Published in Proc Natl Acad Sci U S A on May 16, 2003
The aryl hydrocarbon receptor complex and the control of gene expression. Crit Rev Eukaryot Gene Expr (2008) 3.06
Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol Sci (2011) 2.48
Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells. Nucleic Acids Res (2007) 1.63
Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters. Mol Cell Biol (2005) 1.40
Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene. Endocr Rev (2013) 1.40
Endocrine disrupting chemicals targeting estrogen receptor signaling: identification and mechanisms of action. Chem Res Toxicol (2010) 1.38
Estrogen receptor and aryl hydrocarbon receptor signaling pathways. Nucl Recept Signal (2006) 1.35
Transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver: comparison of rat and mouse. BMC Genomics (2008) 1.18
Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors. Exp Mol Med (2009) 1.07
Estrogen receptor alpha increases basal and cigarette smoke extract-induced expression of CYP1A1 and CYP1B1, but not GSTP1, in normal human bronchial epithelial cells. Mol Carcinog (2005) 1.04
The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats. Horm Behav (2006) 1.02
Expression levels of estrogen receptor beta are modulated by components of the molecular clock. Mol Cell Biol (2007) 1.01
Analysis of the transcriptional activation domain of the Drosophila tango bHLH-PAS transcription factor. Dev Genes Evol (2005) 0.94
Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression. Am J Pathol (2010) 0.94
A truncated Ah receptor blocks the hypoxia and estrogen receptor signaling pathways: a viable approach for breast cancer treatment. Mol Pharm (2006) 0.90
A steroid receptor coactivator acts as the DNA-binding partner of the methoprene-tolerant protein in regulating juvenile hormone response genes. Mol Cell Endocrinol (2014) 0.89
Genomics of estradiol-3-sulfate action in the ovine fetal hypothalamus. Physiol Genomics (2012) 0.87
Estrogen receptor beta inhibits transcriptional activity of hypoxia inducible factor-1 through the downregulation of arylhydrocarbon receptor nuclear translocator. Breast Cancer Res (2011) 0.85
Aryl hydrocarbon nuclear translocator (hypoxia inducible factor 1beta) activity is required more during early than late tumor growth. Mol Carcinog (2010) 0.85
Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines. PLoS One (2012) 0.85
The aryl hydrocarbon receptor-mediated disruption of vitellogenin synthesis in the fish liver: Cross-talk between AHR- and ERalpha-signalling pathways. Comp Hepatol (2004) 0.84
Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines. BMC Med Genomics (2011) 0.84
Intracellular lactate-mediated induction of estrogen receptor beta (ERβ) in biphasic malignant pleural mesothelioma cells. Oncotarget (2015) 0.82
Suppression of the hypoxia inducible factor-1 function by redistributing the aryl hydrocarbon receptor nuclear translocator from nucleus to cytoplasm. Cancer Lett (2012) 0.82
A new coactivator function for Zac1's C2H2 zinc finger DNA-binding domain in selectively controlling PCAF activity. Mol Cell Biol (2008) 0.82
Gene-environment interactions in male reproductive health: special reference to the aryl hydrocarbon receptor signaling pathway. Asian J Androl (2013) 0.80
Reactivation of estrogen receptor α by vorinostat sensitizes mesenchymal-like triple-negative breast cancer to aminoflavone, a ligand of the aryl hydrocarbon receptor. PLoS One (2013) 0.80
The aryl hydrocarbon receptor nuclear translocator-interacting protein 2 suppresses the estrogen receptor signaling via an Arnt-dependent mechanism. Arch Biochem Biophys (2010) 0.80
The immunophilin-like protein XAP2 is a negative regulator of estrogen signaling through interaction with estrogen receptor α. PLoS One (2011) 0.79
Human phosphatidylethanolamine-binding protein 4 promotes transactivation of estrogen receptor alpha (ERalpha) in human cancer cells by inhibiting proteasome-dependent ERalpha degradation via association with Src. J Biol Chem (2010) 0.79
Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer. Proc Natl Acad Sci U S A (2015) 0.79
Beta tubulin affects the aryl hydrocarbon receptor function via an Arnt-mediated mechanism. Biochem Pharmacol (2009) 0.78
Aberrant alteration of vascular endothelial growth factor-family signaling in human tubal ectopic pregnancy: what is known and unknown? Int J Clin Exp Pathol (2013) 0.78
