Published in Biol Proced Online on November 11, 2002
Aurora kinases are expressed in medullary thyroid carcinoma (MTC) and their inhibition suppresses in vitro growth and tumorigenicity of the MTC derived cell line TT. BMC Cancer (2011) 0.83
Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC). PLoS One (2013) 0.80
A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells. Nat Commun (2016) 0.75
The ubiquitin system. Annu Rev Biochem (1998) 43.36
Cyclin is degraded by the ubiquitin pathway. Nature (1991) 17.93
The ubiquitin-proteasome proteolytic pathway. Cell (1994) 9.75
Cell cycle extracts. Methods Cell Biol (1991) 9.47
The ubiquitin system for protein degradation. Annu Rev Biochem (1992) 8.84
The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature (1989) 8.69
CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science (1997) 8.00
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J (1998) 7.39
The ubiquitin-proteasome pathway: on protein death and cell life. EMBO J (1998) 6.37
AIM-1: a mammalian midbody-associated protein required for cytokinesis. EMBO J (1998) 3.73
Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant. Mol Cell Biol (1994) 3.27
The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly. J Cell Sci (1998) 2.67
The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death. Proc Natl Acad Sci U S A (1998) 2.40
The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation. Oncogene (2000) 2.15
Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation. Curr Biol (1996) 2.10
The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5. J Biol Chem (1999) 2.04
Subunits and substrates of the anaphase-promoting complex. Exp Cell Res (1999) 1.87
A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators. J Cell Biol (1997) 1.65
Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway. Oncogene (2000) 1.54
Cell cycle-regulated proteolysis of mitotic target proteins. Mol Biol Cell (1999) 1.29
cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2. Biochem Biophys Res Commun (1998) 1.28
Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1. Cytogenet Cell Genet (1998) 1.10
Identification of a functional destruction box in the Xenopus laevis aurora-A kinase pEg2. FEBS Lett (2001) 1.09
Cell cycle analysis and synchronization of the Xenopus cell line XL2. Exp Cell Res (1998) 0.94
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. Nature (2012) 3.08
Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. J Cell Biol (2002) 3.05
A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nat Cell Biol (2003) 2.86
Aurora kinases, aneuploidy and cancer, a coincidence or a real link? Trends Cell Biol (2005) 2.41
Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. J Cell Sci (2004) 1.93
On the role of aurora-A in centrosome function. Oncogene (2002) 1.68
The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation. EMBO Rep (2006) 1.49
APC/Fizzy-Related targets Aurora-A kinase for proteolysis. EMBO Rep (2002) 1.45
TACC1-chTOG-Aurora A protein complex in breast cancer. Oncogene (2003) 1.33
PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores. J Cell Biol (2007) 1.27
Spindle pole regulation by a discrete Eg5-interacting domain in TPX2. Curr Biol (2008) 1.26
CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage. Cell Cycle (2005) 1.18
Proteomic investigation of phosphorylation sites in poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase. J Proteome Res (2009) 1.14
FBXW7/hCDC4 controls glioma cell proliferation in vitro and is a prognostic marker for survival in glioblastoma patients. Cell Div (2007) 1.13
Phosphorylation of maskin by Aurora-A participates in the control of sequential protein synthesis during Xenopus laevis oocyte maturation. J Biol Chem (2005) 1.11
The D-Box-activating domain (DAD) is a new proteolysis signal that stimulates the silent D-Box sequence of Aurora-A. EMBO Rep (2002) 1.09
Aurora B -TACC1 protein complex in cytokinesis. Oncogene (2004) 1.07
The cyclin A centrosomal localization sequence recruits MCM5 and Orc1 to regulate centrosome reduplication. J Cell Sci (2010) 1.05
Spatio-temporal expression patterns of aurora kinases a, B, and C and cytoplasmic polyadenylation-element-binding protein in bovine oocytes during meiotic maturation. Biol Reprod (2007) 1.04
Centrosome separation: respective role of microtubules and actin filaments. Biol Cell (2002) 1.04
Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A. Cell Cycle (2009) 1.03
Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued. J Cell Biol (2013) 1.02
Retro hydrazino-azapeptoids as peptidomimetics of proteasome inhibitors. J Med Chem (2005) 1.00
Cdk1, Plks, Auroras, and Neks: the mitotic bodyguards. Adv Exp Med Biol (2008) 0.96
Expression of Aurora kinases in human thyroid carcinoma cell lines and tissues. Int J Cancer (2006) 0.96
ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis. Hum Mol Genet (2007) 0.95
Nucleophosmin/B23 activates Aurora A at the centrosome through phosphorylation of serine 89. J Cell Biol (2012) 0.95
