Published in Mol Cell on October 01, 2002
Modification with SUMO. A role in transcriptional regulation. EMBO Rep (2003) 3.25
Mechanisms, regulation and consequences of protein SUMOylation. Biochem J (2010) 3.22
Histone sumoylation is associated with transcriptional repression. Proc Natl Acad Sci U S A (2003) 3.18
Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol Cell Biol (2005) 2.28
A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. Mol Cell Proteomics (2004) 2.21
Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. Mol Cell Biol (2005) 2.18
SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression. Genes Dev (2003) 2.17
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev (2006) 2.15
Role of desumoylation in the development of prostate cancer. Neoplasia (2006) 1.90
SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. Mol Cell Biol (2004) 1.89
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol (2004) 1.86
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. Mol Cell (2009) 1.81
Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery. PLoS Pathog (2009) 1.78
An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity. Mol Cell Biol (2007) 1.69
Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy. Proc Natl Acad Sci U S A (2003) 1.60
NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. Proc Natl Acad Sci U S A (2006) 1.59
Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes. Proc Natl Acad Sci U S A (2004) 1.58
ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP. Genes Dev (2007) 1.57
Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. Mol Cell Biol (2005) 1.55
SUMO-conjugating and SUMO-deconjugating enzymes from Arabidopsis. Plant Physiol (2006) 1.51
SUMO: a multifaceted modifier of chromatin structure and function. Dev Cell (2013) 1.50
SUMO-dependent compartmentalization in promyelocytic leukemia protein nuclear bodies prevents the access of LRH-1 to chromatin. Mol Cell Biol (2005) 1.48
Ikaros SUMOylation: switching out of repression. Mol Cell Biol (2005) 1.48
Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. J Biol Chem (2008) 1.44
Sumoylation Inhibits the Growth Suppressive Properties of Ikaros. PLoS One (2016) 1.41
A small conserved surface in SUMO is the critical structural determinant of its transcriptional inhibitory properties. Mol Cell Biol (2005) 1.40
Genetic analysis connects SLX5 and SLX8 to the SUMO pathway in Saccharomyces cerevisiae. Genetics (2005) 1.40
PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein. Genes Dev (2006) 1.36
SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx. Proc Natl Acad Sci U S A (2005) 1.33
Role for SUMO modification in facilitating transcriptional repression by BKLF. Mol Cell Biol (2005) 1.31
Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification. J Virol (2005) 1.26
Sumoylation dynamics during keratinocyte differentiation. J Cell Sci (2006) 1.26
Negative modulation of androgen receptor transcriptional activity by Daxx. Mol Cell Biol (2004) 1.26
PIASx acts as an Elk-1 coactivator by facilitating derepression. EMBO J (2005) 1.25
SUMO conjugation attenuates the activity of the gypsy chromatin insulator. EMBO J (2006) 1.22
A novel plant cysteine protease has a dual function as a regulator of 1-aminocyclopropane-1-carboxylic Acid synthase gene expression. Plant Cell (2005) 1.21
Arabidopsis nitrate reductase activity is stimulated by the E3 SUMO ligase AtSIZ1. Nat Commun (2011) 1.21
Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis. Mol Cell Biol (2007) 1.20
The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans. Genes Dev (2004) 1.20
Small ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregation. J Biol Chem (2009) 1.19
SUMO-modified Sp3 represses transcription by provoking local heterochromatic gene silencing. EMBO Rep (2008) 1.17
Repression of Smad4 transcriptional activity by SUMO modification. Biochem J (2004) 1.17
SUMO-mediated inhibition of glucocorticoid receptor synergistic activity depends on stable assembly at the promoter but not on DAXX. Mol Endocrinol (2008) 1.12
EBNA3C coactivation with EBNA2 requires a SUMO homology domain. J Virol (2004) 1.12
Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity. BMC Biochem (2006) 1.10
Functional and physical interaction of yeast Mgs1 with PCNA: impact on RAD6-dependent DNA damage tolerance. Mol Cell Biol (2006) 1.10
Stability of the Sp3-DNA complex is promoter-specific: Sp3 efficiently competes with Sp1 for binding to promoters containing multiple Sp-sites. Nucleic Acids Res (2003) 1.09
