| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Guidelines for the use and interpretation of assays for monitoring autophagy.
|
Autophagy
|
2012
|
20.08
|
|
2
|
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure.
|
Proc Natl Acad Sci U S A
|
2008
|
4.00
|
|
3
|
Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator.
|
Cell
|
2006
|
3.73
|
|
4
|
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu.
|
Proc Natl Acad Sci U S A
|
2002
|
3.54
|
|
5
|
Proteotoxicity and cardiac dysfunction--Alzheimer's disease of the heart?
|
N Engl J Med
|
2013
|
3.41
|
|
6
|
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.
|
J Clin Invest
|
2007
|
3.35
|
|
7
|
Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex.
|
J Clin Invest
|
2004
|
3.09
|
|
8
|
Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling.
|
EMBO J
|
2003
|
3.06
|
|
9
|
Protein quality control: U-box-containing E3 ubiquitin ligases join the fold.
|
Trends Biochem Sci
|
2002
|
3.01
|
|
10
|
CHIP: a link between the chaperone and proteasome systems.
|
Cell Stress Chaperones
|
2003
|
2.98
|
|
11
|
CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70.
|
Nature
|
2006
|
2.90
|
|
12
|
The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle.
|
Cell Metab
|
2007
|
2.84
|
|
13
|
CHIP activates HSF1 and confers protection against apoptosis and cellular stress.
|
EMBO J
|
2003
|
2.78
|
|
14
|
Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I.
|
Proc Natl Acad Sci U S A
|
2004
|
2.34
|
|
15
|
Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins.
|
J Clin Invest
|
2007
|
2.25
|
|
16
|
Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy.
|
EMBO J
|
2002
|
2.17
|
|
17
|
Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo.
|
Circ Res
|
2007
|
2.05
|
|
18
|
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.
|
J Neurosci
|
2006
|
1.98
|
|
19
|
Mitochondrial integrity and function in atherogenesis.
|
Circulation
|
2002
|
1.94
|
|
20
|
ERK signaling is a central regulator for BMP-4 dependent capillary sprouting.
|
Cardiovasc Res
|
2007
|
1.90
|
|
21
|
Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes.
|
Cardiovasc Res
|
2005
|
1.87
|
|
22
|
The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways.
|
J Biol Chem
|
2005
|
1.85
|
|
23
|
Differential activation of mitogenic signaling pathways in aortic smooth muscle cells deficient in superoxide dismutase isoforms.
|
Arterioscler Thromb Vasc Biol
|
2005
|
1.84
|
|
24
|
BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation.
|
Mol Cell Biol
|
2003
|
1.83
|
|
25
|
The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching.
|
J Cell Biol
|
2008
|
1.82
|
|
26
|
CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control.
|
Mol Cell Biol
|
2008
|
1.82
|
|
27
|
Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease.
|
Circ Res
|
2010
|
1.78
|
|
28
|
A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting.
|
Am J Respir Crit Care Med
|
2012
|
1.74
|
|
29
|
A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase.
|
J Cell Biol
|
2004
|
1.70
|
|
30
|
Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.
|
Mol Biol Cell
|
2003
|
1.67
|
|
31
|
Akt and CHIP coregulate tau degradation through coordinated interactions.
|
Proc Natl Acad Sci U S A
|
2008
|
1.66
|
|
32
|
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity.
|
Proc Natl Acad Sci U S A
|
2009
|
1.64
|
|
33
|
Chaperone functions of the E3 ubiquitin ligase CHIP.
|
J Biol Chem
|
2007
|
1.63
|
|
34
|
Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy.
|
J Cell Biol
|
2004
|
1.62
|
|
35
|
CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden.
|
Arterioscler Thromb Vasc Biol
|
2007
|
1.59
|
|
36
|
Bone morphogenetic protein endothelial cell precursor-derived regulator regulates retinal angiogenesis in vivo in a mouse model of oxygen-induced retinopathy.
|
Arterioscler Thromb Vasc Biol
|
2011
|
1.56
|
|
37
|
CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation.
|
J Biol Chem
|
2006
|
1.55
|
|
38
|
Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors.
|
J Cell Biol
|
2007
|
1.54
|
|
39
|
BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis.
|
Circ Res
|
2008
|
1.48
|
|
40
|
Regulation of the cytoplasmic quality control protein degradation pathway by BAG2.
|
J Biol Chem
|
2005
|
1.46
|
|
41
|
CHIP, a cochaperone/ubiquitin ligase that regulates protein quality control, is required for maximal cardioprotection after myocardial infarction in mice.
