Published in FEBS Lett on April 24, 2003
The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation. Nucleic Acids Res (2005) 1.76
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Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice. Breast Cancer Res (2011) 1.10
A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer. Clin Exp Metastasis (2004) 1.10
Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner. Clin Cancer Res (2009) 1.08
The role of the insulin-like growth factor-1 system in breast cancer. Mol Cancer (2015) 1.05
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Progression to metastatic stage in a cellular model of prostate cancer is associated with methylation of the androgen receptor gene and transcriptional suppression of the insulin-like growth factor-I receptor gene. Exp Cell Res (2010) 0.85
Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage Differentiation. Front Endocrinol (Lausanne) (2015) 0.85
Identification of Insulin-Like Growth Factor-I Receptor (IGF-IR) Gene Promoter-Binding Proteins in Estrogen Receptor (ER)-Positive and ER-Depleted Breast Cancer Cells. Cancers (Basel) (2010) 0.84
Sp1 facilitates DNA double-strand break repair through a nontranscriptional mechanism. Mol Cell Biol (2012) 0.83
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Absence of the common IGF1 19 CA-repeat allele is more common among BRCA1 mutation carriers than among non-carriers from BRCA1 families. Fam Cancer (2007) 0.78
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Discovery and validation of information theory-based transcription factor and cofactor binding site motifs. Nucleic Acids Res (2016) 0.75
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Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells. Diabetes Metab Res Rev (2009) 3.37
Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. J Biol Chem (2002) 1.92
Retracted BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem (2004) 1.77
STAT1-induced apoptosis is mediated by caspases 2, 3, and 7. J Biol Chem (2003) 1.40
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene (2003) 1.29
ATM activation by ionizing radiation requires BRCA1-associated BAAT1. J Biol Chem (2006) 1.27
Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations. Cancer Lett (2007) 1.22
Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1. J Endocrinol (2006) 1.18
Targeting IGF-1 signaling pathways in gynecologic malignancies. Expert Opin Ther Targets (2013) 1.18
Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling. Oncogene (2005) 1.16
Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. J Biol Chem (2004) 1.11
Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization. J Biol Chem (2002) 1.11
Targeting the IGF1 axis in cancer proliferation. Expert Opin Ther Targets (2009) 1.11
Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners. PLoS One (2013) 1.09
Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner. Clin Cancer Res (2009) 1.08
IFI16 as a negative regulator in the regulation of p53 and p21(Waf1). J Biol Chem (2003) 1.08
Measles virus V protein inhibits p53 family member p73. J Virol (2006) 1.06
Regulation of ATM/DNA-PKcs Phosphorylation by BRCA1-Associated BAAT1. Genes Cancer (2010) 1.05
Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer. Mol Cell Endocrinol (2006) 1.05
BRCA1 affects global DNA methylation through regulation of DNMT1. Cell Res (2010) 1.04
Insulin-like growth factor-I receptor (IGF-IR) translocates to nucleus and autoregulates IGF-IR gene expression in breast cancer cells. J Biol Chem (2011) 1.03
Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53. Endocrinology (2004) 1.03
Essential roles of mTOR/Akt pathway in Aurora-A cell transformation. Int J Biol Sci (2009) 1.02
BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest. Oncogene (2003) 1.01
The application of Toll like receptors for cancer therapy. Int J Biol Sci (2010) 1.01
The intricate involvement of the Insulin-like growth factor receptor signaling in mild traumatic brain injury in mice. Neurobiol Dis (2010) 0.98
Physiological and oncogenic Aurora-A pathway. Int J Biol Sci (2009) 0.97
Role of IFI16 in DNA damage and checkpoint. Front Biosci (2008) 0.96
Autocrine activation of the local insulin-like growth factor I system is up-regulated by estrogen receptor (ER)-independent estrogen actions and accounts for decreased ER expression in type 2 diabetic mesangial cells. Endocrinology (2004) 0.95
IGF signaling defects as causes of growth failure and IUGR. Trends Endocrinol Metab (2008) 0.94
Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1. Endocrinology (2004) 0.93
The molecular and cellular basis of exostosis formation in hereditary multiple exostoses. Int J Exp Pathol (2008) 0.93
WT1-p53 interactions in insulin-like growth factor-I receptor gene regulation. J Biol Chem (2002) 0.93
Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit. Exp Ther Med (2011) 0.92
Insulin-like growth factor-I receptor (IGF-IR) targeting with monoclonal antibody cixutumumab (IMC-A12) inhibits IGF-I action in endometrial cancer cells. Eur J Cancer (2011) 0.91
p53 Regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed targeted therapy. Eur J Cancer (2011) 0.91
The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells. Growth Horm IGF Res (2005) 0.90
Caveolin-1 inhibits anoikis and promotes survival signaling in cancer cells. Adv Enzyme Regul (2006) 0.90
Transcription factor E2F1 is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene. Growth Horm IGF Res (2009) 0.88
Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner. Endocrinology (2008) 0.88