Controlling hematopoiesis through sumoylation-dependent regulation of a GATA factor. Mol Cell (2009) 1.09
Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene. Nucleic Acids Res (2006) 1.08
The C-terminus of p63 contains multiple regulatory elements with different functions. Cell Death Dis (2010) 1.07
SUMO conjugation in plants. Planta (2004) 1.07
Differential intranuclear organization of transcription factors Sp1 and Sp3. Mol Biol Cell (2005) 1.05
Heterologous SUMO-2/3-ubiquitin chains optimize IκBα degradation and NF-κB activity. PLoS One (2012) 1.04
SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells. Proc Natl Acad Sci U S A (2007) 1.03
MafG sumoylation is required for active transcriptional repression. Mol Cell Biol (2006) 1.02
Ubc9 regulates mitosis and cell survival during zebrafish development. Mol Biol Cell (2006) 1.00
Chromatin modification by SUMO-1 stimulates the promoters of translation machinery genes. Nucleic Acids Res (2012) 0.98
Global analysis of SUMO chain function reveals multiple roles in chromatin regulation. J Cell Biol (2013) 0.98
In vivo modeling of polysumoylation uncovers targeting of Topoisomerase II to the nucleolus via optimal level of SUMO modification. Chromosoma (2007) 0.97
TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation. Mol Biol Cell (2005) 0.95
Transcriptional repression by sumoylation of Epstein-Barr virus BZLF1 protein correlates with association of histone deacetylase. J Biol Chem (2010) 0.94
Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity. Nucleic Acids Res (2007) 0.94
A small ubiquitin-related modifier-interacting motif functions as the transcriptional activation domain of Krüppel-like factor 4. J Biol Chem (2010) 0.92
Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5. PLoS One (2011) 0.92
Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis. Proc Natl Acad Sci U S A (2007) 0.92
Scavenger receptors mediate the role of SUMO and Ftz-f1 in Drosophila steroidogenesis. PLoS Genet (2013) 0.92
Role of SUMO modification of human PCNA at stalled replication fork. Nucleic Acids Res (2012) 0.91
Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation. J Biol Chem (2012) 0.91
Sumoylated MEF2A coordinately eliminates orphan presynaptic sites and promotes maturation of presynaptic boutons. J Neurosci (2013) 0.89
Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3. PLoS Genet (2010) 0.89
Modification of papillomavirus E2 proteins by the small ubiquitin-like modifier family members (SUMOs). Virology (2008) 0.89
Post-translational modifications of the progesterone receptors. J Steroid Biochem Mol Biol (2013) 0.88
The SUMO system: a master organizer of nuclear protein assemblies. Chromosoma (2013) 0.88
Sumoylation of Krüppel-like factor 4 inhibits pluripotency induction but promotes adipocyte differentiation. J Biol Chem (2013) 0.87
Coordinated regulation of transcription factor Bcl11b activity in thymocytes by the mitogen-activated protein kinase (MAPK) pathways and protein sumoylation. J Biol Chem (2012) 0.87
Mechanisms underlying the control of progesterone receptor transcriptional activity by SUMOylation. J Biol Chem (2009) 0.87
Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers. Biol Cell (2011) 0.87
SUMOylation of GPS2 protein regulates its transcription-suppressing function. Mol Biol Cell (2014) 0.87
SUMO modification enhances p66-mediated transcriptional repression of the Mi-2/NuRD complex. Mol Cell Biol (2006) 0.86
SUMO-1 possesses DNA binding activity. BMC Res Notes (2010) 0.86
DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair. J Biol Chem (2013) 0.85
An essential set of basic DNA response elements is required for receptor-dependent transcription of the lecithin:retinol acyltransferase (Lrat) gene. Arch Biochem Biophys (2009) 0.85
Interactions between NF-κB and SP3 connect inflammatory signaling with reduced FGF-10 expression. J Biol Chem (2013) 0.85
Mutually exclusive STAT1 modifications identified by Ubc9/substrate dimerization-dependent SUMOylation. Nucleic Acids Res (2009) 0.84
At the crossroads of SUMO and NF-kappaB. Mol Cancer (2003) 0.84
Small ubiquitin-like modifier (SUMO) conjugation impedes transcriptional silencing by the polycomb group repressor Sex Comb on Midleg. J Biol Chem (2011) 0.83
Characterization of the human activator protein-2gamma (AP-2gamma) gene: control of expression by Sp1/Sp3 in breast tumour cells. Biochem J (2003) 0.83
Modulation of CP2 family transcriptional activity by CRTR-1 and sumoylation. PLoS One (2010) 0.82
Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin. J Lipid Res (2010) 0.82