Localization of aurora A and aurora B kinases during interphase: role of the N-terminal domain. Cell Cycle (2008) 0.95
Phosphorylation of histone and histone-like proteins by aurora kinases during mitosis. Prog Cell Cycle Res (2003) 0.93
Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues. Endocr Relat Cancer (2007) 0.90
Cdc2-cyclin B triggers H3 kinase activation of Aurora-A in Xenopus oocytes. J Biol Chem (2003) 0.90
ASAP, a human microtubule-associated protein required for bipolar spindle assembly and cytokinesis. Proc Natl Acad Sci U S A (2005) 0.90
The absence of p53 aggravates polyploidy and centrosome number abnormality induced by Aurora-C overexpression. Cell Cycle (2005) 0.90
Overexpression of active Aurora-C kinase results in cell transformation and tumour formation. PLoS One (2011) 0.90
Aurora-A kinase Ser349 phosphorylation is required during Xenopus laevis oocyte maturation. Dev Biol (2008) 0.88
Regulation of the Aurora-A gene following topoisomerase I inhibition: implication of the Myc transcription factor. Mol Cancer (2010) 0.87
Histologic prognostic factors associated with chromosomal imbalances in a contemporary series of 89 clear cell renal cell carcinomas. Hum Pathol (2013) 0.86
Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells. J Cell Sci (2006) 0.85
Phosphorylation of p53 is regulated by TPX2-Aurora A in xenopus oocytes. J Biol Chem (2009) 0.84
Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein. Biochem Biophys Res Commun (2011) 0.84
Aurora kinases are expressed in medullary thyroid carcinoma (MTC) and their inhibition suppresses in vitro growth and tumorigenicity of the MTC derived cell line TT. BMC Cancer (2011) 0.83
All anti-vascular endothelial growth factor drugs can induce 'pre-eclampsia-like syndrome': a RARe study. Nephrol Dial Transplant (2013) 0.82
Staphylococcus aureus-induced G2/M phase transition delay in host epithelial cells increases bacterial infective efficiency. PLoS One (2013) 0.82
Regulation of EDEN-dependent deadenylation of Aurora A/Eg2-derived mRNA via phosphorylation and dephosphorylation in Xenopus laevis egg extracts. J Cell Sci (2003) 0.82
A SUMOylation Motif in Aurora-A: Implications for Spindle Dynamics and Oncogenesis. Front Oncol (2011) 0.82
Ca2+ homeostasis regulates Xenopus oocyte maturation. Biol Reprod (2007) 0.81
Preparation and characterization of a human aurora-A kinase monoclonal antibody. Mol Cell Biochem (2003) 0.81
Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC). PLoS One (2013) 0.80
Identification of ILK as a new partner of the ADAM12 disintegrin and metalloprotease in cell adhesion and survival. Mol Biol Cell (2012) 0.79
The Protein Kinase Resource: everything you always wanted to know about protein kinases but were afraid to ask. Biol Cell (2005) 0.79
Inhibition of the aurora kinases suppresses in vitro NT2-D1 cell growth and tumorigenicity. J Endocrinol (2009) 0.79
Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint. Mol Interv (2003) 0.78
The subcellular localization of cyclin B2 is required for bipolar spindle formation during Xenopus oocyte maturation. Biochem Biophys Res Commun (2012) 0.78
[Angiotensin-2 type 1 receptors (AT1R) and cancers]. Nephrol Ther (2013) 0.78
Several signaling pathways are involved in the control of cattle oocyte maturation. Mol Reprod Dev (2004) 0.78
MNK1 kinase activity is required for abscission. J Cell Sci (2012) 0.78
Clockwise or anticlockwise? Turning the centriole triplets in the right direction! FEBS Lett (2007) 0.78
Aurora A overexpression and pVHL reduced expression are correlated with a bad kidney cancer prognosis. Dis Markers (2012) 0.77
Epithelial cell division in the Xenopus laevis embryo during gastrulation. Int J Dev Biol (2014) 0.77
Cell cycle. A trigger for centrosome duplication. Science (2002) 0.77
Assessment of Aurora A kinase expression in breast cancer: a tool for early diagnosis? Dis Markers (2013) 0.77
Water-soluble nickel-bis(dithiolene) complexes as photothermal agents. Chem Commun (Camb) (2015) 0.77
Experimental and computational studies indicate specific binding of pVHL protein to Aurora-A kinase. J Phys Chem B (2010) 0.76
Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells. BMC Genomics (2014) 0.76
[The serine/threonine kinases that control cell cycle progression as therapeutic targets]. Bull Cancer (2011) 0.76
Hydrazino-aza and N-azapeptoids with therapeutic potential as anticancer agents. Bioorg Med Chem (2003) 0.76
[Centrosomes, mitotic spindle and cancer: find the odd one out!]. Med Sci (Paris) (2010) 0.75
[Control by centrosome of asymmetric repartition of cellular components]. Med Sci (Paris) (2003) 0.75
Oocyte maturation and cell cycle control: a farewell symposium for Pr Marcel Dorée. Biol Cell (2004) 0.75
Aurora-A: an expedition to the pole of the spindle in Xenopus egg extracts. Int J Dev Biol (2016) 0.75
Flexibility vs. robustness in cell cycle regulation of timing of M-phase entry in Xenopus laevis embryo cell-free extract. Int J Dev Biol (2016) 0.75
Control of timing of embryonic M-phase entry and exit is differentially sensitive to CDK1 and PP2A balance. Int J Dev Biol (2014) 0.75