Published in Oncogene on April 17, 2003
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell (2010) 39.09
Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell (2012) 12.32
Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A (2003) 10.56
Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proc Natl Acad Sci U S A (2005) 6.54
Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS One (2009) 5.08
Rembrandt: helping personalized medicine become a reality through integrative translational research. Mol Cancer Res (2009) 3.58
Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy. Clin Cancer Res (2010) 3.05
A network model of a cooperative genetic landscape in brain tumors. JAMA (2009) 2.86
Unsupervised analysis of transcriptomic profiles reveals six glioma subtypes. Cancer Res (2009) 2.42
Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets. Neoplasia (2005) 2.37
Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age. BMC Med Genomics (2008) 2.29
Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts. Neuro Oncol (2009) 2.23
Modeling Adult Gliomas Using RCAS/t-va Technology. Transl Oncol (2009) 1.89
Massively parallel signature sequencing and bioinformatics analysis identifies up-regulation of TGFBI and SOX4 in human glioblastoma. PLoS One (2010) 1.39
PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. Cell Death Differ (2010) 1.28
Glioblastoma multiforme regional genetic and cellular expression patterns: influence on anatomic and physiologic MR imaging. Radiology (2010) 1.28
Glioma cells on the run - the migratory transcriptome of 10 human glioma cell lines. BMC Genomics (2008) 1.28
A 16-gene signature distinguishes anaplastic astrocytoma from glioblastoma. PLoS One (2014) 1.26
Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas. Clin Cancer Res (2008) 1.25
Gene expression profiling of gliomas: merging genomic and histopathological classification for personalised therapy. Br J Cancer (2010) 1.24
Glioblastoma multiforme: State of the art and future therapeutics. Surg Neurol Int (2014) 1.18
GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma model. Proc Natl Acad Sci U S A (2007) 1.15
Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma. J Clin Invest (2012) 1.12
Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas. PLoS One (2012) 1.11
Transdifferentiation of glioblastoma stem-like cells into mural cells drives vasculogenic mimicry in glioblastomas. J Neurosci (2012) 1.10
Genomic landscape of meningiomas. Brain Pathol (2009) 1.08
Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival. BMC Med Genomics (2011) 1.04
Meta-analysis of glioblastoma multiforme versus anaplastic astrocytoma identifies robust gene markers. Mol Cancer (2009) 1.03
Differential expression of 2',3'-cyclic-nucleotide 3'-phosphodiesterase and neural lineage markers correlate with glioblastoma xenograft infiltration and patient survival. Clin Cancer Res (2012) 1.03
The cellular origin for malignant glioma and prospects for clinical advancements. Expert Rev Mol Diagn (2012) 1.02
Proteoglycans and their roles in brain cancer. FEBS J (2013) 0.98
GSVD comparison of patient-matched normal and tumor aCGH profiles reveals global copy-number alterations predicting glioblastoma multiforme survival. PLoS One (2012) 0.93
Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System. Clin Med Insights Oncol (2011) 0.92
Molecular classification of parathyroid neoplasia by gene expression profiling. Am J Pathol (2004) 0.90
Clinical stratification of glioblastoma based on alterations in retinoblastoma tumor suppressor protein (RB1) and association with the proneural subtype. J Neuropathol Exp Neurol (2012) 0.90
Molecular profiling indicates orthotopic xenograft of glioma cell lines simulate a subclass of human glioblastoma. J Cell Mol Med (2012) 0.90
miRNA expression profiling in migrating glioblastoma cells: regulation of cell migration and invasion by miR-23b via targeting of Pyk2. PLoS One (2012) 0.89
Chromosomal patterns of gene expression from microarray data: methodology, validation and clinical relevance in gliomas. BMC Bioinformatics (2006) 0.88
Studying a complex tumor: potential and pitfalls. Cancer J (2012) 0.87
G protein-coupled receptor FPR1 as a pharmacologic target in inflammation and human glioblastoma. Int Immunopharmacol (2012) 0.86
The LRIG family: enigmatic regulators of growth factor receptor signaling. Endocr Relat Cancer (2014) 0.86
Age-specific signatures of glioblastoma at the genomic, genetic, and epigenetic levels. PLoS One (2013) 0.85
A computational approach to identifying gene-microRNA modules in cancer. PLoS Comput Biol (2015) 0.83
In silico modeling predicts drug sensitivity of patient-derived cancer cells. J Transl Med (2014) 0.82
Expression and functional heterogeneity of chemokine receptors CXCR4 and CXCR7 in primary patient-derived glioblastoma cells. PLoS One (2013) 0.82
ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancers. Front Oncol (2012) 0.82
Candidate genes for the progression of malignant gliomas identified by microarray analysis. Neurosurg Rev (2007) 0.82
Is phosphoproteomics ready for clinical research? Clin Chim Acta (2012) 0.81
AKT pathway genes define 5 prognostic subgroups in glioblastoma. PLoS One (2014) 0.81
Novel therapeutic targets in the brain tumor microenvironment. Oncotarget (2012) 0.81
Diagnostic molecular pathology: current techniques and clinical applications, part I. Proc (Bayl Univ Med Cent) (2003) 0.81
Myosin-X and disease. Exp Cell Res (2015) 0.79
Multi-study integration of brain cancer transcriptomes reveals organ-level molecular signatures. PLoS Comput Biol (2013) 0.79
Biomarkers for glioma immunotherapy: the next generation. J Neurooncol (2015) 0.78
Jumping on the Train of Personalized Medicine: A Primer for Non- Geneticist Clinicians: Part 3. Clinical Applications in the Personalized Medicine Area. Curr Psychiatry Rev (2014) 0.78
Myosins as fundamental components during tumorigenesis: diverse and indispensable. Oncotarget (2016) 0.78
The role of AKT isoforms in glioblastoma: AKT3 delays tumor progression. J Neurooncol (2016) 0.77