Sumoylation of the P protein at K254 plays an important role in growth of parainfluenza virus 5. J Virol (2011) 0.82
SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasome. Mol Cancer Ther (2008) 0.82
Transcription factor Sp3 represses expression of p21CIP¹ via inhibition of productive elongation by RNA polymerase II. Mol Cell Biol (2013) 0.82
Polo-like kinase 1-mediated phosphorylation of Forkhead box protein M1b antagonizes its SUMOylation and facilitates its mitotic function. J Biol Chem (2014) 0.81
Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells. Biochim Biophys Acta (2009) 0.81
SUMO modification of NZFP mediates transcriptional repression through TBP binding. Mol Cells (2012) 0.81
Identification of a non-covalent ternary complex formed by PIAS1, SUMO1, and UBC9 proteins involved in transcriptional regulation. J Biol Chem (2013) 0.81
SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4. PLoS One (2012) 0.80
SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2. Cell Cycle (2013) 0.80
Hematopoiesis: an evolving paradigm for stem cell biology. Cell (2008) 11.95
The zebrafish reference genome sequence and its relationship to the human genome. Nature (2013) 8.52
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature (2007) 7.55
Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol (2003) 5.73
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab (2005) 5.32
Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell (2008) 5.09
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell (2004) 4.91
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell (2009) 4.69
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science (2010) 4.37
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A (2005) 4.15
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell (2012) 4.04
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol (2005) 3.68
Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism. Nat Genet (2005) 3.66
Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes Dev (2007) 3.45
Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE). Nat Biotechnol (2008) 3.43
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature (2011) 3.37
Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev (2005) 3.27
Myc-induced T cell leukemia in transgenic zebrafish. Science (2003) 3.15
The use of zebrafish to understand immunity. Immunity (2004) 3.09
Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99
Hematopoietic stem cell development is dependent on blood flow. Cell (2009) 2.77
Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Blood (2005) 2.65
Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera. Cell Stem Cell (2007) 2.56
The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis. Oncogene (2004) 2.54
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell (2011) 2.53
Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation. Blood (2004) 2.46
TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell (2010) 2.33
Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature (2005) 2.25
DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature (2011) 2.23
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proc Natl Acad Sci U S A (2005) 2.19
BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. Cell Stem Cell (2008) 2.17
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature (2003) 2.16
Mutant-specific gene programs in the zebrafish. Blood (2005) 2.15
Zebrafish as a cancer model system. Cancer Cell (2002) 2.12
Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev Cell (2005) 2.12
Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish. Development (2011) 2.11
An Mll-dependent Hox program drives hematopoietic progenitor expansion. Curr Biol (2004) 2.10
Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell (2011) 2.04
Use of the zebrafish system to study primitive and definitive hematopoiesis. Annu Rev Genet (2005) 2.02
Hooked! Modeling human disease in zebrafish. J Clin Invest (2012) 2.00
The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell (2012) 1.96
The zebrafish as a model organism to study development of the immune system. Adv Immunol (2003) 1.96
Regulation of the lmo2 promoter during hematopoietic and vascular development in zebrafish. Dev Biol (2005) 1.93
Hematopoiesis and stem cells: plasticity versus developmental heterogeneity. Nat Immunol (2002) 1.90
APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol (2008) 1.90
Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors. Nat Methods (2007) 1.90
Small molecules that delay S phase suppress a zebrafish bmyb mutant. Nat Chem Biol (2005) 1.87
