Published in Cell Cycle on May 30, 2003
The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J Cell Biol (2009) 3.48
Cdc25 and Wee1: analogous opposites? Cell Div (2007) 1.54
A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25. Mol Biol Cell (2006) 1.31
Changes in regulatory phosphorylation of Cdc25C Ser287 and Wee1 Ser549 during normal cell cycle progression and checkpoint arrests. Mol Biol Cell (2005) 1.13
Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos. Development (2011) 0.92
A quantitative model of the effect of unreplicated DNA on cell cycle progression in frog egg extracts. J Theor Biol (2009) 0.76
Chk'n out in mitosis. Cell Cycle (2003) 0.75
DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science (2002) 4.88
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat Genet (2004) 3.89
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Nat Genet (2002) 3.32
The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway. Aging (Albany NY) (2010) 3.27
Pseudo-DNA damage response in senescent cells. Cell Cycle (2009) 2.93
Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell (2006) 2.39
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat Immunol (2005) 2.31
Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture. Oncotarget (2011) 2.28
Radiation metabolomics. 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice. Radiat Res (2008) 2.27
Cellular quiescence caused by the Mdm2 inhibitor nutlin-3A. Cell Cycle (2009) 2.22
Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint. Cell Cycle (2003) 2.10
Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients. Cancer Res (2004) 2.04
Differential responses of stress genes to low dose-rate gamma irradiation. Mol Cancer Res (2003) 2.01
Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen. Cancer Res (2008) 2.01
Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation. J Biol Chem (2003) 1.97
Dishevelled mediates ephrinB1 signalling in the eye field through the planar cell polarity pathway. Nat Cell Biol (2005) 1.95
Hypoxia suppresses conversion from proliferative arrest to cellular senescence. Proc Natl Acad Sci U S A (2012) 1.83
Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53. Cancer Res (2002) 1.71
p38 MAP kinase's emerging role as a tumor suppressor. Adv Cancer Res (2004) 1.64
Phosphorylation site interdependence of human p53 post-translational modifications in response to stress. J Biol Chem (2003) 1.63
UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation. Anal Chem (2008) 1.61
Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice. Radiat Res (2009) 1.59
Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a. Oncogene (2002) 1.59
Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nat Cell Biol (2003) 1.58
GSK-3 as potential target for therapeutic intervention in cancer. Oncotarget (2014) 1.56
ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth. Oncogene (2002) 1.55
Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells. Cell Cycle (2012) 1.53
Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity (2002) 1.53
Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med (2006) 1.53
The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway. Nat Immunol (2005) 1.52
The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia. Mol Cell Biol (2002) 1.48
Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis. Proc Natl Acad Sci U S A (2005) 1.47
p38 and Chk1 kinases: different conductors for the G(2)/M checkpoint symphony. Curr Opin Genet Dev (2002) 1.43
Stress-specific signatures: expression profiling of p53 wild-type and -null human cells. Oncogene (2005) 1.43
Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. Development (2004) 1.41
Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a. Mol Cell Biol (2003) 1.38
Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase. Proc Natl Acad Sci U S A (2001) 1.36
Comparison of mouse urinary metabolic profiles after exposure to the inflammatory stressors γ radiation and lipopolysaccharide. Radiat Res (2011) 1.35
Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis. Oncogene (2005) 1.34
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response. Cancer Res (2010) 1.34
Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships. Microbiome (2013) 1.32
G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer. J Biol Chem (2003) 1.30
Functional genomics as a window on radiation stress signaling. Oncogene (2003) 1.26
MetaboLyzer: a novel statistical workflow for analyzing Postprocessed LC-MS metabolomics data. Anal Chem (2013) 1.24
Regulation of the Wip1 phosphatase and its effects on the stress response. Front Biosci (Landmark Ed) (2012) 1.24
Morphogenetic movements underlying eye field formation require interactions between the FGF and ephrinB1 signaling pathways. Dev Cell (2004) 1.24
Metabolomic analysis in severe childhood pneumonia in the Gambia, West Africa: findings from a pilot study. PLoS One (2010) 1.19