Interactions between estrogen- and Ah-receptor signalling pathways in primary culture of salmon hepatocytes exposed to nonylphenol and 3,3',4,4'-tetrachlorobiphenyl (congener 77). Comp Hepatol (2007) 0.77
Comparison of the diagnostic values of circulating steroid hormones, VEGF-A, PIGF, and ADAM12 in women with ectopic pregnancy. J Transl Med (2013) 0.77
Deletion of ARNT (Aryl hydrocarbon receptor nuclear translocator) in β-cells causes islet transplant failure with impaired β-cell function. PLoS One (2014) 0.76
Drosophila Jing is part of the breathless fibroblast growth factor receptor positive feedback loop. Dev Genes Evol (2010) 0.76
Coactivator recruitment of AhR/ARNT1. Int J Mol Sci (2014) 0.76
A model for aryl hydrocarbon receptor-activated gene expression shows potency and efficacy changes and predicts squelching due to competition for transcription co-activators. PLoS One (2015) 0.75
An Activin A/BMP2 chimera, AB215, blocks estrogen signaling via induction of ID proteins in breast cancer cells. BMC Cancer (2014) 0.75
A molecular mechanism to switch the aryl hydrocarbon receptor from a transcription factor to an E3 ubiquitin ligase. Mol Cell Biol (2017) 0.75
The Drosophila jing gene is a downstream target in the Trachealess/Tango tracheal pathway. Dev Genes Evol (2010) 0.75
Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell (2000) 11.10
Cooperation between complexes that regulate chromatin structure and transcription. Cell (2002) 10.38
Role of the CLOCK protein in the mammalian circadian mechanism. Science (1998) 10.03
Mechanisms of estrogen action. Physiol Rev (2001) 5.97
Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science (1998) 5.72
The PAS superfamily: sensors of environmental and developmental signals. Annu Rev Pharmacol Toxicol (2000) 4.79
Nuclear hormone receptors and gene expression. Physiol Rev (2001) 4.56
Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT). Mol Cell Biol (1994) 2.58
cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol Cell Biol (1996) 2.42
Role of estrogen receptor beta in estrogen action. Annu Rev Physiol (2001) 2.40
The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells. J Biol Chem (1996) 2.30
Estrogen receptor interaction with co-activators and co-repressors. Steroids (2000) 1.91
Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor. Mol Cell Biol (1993) 1.67
Estrogen receptor beta acts as a dominant regulator of estrogen signaling. Oncogene (2000) 1.62
cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage. Biochem Biophys Res Commun (1997) 1.61
Chromatin remodeling and transcriptional activation: the cast (in order of appearance). Oncogene (2001) 1.51
Reciprocal recruitment of DRIP/mediator and p160 coactivator complexes in vivo by estrogen receptor. J Biol Chem (2002) 1.48
Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation. Mol Cell Biol (1994) 1.47
Transcriptional activation function of the mouse Ah receptor nuclear translocator. J Biol Chem (1994) 1.43
Dioxin-induced CYP1A1 transcription in vivo: the aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure. Mol Cell Biol (1996) 1.36
Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: an assessment of the biological and epidemiological evidence. Crit Rev Toxicol (1995) 1.35
A comparison of transcriptional activation by ER alpha and ER beta. J Steroid Biochem Mol Biol (1999) 1.31
Role of the PAS domain in regulation of dimerization and DNA binding specificity of the dioxin receptor. Mol Cell Biol (1998) 1.25
Functional differences between the amino-terminal domains of estrogen receptors alpha and beta. Mol Pharmacol (2000) 1.24
Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells. Mol Cell Biol (1995) 1.17
Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Mol Endocrinol (1999) 1.13
Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells. Mol Cell Biol (1998) 1.12
Identification of a motif within the 5' regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression. Biochemistry (1997) 1.12
Purification of the DNA binding form of dioxin receptor. Role of the Arnt cofactor in regulation of dioxin receptor function. J Biol Chem (1994) 1.09
Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists. J Mol Endocrinol (2001) 0.94
Differential usage of nuclear export sequences regulates intracellular localization of the dioxin (aryl hydrocarbon) receptor. J Biol Chem (2001) 0.85
The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci (2006) 6.86