|
Am J Physiol Heart Circ Physiol
|
2005
|
1.43
|
|
42
|
Build it up-Tear it down: protein quality control in the cardiac sarcomere.
|
Cardiovasc Res
|
2008
|
1.42
|
|
43
|
A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling.
|
J Cell Biol
|
2009
|
1.39
|
|
44
|
Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.
|
J Clin Invest
|
2017
|
1.38
|
|
45
|
An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP).
|
J Biol Chem
|
2004
|
1.36
|
|
46
|
Into the heart: the emerging role of the ubiquitin-proteasome system.
|
J Mol Cell Cardiol
|
2006
|
1.35
|
|
47
|
The FoxO family in cardiac function and dysfunction.
|
Annu Rev Physiol
|
2010
|
1.33
|
|
48
|
Muscle ring finger 1 mediates cardiac atrophy in vivo.
|
Am J Physiol Heart Circ Physiol
|
2009
|
1.33
|
|
49
|
Molecular characterization of human breast tumor vascular cells.
|
Am J Pathol
|
2008
|
1.32
|
|
50
|
Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP.
|
J Biol Chem
|
2003
|
1.31
|
|
51
|
Catecholamine-induced vascular wall growth is dependent on generation of reactive oxygen species.
|
Circ Res
|
2003
|
1.30
|
|
52
|
Cardiac muscle ring finger-1 increases susceptibility to heart failure in vivo.
|
Circ Res
|
2009
|
1.29
|
|
53
|
Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP.
|
J Cell Biol
|
2005
|
1.28
|
|
54
|
Brain CHIP: removing the culprits in neurodegenerative disease.
|
Trends Mol Med
|
2006
|
1.27
|
|
55
|
AtCHIP, a U-box-containing E3 ubiquitin ligase, plays a critical role in temperature stress tolerance in Arabidopsis.
|
Plant Physiol
|
2003
|
1.23
|
|
56
|
The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones.
|
FASEB J
|
2006
|
1.23
|
|
57
|
C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation.
|
Arch Biochem Biophys
|
2003
|
1.20
|
|
58
|
Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.
|
J Biol Chem
|
2004
|
1.20
|
|
59
|
Characterization of a model to independently study regression of ventricular hypertrophy.
|
J Surg Res
|
2007
|
1.19
|
|
60
|
Postischemic recovery of contractile function is impaired in SOD2(+/-) but not SOD1(+/-) mouse hearts.
|
Circulation
|
2002
|
1.19
|
|
61
|
Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies.
|
J Biol Chem
|
2006
|
1.18
|
|
62
|
Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP.
|
Hum Mol Genet
|
2013
|
1.17
|
|
63
|
ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.
|
Mol Cell Biol
|
2007
|
1.17
|
|
64
|
BMPER is a conserved regulator of hematopoietic and vascular development in zebrafish.
|
J Mol Cell Cardiol
|
2007
|
1.17
|
|
65
|
Gene expression profiles identify a role for cyclooxygenase 2-dependent prostanoid generation in BMP6-induced angiogenic responses.
|
Blood
|
2007
|
1.16
|
|
66
|
CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism.
|
Hum Mol Genet
|
2007
|
1.16
|
|
67
|
Overexpression of the cochaperone CHIP enhances Hsp70-dependent folding activity in mammalian cells.
|
Mol Cell Biol
|
2003
|
1.16
|
|
68
|
Gene expression profile signatures indicate a role for Wnt signaling in endothelial commitment from embryonic stem cells.
|
Circ Res
|
2006
|
1.14
|
|
69
|
Hold me tight: Role of the heat shock protein family of chaperones in cardiac disease.
|
Circulation
|
2010
|
1.13
|
|
70
|
Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway.
|
Cancer Res
|
2009
|
1.12
|
|
71
|
Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury.
|
J Biol Chem
|
2007
|
1.12
|
|
72
|
Regression of pressure-induced left ventricular hypertrophy is characterized by a distinct gene expression profile.
|
J Thorac Cardiovasc Surg
|
2009
|
1.09
|
|
73
|
Down-regulation of the mixed-lineage dual leucine zipper-bearing kinase by heat shock protein 70 and its co-chaperone CHIP.
|
J Biol Chem
|
2006
|
1.09
|
|
74
|
CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation.
|
Mol Cell
|
2008
|
1.08
|
|
75
|
Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2.
|
Nat Struct Mol Biol
|
2008
|
1.08
|
|
76
|
HoxB5 is an upstream transcriptional switch for differentiation of the vascular endothelium from precursor cells.
