Published in EMBO J on June 02, 2003
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol (2004) 5.44
TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome. J Clin Invest (2004) 4.85
Heart valve development: endothelial cell signaling and differentiation. Circ Res (2004) 4.41
Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A (2007) 3.61
Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development (2005) 2.73
ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha. Mol Biol Cell (2009) 2.46
Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx. Mol Biol Cell (2006) 2.43
Periostin promotes atrioventricular mesenchyme matrix invasion and remodeling mediated by integrin signaling through Rho/PI 3-kinase. Dev Biol (2006) 2.08
Heparin-binding EGF-like growth factor promotes epithelial-mesenchymal transition in human keratinocytes. J Invest Dermatol (2012) 1.70
Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor. Mol Cell Biol (2004) 1.67
ADAM-17: the enzyme that does it all. Crit Rev Biochem Mol Biol (2010) 1.62
Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice. BMC Neurosci (2005) 1.58
The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology. Exp Cell Res (2008) 1.53
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. Oncogene (2006) 1.49
ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site. J Cell Sci (2010) 1.49
Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology. Am J Pathol (2008) 1.47
Growth factors and corneal epithelial wound healing. Brain Res Bull (2009) 1.47
MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis. Dev Cell (2009) 1.46
Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med (2011) 1.46
Valvulogenesis: the moving target. Philos Trans R Soc Lond B Biol Sci (2007) 1.44
Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes. Circ Res (2010) 1.42
Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17. Nat Commun (2011) 1.40
Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. J Exp Med (2012) 1.39
Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities. J Cell Biol (2003) 1.36
ErbB/EGF signaling and EMT in mammary development and breast cancer. J Mammary Gland Biol Neoplasia (2010) 1.36
Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J (2007) 1.31
Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Circ Res (2011) 1.28
Essential role for ADAM19 in cardiovascular morphogenesis. Mol Cell Biol (2004) 1.27
Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Mol Cell Biol (2004) 1.26
Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol (2008) 1.24
Proteolytic cleavage of versican during cardiac cushion morphogenesis. Dev Dyn (2006) 1.22
The role of protease activity in ErbB biology. Exp Cell Res (2008) 1.20
Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice. Endocrinology (2008) 1.18
ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. Mol Cell Biol (2006) 1.15
Maternal heparin-binding-EGF deficiency limits pregnancy success in mice. Proc Natl Acad Sci U S A (2007) 1.15
Partitioning the heart: mechanisms of cardiac septation and valve development. Development (2012) 1.13
Metalloproteinase-mediated, context-dependent function of amphiregulin and HB-EGF in human keratinocytes and skin. J Invest Dermatol (2010) 1.11
Heparin-binding epidermal growth factor-like growth factor gene disruption is associated with delayed intestinal restitution, impaired angiogenesis, and poor survival after intestinal ischemia in mice. J Pediatr Surg (2008) 1.11
iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding. Proc Natl Acad Sci U S A (2013) 1.10
Molecular and cellular mechanisms of ectodomain shedding. Anat Rec (Hoboken) (2010) 1.08
Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon. Mol Cell Biol (2005) 1.08
Trophoblast-uterine interactions at implantation. Reprod Biol Endocrinol (2004) 1.07
The ADAM17-amphiregulin-EGFR axis in mammary development and cancer. J Mammary Gland Biol Neoplasia (2008) 1.06
Insights into the evolution of the ErbB receptor family and their ligands from sequence analysis. BMC Evol Biol (2006) 1.06
Noonan syndrome mutation Q79R in Shp2 increases proliferation of valve primordia mesenchymal cells via extracellular signal-regulated kinase 1/2 signaling. Circ Res (2005) 1.06
A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17. Oncogene (2010) 1.04
Heparin-binding epidermal growth factor-like growth factor is essential for preservation of gut barrier function after hemorrhagic shock and resuscitation in mice. Surgery (2009) 1.04
Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling. J Clin Invest (2007) 1.04
The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling. Dev Dyn (2011) 1.03
Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding. Mol Biol Cell (2009) 1.03
CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation. J Clin Invest (2004) 1.02
Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-alpha. J Physiol (2009) 1.01
Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF. J Immunol (2009) 1.01
Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage. Proc Natl Acad Sci U S A (2004) 1.00
Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation. EMBO Rep (2013) 1.00
Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. Am J Physiol Heart Circ Physiol (2009) 0.99
Formation of the collateral circulation is regulated by vascular endothelial growth factor-A and a disintegrin and metalloprotease family members 10 and 17. Circ Res (2012) 0.99
