Published in Nat Med on June 01, 2003
Safety Study of Stem Cells Treatment in Diabetic Foot Ulcers | NCT01686139
CD133+ Cell Therapy for Refractory Coronary Heart Disease | NCT01049867
Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood (2006) 8.56
Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One (2008) 5.91
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med (2006) 5.22
Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest (2006) 4.51
Assessing identity, phenotype, and fate of endothelial progenitor cells. Arterioscler Thromb Vasc Biol (2008) 4.07
Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest (2010) 3.74
Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest (2007) 3.63
Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells. Circ Res (2008) 3.50
Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood (2010) 3.35
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci U S A (2008) 3.27
Migratory neighbors and distant invaders: tumor-associated niche cells. Genes Dev (2008) 2.95
Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells. Blood (2004) 2.95
Bronchopulmonary dysplasia: where have all the vessels gone? Roles of angiogenic growth factors in chronic lung disease. Am J Respir Crit Care Med (2007) 2.76
Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage. Am J Pathol (2006) 2.70
Engineering complex tissues. Tissue Eng (2006) 2.53
Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart. J Exp Med (2007) 2.25
Endothelial progenitor cells restore renal function in chronic experimental renovascular disease. Circulation (2009) 2.24
Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth. J Clin Invest (2005) 2.20
Myeloid lineage progenitors give rise to vascular endothelium. Proc Natl Acad Sci U S A (2006) 2.13
Generation of functional hemangioblasts from human embryonic stem cells. Nat Methods (2007) 2.06
Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells. J Exp Med (2004) 2.04
Humanized large-scale expanded endothelial colony-forming cells function in vitro and in vivo. Blood (2009) 2.00
Material-based deployment enhances efficacy of endothelial progenitor cells. Proc Natl Acad Sci U S A (2008) 1.96
Controlled activation of morphogenesis to generate a functional human microvasculature in a synthetic matrix. Blood (2011) 1.91
Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells. Circ Res (2008) 1.87
Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue. Curr Opin Hematol (2006) 1.86
Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis. Blood (2007) 1.79
Concise review: bone marrow-derived stem/progenitor cells in cutaneous repair and regeneration. Stem Cells (2010) 1.78
Therapeutic potential of vasculogenesis and osteogenesis promoted by peripheral blood CD34-positive cells for functional bone healing. Am J Pathol (2006) 1.75
Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors. J Clin Invest (2005) 1.74
Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression. Cell (2012) 1.74
Tie2 activation contributes to hemangiogenic regeneration after myelosuppression. Blood (2005) 1.73
Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells. Biomaterials (2007) 1.72
Endothelial progenitor cells in neovascularization of infarcted myocardium. J Mol Cell Cardiol (2008) 1.69
In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma. Cancer Cell (2007) 1.68
Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization. Arterioscler Thromb Vasc Biol (2009) 1.67
Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing. Antioxid Redox Signal (2008) 1.66
Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers. Tissue Eng Part A (2011) 1.66
Two-component protein-engineered physical hydrogels for cell encapsulation. Proc Natl Acad Sci U S A (2009) 1.63
Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels. Adv Funct Mater (2012) 1.63
A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature. J Clin Invest (2006) 1.62
Transplanted endothelial cells repopulate the liver endothelium and correct the phenotype of hemophilia A mice. J Clin Invest (2008) 1.62
Diabetes irreversibly depletes bone marrow-derived mesenchymal progenitor cell subpopulations. Diabetes (2014) 1.61
Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities. BMC Med Genomics (2010) 1.60
Endothelial progenitor cells and a stromal cell-derived factor-1α analogue synergistically improve survival in sepsis. Am J Respir Crit Care Med (2014) 1.59
Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy. Nat Chem Biol (2011) 1.58
Mobilized human hematopoietic stem/progenitor cells promote kidney repair after ischemia/reperfusion injury. Circulation (2010) 1.58
Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med (2006) 1.56
Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis. J Am Coll Cardiol (2008) 1.55
Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia. Circ Res (2008) 1.52
