Published in Nucleic Acids Res on May 20, 2004
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. Proc Natl Acad Sci U S A (2004) 2.25
Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3. J Am Chem Soc (2009) 2.06
DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia. Proc Natl Acad Sci U S A (2006) 1.70
Allosteric modulation of DNA by small molecules. Proc Natl Acad Sci U S A (2009) 1.61
Completion of a Programmable DNA-Binding Small Molecule Library. Tetrahedron (2007) 1.58
Improved nuclear localization of DNA-binding polyamides. Nucleic Acids Res (2006) 1.55
Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders. Proc Natl Acad Sci U S A (2011) 1.36
Fluorescein redirects a ruthenium-octaarginine conjugate to the nucleus. J Am Chem Soc (2009) 1.34
Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit. J Am Chem Soc (2008) 1.23
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element. J Am Chem Soc (2009) 1.21
Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding. J Am Chem Soc (2010) 1.15
Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells. Bioorg Med Chem Lett (2008) 1.08
In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography. Proc Natl Acad Sci U S A (2008) 1.07
Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A (2012) 1.04
Microwave assisted synthesis of Py-Im polyamides. Org Lett (2012) 0.98
Characterization and solubilization of pyrrole-imidazole polyamide aggregates. J Med Chem (2012) 0.96
Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates. Nucleic Acids Res (2006) 0.94
Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns. Nucleic Acids Res (2011) 0.93
Alpha-diaminobutyric acid-linked hairpin polyamides. Bioorg Med Chem (2007) 0.92
Activity of a Py-Im polyamide targeted to the estrogen response element. Mol Cancer Ther (2013) 0.92
Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia. Mol Cancer Ther (2008) 0.91
Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide. Biochemistry (2011) 0.91
Solution-phase synthesis of pyrrole-imidazole polyamides. J Am Chem Soc (2009) 0.89
Binding studies of a large antiviral polyamide to a natural HPV sequence. Biochimie (2014) 0.89
Programmable DNA-binding small molecules. Bioorg Med Chem (2013) 0.89
Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides. J Med Chem (2009) 0.85
Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture. J Med Chem (2009) 0.85
Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA. Angew Chem Int Ed Engl (2012) 0.84
DNA sequence selectivity of hairpin polyamide turn units. Bioorg Med Chem Lett (2009) 0.82
The reach of linear protein-DNA dimerizers. J Am Chem Soc (2007) 0.82
Expanding the repertoire of natural product-inspired ring pairs for molecular recognition of DNA. Org Lett (2011) 0.82
Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response. Nucleic Acids Res (2014) 0.81
A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor. Bioorg Med Chem (2014) 0.80
Small-molecule regulators that mimic transcription factors. Biochim Biophys Acta (2010) 0.80
Oligomerization route to Py-Im polyamide macrocycles. Org Lett (2009) 0.77
Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies. Bioorg Med Chem (2008) 0.77
Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide. PLoS One (2015) 0.77
Tumor xenograft uptake of a pyrrole-imidazole (Py-Im) polyamide varies as a function of cell line grafted. J Med Chem (2014) 0.76
Sequence-specific recognition of DNA minor groove by an NIR-fluorescence switch-on probe and its potential applications. Nucleic Acids Res (2015) 0.75
Design, synthesis, and analysis of minor groove binder pyrrolepolyamide-2'-deoxyguanosine hybrids. J Nucleic Acids (2010) 0.75
Reprogramming cell fate with a genome-scale library of artificial transcription factors. Proc Natl Acad Sci U S A (2016) 0.75
RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif. Proc Natl Acad Sci U S A (2016) 0.75
Recognition of the DNA minor groove by pyrrole-imidazole polyamides. Curr Opin Struct Biol (2003) 3.80
Regulation of gene expression by small molecules. Nature (1997) 2.27
Accessibility of nuclear chromatin by DNA binding polyamides. Chem Biol (2003) 1.81
Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture. Proc Natl Acad Sci U S A (2003) 1.80
Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates. Bioorg Med Chem (2002) 1.52
Specific gain- and loss-of-function phenotypes induced by satellite-specific DNA-binding drugs fed to Drosophila melanogaster. Mol Cell (2000) 1.52
Solid-phase synthesis of DNA binding polyamides on oxime resin. Bioorg Med Chem (2002) 1.45
Controlling the intracellular localization of fluorescent polyamide analogues in cultured cells. Bioorg Med Chem Lett (2003) 1.25
Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-kappaB, and DNA by a designed DNA-binding ligand. J Biol Chem (1999) 1.16
Sequence specific fluorescence detection of double strand DNA. J Am Chem Soc (2003) 1.11
Blocking transcription through a nucleosome with synthetic DNA ligands. J Mol Biol (2002) 1.11
Shape selective recognition of T.A base pairs by hairpin polyamides containing N-terminal 3-methoxy (and 3-chloro) thiophene residues. Bioorg Med Chem (2003) 1.10
