Published in J Immunol on June 01, 2003
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet (2006) 9.56
Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med (2004) 4.02
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med (2006) 3.38
Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol (2010) 2.85
Th17 cells: effector T cells with inflammatory properties. Semin Immunol (2007) 2.81
Psoriasis pathophysiology: current concepts of pathogenesis. Ann Rheum Dis (2005) 2.24
Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris. Proc Natl Acad Sci U S A (2005) 2.12
Dendritic cell-mediated T cell polarization. Springer Semin Immunopathol (2004) 1.72
Pathophysiology of psoriasis: recent advances on IL-23 and Th17 cytokines. Curr Rheumatol Rep (2007) 1.69
CCR6 is required for IL-23-induced psoriasis-like inflammation in mice. J Clin Invest (2009) 1.65
From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited. Immunol Rev (2008) 1.65
Cutting edge: A critical functional role for IL-23 in psoriasis. J Immunol (2010) 1.61
Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant. J Immunol (2006) 1.59
Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J Clin Invest (2012) 1.58
Psoriasis genetics: breaking the barrier. Trends Genet (2010) 1.38
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med (2015) 1.32
Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis. Proc Natl Acad Sci U S A (2009) 1.19
The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effects. Immunology (2006) 1.09
Putting together the psoriasis puzzle: an update on developing targeted therapies. Dis Model Mech (2012) 1.09
Interleukin-23: as a drug target for autoimmune inflammatory diseases. Immunology (2012) 1.07
The role of IL-23 in the immunopathogenesis of psoriasis. F1000 Biol Rep (2010) 0.92
Blowing on embers: commensal microbiota and our immune system. Front Immunol (2014) 0.90
LPS and poly I:C induce chromatin modifications at a novel upstream region of the IL-23 p19 promoter. Inflammation (2008) 0.89
Angiogenic and inflammatory properties of psoriatic arthritis. ISRN Dermatol (2013) 0.83
Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics. Expert Rev Proteomics (2015) 0.77
The interleukin (IL)-23/IL-17 axis in ankylosing spondylitis: new advances and potentials for treatment. Clin Exp Immunol (2015) 0.77
Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis. Anal Chem (2017) 0.75
Autoinflammation and HLA-B27: Beyond Antigen Presentation. Ocul Immunol Inflamm (2016) 0.75
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med (2005) 28.73
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature (2003) 22.89
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity (2005) 14.95
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med (2003) 14.60
Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol (2007) 12.76
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest (2006) 11.89
Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol (2002) 10.15
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol (2002) 9.30
Identification of cells initiating human melanomas. Nature (2008) 8.28
IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity (2002) 8.19
Understanding the IL-23-IL-17 immune pathway. Trends Immunol (2005) 6.79
IL-23 promotes tumour incidence and growth. Nature (2006) 6.30
The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity (2003) 5.60
The vast majority of CLA+ T cells are resident in normal skin. J Immunol (2006) 5.43
The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity (2003) 5.11
IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature (2010) 5.07
IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev (2004) 4.78
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest (2006) 4.77
Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature (2012) 4.64
IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol (2007) 4.54
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells. Nat Med (2012) 4.38
Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology (2007) 3.82
IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med (2007) 3.69
WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol (2004) 3.55
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med (2006) 3.38
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med (2006) 3.36
IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J Immunol (2007) 2.93
Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. J Exp Med (2009) 2.82
Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine. J Exp Med (2008) 2.63
Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity. Nat Med (2010) 2.61
Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med (2009) 2.41
Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells. J Exp Med (2008) 2.41
IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J Immunol (2009) 2.39
IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12. J Immunol (2004) 2.37
Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity. PLoS One (2011) 2.22
Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients. Sci Transl Med (2012) 2.22
Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells. J Exp Med (2007) 2.20
Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med (2012) 2.11
IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J Interferon Cytokine Res (2003) 2.08
The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J Immunol (2006) 2.06
Dynamic programming of CD8+ T cell trafficking after live viral immunization. Immunity (2006) 1.98
Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor. J Invest Dermatol (2011) 1.98
Detection and prediction of active tuberculosis disease by a whole-blood interferon-gamma release assay in HIV-1-infected individuals. Clin Infect Dis (2009) 1.96
IL-27 limits IL-2 production during Th1 differentiation. J Immunol (2006) 1.89
Blood and lymphatic endothelial cell-specific differentiation programs are stringently controlled by the tissue environment. Blood (2007) 1.87
A novel method for the isolation of skin resident T cells from normal and diseased human skin. J Invest Dermatol (2006) 1.86
Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood (2010) 1.85
Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients. Blood (2009) 1.84
Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity (2012) 1.81
Swords into plowshares: IL-23 repurposes tumor immune surveillance. Trends Immunol (2007) 1.77
Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis. Eur J Immunol (2006) 1.75
IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12. J Immunol (2006) 1.68
Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med (2008) 1.67
IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood (2006) 1.64
VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res (2011) 1.62
Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. J Clin Invest (2012) 1.61
Soluble FAS ligand: a discriminating feature between drug-induced skin eruptions and viral exanthemas. J Invest Dermatol (2006) 1.60
Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome. Blood (2007) 1.59
Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant. J Immunol (2006) 1.59
Novel IL-12 family members shed light on the orchestration of Th1 responses. Trends Immunol (2003) 1.55
Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17. J Immunol (2008) 1.50
Determinants of autoantibody induction by conjugated papillomavirus virus-like particles. J Immunol (2002) 1.48
Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen. J Clin Invest (2003) 1.43
Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors. PLoS Genet (2011) 1.43
Classification of anti-FcepsilonRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity. J Allergy Clin Immunol (2002) 1.41
Phase II trial of a toll-like receptor 9-activating oligonucleotide in patients with metastatic melanoma. J Clin Oncol (2006) 1.41
EMPACT syndrome. J Dtsch Dermatol Ges (2005) 1.41
Use of high-dose immunoglobulins in dermatology. J Dtsch Dermatol Ges (2009) 1.40
Identification and characterization of pDC-like cells in normal mouse skin and melanomas treated with imiquimod. J Immunol (2004) 1.39
Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma. Blood (2003) 1.36
Long-lived Th2 memory in experimental allergic asthma. J Immunol (2002) 1.33
Transcriptional profiles predict disease outcome in patients with cutaneous T-cell lymphoma. Clin Cancer Res (2010) 1.31
Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol (2004) 1.31
The PKC inhibitor AEB071 may be a therapeutic option for psoriasis. J Clin Invest (2008) 1.27
TGF-beta, a 'double agent' in the immune pathology war. Nat Immunol (2006) 1.27
Assessment of automated image analysis of breast cancer tissue microarrays for epidemiologic studies. Cancer Epidemiol Biomarkers Prev (2010) 1.25
CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22. J Invest Dermatol (2012) 1.23
Changing views of the role of Langerhans cells. J Invest Dermatol (2012) 1.20
Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis. N Engl J Med (2015) 1.20
The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune response. J Immunol (2009) 1.19
Immunopathologic features of allergic contact dermatitis in humans: participation of plasmacytoid dendritic cells in the pathogenesis of the disease? J Invest Dermatol (2003) 1.19
Differential effects of IL-27 on human B cell subsets. J Immunol (2006) 1.18
Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection. Infect Immun (2006) 1.17
CD43 is a ligand for E-selectin on CLA+ human T cells. Blood (2005) 1.17
Observer variability in the interpretation of HER2/neu immunohistochemical expression with unaided and computer-aided digital microscopy. Arch Pathol Lab Med (2011) 1.17
Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. Cell Signal (2006) 1.15
Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots. J Immunol (2002) 1.15
Increased CCR4 expression in cutaneous T cell lymphoma. J Invest Dermatol (2002) 1.15
Successful treatment of vulvar lichen sclerosus with topical tacrolimus. Arch Dermatol (2003) 1.15
Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity. Sci Transl Med (2014) 1.15
TH2 cytokines from malignant cells suppress TH1 responses and enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma. Clin Cancer Res (2013) 1.15
Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J Invest Dermatol (2009) 1.13
Balance between NF-kappaB and JNK/AP-1 activity controls dendritic cell life and death. Blood (2005) 1.12
T-cell distribution and adhesion receptor expression in metastatic melanoma. Clin Cancer Res (2007) 1.12
CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells. J Immunol (2005) 1.12
Atopic dermatitis: therapeutic concepts evolving from new pathophysiologic insights. J Allergy Clin Immunol (2008) 1.12
Human skin cells support thymus-independent T cell development. J Clin Invest (2005) 1.11
Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4. Proc Natl Acad Sci U S A (2010) 1.08