Systematic reviews of animal models: methodology versus epistemology.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMC 3558708)

Published in Int J Med Sci on January 11, 2013

Authors

Ray Greek1, Andre Menache

Author Affiliations

1: Americans For Medical Advancement, 2251 Refugio Rd, Goleta, CA 93117, USA. DrRayGreek@gmail.com

Articles citing this

Progress in using systematic reviews of animal studies to improve translational research. PLoS Med (2013) 1.34

How multi-organ microdevices can help foster drug development. Adv Drug Deliv Rev (2014) 1.00

Animal Models in Cardiovascular Research: Hypertension and Atherosclerosis. Biomed Res Int (2015) 0.85

Therapeutic properties of a vector carrying the HSV thymidine kinase and GM-CSF genes and delivered as a complex with a cationic copolymer. J Transl Med (2015) 0.83

The impact of ginsenosides on cognitive deficits in experimental animal studies of Alzheimer's disease: a systematic review. BMC Complement Altern Med (2015) 0.78

Recent advances in the production of recombinant subunit vaccines in Pichia pastoris. Bioengineered (2016) 0.77

Alarms about structural alerts. Green Chem (2016) 0.76

Efficacy of ABX196, a new NKT agonist, in prophylactic human vaccination. Vaccine (2014) 0.76

Evolving technology: creating kidney organoids from stem cells. AIMS Bioeng (2016) 0.75

Muscular dystrophy in a dish: engineered human skeletal muscle mimetics for disease modeling and drug discovery. Drug Discov Today (2016) 0.75

A Role for 3D Printing in Kidney-on-a-Chip Platforms. Curr Transplant Rep (2016) 0.75

Effect of exercise on fluoride metabolism in adult humans: a pilot study. Sci Rep (2015) 0.75

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes. Arch Toxicol (2015) 0.75

Micropatterning and Assembly of 3D Microvessels. J Vis Exp (2016) 0.75

The chorioallantoic membrane (CAM) assay for the study of human bone regeneration: a refinement animal model for tissue engineering. Sci Rep (2016) 0.75

Impact of Stroke Therapy Academic Industry Roundtable (STAIR) Guidelines on Peri-Anesthesia Care for Rat Models of Stroke: A Meta-Analysis Comparing the Years 2005 and 2015. PLoS One (2017) 0.75

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip. Nat Biomed Eng (2017) 0.75

Complementary Approaches to Existing Target Based Drug Discovery for Identifying Novel Drug Targets. Biomedicines (2016) 0.75

The ascendance of microphysiological systems to solve the drug testing dilemma. Future Sci OA (2017) 0.75

The Role of Microfluidics for Organ on Chip Simulations. Bioengineering (Basel) (2017) 0.75

Repurposed Therapeutic Agents Targeting the Ebola Virus: A Systematic Review. Curr Ther Res Clin Exp (2017) 0.75

Articles cited by this

(truncated to the top 100)

Evidence based medicine: what it is and what it isn't. BMJ (1996) 66.70

Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med (2010) 36.57

Genetic structure of human populations. Science (2002) 30.91

Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol (2010) 27.58

Genetic analysis of genome-wide variation in human gene expression. Nature (2004) 27.28

Human albumin administration in critically ill patients: systematic review of randomised controlled trials. BMJ (1998) 22.62

Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46

Systems biology: a brief overview. Science (2002) 14.69

A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med (2004) 12.79

International ethical guidelines for biomedical research involving human subjects. Bull Med Ethics (2002) 12.36

Computational systems biology. Nature (2002) 10.33

Common genetic variants account for differences in gene expression among ethnic groups. Nat Genet (2007) 9.04

Ethnic and racial differences in the smoking-related risk of lung cancer. N Engl J Med (2006) 7.82

Reengineering translational science: the time is right. Sci Transl Med (2011) 7.55

1,026 experimental treatments in acute stroke. Ann Neurol (2006) 7.23

Evolution of gene expression in the Drosophila melanogaster subgroup. Nat Genet (2003) 6.60

Can animal models of disease reliably inform human studies? PLoS Med (2010) 6.27

Reverse engineering of biological complexity. Science (2002) 6.06

Where is the evidence that animal research benefits humans? BMJ (2004) 5.99

Inheritance and drug response. N Engl J Med (2003) 5.78

Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br J Cancer (2001) 5.58

Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles. Am J Hum Genet (2008) 5.53

Regional and strain-specific gene expression mapping in the adult mouse brain. Proc Natl Acad Sci U S A (2000) 5.01

APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol (2011) 4.80

Translation of research evidence from animals to humans. JAMA (2006) 4.48

Pooling of animal experimental data reveals influence of study design and publication bias. Stroke (2004) 4.37

Evaluation of genetic variation contributing to differences in gene expression between populations. Am J Hum Genet (2008) 4.01

Gene-expression variation within and among human populations. Am J Hum Genet (2007) 3.84

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res (2009) 3.81

Pharmacogenetics and the practice of medicine. Nature (2000) 3.68

How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci (2007) 3.67

Association of age and sex with myocardial infarction symptom presentation and in-hospital mortality. JAMA (2012) 3.66

Abundant pleiotropy in human complex diseases and traits. Am J Hum Genet (2011) 3.60

Genomics, health care, and society. N Engl J Med (2011) 3.57

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet (2011) 2.99

Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke (2008) 2.98

Modern biomedical research: an internally self-consistent universe with little contact with medical reality? Nat Rev Drug Discov (2003) 2.91

Neuroscience: Standard model. Nature (2008) 2.90

Discovery of sexual dimorphisms in metabolic and genetic biomarkers. PLoS Genet (2011) 2.68