The phospholipase C isozymes and their regulation. Subcell Biochem (2012) 0.97
The waved with open eyelids (woe) locus is a hypomorphic mouse mutation in Adam17. Genetics (2010) 0.97
Metalloproteinase-dependent cleavage of neuregulin and autocrine stimulation of vascular endothelial cells. FASEB J (2010) 0.96
Regulation of heart valve morphogenesis by Eph receptor ligand, ephrin-A1. Dev Dyn (2010) 0.95
Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice. Toxicol Appl Pharmacol (2008) 0.95
Deletion of the heparin-binding epidermal growth factor-like growth factor gene increases susceptibility to necrotizing enterocolitis. J Pediatr Surg (2010) 0.95
iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function. Hum Mol Genet (2014) 0.95
ErbB signaling in cardiac development and disease. Semin Cell Dev Biol (2010) 0.95
Diverse functions of HBEGF during pregnancy. Mol Reprod Dev (2009) 0.94
iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling. Proc Natl Acad Sci U S A (2015) 0.94
Trafficking of epidermal growth factor receptor ligands in polarized epithelial cells. Annu Rev Physiol (2013) 0.94
The nuclear receptor cofactor receptor-interacting protein 140 is a positive regulator of amphiregulin expression and cumulus cell-oocyte complex expansion in the mouse ovary. Endocrinology (2010) 0.93
Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury. J Biol Chem (2011) 0.93
Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice. Lab Invest (2012) 0.93
Bradykinin decreases podocyte permeability through ADAM17-dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangement. J Pharmacol Exp Ther (2010) 0.92
Deficits in spatial learning and motor coordination in ADAM11-deficient mice. BMC Neurosci (2006) 0.92
Heparin-binding epidermal growth factor-like growth factor signaling in flow-induced arterial remodeling. Circ Res (2008) 0.91
Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas. PLoS One (2007) 0.91
BMP signaling in the nephron progenitor niche. Pediatr Nephrol (2011) 0.91
Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735. PLoS One (2012) 0.90
Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev (2013) 0.90
Differential contribution to neuroendocrine tumorigenesis of parallel egfr signaling in cancer cells and pericytes. Genes Cancer (2010) 0.90
EGFR Signaling in Liver Diseases. Int J Mol Sci (2015) 0.90
The living aortic valve: From molecules to function. Glob Cardiol Sci Pract (2014) 0.89
TNF-α-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells. Am J Respir Cell Mol Biol (2010) 0.89
Betacellulin inhibits amylase and glucagon production and promotes beta cell differentiation in mouse embryonic pancreas. Diabetologia (2007) 0.88
BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier. Mol Cell Neurosci (2008) 0.88
Transforming growth factor β, bone morphogenetic protein, and vascular endothelial growth factor mediate phenotype maturation and tissue remodeling by embryonic valve progenitor cells: relevance for heart valve tissue engineering. Tissue Eng Part A (2010) 0.87
Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. Dev Dyn (2010) 0.87
Human epidermal growth factor receptor signaling in acute lung injury. Am J Respir Cell Mol Biol (2012) 0.86
TACE/ADAM17 is essential for oligodendrocyte development and CNS myelination. J Neurosci (2014) 0.85
A potent anti-HB-EGF monoclonal antibody inhibits cancer cell proliferation and multiple angiogenic activities of HB-EGF. PLoS One (2012) 0.85
Replication of the 4p16 susceptibility locus in congenital heart disease in Han Chinese populations. PLoS One (2014) 0.83
Meprinα transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. J Biol Chem (2012) 0.83
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is increased in osteoarthritis and regulates chondrocyte catabolic and anabolic activities. Osteoarthritis Cartilage (2015) 0.83
The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development. J Mol Cell Cardiol (2012) 0.83
Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones. PLoS One (2013) 0.83
Differential functions of genes regulated by VEGF-NFATc1 signaling pathway in the migration of pulmonary valve endothelial cells. FEBS Lett (2010) 0.82
Galnt1 is required for normal heart valve development and cardiac function. PLoS One (2015) 0.81
Loss of ADAM17-Mediated Tumor Necrosis Factor Alpha Signaling in Intestinal Cells Attenuates Mucosal Atrophy in a Mouse Model of Parenteral Nutrition. Mol Cell Biol (2015) 0.81
HB-EGF improves intestinal microcirculation after hemorrhagic shock. J Surg Res (2010) 0.81
Heparin-binding epidermal growth factor-like growth factor promotes murine enteric nervous system development and enteric neural crest cell migration. J Pediatr Surg (2012) 0.80
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Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell (1992) 3.81
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Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors. Nat Med (2002) 2.26
Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells. Nat Med (2002) 2.20
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Proteotoxicity and cardiac dysfunction--Alzheimer's disease of the heart? N Engl J Med (2013) 3.41
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J Clin Invest (2007) 3.35
