Published in JAMA on May 06, 2003
Investigation of a nosocomial outbreak of severe acute respiratory syndrome (SARS) in Toronto, Canada. CMAJ (2003) 3.96
Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice. J Virol (2004) 3.76
Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev (2005) 3.18
Ethics and SARS: lessons from Toronto. BMJ (2003) 2.39
Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins. J Virol (2004) 2.38
Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane. J Virol (2007) 2.18
SARS among critical care nurses, Toronto. Emerg Infect Dis (2004) 2.10
Predictability and epidemic pathways in global outbreaks of infectious diseases: the SARS case study. BMC Med (2007) 1.98
Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques. Nat Med (2013) 1.98
SARS in healthcare facilities, Toronto and Taiwan. Emerg Infect Dis (2004) 1.95
Clinical course and management of SARS in health care workers in Toronto: a case series. CMAJ (2003) 1.92
Aged BALB/c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans. J Virol (2005) 1.79
SARS: systematic review of treatment effects. PLoS Med (2006) 1.74
Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Clin Microbiol Rev (2007) 1.68
Multiple organ infection and the pathogenesis of SARS. J Exp Med (2005) 1.58
Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin. Sci Rep (2013) 1.55
Interpretation of diagnostic laboratory tests for severe acute respiratory syndrome: the Toronto experience. CMAJ (2004) 1.50
Wrestling SARS from uncertainty. Emerg Infect Dis (2004) 1.50
Risk factors for SARS among persons without known contact with SARS patients, Beijing, China. Emerg Infect Dis (2004) 1.48
MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV. PLoS Pathog (2008) 1.47
Pro/con clinical debate: steroids are a key component in the treatment of SARS. Pro: Yes, steroids are a key component of the treatment regimen for SARS. Crit Care (2004) 1.45
Possible SARS coronavirus transmission during cardiopulmonary resuscitation. Emerg Infect Dis (2004) 1.45
Cynomolgus macaque as an animal model for severe acute respiratory syndrome. PLoS Med (2006) 1.40
Short term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome (SARS). Thorax (2003) 1.40
Severe acute respiratory syndrome, Beijing, 2003. Emerg Infect Dis (2004) 1.37
Advances in clinical diagnosis and treatment of severe acute respiratory syndrome. World J Gastroenterol (2003) 1.31
Model parameters and outbreak control for SARS. Emerg Infect Dis (2004) 1.30
Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study. PLoS Negl Trop Dis (2012) 1.29
Small molecules targeting severe acute respiratory syndrome human coronavirus. Proc Natl Acad Sci U S A (2004) 1.25
Promoting best practices for control of respiratory infections: collaboration between primary care and public health services. Can Fam Physician (2006) 1.23
Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings. Thorax (2004) 1.20
Severe acute respiratory syndrome-associated coronavirus in lung tissue. Emerg Infect Dis (2004) 1.16
Why SARS will not return: a polemic. CMAJ (2004) 1.15
Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry. Proc Natl Acad Sci U S A (2004) 1.15
Clinical trials and novel pathogens: lessons learned from SARS. Emerg Infect Dis (2004) 1.14
Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients. Emerg Infect Dis (2004) 1.13
Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease. J Virol (2005) 1.12
Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice. Am J Pathol (2008) 1.12
Initial viral load and the outcomes of SARS. CMAJ (2004) 1.11
Antisense morpholino-oligomers directed against the 5' end of the genome inhibit coronavirus proliferation and growth. J Virol (2004) 1.09
Pathology and pathogenesis of severe acute respiratory syndrome. Am J Pathol (2007) 1.09
The laboratory diagnosis of severe acute respiratory syndrome: emerging laboratory tests for an emerging pathogen. Clin Biochem Rev (2004) 1.08
Neutralizing antibody response and SARS severity. Emerg Infect Dis (2005) 1.08
Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus. J Virol (2010) 1.07
Coronavirus-positive nasopharyngeal aspirate as predictor for severe acute respiratory syndrome mortality. Emerg Infect Dis (2003) 1.07
A comparative epidemiologic analysis of SARS in Hong Kong, Beijing and Taiwan. BMC Infect Dis (2010) 1.06
Molecular pathology of emerging coronavirus infections. J Pathol (2015) 1.05
Respiratory viruses other than influenza virus: impact and therapeutic advances. Clin Microbiol Rev (2008) 1.05
SARS transmission and commercial aircraft. Emerg Infect Dis (2004) 1.04
Index patient and SARS outbreak in Hong Kong. Emerg Infect Dis (2004) 1.02
Mild severe acute respiratory syndrome. Emerg Infect Dis (2003) 1.02
Participation of both host and virus factors in induction of severe acute respiratory syndrome (SARS) in F344 rats infected with SARS coronavirus. J Virol (2006) 1.01
Severe acute respiratory syndrome: providing care in the face of uncertainty. JAMA (2003) 1.01
Hospital preparedness and SARS. Emerg Infect Dis (2004) 1.00
Clinical review: SARS - lessons in disaster management. Crit Care (2005) 1.00
Combining clinical and epidemiologic features for early recognition of SARS. Emerg Infect Dis (2004) 1.00
Therapeutically targeting RNA viruses via lethal mutagenesis. Future Virol (2008) 0.99
Encouraging medical students to do research and write papers. CMAJ (2007) 0.97
Nurses' working conditions: implications for infectious disease. Emerg Infect Dis (2004) 0.97
Infectious diseases in healthcare workers - an analysis of the standardised data set of a German compensation board. J Occup Med Toxicol (2012) 0.97
Communication in the Toronto critical care community: important lessons learned during SARS. Crit Care (2003) 0.96
Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs. Emerg Infect Dis (2004) 0.96
The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome. BMC Infect Dis (2006) 0.95
Severe acute respiratory syndrome: report of treatment and outcome after a major outbreak. Thorax (2004) 0.95
Long-term SARS coronavirus excretion from patient cohort, China. Emerg Infect Dis (2004) 0.94
Occupational deaths among healthcare workers. Emerg Infect Dis (2005) 0.94
Interferon alfacon 1 inhibits SARS-CoV infection in human bronchial epithelial Calu-3 cells. Biochem Biophys Res Commun (2008) 0.93
Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms. J Virol (2013) 0.93
Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov (2016) 0.91
SARS clinical features, United States, 2003. Emerg Infect Dis (2005) 0.91
The SARS-CoV ferret model in an infection-challenge study. Virology (2008) 0.91
Bench-to-bedside review: rare and common viral infections in the intensive care unit--linking pathophysiology to clinical presentation. Crit Care (2008) 0.90
Respiratory Infections in the U.S. Military: Recent Experience and Control. Clin Microbiol Rev (2015) 0.90
Human coronaviruses: insights into environmental resistance and its influence on the development of new antiseptic strategies. Viruses (2012) 0.89
Kinetics of severe acute respiratory syndrome (SARS) coronavirus-specific antibodies in 271 laboratory-confirmed cases of SARS. Clin Diagn Lab Immunol (2004) 0.89
The impact of SARS on a tertiary care pediatric emergency department. CMAJ (2004) 0.89
Bcl-xL inhibits T-cell apoptosis induced by expression of SARS coronavirus E protein in the absence of growth factors. Biochem J (2005) 0.89
Clinical significance of hepatic derangement in severe acute respiratory syndrome. World J Gastroenterol (2005) 0.89
Possible central nervous system infection by SARS coronavirus. Emerg Infect Dis (2004) 0.87
SARS-associated coronavirus transmission, United States. Emerg Infect Dis (2004) 0.87
Influenza aerosols in UK hospitals during the H1N1 (2009) pandemic--the risk of aerosol generation during medical procedures. PLoS One (2013) 0.87
Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors. Thorax (2005) 0.87
