Published in Am J Med on April 15, 2003
Traversing the valley of death: a guide to assessing prospects for translational success. Sci Transl Med (2009) 1.81
Barriers to translating emerging genetic research on smoking into clinical practice. Perspectives of primary care physicians. J Gen Intern Med (2005) 1.54
The case for randomized controlled trials to assess the impact of clinical information systems. J Am Med Inform Assoc (2011) 1.42
Systematic reviews of animal models: methodology versus epistemology. Int J Med Sci (2013) 1.01
Implementation and impact of a translational research training program in pulmonary and critical care medicine. Chest (2008) 0.89
The Nuremberg Code subverts human health and safety by requiring animal modeling. BMC Med Ethics (2012) 0.89
On the use of mobile inflatable hypoxic marquees for sport-specific altitude training in team sports. Br J Sports Med (2013) 0.89
Is the use of sentient animals in basic research justifiable? Philos Ethics Humanit Med (2010) 0.84
The institutional review board is an impediment to human research: the result is more animal-based research. Philos Ethics Humanit Med (2011) 0.81
Finding translational science publications in MEDLINE/PubMed with translational science filters. Clin Transl Sci (2011) 0.79
Regarding "A process-based review of mouse models of pulmonary hypertension". Pulm Circ (2013) 0.75
Effect of cryopreservation on delineation of immune cell subpopulations in tumor specimens as determinated by multiparametric single cell mass cytometry analysis. BMC Immunol (2017) 0.75
Review: in vivo optical spectral tissue sensing-how to go from research to routine clinical application? Lasers Med Sci (2016) 0.75
Translation of highly promising basic science research into clinical applications. Am J Med (2003) 3.74
Central challenges facing the national clinical research enterprise. JAMA (2003) 17.41
The GPR54 gene as a regulator of puberty. N Engl J Med (2003) 9.54
Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates. Proc Natl Acad Sci U S A (2005) 3.16
Reversal of idiopathic hypogonadotropic hypogonadism. N Engl J Med (2007) 2.54
TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. J Clin Endocrinol Metab (2010) 2.50
Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A (2007) 2.23
Oligogenic basis of isolated gonadotropin-releasing hormone deficiency. Proc Natl Acad Sci U S A (2010) 2.10
Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum. J Clin Endocrinol Metab (2008) 1.92
Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A (2006) 1.87
Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes. Mol Cell Endocrinol (2006) 1.62
Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene. J Clin Endocrinol Metab (2004) 1.57
GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A (2009) 1.55
Use of informatics and information technologies in the clinical research enterprise within US academic medical centers: progress and challenges from 2005 to 2007. J Investig Med (2008) 1.49
Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. J Clin Endocrinol Metab (2012) 1.44
The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab (2002) 1.33
Effect of continuous intravenous administration of human metastin 45-54 on the neuroendocrine activity of the hypothalamic-pituitary-testicular axis in the adult male rhesus monkey (Macaca mulatta). Endocrinology (2007) 1.33
Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet (2013) 1.26
Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism. Proc Natl Acad Sci U S A (2011) 1.26
Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab (2002) 1.26
Polycystic ovarian morphology with regular ovulatory cycles: insights into the pathophysiology of polycystic ovarian syndrome. J Clin Endocrinol Metab (2004) 1.25
A genetic basis for functional hypothalamic amenorrhea. N Engl J Med (2011) 1.24
Hypogonadotropic hypogonadism and cerebellar ataxia: detailed phenotypic characterization of a large, extended kindred. J Clin Endocrinol Metab (2002) 1.20
The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations. Endocr Rev (2010) 1.16
Expanding the phenotype and genotype of female GnRH deficiency. J Clin Endocrinol Metab (2011) 1.16
A novel syndrome caused by the E410K amino acid substitution in the neuronal β-tubulin isotype 3. Brain (2013) 1.15
Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men. J Clin Endocrinol Metab (2007) 1.13
Prioritizing genetic testing in patients with Kallmann syndrome using clinical phenotypes. J Clin Endocrinol Metab (2013) 1.09