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol (2004) 1.86
T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell (2010) 1.85
In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc Natl Acad Sci U S A (2004) 1.85
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. Mol Cell (2009) 1.81
The SUMO-specific protease SENP5 is required for cell division. Mol Cell Biol (2006) 1.81
SUMO-1 protease-1 regulates gene transcription through PML. Mol Cell (2002) 1.80
The clinical potential of stem cells. Curr Opin Cell Biol (2004) 1.73
Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood (2013) 1.72
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell (2012) 1.71
Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish. Proc Natl Acad Sci U S A (2007) 1.70
Resolving the controversy about N-cadherin and hematopoietic stem cells. Cell Stem Cell (2010) 1.70
Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning. Dev Biol (2002) 1.70
Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell (2013) 1.68
Organogenesis--heart and blood formation from the zebrafish point of view. Science (2002) 1.67
The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol (2004) 1.64
NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. Proc Natl Acad Sci U S A (2006) 1.59
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development. Mol Cell (2011) 1.55
The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome Biol (2013) 1.54
Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord. Neuron (2007) 1.52
Ontogeny of hematopoiesis: examining the emergence of hematopoietic cells in the vertebrate embryo. Curr Top Dev Biol (2003) 1.51
A chemical genetic screen for cell cycle inhibitors in zebrafish embryos. Chem Biol Drug Des (2006) 1.50
The pu.1 promoter drives myeloid gene expression in zebrafish. Blood (2004) 1.49
The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization. Mol Cell Biol (2007) 1.47
Definition of the zebrafish genome using flow cytometry and cytogenetic mapping. BMC Genomics (2007) 1.46
Cancer genetics and drug discovery in the zebrafish. Nat Rev Cancer (2003) 1.45
Zebrafish scl functions independently in hematopoietic and endothelial development. Dev Biol (2005) 1.45
Hematopoietic development in the zebrafish. Int J Dev Biol (2010) 1.44
The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans. Development (2003) 1.43
Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet (2003) 1.40
Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish. Blood (2007) 1.39
The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis. Dev Biol (2006) 1.39
High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia. Blood (2010) 1.34
Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR. Dev Biol (2012) 1.32
Melanocytes in development, regeneration, and cancer. Cell Stem Cell (2008) 1.31
Hematopoietic gene expression profile in zebrafish kidney marrow. Proc Natl Acad Sci U S A (2004) 1.31
New waves of discovery: modeling cancer in zebrafish. J Clin Oncol (2007) 1.31
The Zon laboratory guide to positional cloning in zebrafish. Methods Cell Biol (2004) 1.30
Zebrafish blood stem cells. J Cell Biochem (2009) 1.30
The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies. Hum Mol Genet (2011) 1.30
AlphaA-crystallin expression prevents gamma-crystallin insolubility and cataract formation in the zebrafish cloche mutant lens. Development (2006) 1.28
Zebrafish as a model for normal and malignant hematopoiesis. Dis Model Mech (2011) 1.28
Ferroportin1 is required for normal iron cycling in zebrafish. J Clin Invest (2005) 1.27
A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood (2009) 1.27
Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110. Proc Natl Acad Sci U S A (2007) 1.24
The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish. Blood (2003) 1.24
Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish. Zebrafish (2009) 1.24
Gene Duplication of the zebrafish kit ligand and partitioning of melanocyte development functions to kit ligand a. PLoS Genet (2007) 1.24
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. Genes Dev (2007) 1.23
PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury. Proc Natl Acad Sci U S A (2010) 1.21
The zebrafish runzel muscular dystrophy is linked to the titin gene. Dev Biol (2007) 1.20
Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Proc Natl Acad Sci U S A (2006) 1.19
Zebrafish kidney stromal cell lines support multilineage hematopoiesis. Blood (2009) 1.19
The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1). Blood (2002) 1.16