Published in Adv Cancer Res on January 01, 2004
Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer (2009) 9.33
Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer (2007) 6.58
p38(MAPK): stress responses from molecular mechanisms to therapeutics. Trends Mol Med (2009) 2.44
Targeting innate immunity protein kinase signalling in inflammation. Nat Rev Drug Discov (2009) 2.01
MEK and the inhibitors: from bench to bedside. J Hematol Oncol (2013) 1.90
Role of p38 MAP Kinase Signal Transduction in Solid Tumors. Genes Cancer (2013) 1.73
CXCR4 chemokine receptor mediates prostate tumor cell adhesion through alpha5 and beta3 integrins. Neoplasia (2006) 1.52
ERK1/2 and p38α/β signaling in tumor cell quiescence: opportunities to control dormant residual disease. Clin Cancer Res (2011) 1.44
Computational identification of a p38SAPK-regulated transcription factor network required for tumor cell quiescence. Cancer Res (2009) 1.41
Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther (2007) 1.38
Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. J Biol Chem (2011) 1.23
Radiation metabolomics and its potential in biodosimetry. Int J Radiat Biol (2011) 1.20
Opposing roles of mitogenic and stress signaling pathways in the induction of cancer dormancy. Cell Cycle (2006) 1.19
Tumor cell dormancy induced by p38SAPK and ER-stress signaling: an adaptive advantage for metastatic cells? Cancer Biol Ther (2006) 1.16
The HBP1 transcriptional repressor participates in RAS-induced premature senescence. Mol Cell Biol (2006) 1.16
The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress. EMBO J (2012) 1.12
A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis. EMBO J (2007) 1.10
Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence. Trends Biochem Sci (2014) 1.10
Digitoxin and its analogs as novel cancer therapeutics. Exp Hematol Oncol (2012) 1.06
Cell density-dependent inhibition of epidermal growth factor receptor signaling by p38alpha mitogen-activated protein kinase via Sprouty2 downregulation. Mol Cell Biol (2009) 1.04
Signaling pathway networks mined from human pituitary adenoma proteomics data. BMC Med Genomics (2010) 1.03
Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders. Eur J Hum Genet (2011) 0.99
Reverse-phase phosphoproteome analysis of signaling pathways induced by Rift valley fever virus in human small airway epithelial cells. PLoS One (2010) 0.98
Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening. Mol Cancer Ther (2011) 0.94
Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth. J Biol Chem (2011) 0.91
Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 MAPK and ROS. PLoS One (2013) 0.90
Interactions between IGF-I, estrogen receptor-α (ERα), and ERβ in regulating growth/apoptosis of MCF-7 human breast cancer cells. J Endocrinol (2010) 0.90
Expression of MMP-9 and WAVE3 in colorectal cancer and its relationship to clinicopathological features. J Cancer Res Clin Oncol (2012) 0.89
Type III transforming growth factor-beta (TGF-beta) receptor mediates apoptosis in renal cell carcinoma independent of the canonical TGF-beta signaling pathway. Clin Cancer Res (2008) 0.88
Mitogen-activated protein kinase signaling pathway and invasion and metastasis of gastric cancer. World J Gastroenterol (2015) 0.86
LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1). PLoS One (2011) 0.86
p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis. Genes Dev (2016) 0.85
Chemoembolisation of rat colorectal liver metastases with drug eluting beads loaded with irinotecan or doxorubicin. Clin Exp Metastasis (2008) 0.85
Long-term temozolomide treatment induces marked amino metabolism modifications and an increase in TMZ sensitivity in Hs683 oligodendroglioma cells. Neoplasia (2010) 0.84
Loss of p38δ mitogen-activated protein kinase expression promotes oesophageal squamous cell carcinoma proliferation, migration and anchorage-independent growth. Int J Oncol (2013) 0.84
The tyrosine kinase c-Met contributes to the pro-tumorigenic function of the p38 kinase in human bile duct cholangiocarcinoma cells. J Biol Chem (2012) 0.82
The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines. Int J Oncol (2014) 0.82