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CHIP activates HSF1 and confers protection against apoptosis and cellular stress. EMBO J (2003) 2.78
Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development (2005) 2.73
Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach. Nat Med (2005) 2.61
Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Proc Natl Acad Sci U S A (2004) 2.34
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Mitochondrial integrity and function in atherogenesis. Circulation (2002) 1.94
ERK signaling is a central regulator for BMP-4 dependent capillary sprouting. Cardiovasc Res (2007) 1.90
Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes. Cardiovasc Res (2005) 1.87
The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways. J Biol Chem (2005) 1.85
Differential activation of mitogenic signaling pathways in aortic smooth muscle cells deficient in superoxide dismutase isoforms. Arterioscler Thromb Vasc Biol (2005) 1.84
BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol Cell Biol (2003) 1.83
The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching. J Cell Biol (2008) 1.82
CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control. Mol Cell Biol (2008) 1.82
Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemia. Shock (2006) 1.80
Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease. Circ Res (2010) 1.78
Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha. J Clin Invest (2005) 1.76
Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling. J Mol Med (Berl) (2003) 1.76
A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Am J Respir Crit Care Med (2012) 1.74
A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase. J Cell Biol (2004) 1.70
Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol. Mol Biol Cell (2003) 1.67
Akt and CHIP coregulate tau degradation through coordinated interactions. Proc Natl Acad Sci U S A (2008) 1.66
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. Proc Natl Acad Sci U S A (2009) 1.64
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Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy. J Cell Biol (2004) 1.62
CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden. Arterioscler Thromb Vasc Biol (2007) 1.59
Bone morphogenetic protein endothelial cell precursor-derived regulator regulates retinal angiogenesis in vivo in a mouse model of oxygen-induced retinopathy. Arterioscler Thromb Vasc Biol (2011) 1.56
CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation. J Biol Chem (2006) 1.55
Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors. J Cell Biol (2007) 1.54
TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase. Ann N Y Acad Sci (2003) 1.52
Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo. J Biol Chem (2002) 1.52
A rationale for continuing mass antibiotic distributions for trachoma. BMC Infect Dis (2007) 1.48
BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. Circ Res (2008) 1.48
Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency. J Biol Chem (2004) 1.47
Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med (2011) 1.46
Regulation of the cytoplasmic quality control protein degradation pathway by BAG2. J Biol Chem (2005) 1.46
Genomewide clonal analysis of lethal mutations in the Drosophila melanogaster eye: comparison of the X chromosome and autosomes. Genetics (2007) 1.44
Amphiregulin: an early trigger of liver regeneration in mice. Gastroenterology (2005) 1.44
Heparin-binding epidermal growth factor-like growth factor links hepatocyte priming with cell cycle progression during liver regeneration. J Biol Chem (2004) 1.44
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CHIP, a cochaperone/ubiquitin ligase that regulates protein quality control, is required for maximal cardioprotection after myocardial infarction in mice. Am J Physiol Heart Circ Physiol (2005) 1.43
Build it up-Tear it down: protein quality control in the cardiac sarcomere. Cardiovasc Res (2008) 1.42
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A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. J Cell Biol (2009) 1.39
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An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP). J Biol Chem (2004) 1.36
Into the heart: the emerging role of the ubiquitin-proteasome system. J Mol Cell Cardiol (2006) 1.35
The FoxO family in cardiac function and dysfunction. Annu Rev Physiol (2010) 1.33
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Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP. J Biol Chem (2003) 1.31
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Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP. J Cell Biol (2005) 1.28
Brain CHIP: removing the culprits in neurodegenerative disease. Trends Mol Med (2006) 1.27
AtCHIP, a U-box-containing E3 ubiquitin ligase, plays a critical role in temperature stress tolerance in Arabidopsis. Plant Physiol (2003) 1.23
The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones. FASEB J (2006) 1.23
Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs. EMBO J (2002) 1.22
Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase. J Biol Chem (2004) 1.20
C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation. Arch Biochem Biophys (2003) 1.20
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Novel role for amphiregulin in protection from liver injury. J Biol Chem (2005) 1.19
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