Notch signaling induces multilineage myeloid differentiation and up-regulates PU.1 expression.

PubWeight™: 1.29‹?› | Rank: Top 10%

🔗 View Article (PMID 12759431)

Published in J Immunol on June 01, 2003

Authors

Timm Schroeder1, Hella Kohlhof, Nikolaus Rieber, Ursula Just

Author Affiliations

1: Institute of Clinical Molecular Biology and Tumor Genetics, GSF-National Research Center for Environment and Health, Munich, Germany.

Articles citing this

MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation. Blood (2009) 2.07

Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling. Genes Dev (2005) 1.98

Potential autoregulation of transcription factor PU.1 by an upstream regulatory element. Mol Cell Biol (2005) 1.96

Notch pathway activation targets AML-initiating cell homeostasis and differentiation. J Exp Med (2013) 1.71

Notch activation inhibits AML growth and survival: a potential therapeutic approach. J Exp Med (2013) 1.54

Notch-dependent control of myelopoiesis is regulated by fucosylation. Blood (2008) 1.40

Notch and wingless signaling cooperate in regulation of dendritic cell differentiation. Immunity (2009) 1.37

Notch signaling: switching an oncogene to a tumor suppressor. Blood (2014) 1.32

Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors. PLoS One (2010) 1.30

Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation. Mol Cell Biol (2007) 1.26

Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells. Br J Cancer (2005) 1.19

Cellular target genes of Epstein-Barr virus nuclear antigen 2. J Virol (2006) 1.10

Down-regulation of PLCγ2-β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer. J Exp Med (2013) 0.98

PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis. J Cell Mol Med (2009) 0.96

Notch signaling in developmental and tumor angiogenesis. Genes Cancer (2011) 0.93

Notch signaling in differentiation and function of dendritic cells. Immunol Res (2008) 0.91

The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity. Mol Immunol (2011) 0.88

JAK2 V617F-dependent upregulation of PU.1 expression in the peripheral blood of myeloproliferative neoplasm patients. PLoS One (2011) 0.88

Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation. J Biol Chem (2010) 0.88

Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages. Angiogenesis (2012) 0.86

Fucose-deficient hematopoietic stem cells have decreased self-renewal and aberrant marrow niche occupancy. Transfusion (2010) 0.83

Notch1-mediated signaling induces MHC class II expression through activation of class II transactivator promoter III in mast cells. J Biol Chem (2011) 0.81

Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons. Development (2014) 0.81

Pleiotropic roles of Notch signaling in normal, malignant, and developmental hematopoiesis in the human. EMBO Rep (2014) 0.81

Hematopoietic cytokine-induced transcriptional regulation and Notch signaling as modulators of MDSC expansion. Int Immunopharmacol (2011) 0.80

The NOTCH pathway contributes to cell fate decision in myelopoiesis. Haematologica (2011) 0.80

The zebrafish reveals dependence of the mast cell lineage on Notch signaling in vivo. Blood (2012) 0.79

GATA2(-/-) human ESCs undergo attenuated endothelial to hematopoietic transition and thereafter granulocyte commitment. Cell Regen (Lond) (2015) 0.78

Chemokine polyreactivity of IL7Rα+CSF-1R+ lympho-myeloid progenitors in the developing fetal liver. Sci Rep (2015) 0.77

Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer. Mol Immunol (2014) 0.77

The Notch signaling pathway in hematopoiesis and hematologic malignancies. Haematologica (2011) 0.77

Aberrant activation of canonical Notch1 signaling in the mouse uterus decreases progesterone receptor by hypermethylation and leads to infertility. Proc Natl Acad Sci U S A (2016) 0.76

Jagged-1 Signaling in the Bone Marrow Microenvironment Promotes Endothelial Progenitor Cell Expansion and Commitment of CD133+ Human Cord Blood Cells for Postnatal Vasculogenesis. PLoS One (2016) 0.75

Myeloid-Specific Blockade of Notch Signaling Attenuates Choroidal Neovascularization through Compromised Macrophage Infiltration and Polarization in Mice. Sci Rep (2016) 0.75

Myeloproliferation and hematopoietic stem cell dysfunction due to defective Notch receptor modification by O-fucose glycans. Semin Immunopathol (2012) 0.75

Articles by these authors

Retracted CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation. Nat Med (2010) 2.17

Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol (2004) 2.12

Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors. Arterioscler Thromb Vasc Biol (2006) 1.86

Regulatory T-cell impairment in cystic fibrosis patients with chronic pseudomonas infection. Am J Respir Crit Care Med (2015) 1.51

Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesis. Proc Natl Acad Sci U S A (2003) 1.45