p38 MAPK inhibits breast cancer metastasis through regulation of stromal expansion. Int J Cancer (2014) 0.82
The effects of chromium(VI) on the thioredoxin system: implications for redox regulation. Free Radic Biol Med (2012) 0.81
HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence. Mol Cell Biol (2012) 0.81
p38δ MAPK: Emerging Roles of a Neglected Isoform. Int J Cell Biol (2014) 0.81
TIMP3 controls cell fate to confer hepatocellular carcinoma resistance. Oncogene (2014) 0.81
HPV16 E7-dependent transformation activates NHE1 through a PKA-RhoA-induced inhibition of p38alpha. PLoS One (2008) 0.80
Senescence in adipose-derived stem cells and its implications in nerve regeneration. Neural Regen Res (2014) 0.80
Tumorigenicity of MCF-7 human breast cancer cells lacking the p38α mitogen-activated protein kinase. J Endocrinol (2010) 0.79
Differential sensitivity of human endometrial carcinoma cells with different PTEN expression to mitogen-activated protein kinase signaling inhibits and implications for therapy. J Cancer Res Clin Oncol (2010) 0.78
OSU-DY7, a novel D-tyrosinol derivative, mediates cytotoxicity in chronic lymphocytic leukaemia and Burkitt lymphoma through p38 mitogen-activated protein kinase pathway. Br J Haematol (2011) 0.78
Anticancer effect of Tamarix gallica extracts on human colon cancer cells involves Erk1/2 and p38 action on G2/M cell cycle arrest. Cytotechnology (2013) 0.77
Cancer suppression by systemic inactivation of p38MAPK. Oncotarget (2017) 0.75
A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs. Sci Rep (2017) 0.75
p38 mitogen-activated protein kinase inhibits USP22 transcription in HeLa cells. Biomed Rep (2015) 0.75
Identification of Poor-outcome Biliopancreatic Carcinoma Patients With Two-marker Signature Based on ATF6α and p-p38 "STARD Compliant". Medicine (Baltimore) (2015) 0.75
Deoxyarbutin displays antitumour activity against melanoma in vitro and in vivo through a p38-mediated mitochondria associated apoptotic pathway. Sci Rep (2017) 0.75
DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science (2002) 4.88
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat Genet (2004) 3.89
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Nat Genet (2002) 3.32
Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell (2006) 2.39
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat Immunol (2005) 2.31
Radiation metabolomics. 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice. Radiat Res (2008) 2.27
Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint. Cell Cycle (2003) 2.10
Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients. Cancer Res (2004) 2.04
Differential responses of stress genes to low dose-rate gamma irradiation. Mol Cancer Res (2003) 2.01
Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen. Cancer Res (2008) 2.01
Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation. J Biol Chem (2003) 1.97
Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53. Cancer Res (2002) 1.71
Phosphorylation site interdependence of human p53 post-translational modifications in response to stress. J Biol Chem (2003) 1.63
UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation. Anal Chem (2008) 1.61
Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice. Radiat Res (2009) 1.59
Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a. Oncogene (2002) 1.59
Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nat Cell Biol (2003) 1.58
ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth. Oncogene (2002) 1.55
Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity (2002) 1.53
Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med (2006) 1.53
The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway. Nat Immunol (2005) 1.52
Phosphorylation of Xenopus Cdc25C at Ser285 interferes with ability to activate a DNA damage replication checkpoint in pre-midblastula embryos. Cell Cycle (2003) 1.48
Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis. Proc Natl Acad Sci U S A (2005) 1.47
p38 and Chk1 kinases: different conductors for the G(2)/M checkpoint symphony. Curr Opin Genet Dev (2002) 1.43
Stress-specific signatures: expression profiling of p53 wild-type and -null human cells. Oncogene (2005) 1.43
Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a. Mol Cell Biol (2003) 1.38
Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase. Proc Natl Acad Sci U S A (2001) 1.36
Comparison of mouse urinary metabolic profiles after exposure to the inflammatory stressors γ radiation and lipopolysaccharide. Radiat Res (2011) 1.35
Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis. Oncogene (2005) 1.34
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response. Cancer Res (2010) 1.34
Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships. Microbiome (2013) 1.32
G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer. J Biol Chem (2003) 1.30
Functional genomics as a window on radiation stress signaling. Oncogene (2003) 1.26
MetaboLyzer: a novel statistical workflow for analyzing Postprocessed LC-MS metabolomics data. Anal Chem (2013) 1.24
Regulation of the Wip1 phosphatase and its effects on the stress response. Front Biosci (Landmark Ed) (2012) 1.24
Metabolomic analysis in severe childhood pneumonia in the Gambia, West Africa: findings from a pilot study. PLoS One (2010) 1.19
Senescent growth arrest in mesenchymal stem cells is bypassed by Wip1-mediated downregulation of intrinsic stress signaling pathways. Stem Cells (2009) 1.18
Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development. Cancer Res (2003) 1.17
Cytokine-driven cell cycling is mediated through Cdc25A. J Cell Biol (2005) 1.15
Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse. J Proteome Res (2010) 1.13
Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress. Cancer Res (2010) 1.12
Gadd45 in stress signaling, cell cycle control, and apoptosis. Adv Exp Med Biol (2013) 1.11
Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis. Cancer Biol Ther (2005) 1.09
Boolean relationships among genes responsive to ionizing radiation in the NCI 60 ACDS. Bioinformatics (2004) 1.08
Development of urinary biomarkers for internal exposure by cesium-137 using a metabolomics approach in mice. Radiat Res (2013) 1.08
Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact. Nat Rev Drug Discov (2010) 1.08
t4 workshop report: Pathways of Toxicity. ALTEX (2013) 1.06
p38 Mitogen-activated protein kinase inhibitor protects the epidermis against the acute damaging effects of ultraviolet irradiation by blocking apoptosis and inflammatory responses. J Invest Dermatol (2004) 1.06
Enhanced intestinal tumor multiplicity and grade in vivo after HZE exposure: mouse models for space radiation risk estimates. Radiat Environ Biophys (2010) 1.05
UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model. J Proteome Res (2011) 1.05
Activating p38 MAPK: new tricks for an old kinase. Cell Cycle (2005) 1.05
Detection of Radiation-Exposure Biomarkers by Differential Mobility Prefiltered Mass Spectrometry (DMS-MS). Int J Mass Spectrom (2010) 1.04
A functional role for p38 MAPK in modulating mitotic transit in the absence of stress. J Biol Chem (2007) 1.04
Heavy ion radiation exposure triggered higher intestinal tumor frequency and greater β-catenin activation than γ radiation in APC(Min/+) mice. PLoS One (2013) 1.03
Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine. PLoS One (2012) 1.03
Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cells. Toxicol Appl Pharmacol (2004) 1.02
The effect of low dose rate on metabolomic response to radiation in mice. Radiat Environ Biophys (2014) 1.00
Functional genomics of UV radiation responses in human cells. Mutat Res (2004) 0.99
Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase. J Biol Chem (2009) 0.99
Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK. J Biol Chem (2005) 0.99
Gadd45a regulates matrix metalloproteinases by suppressing DeltaNp63alpha and beta-catenin via p38 MAP kinase and APC complex activation. Oncogene (2004) 0.99
Gadd34 requirement for normal hemoglobin synthesis. Mol Cell Biol (2006) 0.99
Characterization and interlaboratory comparison of a gene expression signature for differentiating genotoxic mechanisms. Toxicol Sci (2009) 0.99
Development of a metabolomic radiation signature in urine from patients undergoing total body irradiation. Radiat Res (2014) 0.98