Treatment of severe acute respiratory syndrome. Eur J Clin Microbiol Infect Dis (2005) 0.87
An Evaluation of the Additive Effect of Natural Herbal Medicine on SARS or SARS-like Infectious Diseases in 2003: A Randomized, Double-blind, and Controlled Pilot Study. Evid Based Complement Alternat Med (2008) 0.86
Early diagnosis of SARS: lessons from the Toronto SARS outbreak. Eur J Clin Microbiol Infect Dis (2006) 0.85
Severe acute respiratory syndrome (SARS): lessons learnt in Hong Kong. J Thorac Dis (2013) 0.85
Paediatric emergency department staff perceptions of infection control measures against severe acute respiratory syndrome. Emerg Med J (2006) 0.84
Controlling droplet-transmitted respiratory infections: best practices and cost. Can Fam Physician (2006) 0.84
Clinical and epidemiological predictors of transmission in Severe Acute Respiratory Syndrome (SARS). BMC Infect Dis (2006) 0.84
Future treatment strategies for novel Middle East respiratory syndrome coronavirus infection. Future Med Chem (2013) 0.84
Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross. PLoS Genet (2015) 0.84
Severe acute respiratory syndrome coronaviruses with mutations in the E protein are attenuated and promising vaccine candidates. J Virol (2015) 0.83
Clinical Features and Outcome of 65 Laboratory Confirmed Cases of H1N1 in Muscat, Sultanate of Oman. Oman Med J (2012) 0.83
The ongoing H1N1 flu pandemic and the intensive care community: challenges, opportunities, and the duties of scientific societies and intensivists. Intensive Care Med (2009) 0.83
Infrastructure and contamination of the physical environment in three Bangladeshi hospitals: putting infection control into context. PLoS One (2014) 0.82
Using patient-collected clinical samples and sera to detect and quantify the severe acute respiratory syndrome coronavirus (SARS-CoV). Virol J (2007) 0.82
Antiviral treatment of SARS: can we draw any conclusions? CMAJ (2003) 0.82
Pathology and virus dispersion in cynomolgus monkeys experimentally infected with severe acute respiratory syndrome coronavirus via different inoculation routes. Int J Exp Pathol (2007) 0.82
Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med (2009) 19.90
The immediate psychological and occupational impact of the 2003 SARS outbreak in a teaching hospital. CMAJ (2003) 7.46
Relationships between authors of clinical practice guidelines and the pharmaceutical industry. JAMA (2002) 4.66
Does this patient with headache have a migraine or need neuroimaging? JAMA (2006) 4.35
Does this patient have hearing impairment? JAMA (2006) 4.34
Public health measures to control the spread of the severe acute respiratory syndrome during the outbreak in Toronto. N Engl J Med (2004) 4.22
A comprehensive evidence-based approach to fever of unknown origin. Arch Intern Med (2003) 3.92
Is this patient dead, vegetative, or severely neurologically impaired? Assessing outcome for comatose survivors of cardiac arrest. JAMA (2004) 3.80
Late presentation for human immunodeficiency virus care in the United States and Canada. Clin Infect Dis (2010) 3.72
The inevitable application of big data to health care. JAMA (2013) 3.33
Negative mucosal synergy between Herpes simplex type 2 and HIV in the female genital tract. AIDS (2007) 3.14
Critically ill patients with severe acute respiratory syndrome. JAMA (2003) 3.10
Enhanced recovery pathways optimize health outcomes and resource utilization: a meta-analysis of randomized controlled trials in colorectal surgery. Surgery (2011) 3.04
West Nile virus infection in 2002: morbidity and mortality among patients admitted to hospital in southcentral Ontario. CMAJ (2003) 3.03
How should patients with unstable angina and non-ST-segment elevation myocardial infarction be managed? A meta-analysis of randomized trials. Am J Med (2005) 2.76
Does this adult patient with suspected bacteremia require blood cultures? JAMA (2012) 2.75
Everyone's a little bit biased (even physicians). JAMA (2008) 2.48
