Published in J Med Chem on June 05, 2003
A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med (2014) 2.51
The synthesis of highly substituted isoxazoles by electrophilic cyclization: an efficient synthesis of valdecoxib. J Org Chem (2007) 1.21
Strategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspective. Br J Pharmacol (2008) 1.07
Recent methodologies toward the synthesis of valdecoxib: a potential 3,4-diarylisoxazolyl COX-II inhibitor. Eur J Med Chem (2010) 0.86
A critical assessment of combined ligand- and structure-based approaches to HERG channel blocker modeling. J Chem Inf Model (2011) 0.86
Characterization of a catalytic ligand bridging metal ions in phosphodiesterases 4 and 5 by molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations. Biophys J (2006) 0.84
The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor. ACS Med Chem Lett (2010) 0.80
Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists. ACS Med Chem Lett (2016) 0.80
Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase. J Med Chem (2006) 0.79
Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents. ACS Med Chem Lett (2016) 0.78
The effects of apremilast on the QTc interval in healthy male volunteers: a formal, thorough QT study. Int J Clin Pharmacol Ther (2016) 0.75
Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest (2003) 4.14
MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood (2007) 2.40
Catalytic alkane metathesis by tandem alkane dehydrogenation-olefin metathesis. Science (2006) 2.06
Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086 vaccine in healthy adolescents: a randomised, single-blind, placebo-controlled, phase 2 trial. Lancet Infect Dis (2012) 2.05
Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Blood (2011) 2.02
Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy. J Am Chem Soc (2006) 1.87
Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1. J Biol Chem (2004) 1.67
Broad vaccine coverage predicted for a bivalent recombinant factor H binding protein based vaccine to prevent serogroup B meningococcal disease. Vaccine (2010) 1.67
Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. J Clin Invest (2002) 1.62
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett (2008) 1.60
Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication. J Med Chem (2004) 1.57
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells. J Med Chem (2003) 1.55
Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell (2010) 1.49
Labour before a Caesarean section and the morphology of the lower uterine segment in the next pregnancy. J Obstet Gynaecol Can (2011) 1.45
Comparison of electrophysiological and antiarrhythmic effects of vernakalant, ranolazine, and sotalol in canine pulmonary vein sleeve preparations. Heart Rhythm (2011) 1.44
Color doppler hemodynamic study of the superficial temporal arteries in superficial temporal artery-middle cerebral artery (STA-MCA) bypass surgery for Moyamoya disease. World Neurosurg (2011) 1.43
Approach to validating an opsonophagocytic assay for Streptococcus pneumoniae. Clin Diagn Lab Immunol (2005) 1.40
Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival. J Immunol (2005) 1.36
Identification of the proliferation/differentiation switch in the cellular network of multicellular organisms. PLoS Comput Biol (2006) 1.32
Chytridiomycosis in native Arizona frogs. J Wildl Dis (2002) 1.32
Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase. Cell Res (2011) 1.24
Preclinical studies in normal canine prostate of a novel palladium-bacteriopheophorbide (WST09) photosensitizer for photodynamic therapy of prostate cancers. Photochem Photobiol (2002) 1.23
MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. J Pharmacol Exp Ther (2008) 1.23
Detection of LP2086 on the cell surface of Neisseria meningitidis and its accessibility in the presence of serogroup B capsular polysaccharide. Vaccine (2009) 1.22
1,5-asymmetric induction in boron-mediated beta-alkoxy methyl ketone aldol addition reactions. J Am Chem Soc (2003) 1.18
Low-dose chest CT: optimizing radiation protection for patients. AJR Am J Roentgenol (2004) 1.17
Inhibition of autophagosome formation by the benzoporphyrin derivative verteporfin. J Biol Chem (2010) 1.15
The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. Exp Cell Res (2007) 1.13
Safety and immunogenicity of a 13-valent pneumococcal conjugate vaccine compared to those of a 7-valent pneumococcal conjugate vaccine given as a three-dose series with routine vaccines in healthy infants and toddlers. Clin Vaccine Immunol (2010) 1.12
A potent and orally active HIV-1 integrase inhibitor. Bioorg Med Chem Lett (2006) 1.10
Fusion of 3D QCA and IVUS/OCT. Int J Cardiovasc Imaging (2011) 1.08
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett (2007) 1.05
Catalytic inactivation of protein tyrosine phosphatase CD45 and protein tyrosine phosphatase 1B by polyaromatic quinones. Biochemistry (2004) 1.05
Identification of small molecule compounds that selectively inhibit varicella-zoster virus replication. J Virol (2003) 1.03
