Published in Apoptosis on June 01, 2003
Interleukin-6 as a therapeutic target in human ovarian cancer. Clin Cancer Res (2011) 2.85
Biomarker method validation in anticancer drug development. Br J Pharmacol (2007) 1.41
Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP. Br J Cancer (2005) 1.36
Clinical evaluation of M30 and M65 ELISA cell death assays as circulating biomarkers in a drug-sensitive tumor, testicular cancer. Neoplasia (2008) 1.25
Loss of cell membrane integrity in puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin. J Virol (2006) 1.09
Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice. Toxicol Appl Pharmacol (2013) 1.08
Cell death serum biomarkers are early predictors for survival in severe septic patients with hepatic dysfunction. Crit Care (2009) 1.05
Biomarkers of apoptosis. Br J Cancer (2008) 1.01
Cytokeratin 18 in plasma of patients with gastrointestinal adenocarcinoma as a biomarker of tumour response. Br J Cancer (2009) 0.97
Neoadjuvant docetaxel and capecitabine in patients with high risk prostate cancer. J Urol (2008) 0.96
Biomarkers distinguish apoptotic and necrotic cell death during hepatic ischemia/reperfusion injury in mice. Liver Transpl (2014) 0.96
Circulating biomarkers of cell death after treatment with the BH-3 mimetic ABT-737 in a preclinical model of small-cell lung cancer. Clin Cancer Res (2008) 0.92
Circulating cell death products predict clinical outcome of colorectal cancer patients. BMC Cancer (2009) 0.89
Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours. Br J Cancer (2011) 0.88
A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers. Cell Death Dis (2013) 0.85
The HIV protease inhibitor ritonavir synergizes with butyrate for induction of apoptotic cell death and mediates expression of heme oxygenase-1 in DLD-1 colon carcinoma cells. Br J Pharmacol (2004) 0.80
Total and caspase-cleaved cytokeratin 18 in chronic cholecystitis: a prospective study. BMC Gastroenterol (2008) 0.80
The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells. Sci Rep (2016) 0.77
Evaluation of cell death mechanisms induced by the vascular disrupting agent OXi4503 during a phase I clinical trial. Br J Cancer (2012) 0.77
Propofol or sevoflurane anaesthesia does not affect hepatic integrity as assessed by the M30 & M65 cell death markers & liver enzymes. Indian J Med Res (2014) 0.75
Circulating Levels of M30 and M65 Molecules in Transitional Cell Carcinoma of the Bladder and Their Relation to Tumor Progression. Iran J Cancer Prev (2016) 0.75
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J (2000) 41.48
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell (1999) 19.48
Preservation of duplicate genes by complementary, degenerative mutations. Genetics (1999) 18.29
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A (1998) 16.04
Are the problems of primary care in inner cities fact or fiction? Br Med J (Clin Res Ed) (1983) 7.90
Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature (1998) 7.43
Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n. Science (1991) 5.99
The global carbon cycle: a test of our knowledge of earth as a system. Science (2000) 5.61
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ (2006) 5.18
Estimate of the genomic mutation rate deleterious to overall fitness in E. coli. Nature (1996) 4.88
Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Mol Biol Cell (1999) 4.68
Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. Proc Natl Acad Sci U S A (1995) 4.37
Fragile X genotype characterized by an unstable region of DNA. Science (1991) 4.33
Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation (2001) 4.01
Active versus expectant management of third stage of labour: the Hinchingbrooke randomised controlled trial. Lancet (1998) 4.01
Syk tyrosine kinase required for mouse viability and B-cell development. Nature (1995) 3.87
Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin Cancer Res (2000) 3.86
Transgene and transposon silencing in Chlamydomonas reinhardtii by a DEAH-box RNA helicase. Science (2000) 3.84
Array-based genomic resequencing of human leukemia. Oncogene (2010) 3.77
