Published in Biochem J on August 01, 2003
Activator protein-2gamma (AP-2gamma) expression is specifically induced by oestrogens through binding of the oestrogen receptor to a canonical element within the 5'-untranslated region. Biochem J (2004) 0.90
Involvement of a specificity proteins-binding element in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene. Breast Cancer Res (2008) 0.84
Inhibition of cystathionine β-synthase is associated with glucocorticoids over-secretion in psychological stress-induced hyperhomocystinemia rat liver. Cell Stress Chaperones (2013) 0.83
Down-regulation of human topoisomerase IIalpha expression correlates with relative amounts of specificity factors Sp1 and Sp3 bound at proximal and distal promoter regions. BMC Mol Biol (2007) 0.82
Tumor Suppressor DLEC1 can Stimulate the Proliferation of Cancer Cells When AP-2ɑ2 is Down-Regulated in HCT116. Hepat Mon (2015) 0.75
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
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DNA sequence requirements for transcriptional initiator activity in mammalian cells. Mol Cell Biol (1994) 3.76
Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes Dev (1988) 3.72
Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature (1996) 3.27
Sp1-mediated transcriptional activation is repressed by Sp3. EMBO J (1994) 3.27
Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature (1996) 2.98
SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol Cell (2002) 2.93
Transcription factor Sp3 is silenced through SUMO modification by PIAS1. EMBO J (2002) 2.41
A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma. Oncogene (1996) 2.00
Cloning and characterization of a second AP-2 transcription factor: AP-2 beta. Development (1995) 1.95
AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression. Nat Genet (1997) 1.85
The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma. Proc Natl Acad Sci U S A (1995) 1.76
Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta. Genes Dev (1997) 1.76
An inhibitor domain in Sp3 regulates its glutamine-rich activation domains. EMBO J (1996) 1.68
Generality of a functional initiator consensus sequence. Gene (1996) 1.65
Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus. Nat Genet (2000) 1.62
Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development. Development (2002) 1.62
Immunohistochemical analysis reveals a tumour suppressor-like role for the transcription factor AP-2 in invasive breast cancer. J Pathol (1999) 1.47
Transcription factor Sp3 is regulated by acetylation. Nucleic Acids Res (2001) 1.47
Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways. Cancer Res (1998) 1.44
AP-2.2, a novel gene related to AP-2, is expressed in the forebrain, limbs and face during mouse embryogenesis. Mech Dev (1996) 1.43
Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors. Genomics (1996) 1.37
Cloning and characterization of a novel mouse AP-2 transcription factor, AP-2delta, with unique DNA binding and transactivation properties. J Biol Chem (2001) 1.36
Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. J Biol Chem (2002) 1.36
Transcription factor gene AP-2 gamma essential for early murine development. Mol Cell Biol (2002) 1.33
Identification of ERF-1 as a member of the AP2 transcription factor family. Proc Natl Acad Sci U S A (1997) 1.31
Comparative analysis of AP-2 alpha and AP-2 beta gene expression during murine embryogenesis. Dev Dyn (1997) 1.28
High Sp1/Sp3 ratios in epithelial cells during epithelial differentiation and cellular transformation correlate with the activation of the HPV-16 promoter. Virology (1996) 1.27
Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element. J Biol Chem (1998) 1.22
Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor. Mol Cell Biol (1999) 1.21
Requirement for AP-2alpha in cardiac outflow tract morphogenesis. Mech Dev (2002) 1.18
Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer. Oncogene (2000) 1.18
Sp3 and Sp4 can repress transcription by competing with Sp1 for the core cis-elements on the human ADH5/FDH minimal promoter. J Biol Chem (1999) 1.17
The genomic structure of the human AP-2 transcription factor. Nucleic Acids Res (1994) 1.04
Sp1 activation of a TATA-less promoter requires a species-specific interaction involving transcription factor IID. Nucleic Acids Res (1998) 1.00
Dominant negative interference of transcription factor AP-2 causes inhibition of ErbB-3 expression and suppresses malignant cell growth. Breast Cancer Res Treat (2002) 0.96
Sp1/Sp3 and PU.1 differentially regulate beta(5) integrin gene expression in macrophages and osteoblasts. J Biol Chem (2000) 0.89
Comparative and functional analysis of the AP2 promoter indicates that conserved octamer and initiator elements are critical for activity. Nucleic Acids Res (1996) 0.84
GLUT1 glucose transporter gene transcription is repressed by Sp3. Evidence for a regulatory role of Sp3 during myogenesis. J Mol Biol (1999) 0.84
Transcriptional regulation of the c-erbB-3 gene in human breast carcinoma cell lines. Oncogene (1993) 0.84
Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes. EMBO J (2002) 2.02
Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. J Biol Chem (2003) 1.65
Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. J Biol Chem (2002) 1.36
Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. J Biol Chem (2001) 1.35
Differentiation of Campylobacter coli, Campylobacter jejuni, Campylobacter lari, and Campylobacter upsaliensis by a multiplex PCR developed from the nucleotide sequence of the lipid A gene lpxA. J Clin Microbiol (2004) 1.32
FGFR4 overexpression in pancreatic cancer is mediated by an intronic enhancer activated by HNF1alpha. Oncogene (2002) 1.03
Arylamine N-acetyltransferase 1 expression in breast cancer cell lines: a potential marker in estrogen receptor-positive tumors. Genes Chromosomes Cancer (2008) 0.99
Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21(cip) (CDKN1A). Mol Cell Biol (2012) 0.98
AP-2gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene. EMBO J (2009) 0.97
Activator protein-2gamma (AP-2gamma) expression is specifically induced by oestrogens through binding of the oestrogen receptor to a canonical element within the 5'-untranslated region. Biochem J (2004) 0.90
Dual association by TFAP2A during activation of the p21cip/CDKN1A promoter. Cell Cycle (2010) 0.86
Alternative TFAP2A isoforms have distinct activities in breast cancer. Breast Cancer Res (2011) 0.85
Role of the HSP90-associated cochaperone p23 in enhancing activity of the androgen receptor and significance for prostate cancer. Mol Endocrinol (2012) 0.85
Androgen receptor is targeted to distinct subcellular compartments in response to different therapeutic antiandrogens. Clin Cancer Res (2004) 0.81
Competition on nitrocellulose-immobilized antibody arrays: from bacterial protein binding assay to protein profiling in breast cancer cells. Mol Cell Proteomics (2005) 0.78
Functional analysis of a breast cancer-associated FGFR2 single nucleotide polymorphism using zinc finger mediated genome editing. PLoS One (2013) 0.76