Reducing antimicrobial therapy for asymptomatic bacteriuria among noncatheterized inpatients: a proof-of-concept study. Clin Infect Dis (2014) 2.37
Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome. J Virol (2007) 2.35
Interdisciplinary inpatient care for elderly people with hip fracture: a randomized controlled trial. CMAJ (2002) 2.25
Composite end points in randomized trials: there is no free lunch. JAMA (2010) 2.16
Trends in multidrug treatment failure and subsequent mortality among antiretroviral therapy-experienced patients with HIV infection in North America. Clin Infect Dis (2009) 2.05
Avoidable mortality by neighbourhood income in Canada: 25 years after the establishment of universal health insurance. J Epidemiol Community Health (2007) 2.02
A metagenomic analysis of pandemic influenza A (2009 H1N1) infection in patients from North America. PLoS One (2010) 1.99
Clinical course and management of SARS in health care workers in Toronto: a case series. CMAJ (2003) 1.92
Publishing history does not correlate with clinical performance among internal medicine residents. Med Educ (2010) 1.92
Evaluation of the RealArt Malaria LC real-time PCR assay for malaria diagnosis. J Clin Microbiol (2004) 1.91
Durable efficacy of enfuvirtide over 48 weeks in heavily treatment-experienced HIV-1-infected patients in the T-20 versus optimized background regimen only 1 and 2 clinical trials. J Acquir Immune Defic Syndr (2005) 1.87
Fertility desires and intentions of HIV-positive women of reproductive age in Ontario, Canada: a cross-sectional study. PLoS One (2009) 1.87
Cumulative Incidence of Cancer Among Persons With HIV in North America: A Cohort Study. Ann Intern Med (2015) 1.86
SARS control and psychological effects of quarantine, Toronto, Canada. Emerg Infect Dis (2004) 1.83
Is there an optimal comorbidity index for prostate cancer? Cancer (2008) 1.80
The effect of English language proficiency on length of stay and in-hospital mortality. J Gen Intern Med (2004) 1.80
The laboratory impact of changing syphilis screening from the rapid-plasma reagin to a treponemal enzyme immunoassay: a case-study from the Greater Toronto Area. Sex Transm Dis (2011) 1.77
Illness in intensive care staff after brief exposure to severe acute respiratory syndrome. Emerg Infect Dis (2003) 1.76
New Delhi metallo-β-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection. CMAJ (2011) 1.73
Does this patient with diabetes have osteomyelitis of the lower extremity? JAMA (2008) 1.72
Do richer provinces have shorter waiting times to see specialists? CMAJ (2006) 1.72
Discussing radiation risks associated with CT scans with patients. JAMA (2010) 1.72
Do blood tests cause anemia in hospitalized patients? The effect of diagnostic phlebotomy on hemoglobin and hematocrit levels. J Gen Intern Med (2005) 1.66
Are applicants to Canadian residency programs rejected because of their sex? CMAJ (2005) 1.63
Tuberculosis: evidence review for newly arriving immigrants and refugees. CMAJ (2010) 1.62
Methods to elicit beliefs for Bayesian priors: a systematic review. J Clin Epidemiol (2009) 1.59
Effect of warfarin on survival in scleroderma-associated pulmonary arterial hypertension (SSc-PAH) and idiopathic PAH. Belief elicitation for Bayesian priors. J Rheumatol (2010) 1.58
The impact of infection on population health: results of the Ontario burden of infectious diseases study. PLoS One (2012) 1.58
Disproportionately high semen shedding of HIV is associated with compartmentalized cytomegalovirus reactivation. J Infect Dis (2005) 1.58
The incidence and effect of bacteriospermia and elevated seminal leukocytes on semen parameters. Fertil Steril (2012) 1.55
Utility of gastric aspirates for diagnosing tuberculosis in children in a low prevalence area: predictors of positive cultures and significance of non-tuberculous mycobacteria. Pediatr Infect Dis J (2015) 1.54
Shifting our thinking about uncommon disease trials: the case of methotrexate in scleroderma. J Rheumatol (2009) 1.54
Meta-analysis: effect of prophylactic hematopoietic colony-stimulating factors on mortality and outcomes of infection. Ann Intern Med (2007) 1.53