X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease. Blood (2010) 1.40

Activated Notch1 alters differentiation of embryonic stem cells into mesodermal cell lineages at multiple stages of development. Mech Dev (2006) 1.35

Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors. PLoS One (2010) 1.30

Dendritic cells under influence of mouse cytomegalovirus have a physiologic dual role: to initiate and to restrict T cell activation. J Infect Dis (2003) 1.28

The Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms. Mol Biol Cell (2008) 1.27

The Notch signaling pathway: molecular basis of cell context dependency. Eur J Cell Biol (2010) 1.16

Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism. J Clin Invest (2013) 1.12

Identification of a mouse cytomegalovirus gene selectively targeting CD86 expression on antigen-presenting cells. J Virol (2004) 1.11

Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis. J Allergy Clin Immunol (2010) 1.03

Localization and functionality of the inflammasome in neutrophils. J Biol Chem (2014) 1.00

Transient expression of PU.1 commits multipotent progenitors to a myeloid fate whereas continued expression favors macrophage over granulocyte differentiation. Exp Hematol (2003) 0.94

Notch signaling in embryonic and adult myelopoiesis. Cells Tissues Organs (2008) 0.94

The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease. PLoS One (2011) 0.92

Impaired suppression of synovial fluid CD4+CD25- T cells from patients with juvenile idiopathic arthritis by CD4+CD25+ Treg cells. Arthritis Rheum (2011) 0.92

Granulocytic myeloid derived suppressor cells expand in human pregnancy and modulate T-cell responses. Eur J Immunol (2014) 0.90

A critical role for Sox9 in notch-induced astrogliogenesis and stem cell maintenance. Stem Cells (2013) 0.89

Neutrophils express distinct RNA receptors in a non-canonical way. J Biol Chem (2012) 0.88

Proteins involved in sterol synthesis interact with Ste20 and regulate cell polarity. J Cell Sci (2007) 0.87

A novel gain-of-function IKBA mutation underlies ectodermal dysplasia with immunodeficiency and polyendocrinopathy. J Clin Immunol (2013) 0.86

AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? Immunol Lett (2009) 0.83

mNotch1 signaling and erythropoietin cooperate in erythroid differentiation of multipotent progenitor cells and upregulate beta-globin. Exp Hematol (2007) 0.83

Inhibition of Notch Signaling Ameliorates Acute Kidney Failure and Downregulates Platelet-Derived Growth Factor Receptor β in the Mouse Model. Cells Tissues Organs (2016) 0.81

CXCR1 and CXCR2 haplotypes synergistically modulate cystic fibrosis lung disease. Eur Respir J (2011) 0.81

Modulation of sterol homeostasis by the Cdc42p effectors Cla4p and Ste20p in the yeast Saccharomyces cerevisiae. FEBS J (2009) 0.80

The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway. Mol Biol Cell (2009) 0.79

Induction of Myeloid-Derived Suppressor Cells in Cryopyrin-Associated Periodic Syndromes. J Innate Immun (2016) 0.79

A novel microtubule inhibitor 4SC-207 with anti-proliferative activity in taxane-resistant cells. PLoS One (2013) 0.78

Determination of donor-type chimerism using a semi-quantitative PCR-based method in a canine model for bone marrow transplantation. Vet Immunol Immunopathol (2002) 0.78

Reactogenicity of tetanus, diphtheria, 5-component acellular pertussis vaccine administered as a sixth consecutive acellular pertussis vaccine dose to adolescents. Pediatr Infect Dis J (2010) 0.78

Suppression of the PI3K subunit p85α delays embryoid body development and inhibits cell adhesion. J Cell Biochem (2011) 0.77

Immune response, diagnosis and treatment of allergic bronchopulmonary aspergillosis in cystic fibrosis lung disease. Curr Pharm Des (2013) 0.77

The Notch signaling pathway in hematopoiesis and hematologic malignancies. Haematologica (2011) 0.77

Expression and regulation of interferon-related development regulator-1 in cystic fibrosis neutrophils. Am J Respir Cell Mol Biol (2012) 0.77

Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1δ and ε with nanomolar inhibitory activity on cancer cell proliferation. J Med Chem (2014) 0.76

Cell and virus genetics at the roots of gene therapy, retrovirology, and hematopoietic stem cell biology: Wolfram Ostertag (1937-2010). Hum Gene Ther (2010) 0.75

Impaired cellular immune response to diphtheria and tetanus vaccines in children after thoracic transplantation. Pediatr Transplant (2011) 0.75

Stem cells, tissue regeneration and repair. Preface. Cells Tissues Organs (2008) 0.75