A gold standard publication checklist to improve the quality of animal studies, to fully integrate the Three Rs, and to make systematic reviews more feasible. Altern Lab Anim (2010) 2.67

Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet (2005) 2.63

Chimpanzees in hepatitis C virus research: 1998-2007. J Med Primatol (2009) 2.57

Papers that summarise other papers (systematic reviews and meta-analyses). BMJ (1997) 2.49

Scientists on trial: At fault? Nature (2011) 2.45

Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs. Pharmacogenomics J (2010) 2.43

Biological networks. Curr Opin Struct Biol (2003) 2.43

The limits of reductionism in medicine: could systems biology offer an alternative? PLoS Med (2006) 2.13

Reporting animal use in scientific papers. Lab Anim (1997) 2.09

Three periods of regulatory innovation during vertebrate evolution. Science (2011) 2.09

The ethics of animal research. Talking Point on the use of animals in scientific research. EMBO Rep (2007) 2.05

Biomedical research. Of mice and women: the bias in animal models. Science (2010) 2.00

A genome-wide study of DNA methylation patterns and gene expression levels in multiple human and chimpanzee tissues. PLoS Genet (2011) 1.92

THE CONCEPT OF INTEGRATIVE LEVELS AND BIOLOGY. Science (1945) 1.92

Revisiting lab-on-a-chip technology for drug discovery. Nat Rev Drug Discov (2012) 1.91

50 years of preclinical anticancer drug screening: empirical to target-driven approaches. Clin Cancer Res (2005) 1.86

Reductionism and complexity in molecular biology. Scientists now have the tools to unravel biological and overcome the limitations of reductionism. EMBO Rep (2004) 1.83

Animal research: reporting in vivo experiments--the ARRIVE guidelines. J Cereb Blood Flow Metab (2011) 1.80

Principles of early drug discovery. Br J Pharmacol (2011) 1.68

Big pharma moves from 'blockbusters' to 'niche busters'. Nat Med (2010) 1.68

Are animal models predictive for humans? Philos Ethics Humanit Med (2009) 1.57

MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates. PLoS Biol (2011) 1.57

Of mice and men: bridging the translational disconnect in CNS drug discovery. CNS Drugs (2009) 1.56

Specification of laboratory animal use in scientific articles: current low detail in the journals' instructions for authors and some proposals. Methods Find Exp Clin Pharmacol (2005) 1.54

Biological spectra analysis: Linking biological activity profiles to molecular structure. Proc Natl Acad Sci U S A (2004) 1.51

Systems for identifying new drugs are often faulty. Science (1997) 1.51

Research agenda. Promoting convergence in biomedical science. Science (2011) 1.51

Reprint: Good laboratory practice: preventing introduction of bias at the bench. J Cereb Blood Flow Metab (2008) 1.47

Managing the challenge of chemically reactive metabolites in drug development. Nat Rev Drug Discov (2011) 1.45

Copy number variation of KIR genes influences HIV-1 control. PLoS Biol (2011) 1.44

The complexity of the mammalian transcriptome. J Physiol (2006) 1.43

Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment - a systematic approach. Osteoarthritis Cartilage (2008) 1.40

Surveying the literature from animal experiments: systematic review and meta-analysis are important contributions. BMJ (2005) 1.38

Gene therapy on trial. Science (2000) 1.34

Basic research in HIV vaccinology is hampered by reductionist thinking. Front Immunol (2012) 1.33

Why animal research needs to improve. Nature (2011) 1.32

Translation of basic research into useful treatments: how often does it occur? Am J Med (2003) 1.30

Finding the tumor copycat. Therapy fails, patients don't. Nat Med (2010) 1.29

Treatment of intracerebral hemorrhage in animal models: meta-analysis. Ann Neurol (2011) 1.26

Interethnic variation of drug metabolism. Trends Pharmacol Sci (1991) 1.25

Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology. Annu Rev Pathol (2011) 1.25

Sex and the suffering brain. Science (2005) 1.24

Species similarities and differences in pharmacokinetics. Drug Metab Dispos (1995) 1.22

Genomically humanized mice: technologies and promises. Nat Rev Genet (2011) 1.18

Stroke research at a road block: the streets from adversity should be paved with meta-analysis and good laboratory practice. Br J Pharmacol (2009) 1.18

Wanted: women in clinical trials. Science (2005) 1.17

Comparative features of hepatitis C virus infection in humans and chimpanzees. Springer Semin Immunopathol (1997) 1.16

Engineering complex systems. Nature (2004) 1.15

Progress towards personalized medicine. Drug Discov Today (2009) 1.15

Why animal studies are often poor predictors of human reactions to exposure. J R Soc Med (2009) 1.13

Systems biology. Modular biological complexity. Science (2012) 1.13

Preclinical studies of human disease: time to take methodological quality seriously. J Mol Cell Cardiol (2011) 1.13

Predictive in vivo animal models and translation to clinical trials. Drug Discov Today (2012) 1.12

Comparative analysis of cancer genes in the human and chimpanzee genomes. BMC Genomics (2006) 1.10

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol (2010) 1.08

Inbred strains should replace outbred stocks in toxicology, safety testing, and drug development. Toxicol Pathol (2010) 1.08

Senile macular changes in the black African. Br J Ophthalmol (1978) 1.06

Surviving a knockout blow. Nature (2002) 1.05

Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing. J Cereb Blood Flow Metab (2010) 1.02

Genetic factors in pain and its treatment. Curr Opin Anaesthesiol (2007) 1.01

The contributions of normal variation and genetic background to mammalian gene expression. Genome Biol (2006) 1.01