Telocytes as supporting cells for myocardial tissue organization in developing and adult heart. J Cell Mol Med (2010) 1.52
Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging. FASEB J (2005) 1.52
Regeneration: Thomas Hunt Morgan's window into development. J Hist Biol (2010) 1.46
Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: contrasting, overlapping and compensatory functions. Biochim Biophys Acta (2009) 1.46
Brain endothelial dysfunction in cerebral adrenoleukodystrophy. Brain (2015) 1.42
Circulating endothelial cells, endothelial progenitor cells, and endothelial microparticles in cancer. Neoplasia (2006) 1.41
Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosis. Fibrogenesis Tissue Repair (2008) 1.37
CD133+ renal progenitor cells contribute to tumor angiogenesis. Am J Pathol (2006) 1.36
Hypoxia and stem cell-based engineering of mesenchymal tissues. Biotechnol Prog (2009) 1.36
The role of dendritic cell precursors in tumour vasculogenesis. Br J Cancer (2005) 1.35
Peripheral blood stem cell mobilization: new regimens, new cells, where do we stand. Curr Opin Hematol (2008) 1.33
Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins. Proc Natl Acad Sci U S A (2004) 1.33
Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature. Angiogenesis (2009) 1.31
Endothelial cell differentiation of human breast tumour stem/progenitor cells. J Cell Mol Med (2009) 1.30
Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing. J Clin Invest (2012) 1.29
Human CD34/CD90 ASCs are capable of growing as sphere clusters, producing high levels of VEGF and forming capillaries. PLoS One (2009) 1.29
Heart valve tissue engineering: concepts, approaches, progress, and challenges. Ann Biomed Eng (2006) 1.26
Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: a combined gene therapy-cell transplantation approach. Proc Natl Acad Sci U S A (2008) 1.25
Biomaterials approach to expand and direct differentiation of stem cells. Mol Ther (2007) 1.24
Engineered alginate hydrogels for effective microfluidic capture and release of endothelial progenitor cells from whole blood. Langmuir (2011) 1.23
HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature. Dev Cell (2006) 1.23
Biologic properties of endothelial progenitor cells and their potential for cell therapy. Prog Cardiovasc Dis (2007) 1.22
Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. PLoS One (2010) 1.21
Clinical and therapeutical implications of EPC biology in atherosclerosis. J Cell Mol Med (2006) 1.18
Isolation, characterization, and in vitro propagation of infantile hemangioma stem cells and an in vivo mouse model. J Hematol Oncol (2011) 1.18
Endothelial colony-forming cells from preterm infants are increased and more susceptible to hyperoxia. Am J Respir Crit Care Med (2009) 1.17
Endothelial progenitor cells, cardiovascular risk factors, cytokine levels and atherosclerosis--results from a large population-based study. PLoS One (2007) 1.16
Role of endothelial progenitor cells during ischemia-induced vasculogenesis and collateral formation. Microvasc Res (2010) 1.16
Stromal cell-derived factor-1 stimulates vasculogenesis and enhances Ewing's sarcoma tumor growth in the absence of vascular endothelial growth factor. Int J Cancer (2008) 1.16
Phage nanofibers induce vascularized osteogenesis in 3D printed bone scaffolds. Adv Mater (2014) 1.16
Beneficial effects of concurrent autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the mouse hindlimb. Proc Natl Acad Sci U S A (2005) 1.15
Bone marrow and the control of immunity. Cell Mol Immunol (2011) 1.15
Oxidative stress impairs endothelial progenitor cell function. Antioxid Redox Signal (2008) 1.15
Vascular wall-resident CD44+ multipotent stem cells give rise to pericytes and smooth muscle cells and contribute to new vessel maturation. PLoS One (2011) 1.14
Endothelial differentiation of mesenchymal stromal cells. PLoS One (2012) 1.14
Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury. Respir Res (2007) 1.14
Adult stem cells and their trans-differentiation potential--perspectives and therapeutic applications. J Mol Med (Berl) (2008) 1.12
Sept4/ARTS regulates stem cell apoptosis and skin regeneration. Science (2013) 1.11
Circulating endothelial progenitor cells in patients with cardiac syndrome X. Heart (2006) 1.11
Engineering of multifunctional gels integrating highly efficient growth factor delivery with endothelial cell transplantation. FASEB J (2008) 1.11
Gelatinase B/MMP-9 in Tumour Pathogenesis and Progression. Cancers (Basel) (2014) 1.10
Erythropoietin promotes the growth of tumors lacking its receptor and decreases survival of tumor-bearing mice by enhancing angiogenesis. Neoplasia (2008) 1.08
Sca-1 identifies the tumor-initiating cells in mammary tumors of BALB-neuT transgenic mice. Neoplasia (2008) 1.07