Estrogen receptors: how do they signal and what are their targets. Physiol Rev (2007) 5.27
Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air. Environ Health Perspect (2002) 4.07
A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. Proc Natl Acad Sci U S A (2002) 1.82
Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations. Environ Health Perspect (2008) 1.61
Regulation of postnatal lung development and homeostasis by estrogen receptor beta. Mol Cell Biol (2003) 1.44
Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells. Cancer Res (2007) 1.35
Integration of genome-wide computation DRE search, AhR ChIP-chip and gene expression analyses of TCDD-elicited responses in the mouse liver. BMC Genomics (2011) 1.23
Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders. J Mol Endocrinol (2009) 1.23
Dioxin increases the interaction between aryl hydrocarbon receptor and estrogen receptor alpha at human promoters. Toxicol Sci (2009) 1.09
AhR and ARNT modulate ER signaling. Toxicology (2009) 1.07
The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin. Mol Endocrinol (2007) 1.05
EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation. Nucleic Acids Res (2005) 1.03
Expression levels of estrogen receptor beta are modulated by components of the molecular clock. Mol Cell Biol (2007) 1.01
Risk to all or none? A comparative analysis of controversies in the health risk assessment of Bisphenol A. Reprod Toxicol (2009) 0.99
Estrogen receptor subtype- and promoter-specific modulation of aryl hydrocarbon receptor-dependent transcription. Mol Cancer Res (2009) 0.96
High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci (2012) 0.96
Diet-derived polyphenol metabolite enterolactone is a tissue-specific estrogen receptor activator. Endocrinology (2007) 0.96
Estrogen receptor-dependent regulation of CYP2B6 in human breast cancer cells. Biochim Biophys Acta (2010) 0.96
Facilitating the use of non-standard in vivo studies in health risk assessment of chemicals: a proposal to improve evaluation criteria and reporting. J Appl Toxicol (2014) 0.95
Regulation of estrogen receptor beta activity and implications in health and disease. Cell Mol Life Sci (2009) 0.94
Deoxyribonucleic acid response element-dependent regulation of transcription by orphan nuclear receptor estrogen receptor-related receptor gamma. Mol Endocrinol (2003) 0.92
2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. Nucleic Acids Res (2012) 0.92
An amphioxus orthologue of the estrogen receptor that does not bind estradiol: insights into estrogen receptor evolution. BMC Evol Biol (2008) 0.91
Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver. Toxicol Appl Pharmacol (2010) 0.91
Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver. Drug Metab Dispos (2008) 0.90
Inhibition of aryl hydrocarbon receptor-dependent transcription by resveratrol or kaempferol is independent of estrogen receptor α expression in human breast cancer cells. Cancer Lett (2010) 0.89
3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters. Toxicol Sci (2010) 0.89
The co-chaperone XAP2 is required for activation of hypothalamic thyrotropin-releasing hormone transcription in vivo. EMBO Rep (2006) 0.88
A CASCADE of effects of bisphenol A. Reprod Toxicol (2009) 0.88
High-throughput protein production--lessons from scaling up from 10 to 288 recombinant proteins per week. Biotechnol J (2009) 0.88
Thyroid hormone-mediated negative transcriptional regulation of Necdin expression. J Mol Endocrinol (2006) 0.88
The constitutively active Ah receptor (CA-Ahr) mouse as a potential model for dioxin exposure--effects in vital organs. Toxicology (2006) 0.87
Prenatal exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) may influence birth weight among infants in a Swedish cohort with background exposure: a cross-sectional study. Environ Health (2013) 0.86
Epigenetic regulation of glucose transporter 4 by estrogen receptor β. Mol Endocrinol (2011) 0.86
Assessment factors--applications in health risk assessment of chemicals. Environ Res (2006) 0.85
The constitutively active Ah receptor (CA-AhR) mouse as a model for dioxin exposure - effects in reproductive organs. Chemosphere (2011) 0.85
3-Methylcholanthrene displays dual effects on estrogen receptor (ER) alpha and ER beta signaling in a cell-type specific fashion. Mol Pharmacol (2007) 0.84
FOXA1 is essential for aryl hydrocarbon receptor-dependent regulation of cyclin G2. Mol Cancer Res (2012) 0.84