Design of artificial transcriptional activators with rigid poly-L-proline linkers. J Am Chem Soc (2002) 1.09
Targeting the ets binding site of the HER2/neu promoter with pyrrole-imidazole polyamides. J Biol Chem (2000) 1.05
Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides. EMBO J (2001) 1.04
Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides. Biochemistry (1999) 1.04
Toward artificial developmental regulators. J Am Chem Soc (2003) 1.02
DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate. Nucleic Acids Res (2003) 1.01
Imidazopyridine/Pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition. J Am Chem Soc (2003) 1.01
Use of fluorescent sequence-specific polyamides to discriminate human chromosomes by microscopy and flow cytometry. Nucleic Acids Res (2002) 1.00
Lifetime-based pH sensors: indicators for acidic environments. Anal Biochem (1999) 0.99
Extended hairpin polyamide motif for sequence-specific recognition in the minor groove of DNA. Chem Biol (1996) 0.98
Inhibition of DNA binding by NF-kappa B with pyrrole-imidazole polyamides. Biochemistry (2002) 0.97
Promoter scanning for transcription inhibition with DNA-binding polyamides. Mol Cell Biol (2002) 0.96
Allosteric inhibition of protein--DNA complexes by polyamide--intercalator conjugates. J Am Chem Soc (2003) 0.96
Sequence-specific trapping of topoisomerase I by DNA binding polyamide-camptothecin conjugates. J Am Chem Soc (2001) 0.95
Kinetic consequences of covalent linkage of DNA binding polyamides. Biochemistry (2001) 0.94
U-pin polyamide motif for recognition of the DNA minor groove. Chemistry (2003) 0.89
Inhibition of human papilloma virus E2 DNA binding protein by covalently linked polyamides. Nucleic Acids Res (2003) 0.86
Search for the optimal linker in tandem hairpin polyamides. Bioorg Med Chem (2002) 0.85
Alternative heterocycles for DNA recognition: the benzimidazole/imidazole pair. Chemistry (2003) 0.85
Minor groove DNA-protein contacts upstream of a tRNA gene detected with a synthetic DNA binding ligand. J Mol Biol (1999) 0.84
Synthesis and fluorescence properties of Oregon Green 514 labeled peptides. Bioorg Med Chem Lett (1999) 0.82
Parallel synthesis of H-pin polyamides by alkene metathesis on solid phase. J Am Chem Soc (2003) 0.80
Inhibition of Moloney murine leukemia virus integration using polyamides targeting the long-terminal repeat sequences. Biochemistry (2003) 0.80
Inhibition of major groove DNA binding bZIP proteins by positive patch polyamides. Bioorg Med Chem (2001) 0.80
Biologically active molecules with a "light switch". Angew Chem Int Ed Engl (2006) 3.92
Defining the sequence-recognition profile of DNA-binding molecules. Proc Natl Acad Sci U S A (2006) 2.97
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. Proc Natl Acad Sci U S A (2004) 2.25
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide. Proc Natl Acad Sci U S A (2007) 2.04
Light-controlled tools. Angew Chem Int Ed Engl (2012) 1.96
Arresting cancer proliferation by small-molecule gene regulation. Chem Biol (2004) 1.90
Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface. ACS Chem Biol (2007) 1.84
Accessibility of nuclear chromatin by DNA binding polyamides. Chem Biol (2003) 1.81
Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture. Proc Natl Acad Sci U S A (2003) 1.80
TADDOLs, Their Derivatives, and TADDOL Analogues: Versatile Chiral Auxiliaries. Angew Chem Int Ed Engl (2001) 1.73
DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia. Proc Natl Acad Sci U S A (2006) 1.70
Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors. J Infect Dis (2004) 1.64
Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands. J Mol Biol (2003) 1.63
Allosteric modulation of DNA by small molecules. Proc Natl Acad Sci U S A (2009) 1.61
Completion of a Programmable DNA-Binding Small Molecule Library. Tetrahedron (2007) 1.58
Improved nuclear localization of DNA-binding polyamides. Nucleic Acids Res (2006) 1.55
Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates. Bioorg Med Chem (2002) 1.52
Solid-phase synthesis of DNA binding polyamides on oxime resin. Bioorg Med Chem (2002) 1.45
Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression. Proc Natl Acad Sci U S A (2009) 1.38
Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders. Proc Natl Acad Sci U S A (2011) 1.36
Light-dependent RNA interference with nucleobase-caged siRNAs. RNA (2007) 1.31
Quantitative microarray profiling of DNA-binding molecules. J Am Chem Soc (2007) 1.30
Programmable DNA binding oligomers for control of transcription. Curr Med Chem Anticancer Agents (2005) 1.28
Molecular recognition of the nucleosomal "supergroove". Proc Natl Acad Sci U S A (2004) 1.25
Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides. J Virol (2002) 1.24
Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit. J Am Chem Soc (2008) 1.23
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element. J Am Chem Soc (2009) 1.21
The Bowen-Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Ψ1191 in yeast 18S rRNA. Nucleic Acids Res (2010) 1.17
The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase. Nucleic Acids Res (2010) 1.16