Endothelial progenitor cells and integrins: adhesive needs. Fibrogenesis Tissue Repair (2012) 1.07
EPCs and pathological angiogenesis: when good cells go bad. Microvasc Res (2010) 1.07
Bone marrow mesenchymal stem cells can differentiate and assume corneal keratocyte phenotype. J Cell Mol Med (2012) 1.06
Stem cell therapy for retinal diseases: update. Stem Cell Res Ther (2011) 1.05
Retracted Peripheral blood mono-nuclear cells implantation in patients with peripheral arterial disease: a pilot study for clinical and biochemical outcome of neoangiogenesis. BMC Surg (2012) 1.04
Adiponectin promotes endothelial progenitor cell number and function. FEBS Lett (2008) 1.04
Recent insights into the mechanisms of vasospastic angina. Korean Circ J (2009) 1.03
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature (2005) 15.57
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med (2012) 11.14
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell (2002) 9.36
Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science (2003) 7.86
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J Clin Invest (2008) 5.96
The metastatic niche: adapting the foreign soil. Nat Rev Cancer (2009) 5.28
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med (2006) 5.22
Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? Nat Rev Cancer (2002) 5.02
Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature (2010) 4.78
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med (2003) 4.69
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med (2002) 4.00
The perivascular niche regulates breast tumour dormancy. Nat Cell Biol (2013) 3.36
Migratory neighbors and distant invaders: tumor-associated niche cells. Genes Dev (2008) 2.95
Preparing the "soil": the premetastatic niche. Cancer Res (2006) 2.92
The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts. Semin Cancer Biol (2011) 2.83
AC133/CD133/Prominin-1. Int J Biochem Cell Biol (2005) 2.80
Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent. Nat Biotechnol (2010) 2.54
Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ Res (2002) 2.03
Bone marrow cells in the 'pre-metastatic niche': within bone and beyond. Cancer Metastasis Rev (2006) 1.89
Niche-to-niche migration of bone-marrow-derived cells. Trends Mol Med (2007) 1.72
The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis. Neoplasia (2013) 1.58
Neoangiogenesis contributes to the development of hemophilic synovitis. Blood (2010) 1.48
Priming the 'soil' for breast cancer metastasis: the pre-metastatic niche. Breast Dis (2007) 1.47
The evolution of the cancer niche during multistage carcinogenesis. Nat Rev Cancer (2013) 1.36
Contribution of marrow-derived progenitors to vascular and cardiac regeneration. Semin Cell Dev Biol (2002) 1.31
Cancer. A few to flip the angiogenic switch. Science (2008) 1.30
STAT3 negatively regulates thyroid tumorigenesis. Proc Natl Acad Sci U S A (2012) 1.23
S100 chemokines mediate bookmarking of premetastatic niches. Nat Cell Biol (2006) 1.17
Regulation of vasculogenesis by platelet-mediated recruitment of bone marrow-derived cells. Arterioscler Thromb Vasc Biol (2007) 1.13
A catalytic role for proangiogenic marrow-derived cells in tumor neovascularization. Cancer Cell (2008) 1.04
Stat3 mediates expression of autotaxin in breast cancer. PLoS One (2011) 1.03
Medulloblastoma subgroups remain stable across primary and metastatic compartments. Acta Neuropathol (2015) 1.00
Roadblocks to translational advances on metastasis research. Nat Med (2013) 0.98
Inflammation joins the "niche". Cancer Cell (2008) 0.94
p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow. Proc Natl Acad Sci U S A (2005) 0.89
Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes. Mol Biol Cell (2013) 0.88
Patterns of failure using a conformal radiation therapy tumor bed boost for medulloblastoma. J Clin Oncol (2003) 0.87
A phase II trial of carboplatin for intraocular retinoblastoma. Pediatr Blood Cancer (2007) 0.87
Macromolecular crowding meets tissue engineering by self-assembly: a paradigm shift in regenerative medicine. Adv Mater (2014) 0.86
Primary leptomeningeal primitive neuroectodermal tumor. J Neurooncol (2003) 0.85
Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis. PLoS One (2009) 0.84
Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas. J Clin Invest (2010) 0.83
Epstein-Barr virus-associated lymphoma in a child undergoing an autologous stem cell rescue. J Pediatr Hematol Oncol (2002) 0.83
Molecular diagnostics in paediatric glial tumours. Lancet Oncol (2013) 0.78
A TeNaCious foundation for the metastatic niche. Cancer Cell (2011) 0.77
Chapter 11. The role of bone marrow-derived cells in tumor angiogenesis and metastatic progression. Methods Enzymol (2008) 0.77
A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma. J Clin Invest (2017) 0.75
Corrigendum: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med (2016) 0.75