem Lett (2011) 0.88
Correlation of local effects of DNA sequence and position of β-alanine inserts with polyamide-DNA complex binding affinities and kinetics. Biochemistry (2012) 0.88
Fluorescence assay of polyamide-DNA interactions. Anal Biochem (2012) 0.85
Different thermodynamic signatures for DNA minor groove binding with changes in salt concentration and temperature. Chem Commun (Camb) (2013) 0.82
Stereochemical requirements for the mineralocorticoid receptor antagonist activity of dihydropyridines. J Med Chem (2010) 0.82
Discovery of novel cyanodihydropyridines as potent mineralocorticoid receptor antagonists. J Med Chem (2010) 0.81
Leaching of indaziflam applied at two rates under different rainfall situations in Florida Candler soil. Bull Environ Contam Toxicol (2012) 0.80
Structure based design of novel irreversible FAAH inhibitors. Bioorg Med Chem Lett (2009) 0.80
Mapping small DNA ligand hydroxyl radical footprinting and affinity cleavage products for capillary electrophoresis. Anal Biochem (2013) 0.78
Modulation of DNA-polyamide interaction by β-alanine substitutions: a study of positional effects on binding affinity, kinetics and thermodynamics. Org Biomol Chem (2014) 0.78
Structure analysis reveals the flexibility of the ADAMTS-5 active site. Protein Sci (2011) 0.78
Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane as lead scaffolds. Bioorg Med Chem Lett (2011) 0.77
Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist. Bioorg Med Chem Lett (2010) 0.77
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Thienopyrimidine-based P2Y12 platelet aggregation inhibitors. Bioorg Med Chem Lett (2009) 0.76
Synthesis and evaluation of RNA transesterification efficiency using stereospecific serinol-terpyridine conjugates. Nucleosides Nucleotides Nucleic Acids (2005) 0.75
134 Large antiviral polyamide-DNA interactions. J Biomol Struct Dyn (2015) 0.75