Senescent growth arrest in mesenchymal stem cells is bypassed by Wip1-mediated downregulation of intrinsic stress signaling pathways. Stem Cells (2009) 1.18
Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development. Cancer Res (2003) 1.17
Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors. Cancer Res (2005) 1.16
Step-wise specification of retinal stem cells during normal embryogenesis. Biol Cell (2005) 1.15
Cytokine-driven cell cycling is mediated through Cdc25A. J Cell Biol (2005) 1.15
Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse. J Proteome Res (2010) 1.13
Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress. Cancer Res (2010) 1.12
Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion. Dev Biol (2008) 1.12
Gadd45 in stress signaling, cell cycle control, and apoptosis. Adv Exp Med Biol (2013) 1.11
Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis. Cancer Biol Ther (2005) 1.09
Morphogenesis during Xenopus gastrulation requires Wee1-mediated inhibition of cell proliferation. Development (2004) 1.09
Boolean relationships among genes responsive to ionizing radiation in the NCI 60 ACDS. Bioinformatics (2004) 1.08
Development of urinary biomarkers for internal exposure by cesium-137 using a metabolomics approach in mice. Radiat Res (2013) 1.08
Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact. Nat Rev Drug Discov (2010) 1.08
t4 workshop report: Pathways of Toxicity. ALTEX (2013) 1.06
p38 Mitogen-activated protein kinase inhibitor protects the epidermis against the acute damaging effects of ultraviolet irradiation by blocking apoptosis and inflammatory responses. J Invest Dermatol (2004) 1.06
Advances in targeting signal transduction pathways. Oncotarget (2012) 1.06
Enhanced intestinal tumor multiplicity and grade in vivo after HZE exposure: mouse models for space radiation risk estimates. Radiat Environ Biophys (2010) 1.05
UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model. J Proteome Res (2011) 1.05
Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone. PLoS One (2011) 1.05
Activating p38 MAPK: new tricks for an old kinase. Cell Cycle (2005) 1.05
Detection of Radiation-Exposure Biomarkers by Differential Mobility Prefiltered Mass Spectrometry (DMS-MS). Int J Mass Spectrom (2010) 1.04
A functional role for p38 MAPK in modulating mitotic transit in the absence of stress. J Biol Chem (2007) 1.04
Heavy ion radiation exposure triggered higher intestinal tumor frequency and greater β-catenin activation than γ radiation in APC(Min/+) mice. PLoS One (2013) 1.03
Induction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organs. Biol Cell (2005) 1.03
Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine. PLoS One (2012) 1.03
Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cells. Toxicol Appl Pharmacol (2004) 1.02
foxD5 plays a critical upstream role in regulating neural ectodermal fate and the onset of neural differentiation. Dev Biol (2009) 1.02
Cloning and characterization of the 5'-flanking region of the rat neuron-specific Class III beta-tubulin gene. Gene (2002) 1.00
The effect of low dose rate on metabolomic response to radiation in mice. Radiat Environ Biophys (2014) 1.00
Functional genomics of UV radiation responses in human cells. Mutat Res (2004) 0.99
Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase. J Biol Chem (2009) 0.99
Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK. J Biol Chem (2005) 0.99
Gadd45a regulates matrix metalloproteinases by suppressing DeltaNp63alpha and beta-catenin via p38 MAP kinase and APC complex activation. Oncogene (2004) 0.99
Characterization and interlaboratory comparison of a gene expression signature for differentiating genotoxic mechanisms. Toxicol Sci (2009) 0.99
Gadd34 requirement for normal hemoglobin synthesis. Mol Cell Biol (2006) 0.99
Development of a metabolomic radiation signature in urine from patients undergoing total body irradiation. Radiat Res (2014) 0.98
Metabolomic and lipidomic analysis of serum from mice exposed to an internal emitter, cesium-137, using a shotgun LC-MS(E) approach. J Proteome Res (2014) 0.98
G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin. J Biol Chem (2006) 0.98
Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells. Cell Cycle (2005) 0.97
Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycin. PLoS One (2011) 0.97
Paclitaxel induces primary and postmitotic G1 arrest in human arterial smooth muscle cells. Cell Cycle (2004) 0.96
Gadd34 functional domains involved in growth suppression and apoptosis. Oncogene (2003) 0.95
Monitoring human radiation exposure by gene expression profiling: possibilities and pitfalls. Health Phys (2003) 0.95
Alterations of rx1 and pax6 expression levels at neural plate stages differentially affect the production of retinal cell types and maintenance of retinal stem cell qualities. Dev Biol (2007) 0.95
Neural induction and factors that stabilize a neural fate. Birth Defects Res C Embryo Today (2009) 0.95
S6K in geroconversion. Cell Cycle (2013) 0.94
p21 (CDKN1A) is a negative regulator of p53 stability. Cell Cycle (2007) 0.91