|
Mol Cell Biol
|
2003
|
1.07
|
|
77
|
Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.
|
FASEB J
|
2010
|
1.07
|
|
78
|
Mechanisms of endothelial differentiation in embryonic vasculogenesis.
|
Arterioscler Thromb Vasc Biol
|
2005
|
1.07
|
|
79
|
CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.
|
Arch Biochem Biophys
|
2008
|
1.06
|
|
80
|
The ubiquitin ligase MuRF1 protects against cardiac ischemia/reperfusion injury by its proteasome-dependent degradation of phospho-c-Jun.
|
Am J Pathol
|
2011
|
1.06
|
|
81
|
Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation.
|
Brain Res Mol Brain Res
|
2004
|
1.06
|
|
82
|
NF-κB inhibition protects against tumor-induced cardiac atrophy in vivo.
|
Am J Pathol
|
2011
|
1.05
|
|
83
|
CHIP represses myocardin-induced smooth muscle cell differentiation via ubiquitin-mediated proteasomal degradation.
|
Mol Cell Biol
|
2009
|
1.05
|
|
84
|
Back to your heart: ubiquitin proteasome system-regulated signal transduction.
|
J Mol Cell Cardiol
|
2011
|
1.05
|
|
85
|
PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response.
|
J Clin Invest
|
2012
|
1.04
|
|
86
|
mTORC1 links protein quality and quantity control by sensing chaperone availability.
|
J Biol Chem
|
2010
|
1.04
|
|
87
|
Brothers and sisters: molecular insights into arterial-venous heterogeneity.
|
Circ Res
|
2008
|
1.03
|
|
88
|
The opening act: vasculogenesis and the origins of circulation.
|
Arterioscler Thromb Vasc Biol
|
2008
|
1.03
|
|
89
|
C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis.
|
Cell Stress Chaperones
|
2005
|
1.03
|
|
90
|
ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF.
|
Mol Cell Biol
|
2012
|
1.03
|
|
91
|
Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response.
|
EMBO J
|
2013
|
1.02
|
|
92
|
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
|
Mol Cell Biol
|
2004
|
1.01
|
|
93
|
BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium.
|
Blood
|
2011
|
1.01
|
|
94
|
Bone morphogenetic proteins and vascular differentiation: BMPing up vasculogenesis.
|
Thromb Haemost
|
2005
|
1.00
|
|
95
|
LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.
|
Circ Res
|
2012
|
0.99
|
|
96
|
SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration.
|
Proc Natl Acad Sci U S A
|
2009
|
0.99
|
|
97
|
Ubiquitin-proteasome degradation of serum- and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperone-dependent E3 ligase CHIP.
|
Biochem J
|
2006
|
0.99
|
|
98
|
Tearin' up my heart: proteolysis in the cardiac sarcomere.
|
J Biol Chem
|
2011
|
0.99
|
|
99
|
The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.
|
Mol Cell Biol
|
2013
|
0.99
|
|
100
|
p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.
|
Circ Res
|
2012
|
0.98
|
|
101
|
LE-PAS, a novel Arnt-dependent HLH-PAS protein, is expressed in limbic tissues and transactivates the CNS midline enhancer element.
|
Brain Res Mol Brain Res
|
2004
|
0.97
|
|
102
|
p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation.
|
J Biol Chem
|
2004
|
0.96
|
|
103
|
Selection and initial characterization of novel peptide ligands that bind specifically to human blood outgrowth endothelial cells.
|
Biotechnol Bioeng
|
2007
|
0.96
|
|
104
|
HoxB5 induces endothelial sprouting in vitro and modifies intussusceptive angiogenesis in vivo involving angiopoietin-2.
|
Cardiovasc Res
|
2009
|
0.96
|
|
105
|
Selective endothelial cell attachment to peptide-modified terpolymers.
|
Biomaterials
|
2008
|
0.95
|
|
106
|
The role of calcineurin/NFAT in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimus.
|
PLoS One
|
2011
|
0.95
|
|
107
|
Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo.
|
Cell Biochem Funct
|
2013
|
0.94
|
|
108
|
Development of the endothelium: an emphasis on heterogeneity.
|
Semin Thromb Hemost
|
2010
|
0.94
|
|
109
|
Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transfer.
|
J Biol Chem
|
2009
|
0.94
|
|
110
|
The ubiquitin-proteasome system and cardiovascular disease.
|
Prog Mol Biol Transl Sci
|
2012
|
0.93
|
|
111
|
Stress-dependent Daxx-CHIP interaction suppresses the p53 apoptotic program.