Forging stronger partnerships between academic health centers and patient-driven organizations. Acad Med (2013) 1.06
Human GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neurons. Neuroendocrinology (2010) 1.06
Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes. J Clin Endocrinol Metab (2010) 1.05
Kisspeptin resets the hypothalamic GnRH clock in men. J Clin Endocrinol Metab (2011) 1.05
The relative role of gonadal sex steroids and gonadotropin-releasing hormone pulse frequency in the regulation of follicle-stimulating hormone secretion in men. J Clin Endocrinol Metab (2008) 1.03
Isolated GnRH deficiency: a disease model serving as a unique prism into the systems biology of the GnRH neuronal network. Mol Cell Endocrinol (2011) 1.03
Safety of frequent venous blood sampling in a pediatric research population. J Pediatr (2008) 1.02
Neuroendocrine, gonadal, placental, and obstetric phenotypes in patients with IHH and mutations in the G-protein coupled receptor, GPR54. Mol Cell Endocrinol (2006) 1.01
Deciphering genetic disease in the genomic era: the model of GnRH deficiency. Sci Transl Med (2010) 0.94
Mass spectrometric and physiological validation of a sensitive, automated, direct immunoassay for serum estradiol using the Architect. Clin Chim Acta (2007) 0.93
GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone. J Clin Endocrinol Metab (2004) 0.93
Olfactory phenotypic spectrum in idiopathic hypogonadotropic hypogonadism: pathophysiological and genetic implications. J Clin Endocrinol Metab (2011) 0.92
Genetic counseling for isolated GnRH deficiency. Mol Cell Endocrinol (2011) 0.92
Relative roles of inhibin B and sex steroids in the negative feedback regulation of follicle-stimulating hormone in men across the full spectrum of seminiferous epithelium function. J Clin Endocrinol Metab (2008) 0.91
Autosomal recessive idiopathic hypogonadotropic hypogonadism: genetic analysis excludes mutations in the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes. J Clin Endocrinol Metab (2003) 0.90
When genetic load does not correlate with phenotypic spectrum: lessons from the GnRH receptor (GNRHR). J Clin Endocrinol Metab (2012) 0.86
Recombinant factor VIIa for the treatment of severe postoperative and traumatic hemorrhage. Am J Surg (2005) 0.86
An ancient founder mutation in PROKR2 impairs human reproduction. Hum Mol Genet (2012) 0.85
A high-throughput small-molecule ligand screen targeted to agonists and antagonists of the G-protein-coupled receptor GPR54. J Biomol Screen (2010) 0.85
The long-term clinical follow-up and natural history of men with adult-onset idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab (2010) 0.85
Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab (2013) 0.83
The developmental biology of the GnRH neurons. Mol Cell Endocrinol (2011) 0.83
Testis morphology in patients with idiopathic hypogonadotropic hypogonadism. Hum Reprod (2006) 0.82
Interplay between dose and frequency of GnRH administration in determining pituitary gonadotropin responsiveness. Neuroendocrinology (2007) 0.80
Genetic approaches to unraveling reproductive disorders: examples of bedside to bench research in the genomic era. Endocr Rev (2002) 0.80
The puzzles of the prokineticin 2 pathway in human reproduction. Mol Cell Endocrinol (2011) 0.79
A locus for autosomal recessive idiopathic hypogonadotropic hypogonadism on chromosome 19p13.3. J Clin Endocrinol Metab (2003) 0.78
Role of seminiferous tubular development in determining the FSH versus LH responsiveness to GnRH in early sexual maturation. Neuroendocrinology (2009) 0.77
Responsiveness to a physiological regimen of GnRH therapy and relation to genotype in women with isolated hypogonadotropic hypogonadism. J Clin Endocrinol Metab (2013) 0.76
Absence of central circadian pacemaker abnormalities in humans with loss of function mutation in prokineticin 2. J Clin Endocrinol Metab (2014) 0.75
MicroRNA-7a2 suppression causes hypogonadotropism and uncovers signaling pathways in gonadotropes. J Clin Invest (2017) 0.75
Kallmann Syndrome and hypogonadotropic Hypogonadism.Concluding remarks. Front Horm Res (2010) 0.75
Endocrine Society 2014 Laureate Awards. Horm Cancer (2014) 0.75
Corrigendum: SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Nat Genet (2017) 0.75
An instrument for determining the amount of NIH support for clinical investigations at one academic health center. Acad Med (2002) 0.75
Acute stress masking the biochemical phenotype of partial androgen insensitivity syndrome in a patient with a novel mutation in the androgen receptor. J Clin Endocrinol Metab (2004) 0.75