Weekend hospitalization and additional risk of death: an analysis of inpatient data. J R Soc Med (2012) 3.77
The rate of polygenic mutation. Genet Res (1988) 3.58
Comparing mutational variabilities. Genetics (1996) 3.54
The rate of spontaneous mutation for life-history traits in Caenorhabditis elegans. Genetics (1999) 3.44
Role of Drosophila IKK gamma in a toll-independent antibacterial immune response. Nat Immunol (2000) 3.35
Does the underprivileged area index work? Br Med J (Clin Res Ed) (1985) 3.35
The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3. J Biol Chem (2000) 3.33
Association of CYP2C9*2 with bosentan-induced liver injury. Clin Pharmacol Ther (2013) 3.29
Inter-RNA interaction of phage phi29 pRNA to form a hexameric complex for viral DNA transportation. Mol Cell (1998) 3.21
In vitro activity of a new pneumocandin antifungal, L-743,872, against azole-susceptible and -resistant Candida species. Antimicrob Agents Chemother (1997) 3.17
Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation. Eur J Cancer (1996) 3.07
Impact of face-washing on trachoma in Kongwa, Tanzania. Lancet (1995) 3.06
Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res (2000) 3.03
Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript. J Virol (1990) 2.87
Medical services in social health maintenance organizations. Gerontologist (1993) 2.81
High direct estimate of the mutation rate in the mitochondrial genome of Caenorhabditis elegans. Science (2000) 2.78
Cross-protective immunity can account for the alternating epidemic pattern of dengue virus serotypes circulating in Bangkok. Proc Natl Acad Sci U S A (2006) 2.77
Toward an ecological/transactional model of community violence and child maltreatment: consequences for children's development. Psychiatry (1993) 2.73
FIERY1 encoding an inositol polyphosphate 1-phosphatase is a negative regulator of abscisic acid and stress signaling in Arabidopsis. Genes Dev (2001) 2.73
Intraglottal pressure profiles for a symmetric and oblique glottis with a divergence angle of 10 degrees. J Acoust Soc Am (2001) 2.72
A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. Genes Dev (2000) 2.72
An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation. Br J Pharmacol (1985) 2.68
Comparison of alfentanil with suxamethonium in facilitating nasotracheal intubation in day-case anaesthesia. Br J Anaesth (1993) 2.65
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Proc Natl Acad Sci U S A (2000) 2.65
Pharmacological management of chronic neuropathic pain - consensus statement and guidelines from the Canadian Pain Society. Pain Res Manag (2007) 2.59
Professional attitudes to patient participation groups: an exploratory study. J R Coll Gen Pract (1980) 2.56
Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma. Cancer (2001) 2.51
Characterization of recombinant pig enamelysin activity and cleavage of recombinant pig and mouse amelogenins. J Dent Res (1999) 2.50
A survey of prelicensure pain curricula in health science faculties in Canadian universities. Pain Res Manag (2009) 2.49
Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell. Mol Microbiol (2000) 2.48
Hygiene factors and increased risk of trachoma in central Tanzania. Arch Ophthalmol (1989) 2.45
Can some in-hospital cardio-respiratory arrests be prevented? A prospective survey. Resuscitation (1998) 2.44
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci U S A (1999) 2.44
Differentiation of normal and abnormal airway protection during swallowing using the penetration-aspiration scale. Dysphagia (1999) 2.44
Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene (2012) 2.41
Contributions of Anopheles larval control to malaria suppression in tropical Africa: review of achievements and potential. Med Vet Entomol (2007) 2.37
The fitness effects of spontaneous mutations in Caenorhabditis elegans. Evolution (2000) 2.36
Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature (2000) 2.34
Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill (2013) 2.34
Prophylactic use of oxytocin in the third stage of labour. Cochrane Database Syst Rev (2001) 2.30