Large variation in breast milk levels of organohalogenated compounds is dependent on mother's age, changes in body composition and exposures early in life. J Environ Monit (2011) 0.84
The influence of study design and sex-differences on results from developmental neurotoxicity studies of bisphenol A: implications for toxicity testing. Toxicology (2013) 0.84
Transgenic mice with a constitutively active aryl hydrocarbon receptor display a gender-specific bone phenotype. Toxicol Sci (2009) 0.83
A single dose of enterolactone activates estrogen signaling and regulates expression of circadian clock genes in mice. J Nutr (2011) 0.82
A new class of estrogen receptor beta-selective activators. Mol Interv (2010) 0.82
Tryptamine serves as a proligand of the AhR transcriptional pathway whose activation is dependent of monoamine oxidases. Mol Endocrinol (2012) 0.82
Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol (2011) 0.82
The Ah receptor inhibits estrogen-induced estrogen receptor beta in breast cancer cells. Biochem Biophys Res Commun (2004) 0.82
Gastric hamartomatous tumours in a transgenic mouse model expressing an activated dioxin/Ah receptor. Anticancer Res (2005) 0.81
Two parallel pathways mediate cytoplasmic localization of the dioxin (aryl hydrocarbon) receptor. J Biol Chem (2002) 0.81
A constitutively active aryl hydrocarbon receptor causes loss of peritoneal B1 cells. Biochem Biophys Res Commun (2003) 0.81
The dioxin/aryl hydrocarbon receptor mediates downregulation of osteopontin gene expression in a mouse model of gastric tumourigenesis. Oncogene (2005) 0.80
Functional analysis of six human aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines. Toxicology (2010) 0.80
Two distinct regions of the immunophilin-like protein XAP2 regulate dioxin receptor function and interaction with hsp90. J Biol Chem (2002) 0.80
Activation function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1. Biochem Biophys Res Commun (2009) 0.79
The human RAP250 gene: genomic structure and promoter analysis. Gene (2004) 0.79
Synthesis and biological evaluation of novel tamoxifen analogues. Bioorg Med Chem (2013) 0.79
The aryl hydrocarbon receptor and estrogen receptor alpha differentially modulate nuclear factor erythroid-2-related factor 2 transactivation in MCF-7 breast cancer cells. Toxicol Appl Pharmacol (2013) 0.79
The immunophilin-like protein XAP2 is a negative regulator of estrogen signaling through interaction with estrogen receptor α. PLoS One (2011) 0.79
Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells. Mol Pharmacol (2012) 0.79
Differential ligand-dependent activation and a role for Y322 in aryl hydrocarbon receptor-mediated regulation of gene expression. Biochem Biophys Res Commun (2011) 0.78
The endogenous retinoid metabolite S-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo. FEBS J (2009) 0.78
Zinc finger nuclease-mediated knockout of AHR or ARNT in human breast cancer cells abolishes basal and ligand-dependent regulation of CYP1B1 and differentially affects estrogen receptor α transactivation. Toxicol Sci (2013) 0.78
Toxicity of Bromkal 70-5DE, a technical mixture of polybrominated diphenyl ethers, following 28 d of oral exposure in rats and impact of analysed impurities. Chemosphere (2010) 0.77
Receptors mediating toxicity and their involvement in endocrine disruption. EXS (2009) 0.76
The aryl hydrocarbon receptor ligands 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene regulate distinct genetic networks. Mol Cell Endocrinol (2012) 0.76
Health risk assessment procedures for endocrine disrupting compounds within different regulatory frameworks in the European Union. Regul Toxicol Pharmacol (2009) 0.76
Model selection and evaluation for risk assessment of dioxin-contaminated sites. Ambio (2007) 0.76
Case 29-2003: a 60-year-old man with fever, rigors, and sweats. N Engl J Med (2003) 0.75
O-010 Microbial Metabolites Establish a Gradient of Protons, Which Mediate Interkingdom Host-Microbiome Cross-Talk and Maintain Intestinal Homeostasis via Two Proton-Sensing GPRs. Inflamm Bowel Dis (2017) 0.75
Exposure assessment at a PCDD/F contaminated site in Sweden--field measurements of exposure media and blood serum analysis. Environ Sci Pollut Res Int (2009) 0.75
Mammalian two-hybrid assay showing redox control of HIF-like factor. Methods Enzymol (2002) 0.75
Osteopontin: a rapid and sensitive response to dioxin exposure in the osteoblastic cell line UMR-106. Biochem Biophys Res Commun (2006) 0.75