In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide. J Pharmacol Exp Ther (2005) 1.02
Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirus. J Virol (2004) 1.02
Safety and immunogenicity of a meningococcal B bivalent rLP2086 vaccine in healthy toddlers aged 18-36 months: a phase 1 randomized-controlled clinical trial. Pediatr Infect Dis J (2012) 1.02
The C3a receptor antagonist SB 290157 has agonist activity. Immunol Lett (2005) 1.01
Assignment of weight-based immunoglobulin G1 (IgG1) and IgG2 units in antipneumococcal reference serum lot 89-S(F) for pneumococcal polysaccharide serotypes 1, 4, 5, 7F, 9V, and 18C. Clin Diagn Lab Immunol (2005) 1.01
Laser-fabricated porous alumina membranes for the preparation of metal nanodot arrays. Small (2008) 1.00
Choroidal involution is a key component of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci (2011) 1.00
Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure. J Pharmacol Exp Ther (2007) 0.99
Vaginal calculi secondary to urethrovaginal fistula with vaginal stenosis in a 14-year-old girl. Urol Res (2008) 0.98
RFI-641, a potent respiratory syncytial virus inhibitor. Antimicrob Agents Chemother (2002) 0.97
Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores. PLoS One (2007) 0.97
Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. Bioorg Med Chem Lett (2003) 0.97
Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem (2011) 0.97
Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors. J Pharmacol Exp Ther (2005) 0.96
A novel three-dimensional quantitative coronary angiography system: In-vivo comparison with intravascular ultrasound for assessing arterial segment length. Catheter Cardiovasc Interv (2010) 0.95
In vitro study of haematoporphyrin monomethyl ether-mediated sonodynamic effects on C6 glioma cells. Neurol Sci (2008) 0.95
Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524). J Med Chem (2007) 0.95
Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines. J Med Chem (2003) 0.95
Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett (2009) 0.95
Improvement of tumor response by manipulation of tumor oxygenation during photodynamic therapy. Photochem Photobiol (2002) 0.94
Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma. Am J Respir Cell Mol Biol (2005) 0.94
A phase 2 open-label safety and immunogenicity study of a meningococcal B bivalent rLP2086 vaccine in healthy adults. Vaccine (2013) 0.94
Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties. ChemMedChem (2012) 0.94
The new antiarrhythmic drug vernakalant: ex vivo study of human atrial tissue from sinus rhythm and chronic atrial fibrillation. Cardiovasc Res (2013) 0.93
Therapeutic and immune effects of 5-aminolevulinic acid photodynamic therapy on UVB-induced squamous cell carcinomas in hairless mice. Exp Dermatol (2013) 0.93
Treatment of perianal Paget's disease using photodynamic therapy with assistance of fluorescence examination: case report. Lasers Med Sci (2009) 0.93
Imiquimod-induced localized vitiligo in wife and lichen planus in husband. Chin Med J (Engl) (2013) 0.93
Substituted coumarins as potent 5-lipoxygenase inhibitors. Bioorg Med Chem Lett (2006) 0.93
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett (2009) 0.93
In vitro characterization of MK-1439, a novel HIV-1 nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother (2013) 0.93
A randomized, controlled, phase 1/2 trial of a Neisseria meningitidis serogroup B bivalent rLP2086 vaccine in healthy children and adolescents. Pediatr Infect Dis J (2013) 0.93
Comparison of photodynamic therapy and pulsed dye laser in patients with port wine stain birthmarks: a retrospective analysis. Photodiagnosis Photodyn Ther (2008) 0.92
Pharmacological characterization of a selective COX-2 inhibitor MF-tricyclic, [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone], in multiple preclinical species. Eur J Pharmacol (2007) 0.92
Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem (2007) 0.92
Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist. J Med Chem (2007) 0.92
Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J Pharmacol Exp Ther (2010) 0.92
Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats. Mol Pharmacol (2005) 0.92
Integrative analysis of porcine microRNAome during skeletal muscle development. PLoS One (2013) 0.92
Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation. J Am Chem Soc (2008) 0.91
The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14. Bioorg Med Chem Lett (2011) 0.91
In vivo cardiac electrophysiologic and antiarrhythmic effects of an isoquinoline IKur blocker, ISQ-1, in rat, dog, and nonhuman primate. J Cardiovasc Pharmacol (2007) 0.91
Photocatalytic oxidation of bacteria, bacterial and fungal spores, and model biofilm components to carbon dioxide on titanium dioxide-coated surfaces. Environ Sci Technol (2002) 0.91
Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. J Med Chem (2005) 0.91
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells. Bioorg Med Chem Lett (2005) 0.91
Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides. ChemMedChem (2006) 0.91