Adult stem cells and their trans-differentiation potential--perspectives and therapeutic applications.

PubWeight™: 1.12‹?› | Rank: Top 10%

🔗 View Article (PMC 2954191)

Published in J Mol Med (Berl) on July 16, 2008

Authors

Sabine Hombach-Klonisch1, Soumya Panigrahi, Iran Rashedi, Anja Seifert, Esteban Alberti, Paola Pocar, Maciej Kurpisz, Klaus Schulze-Osthoff, Andrzej Mackiewicz, Marek Los

Author Affiliations

1: Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Canada.

Articles citing this

Cytosine methylation dysregulation in neonates following intrauterine growth restriction. PLoS One (2010) 2.10

Human CD34/CD90 ASCs are capable of growing as sphere clusters, producing high levels of VEGF and forming capillaries. PLoS One (2009) 1.29

Characterization of stem and progenitor cells in the dental pulp of erupted and unerupted murine molars. Bone (2010) 1.07

Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELM alpha) recruits bone marrow-derived cells to the murine pulmonary vasculature. PLoS One (2010) 1.01

Pituitary stem cell update and potential implications for treating hypopituitarism. Endocr Rev (2011) 0.99

Paracrine molecules of mesenchymal stem cells for hematopoietic stem cell niche. Bone Marrow Res (2011) 0.96

Cancer stem cells as targets for cancer therapy: selected cancers as examples. Arch Immunol Ther Exp (Warsz) (2008) 0.95

Human dental pulp stem cells produce mineralized matrix in 2D and 3D cultures. Eur J Histochem (2010) 0.94

Nestin negatively regulates postsynaptic differentiation of the neuromuscular synapse. Nat Neurosci (2011) 0.89

Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation potential. Stem Cells Int (2013) 0.88

Stem cells isolated from adipose tissue of obese patients show changes in their transcriptomic profile that indicate loss in stemcellness and increased commitment to an adipocyte-like phenotype. BMC Genomics (2013) 0.87

Adult human brain neural progenitor cells (NPCs) and fibroblast-like cells have similar properties in vitro but only NPCs differentiate into neurons. PLoS One (2012) 0.87

Pre-transplantation specification of stem cells to cardiac lineage for regeneration of cardiac tissue. Stem Cell Rev (2009) 0.83

Isolation and characterization of novel, highly proliferative human CD34/CD73-double-positive testis-derived stem cells for cell therapy. Stem Cells Dev (2013) 0.83

Evidence for bone marrow adult stem cell plasticity: properties, molecular mechanisms, negative aspects, and clinical applications of hematopoietic and mesenchymal stem cells transdifferentiation. Stem Cells Int (2013) 0.83

Positron emission tomography-computer tomography scan used as a monitoring tool following cellular therapy in cerebral palsy and mental retardation-a case report. Case Rep Neurol Med (2013) 0.83

Nestin-expressing cells in the developing, mature and noise-exposed cochlear epithelium. Mol Cell Neurosci (2011) 0.80

Inmunohistochemical profile of solid cell nest of thyroid gland. Endocr Pathol (2011) 0.80

Activation of type II cells into regenerative stem cell antigen-1(+) cells during alveolar repair. Am J Respir Cell Mol Biol (2015) 0.80

Minor salivary glands of the lips: a novel, easily accessible source of potential stem/progenitor cells. Clin Oral Investig (2013) 0.79

The role of purinergic receptors in stem cell differentiation. Comput Struct Biotechnol J (2014) 0.78

Bone marrow-derived stromal cell therapy in cirrhosis: clinical evidence, cellular mechanisms, and implications for the treatment of hepatocellular carcinoma. Int J Radiat Oncol Biol Phys (2014) 0.78

Expression of neural cell adhesion molecule and polysialic acid in human bone marrow-derived mesenchymal stromal cells. Stem Cell Res Ther (2016) 0.75

Expression of the clustered NeuAcα2-3Galβ O-glycan determines the cell differentiation state of the cells. J Biol Chem (2014) 0.75

CD117(+)CD44(+) Stem T Cells Develop in the Thymus and Potently Suppress T-cell Proliferation by Modulating the CTLA-4 Pathway. Stem Cell Res Ther (2017) 0.75

Potential involvement of the stem cell factor receptor c-kit in alopecia areata and androgenetic alopecia: histopathological, immunohistochemical, and semiquantitative investigations. Acta Histochem Cytochem (2010) 0.75

Articles cited by this

(truncated to the top 100)

Multilineage potential of adult human mesenchymal stem cells. Science (1999) 66.19

Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell (2005) 24.00

Pluripotency of mesenchymal stem cells derived from adult marrow. Nature (2002) 19.57

Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell (1998) 19.05

Generation of a functional mammary gland from a single stem cell. Nature (2006) 18.30

Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell (2001) 12.42

Satellite cell of skeletal muscle fibers. J Biophys Biochem Cytol (1961) 11.41

Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med (2000) 11.35

Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci U S A (2000) 10.88

Muscle regeneration by bone marrow-derived myogenic progenitors. Science (1998) 10.66

Long-term trends in the incidence of and survival with heart failure. N Engl J Med (2002) 10.37

Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood (2000) 9.24

Bone marrow as a potential source of hepatic oval cells. Science (1999) 8.52

Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature (1999) 7.73

Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest (2001) 7.20

Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A (2001) 7.19

Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med (2003) 7.14

Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature (2003) 6.92

Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol (2001) 6.76

From marrow to brain: expression of neuronal phenotypes in adult mice. Science (2000) 6.53

Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature (2003) 6.35

Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science (2000) 6.16

Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest (2000) 5.88

Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med (1989) 5.81

Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. Dev Biol (2002) 5.74

Regenerating the heart. Nat Biotechnol (2005) 5.58

Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci U S A (1999) 5.20

Plasticity of adult stem cells. Cell (2004) 5.13

Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells. J Cell Biol (2000) 5.04

A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med (2004) 4.37

Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol (2006) 4.32

Pluripotency of spermatogonial stem cells from adult mouse testis. Nature (2006) 4.29

Cord-blood transplants from unrelated donors in patients with Hurler's syndrome. N Engl J Med (2004) 4.15

Liver from bone marrow in humans. Hepatology (2000) 4.10

The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood (2002) 4.02

Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations. Nat Med (2002) 3.94

Purification of a pluripotent neural stem cell from the adult mouse brain. Nature (2001) 3.78

The intestinal epithelial stem cell: the mucosal governor. Int J Exp Pathol (1997) 3.32

The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation. Circulation (2008) 3.30

Cardiac stem cells and mechanisms of myocardial regeneration. Physiol Rev (2005) 3.30

Allogeneic peripheral blood stem-cell compared with bone marrow transplantation in the management of hematologic malignancies: an individual patient data meta-analysis of nine randomized trials. J Clin Oncol (2005) 3.17

Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential. J Cell Sci (2004) 2.96

Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment. Exp Hematol (1997) 2.92

Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system. Annu Rev Med (2005) 2.92

The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci (Lond) (2005) 2.89

The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone. Blood (2005) 2.79

Stem cells in postnatal myogenesis: molecular mechanisms of satellite cell quiescence, activation and replenishment. Trends Cell Biol (2005) 2.74

Dedifferentiation of mammalian myotubes induced by msx1. Cell (2000) 2.72

Myoblast transplantation for heart failure. Lancet (2001) 2.71

Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene (2006) 2.65

In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest (2003) 2.63

Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure: clinical experience with six-month follow-up. J Am Coll Cardiol (2003) 2.56

Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation. J Am Coll Cardiol (2003) 2.35

Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures. Stem Cells (2005) 2.23

Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist Updat (2007) 2.21

Stem cells: a revolution in therapeutics-recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies. Clin Pharmacol Ther (2007) 2.19

PSA-NCAM in mammalian structural plasticity and neurogenesis. Prog Neurobiol (2006) 2.04

Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted mice. Stem Cells (2003) 2.03

Results of minimally toxic nonmyeloablative transplantation in patients with sickle cell anemia and beta-thalassemia. Biol Blood Marrow Transplant (2003) 1.81

Thy-1, a versatile modulator of signaling affecting cellular adhesion, proliferation, survival, and cytokine/growth factor responses. Biochim Biophys Acta (2006) 1.73

Dedifferentiation of lineage-committed cells by a small molecule. J Am Chem Soc (2004) 1.56

Potential of stem-cell-based therapies for heart disease. Nature (2006) 1.56

Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues. Brain (2004) 1.52

Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells. Leukemia (2005) 1.51

Targeting the EGFR pathway for cancer therapy. Curr Med Chem (2006) 1.48

The role of stem cells in skeletal and cardiac muscle repair. J Histochem Cytochem (2002) 1.44

Continuous separation of lipid particles from erythrocytes by means of laminar flow and acoustic standing wave forces. Lab Chip (2004) 1.43

Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration. Nat Clin Pract Cardiovasc Med (2006) 1.41

Plasticity, niches, and the use of stem cells. Dev Cell (2002) 1.36

Functional heterogeneity of side population cells in skeletal muscle. Biochem Biophys Res Commun (2006) 1.33