Enzyme-labeling of antibodies and their fragments for enzyme immunoassay and immunohistochemical staining. J Immunoassay (1983) 2.26
An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing. J Neurosci (2001) 2.25
Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance. Circulation (2001) 2.21
Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Mol Psychiatry (2010) 2.21
Chemical mapping of a single molecule by plasmon-enhanced Raman scattering. Nature (2013) 2.19
The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J Biol Chem (1997) 2.16
Peripheral blood stem cells (PBSCs) collected after recombinant granulocyte colony stimulating factor (rhG-CSF): an analysis of factors correlating with the tempo of engraftment after transplantation. Br J Haematol (1994) 2.11
Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation. Stem Cells (2012) 2.09
Rapid immune response to influenza vaccination. Lancet (1993) 2.09
Reelin gene alleles and susceptibility to autism spectrum disorders. Mol Psychiatry (2002) 2.05
Risk factors for constant, severe trachoma among preschool children in Kongwa, Tanzania. Am J Epidemiol (1996) 2.03
Recovery from exercise-induced desaturation in the quadriceps muscles of elite competitive rowers. Am J Physiol (1992) 2.02
Strand displacement amplification and homogeneous real-time detection incorporated in a second-generation DNA probe system, BDProbeTecET. Clin Chem (1999) 2.01
Proteinuria with streptokinase. Lancet (1993) 2.01
Unnatural ligands for engineered proteins: new tools for chemical genetics. Annu Rev Biophys Biomol Struct (2000) 1.99
Patterns of genetic architecture for life-history traits and molecular markers in a subdivided species. Evolution (2001) 1.98
Phospholipase D1 is an effector of Rheb in the mTOR pathway. Proc Natl Acad Sci U S A (2008) 1.97
Testicular implants and patient satisfaction: a questionnaire-based study of men after orchidectomy for testicular cancer. BJU Int (2001) 1.94
Selective expression of the large neutral amino acid transporter at the blood-brain barrier. Proc Natl Acad Sci U S A (1999) 1.93
Emergence of a novel GII.17 norovirus – End of the GII.4 era? Euro Surveill (2015) 1.92
Etiology of acute conjunctivitis in children. J Pediatr (1981) 1.92
A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2. Cell Mol Life Sci (2006) 1.92
Augmentation of postnatal neovascularization with autologous bone marrow transplantation. Circulation (2001) 1.92
The NAF domain defines a novel protein-protein interaction module conserved in Ca2+-regulated kinases. EMBO J (2001) 1.91
Peripheral blood levels of matrix metalloproteases-2 and -9 are elevated in patients with acute coronary syndromes. J Am Coll Cardiol (1998) 1.91
Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma. J Natl Cancer Inst (1997) 1.91
Purification from Dictyostelium discoideum of a low-molecular-weight myosin that resembles myosin I from Acanthamoeba castellanii. J Biol Chem (1985) 1.88
Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma. J Natl Cancer Inst (1997) 1.87
Constraints to growth of boreal forests. Nature (2000) 1.87
Reactions of electron-deficient alkynes and allenes under phosphine catalysis. Acc Chem Res (2001) 1.86
Fragile-X syndrome: unique genetics of the heritable unstable element. Am J Hum Genet (1992) 1.85
Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. Mol Psychiatry (2012) 1.84
High-energy surface X-ray diffraction for fast surface structure determination. Science (2014) 1.84
Evaluation of barriers to surgical compliance in the treatment of trichiasis. Int Ophthalmol (1998) 1.84
Prenatal diagnosis of fragile X syndrome by direct detection of the unstable DNA sequence. N Engl J Med (1991) 1.83
Learning from the Arabidopsis experience. The next gene search paradigm. Plant Physiol (2001) 1.82
Age effects on lingual pressure generation as a risk factor for dysphagia. J Gerontol A Biol Sci Med Sci (1995) 1.82
A retrospective study of the application on double-balloon enteroscopy in 378 patients with suspected small-bowel diseases. Endoscopy (2007) 1.81
Climate change and the integrity of science. Science (2010) 1.80