Baseline HIV-1 RNA level and CD4 cell count predict time to loss of virologic response to nelfinavir, but not lopinavir/ritonavir, in antiretroviral therapy-naive patients. J Infect Dis (2004) 1.52
Professional monopolies in medicine. JAMA (2009) 1.51
Interpretation of diagnostic laboratory tests for severe acute respiratory syndrome: the Toronto experience. CMAJ (2004) 1.50
The association between exit site infection and subsequent peritonitis among peritoneal dialysis patients. Clin J Am Soc Nephrol (2012) 1.48
Use of, effectiveness of, and attitudes regarding influenza vaccine among house staff. Infect Control Hosp Epidemiol (2003) 1.48
Rubella outbreak in the Netherlands, 2004-2005: high burden of congenital infection and spread to Canada. Pediatr Infect Dis J (2009) 1.45
Possible SARS coronavirus transmission during cardiopulmonary resuscitation. Emerg Infect Dis (2004) 1.45
The role of parenteral lipids in the development of advanced intestinal failure-associated liver disease in infants: a multiple-variable analysis. JPEN J Parenter Enteral Nutr (2011) 1.44
The education and training of future physicians: why coaches can't be judges. JAMA (2011) 1.44
Company stock prices before and after public announcements related to oncology drugs. J Natl Cancer Inst (2011) 1.42
Pulmonary pathology of severe acute respiratory syndrome in Toronto. Mod Pathol (2005) 1.41
Osteoporosis and fractures: missing the bridge? JAMA (2008) 1.40
The meaning of author order in medical research. J Investig Med (2007) 1.39
A patient with a leg rash, pedal edema, renal failure, and thrombocytopenia. Clin Chem (2009) 1.39
Clinical problem-solving. A twist of fate? N Engl J Med (2004) 1.39
Performance of the xTAG® gastrointestinal pathogen panel, a multiplex molecular assay for simultaneous detection of bacterial, viral, and parasitic causes of infectious gastroenteritis. J Microbiol Biotechnol (2013) 1.39
Self-collected mid-turbinate swabs for the detection of respiratory viruses in adults with acute respiratory illnesses. PLoS One (2011) 1.33
Severe acute respiratory syndrome diagnostics using a coronavirus protein microarray. Proc Natl Acad Sci U S A (2006) 1.31
Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in Canada during 2000. Antimicrob Agents Chemother (2002) 1.30
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival. J Exp Med (2013) 1.30
Reducing the risk of infection in a patient who will undergo splenectomy. CMAJ (2012) 1.30
In vitro antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates obtained in Canada in 2002. Antimicrob Agents Chemother (2004) 1.30
Sources of bias for authors of clinical practice guidelines. CMAJ (2006) 1.30
Is there age bias in the treatment of localized prostate carcinoma? Cancer (2004) 1.29
A framework for applying unfamiliar trial designs in studies of rare diseases. J Clin Epidemiol (2011) 1.26
Evolution of the randomized controlled trial in oncology over three decades. J Clin Oncol (2008) 1.25
Canadian consensus guidelines for the care of HIV-positive pregnant women: putting recommendations into practice. CMAJ (2003) 1.25
The impact of severe acute respiratory syndrome on medical house staff: a qualitative study. J Gen Intern Med (2005) 1.24
Severe acute respiratory syndrome. Clin Infect Dis (2004) 1.23
No impact of oral tenofovir disoproxil fumarate on herpes simplex virus shedding in HIV-infected adults. AIDS (2011) 1.22
Physician communication in the 21st century: to talk or to text? JAMA (2011) 1.21
Efficacy of the protease inhibitors tipranavir plus ritonavir in treatment-experienced patients: 24-week analysis from the RESIST-1 trial. Clin Infect Dis (2006) 1.20
Seven items were identified for inclusion when reporting a Bayesian analysis of a clinical study. J Clin Epidemiol (2005) 1.19
Public reporting of hospital hand hygiene compliance--helpful or harmful? JAMA (2010) 1.19
Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus. J Infect Dis (2004) 1.18