Insulin-like growth factor binding protein-4 and -5 modulate ligand-dependent estrogen receptor-α activation in breast cancer cells in an IGF-independent manner. Cell Signal (2013) 0.88
Caveolin-1 up-regulates IGF-I receptor gene transcription in breast cancer cells via Sp1- and p53-dependent pathways. Exp Cell Res (2006) 0.88
Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein. Oncogene (2002) 0.87
Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transduction. Endocrinology (2013) 0.87
Effects of omega-3 and omega-6 fatty acids on IGF-I receptor signalling in colorectal cancer cells. Arch Physiol Biochem (2009) 0.87
Differential regulation of insulin-like growth factor-I receptor gene expression by wild type and mutant androgen receptor in prostate cancer cells. Mol Cell Endocrinol (2010) 0.87
IGF, IGF receptor and overgrowth syndromes. Pediatr Endocrinol Rev (2004) 0.86
The WT1 Wilms' tumor suppressor gene product interacts with estrogen receptor-alpha and regulates IGF-I receptor gene transcription in breast cancer cells. J Mol Endocrinol (2005) 0.85
Insulin receptor compensates for IGF1R inhibition and directly induces mitogenic activity in prostate cancer cells. Endocr Connect (2014) 0.85
Progression to metastatic stage in a cellular model of prostate cancer is associated with methylation of the androgen receptor gene and transcriptional suppression of the insulin-like growth factor-I receptor gene. Exp Cell Res (2010) 0.85
BRCA1 phosphorylation regulates caspase-3 activation in UV-induced apoptosis. Cancer Res (2005) 0.85
The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway. PLoS One (2011) 0.85
Identification of Insulin-Like Growth Factor-I Receptor (IGF-IR) Gene Promoter-Binding Proteins in Estrogen Receptor (ER)-Positive and ER-Depleted Breast Cancer Cells. Cancers (Basel) (2010) 0.84
HMGA1 protein is a positive regulator of the insulin-like growth factor-I receptor gene. Eur J Cancer (2010) 0.83
Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of γ-H2AX and DNA damage responses in Huntington's disease. Mol Neurobiol (2012) 0.82
BRCA1 is expressed in uterine serous carcinoma (USC) and controls insulin-like growth factor I receptor (IGF-IR) gene expression in USC cell lines. Int J Gynecol Cancer (2012) 0.82
Insulin-like Growth Factor 1 Differentially Affects Lithium Sensitivity of Lymphoblastoid Cell Lines from Lithium Responder and Non-responder Bipolar Disorder Patients. J Mol Neurosci (2015) 0.81
Deregulation of DNA damage response pathway by intercellular contact. J Biol Chem (2012) 0.81
Caveolin-1 controls BRCA1 gene expression and cellular localization in human breast cancer cells. FEBS Lett (2006) 0.80
The WT1 Wilms' tumor suppressor gene: a novel target for insulin-like growth factor-I action. Endocrinology (2003) 0.80
Use of confocal microscopy for the study of spermatogenesis. Methods Cell Sci (2002) 0.80
Using Free and Open-Source Bioconductor Packages to Analyze Array Comparative Genomics Hybridization (aCGH) Data. Curr Genomics (2009) 0.80
BRCA1/2 germline mutations in Jewish patients with uterine serous carcinoma. Int J Gynecol Cancer (2010) 0.79
IGF1R-directed targeted therapy enhances the cytotoxic effect of chemotherapy in endometrial cancer. Cancer Lett (2013) 0.79
Does IGF-1 administration after a mild traumatic brain injury in mice activate the adaptive arm of ER stress? Neurochem Int (2011) 0.79
The WT1 Wilms' tumor suppressor gene is a downstream target for insulin-like growth factor-I (IGF-I) action in PC12 cells. J Neurochem (2006) 0.79
Loss of p53-regulatory protein IFI16 induces NBS1 leading to activation of p53-mediated checkpoint by phosphorylation of p53 SER37. Front Biosci (2008) 0.78
Insulin-like growth factor-I receptor inhibition by specific tyrosine kinase inhibitor NVP-AEW541 in endometrioid and serous papillary endometrial cancer cell lines. Gynecol Oncol (2011) 0.78
Upregulated ATM gene expression and activated DNA crosslink-induced damage response checkpoint in Fanconi anemia: implications for carcinogenesis. Mol Med (2008) 0.78
The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities. Cell Cycle (2012) 0.78
A novel aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment. Int J Biol Sci (2013) 0.77
Signal transducer and activator of transcription-1 (STAT1), but not STAT5b, regulates IGF-I receptor gene expression in an osteosarcoma cell line. J Pediatr Endocrinol Metab (2004) 0.77
Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice. Arch Physiol Biochem (2013) 0.77
Insulin analogues display atypical differentiative activities in skin keratinocytes. Arch Physiol Biochem (2015) 0.77
Distinct DNA damage determines differential phosphorylation of Chk2. Cancer Biol Ther (2014) 0.76
Tumor suppression by resistant maltodextrin, Fibersol-2. Cancer Biol Ther (2015) 0.76
Cellular commitment to reentry into the cell cycle after stalled DNA is determined by site-specific phosphorylation of Chk1 and PTEN. Mol Cancer Ther (2008) 0.76
Integrity of p53 associated pathways determines induction of apoptosis of tumor cells resistant to Aurora-A kinase inhibitors. PLoS One (2013) 0.75
The mitogenicity of insulin analogues in vitro relative to insulin and IGF-I - Response to Kazda et al. Diabetes Metab Res Rev (2010) 0.75
The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses. Exp Mol Pathol (2003) 0.75
Modulation of brain insulin-like growth factor I (IGF-I) binding sites and hypothalamic GHRH and somatostatin levels by exogenous growth hormone and IGF-I in juvenile rats. J Mol Neurosci (2004) 0.75