Metabolomic and lipidomic analysis of serum from mice exposed to an internal emitter, cesium-137, using a shotgun LC-MS(E) approach. J Proteome Res (2014) 0.98
G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin. J Biol Chem (2006) 0.98
Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells. Cell Cycle (2005) 0.97
Gadd34 functional domains involved in growth suppression and apoptosis. Oncogene (2003) 0.95
Monitoring human radiation exposure by gene expression profiling: possibilities and pitfalls. Health Phys (2003) 0.95
Gadd45alpha regulates p38-dependent dendritic cell cytokine production and Th1 differentiation. J Immunol (2007) 0.89
Gadd45a: an elusive yet attractive candidate gene in pancreatic cancer. Clin Cancer Res (2002) 0.88
Accelerated hematopoietic toxicity by high energy (56)Fe radiation. Int J Radiat Biol (2011) 0.88
Exposure to ionizing radiation causes long-term increase in serum estradiol and activation of PI3K-Akt signaling pathway in mouse mammary gland. Int J Radiat Oncol Biol Phys (2012) 0.87
Tumor susceptibility and apoptosis defect in a mouse strain expressing a human p53 transgene. Cancer Res (2006) 0.86
Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J Biol Chem (2004) 0.86
Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production. Aging (Albany NY) (2013) 0.85
Zap70 functions to maintain stemness of mouse embryonic stem cells by negatively regulating Jak1/Stat3/c-Myc signaling. Stem Cells (2010) 0.85
Modulation of fatty acid and bile acid metabolism by peroxisome proliferator-activated receptor α protects against alcoholic liver disease. Alcohol Clin Exp Res (2014) 0.84
Metabolic phenotyping reveals a lipid mediator response to ionizing radiation. J Proteome Res (2014) 0.84
High-energy particle-induced tumorigenesis throughout the gastrointestinal tract. Radiat Res (2014) 0.84
Toxicogenomics: overview and potential applications for the study of non-covalent DNA interacting chemicals. Mutat Res (2007) 0.84
The dark side of light: the damaging effects of UV rays and the protective efforts of MAP kinase signaling in the epidermis. DNA Repair (Amst) (2004) 0.82
Neural tube development requires the cooperation of p53- and Gadd45a-associated pathways. Birth Defects Res A Clin Mol Teratol (2006) 0.82
Sex-dependent differences in intestinal tumorigenesis induced in Apc1638N/+ mice by exposure to γ rays. Int J Radiat Oncol Biol Phys (2012) 0.81
Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland. Radiat Oncol (2012) 0.81
Metabolomic profiling of urine samples from mice exposed to protons reveals radiation quality and dose specific differences. Radiat Res (2015) 0.81
Generation of cancerous neural stem cells forming glial tumor by oncogenic stimulation. Stem Cell Rev (2012) 0.80
Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells. Am J Physiol Renal Physiol (2006) 0.80
Loss of Gadd45a does not modify the pulmonary response to oxidative stress. Am J Physiol Lung Cell Mol Physiol (2005) 0.80
Inactivation of gadd45a sensitizes epithelial cancer cells to ionizing radiation in vivo resulting in prolonged survival. Cancer Res (2008) 0.80
Genetic toxicity assessment: employing the best science for human safety evaluation Part VII: Why not start with a single test: a transformational alternative to genotoxicity hazard and risk assessment. Toxicol Sci (2007) 0.80
Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response. Radiat Oncol (2012) 0.79
Identifying radiation exposure biomarkers from mouse blood transcriptome. Int J Bioinform Res Appl (2013) 0.79
p16Ink4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation. J Thorac Oncol (2011) 0.79
Microarray approaches for analysis of cell cycle regulatory genes. Methods Mol Biol (2004) 0.78
Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival. Food Chem Toxicol (2013) 0.78
Differential mobility spectrometry with nanospray ion source as a compact detector for small organics and inorganics. Int J Ion Mobil Spectrom (2013) 0.78
Comparative analysis of the genetic structure and chromosomal mapping of the murine Gadd45g/CR6 gene. DNA Cell Biol (2003) 0.78
Radioprotective effects of ON 01210.Na upon oral administration. J Radiat Res (2012) 0.78
Chemotherapeutic targeting of p53. Cancer Biol Ther (2002) 0.78