|
J Biol Chem
|
2009
|
0.93
|
|
112
|
PRDM6 is enriched in vascular precursors during development and inhibits endothelial cell proliferation, survival, and differentiation.
|
J Mol Cell Cardiol
|
2007
|
0.92
|
|
113
|
BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1.
|
Arterioscler Thromb Vasc Biol
|
2009
|
0.92
|
|
114
|
Tiny dancers: the integrin-growth factor nexus in angiogenic signaling.
|
J Cell Biol
|
2002
|
0.92
|
|
115
|
Regulation of AMPK by the ubiquitin proteasome system.
|
Am J Pathol
|
2010
|
0.92
|
|
116
|
Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase.
|
Am J Physiol Heart Circ Physiol
|
2007
|
0.92
|
|
117
|
You spin me round: MaFBx/Atrogin-1 feeds forward on FOXO transcription factors (like a record).
|
Cell Cycle
|
2007
|
0.92
|
|
118
|
Tobacco use induces anti-apoptotic, proliferative patterns of gene expression in circulating leukocytes of Caucasian males.
|
BMC Med Genomics
|
2008
|
0.92
|
|
119
|
ATP stimulates MMP-2 release from human aortic smooth muscle cells via JNK signaling pathway.
|
Am J Physiol Heart Circ Physiol
|
2005
|
0.91
|
|
120
|
C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1.
|
J Biol Chem
|
2009
|
0.91
|
|
121
|
Hard luck stories: the reality of endothelial progenitor cells continues to fall short of the promise.
|
Circulation
|
2010
|
0.91
|
|
122
|
New insights into bone morphogenetic protein signaling: focus on angiogenesis.
|
Curr Opin Hematol
|
2009
|
0.91
|
|
123
|
Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease.
|
Future Cardiol
|
2008
|
0.90
|
|
124
|
Stable patterns of gene expression regulating carbohydrate metabolism determined by geographic ancestry.
|
PLoS One
|
2009
|
0.90
|
|
125
|
Proteotoxicity and cardiac dysfunction.
|
N Engl J Med
|
2013
|
0.89
|
|
126
|
2-methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cells.
|
Cancer Res
|
2007
|
0.89
|
|
127
|
Lysine 48-linked polyubiquitination of organic anion transporter-1 is essential for its protein kinase C-regulated endocytosis.
|
Mol Pharmacol
|
2012
|
0.89
|
|
128
|
Direct identification of ubiquitination sites on ubiquitin-conjugated CHIP using MALDI mass spectrometry.
|
J Proteome Res
|
2005
|
0.89
|
|
129
|
A novel monoclonal antibody to secreted frizzled-related protein 2 inhibits tumor growth.
|
Mol Cancer Ther
|
2013
|
0.89
|
|
130
|
Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation.
|
BMC Neurosci
|
2011
|
0.89
|
|
131
|
Inhibition of BMP activity protects epithelial barrier function in lung injury.
|
J Pathol
|
2013
|
0.88
|
|
132
|
Bmper inhibits endothelial expression of inflammatory adhesion molecules and protects against atherosclerosis.
|
Arterioscler Thromb Vasc Biol
|
2012
|
0.88
|
|
133
|
Universal mouse reference RNA derived from neonatal mice.
|
Biotechniques
|
2004
|
0.88
|
|
134
|
Efficient in vivo selection of a novel tumor-associated peptide from a phage display library.
|
Molecules
|
2011
|
0.88
|
|
135
|
Recovery from decompensated heart failure is associated with a distinct, phase-dependent gene expression profile.
|
J Surg Res
|
2012
|
0.87
|
|
136
|
CHIP protects against cardiac pressure overload through regulation of AMPK.
|
J Clin Invest
|
2013
|
0.87
|
|
137
|
Seek and destroy: the ubiquitin----proteasome system in cardiac disease.
|
Curr Hypertens Rep
|
2009
|
0.87
|
|
138
|
CHIP-dependent p53 regulation occurs specifically during cellular senescence.
|
Free Radic Biol Med
|
2010
|
0.87
|
|
139
|
Life is a pattern: vascular assembly within the embryo.
|
Front Biosci (Elite Ed)
|
2012
|
0.86
|
|
140
|
PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21Cip1 expression: involvement of p38 mitogen activated protein kinase.
|
J Cell Physiol
|
2004
|
0.86
|
|
141
|
Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein.
|
J Mol Biol
|
2004
|
0.86
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