A double-stranded DNA rotaxane. Nat Nanotechnol (2010) 1.16
Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding. J Am Chem Soc (2010) 1.15
Photoinduced transcription by using temporarily mismatched caged oligonucleotides. Angew Chem Int Ed Engl (2005) 1.13
Antitumor activity of a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A (2013) 1.13
Sequence specific fluorescence detection of double strand DNA. J Am Chem Soc (2003) 1.11
Blocking transcription through a nucleosome with synthetic DNA ligands. J Mol Biol (2002) 1.11
Shape selective recognition of T.A base pairs by hairpin polyamides containing N-terminal 3-methoxy (and 3-chloro) thiophene residues. Bioorg Med Chem (2003) 1.10
Small molecule transcription factor mimic. J Am Chem Soc (2004) 1.10
Design of artificial transcriptional activators with rigid poly-L-proline linkers. J Am Chem Soc (2002) 1.09
Role of mismatch repair enzymes in GAA·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells. J Biol Chem (2012) 1.09
Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells. Bioorg Med Chem Lett (2008) 1.08
In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography. Proc Natl Acad Sci U S A (2008) 1.07
DNA-templated dimerization of hairpin polyamides. J Am Chem Soc (2003) 1.07
Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly. ACS Chem Biol (2008) 1.06
Programmable oligomers for minor groove DNA recognition. J Am Chem Soc (2006) 1.06
Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A (2012) 1.04
Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear. J Am Chem Soc (2012) 1.03
Toward artificial developmental regulators. J Am Chem Soc (2003) 1.02
Addressing single molecules on DNA nanostructures. Angew Chem Int Ed Engl (2007) 1.02
Sequence-specific fluorescence detection of DNA by polyamide-thiazole orange conjugates. J Am Chem Soc (2005) 1.02
Structure of a beta-alanine-linked polyamide bound to a full helical turn of purine tract DNA in the 1:1 motif. J Mol Biol (2002) 1.01
DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate. Nucleic Acids Res (2003) 1.01
Imidazopyridine/Pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition. J Am Chem Soc (2003) 1.01
A ribozyme for the aldol reaction. Chem Biol (2005) 1.00
Light-induced formation of G-quadruplex DNA secondary structures. Chembiochem (2005) 0.99
NMR structure of a cyclic polyamide-DNA complex. J Am Chem Soc (2004) 0.99
Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus. Proc Natl Acad Sci U S A (2013) 0.98
Microwave assisted synthesis of Py-Im polyamides. Org Lett (2012) 0.98
Nucleosomes in solution exist as a mixture of twist-defect states. J Mol Biol (2005) 0.98
Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing. J Am Chem Soc (2012) 0.97
Minimization of a protein-DNA dimerizer. J Am Chem Soc (2007) 0.97
Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice. Cancer Chemother Pharmacol (2012) 0.97
Inhibition of DNA binding by NF-kappa B with pyrrole-imidazole polyamides. Biochemistry (2002) 0.97
Promoter scanning for transcription inhibition with DNA-binding polyamides. Mol Cell Biol (2002) 0.96
Characterization and solubilization of pyrrole-imidazole polyamide aggregates. J Med Chem (2012) 0.96
Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands. Biochemistry (2004) 0.96
Allosteric inhibition of protein--DNA complexes by polyamide--intercalator conjugates. J Am Chem Soc (2003) 0.96
Design of a sequence-specific DNA bisintercalator. Angew Chem Int Ed Engl (2004) 0.96
Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates. Nucleic Acids Res (2006) 0.94
A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate. Cell Cycle (2006) 0.94
Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns. Nucleic Acids Res (2011) 0.93
Fluorescent sequence-specific dsDNA binding oligomers. J Am Chem Soc (2007) 0.93
Alpha-diaminobutyric acid-linked hairpin polyamides. Bioorg Med Chem (2007) 0.92
Activity of a Py-Im polyamide targeted to the estrogen response element. Mol Cancer Ther (2013) 0.92
Temperature-sensitive protein-DNA dimerizers. Proc Natl Acad Sci U S A (2005) 0.92
Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide. Biochemistry (2011) 0.91
Programming multiple protein patterns on a single DNA nanostructure. J Am Chem Soc (2008) 0.91
Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia. Mol Cancer Ther (2008) 0.91
Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides. Biochemistry (2005) 0.91
Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-kappaB binding inhibition. Bioorg Med Chem (2006) 0.91
Recognition of "mirror-image" DNA by small molecules. Angew Chem Int Ed Engl (2007) 0.90
Recognition of ten base pairs of DNA by head-to-head hairpin dimers. J Am Chem Soc (2002) 0.90
Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site. Bioorg Med Chem (2006) 0.90
Construction of a structurally defined double-stranded DNA catenane. Nano Lett (2011) 0.90
U-pin polyamide motif for recognition of the DNA minor groove. Chemistry (2003) 0.89
Solution-phase synthesis of pyrrole-imidazole polyamides. J Am Chem Soc (2009) 0.89
Enantioselective organocatalytic alpha-sulfenylation of substituted diketopiperazines. Tetrahedron Asymmetry (2009) 0.89