Prognostic significance of neuronal marker expression in glioblastomas. Childs Nerv Syst (2012) 0.76
Paul Mischel: all about brains. Text and Interview by Ruth Williams. J Cell Biol (2008) 0.75
Molecular determinants of glioblastoma response to epidermal growth factor receptor kinase inhibitors. Clin Med Oncol (2008) 0.75
Surprisal analysis of Glioblastoma Multiform (GBM) microRNA dynamics unveils tumor specific phenotype. PLoS One (2014) 0.75
Estimating survival time of patients with glioblastoma multiforme and characterization of the identified microRNA signatures. BMC Genomics (2016) 0.75
Molecular signatures of cell cycle transcripts in the pathogenesis of Glial tumors. J Carcinog (2004) 0.75
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning. Nature (2008) 26.78
Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science (2008) 20.68
Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays. PLoS Genet (2008) 20.38
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature (2009) 19.65
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature (2010) 18.69
WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics (2008) 18.58
A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol (2005) 17.23
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med (2005) 15.42
Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J Clin Oncol (2010) 14.79
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
High-throughput oncogene mutation profiling in human cancer. Nat Genet (2007) 12.68
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature (2011) 10.16
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature (2010) 10.09
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature (2012) 8.10
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell (2008) 8.01
Gene expression profiling of gliomas strongly predicts survival. Cancer Res (2004) 7.79
Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R. Bioinformatics (2007) 7.72
BFAST: an alignment tool for large scale genome resequencing. PLoS One (2009) 7.48
DNA methylation age of human tissues and cell types. Genome Biol (2013) 7.48
Role of the murine reprogramming factors in the induction of pluripotency. Cell (2009) 7.46
Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. Am J Hum Genet (2008) 7.13
Global histone modification patterns predict risk of prostate cancer recurrence. Nature (2005) 7.03
Functional organization of the transcriptome in human brain. Nat Neurosci (2008) 7.02
Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol (2011) 6.16
Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet (2006) 5.82
Conservation and evolution of gene coexpression networks in human and chimpanzee brains. Proc Natl Acad Sci U S A (2006) 5.69
Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med (2008) 5.54
Exome sequencing-based copy-number variation and loss of heterozygosity detection: ExomeCNV. Bioinformatics (2011) 5.45
DNA sequencing of maternal plasma to detect Down syndrome: an international clinical validation study. Genet Med (2011) 4.98
Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance. Nat Commun (2012) 4.94
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
IFITM3 restricts the morbidity and mortality associated with influenza. Nature (2012) 4.66
Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. PLoS Med (2006) 4.63
The functional spectrum of low-frequency coding variation. Genome Biol (2011) 4.42
Progression-free survival: an important end point in evaluating therapy for recurrent high-grade gliomas. Neuro Oncol (2008) 4.39
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J Clin Oncol (2010) 4.23
Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature (2012) 4.13
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet (2012) 4.08
Eigengene networks for studying the relationships between co-expression modules. BMC Syst Biol (2007) 4.06
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks. BMC Genomics (2006) 3.87
Gene network interconnectedness and the generalized topological overlap measure. BMC Bioinformatics (2007) 3.83
Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome (2007) 3.59
Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. J Clin Oncol (2008) 3.50
Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci. PLoS Genet (2007) 3.47
Epigenetic predictor of age. PLoS One (2011) 3.46
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42
Distinct transcription profiles of primary and secondary glioblastoma subgroups. Cancer Res (2006) 3.41
Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology (2008) 3.38
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res (2003) 3.36
Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment. Clin Cancer Res (2005) 3.35
Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells. Cancer Res (2006) 3.31
Understanding network concepts in modules. BMC Syst Biol (2007) 3.28
Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. Clin Cancer Res (2003) 3.25
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. J Clin Oncol (2011) 3.23
DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13 as well as Down syndrome: an international collaborative study. Genet Med (2012) 3.18
Gene expression profiling identifies molecular subtypes of gliomas. Oncogene (2003) 3.13
Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing. Nature (2013) 3.06
Aging effects on DNA methylation modules in human brain and blood tissue. Genome Biol (2012) 3.05
Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy. Clin Cancer Res (2010) 3.05
Geographical structure and differential natural selection among North European populations. Genome Res (2009) 3.03
Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci U S A (2006) 3.03
Targeted molecular therapy of GBM. Brain Pathol (2003) 3.02
Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis. Science (2004) 3.01
U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line. PLoS Genet (2010) 2.99
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Is my network module preserved and reproducible? PLoS Comput Biol (2011) 2.91