Autologous skeletal myoblast transplantation for the treatment of postinfarction myocardial injury: phase I clinical study with 12 months of follow-up. Am Heart J (2004) 1.29

Multiparameter analysis of murine bone marrow side population cells. Blood (2003) 1.28

Enrichment of human hematopoietic stem cell activity in the CD34+Thy-1+Lin- subpopulation from mobilized peripheral blood. Blood (1995) 1.26

Nuclear reprogramming: a key to stem cell function in regenerative medicine. Nat Cell Biol (2004) 1.26

The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins. Trends Pharmacol Sci (2005) 1.22

Characterization of the inducer required for the development of macrophage and granulocyte colonies. Proc Natl Acad Sci U S A (1971) 1.19

Autologous human serum for cell culture avoids the implantation of cardioverter-defibrillators in cellular cardiomyoplasty. Int J Cardiol (2004) 1.14

Detection and characterization of primitive malignant and normal progenitors in patients with acute myelogenous leukemia using long-term coculture with supportive feeder layers and cytokines. Blood (1997) 1.13

Cell differentiation and cell fate during urodele tail and limb regeneration. Curr Opin Genet Dev (2003) 1.13

Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction. Eur Heart J (2003) 1.10

Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway. J Cell Mol Med (2008) 1.09

Percutaneous trans-coronary-venous transplantation of autologous skeletal myoblasts in the treatment of post-infarction myocardial contractility impairment: the POZNAN trial. Eur Heart J (2005) 1.07

Cellular and molecular regulation of skeletal muscle side population cells. Stem Cells (2004) 1.05

Cell isolation and expansion using Dynabeads. Adv Biochem Eng Biotechnol (2007) 1.03

Biology of Isl1+ cardiac progenitor cells in development and disease. Cell Mol Life Sci (2007) 1.02

A randomized phase 2 study of PBPC mobilization by stem cell factor and filgrastim in heavily pretreated patients with Hodgkin's disease or non-Hodgkin's lymphoma. Bone Marrow Transplant (2000) 1.00

Cell fusion: an alternative to stem cell plasticity and its therapeutic implications. Curr Opin Genet Dev (2003) 1.00

Gene transfer of connexin43 into skeletal muscle. Hum Gene Ther (2004) 0.99

Quantitative evaluation of morpholino-mediated protein knockdown of GFP, MSX1, and PAX7 during tail regeneration in Ambystoma mexicanum. Dev Dyn (2005) 0.99

Characterization of peripheral blood stem cells in mice. Blood (1996) 0.97

Isolation of bone marrow-derived stem cells using density-gradient separation. Exp Hematol (2007) 0.97

Stem cell transplantation for the Wiskott-Aldrich syndrome: a single-center experience confirms efficacy of matched unrelated donor transplantation. Bone Marrow Transplant (2006) 0.96

Issues in stem cell plasticity. J Cell Mol Med (2004) 0.96

Cancer stem cells as targets for cancer therapy: selected cancers as examples. Arch Immunol Ther Exp (Warsz) (2008) 0.95

CD150 is a member of a family of genes that encode glycoproteins on the surface of hematopoietic cells. Immunogenetics (2001) 0.94

Cellular, but not direct, adenoviral delivery of vascular endothelial growth factor results in improved left ventricular function and neovascularization in dilated ischemic cardiomyopathy. J Am Coll Cardiol (2004) 0.94

Dielectrophoretic segregation of different human cell types on microscope slides. Anal Chem (2005) 0.94

Cancer-selective therapy of the future: apoptin and its mechanism of action. Cancer Biol Ther (2006) 0.94

Akt is transferred to the nucleus of cells treated with apoptin, and it participates in apoptin-induced cell death. Cell Prolif (2007) 0.93

Articles by these authors

Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med (2014) 5.65

T-helper-1-cell cytokines drive cancer into senescence. Nature (2013) 4.47

Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell (2003) 3.68

Regulation of apoptosis by alternative pre-mRNA splicing. Mol Cell (2005) 2.89

X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men. N Engl J Med (2015) 2.71

Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis. Hepatology (2011) 2.49

Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury. Hepatology (2004) 2.41

MicroRNAs play a role in spontaneous recovery from acute liver failure. Hepatology (2014) 2.23

Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist Updat (2007) 2.21

Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol Biol Cell (2002) 2.05

Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver. Hepatology (2007) 1.97

A high proportion of founder BRCA1 mutations in Polish breast cancer families. Int J Cancer (2004) 1.96

S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway. J Leukoc Biol (2008) 1.82

Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells. J Exp Med (2011) 1.81

Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A. J Biol Chem (2007) 1.75

Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFα treatment. Gut (2011) 1.75

Cancer stem cell markers in common cancers - therapeutic implications. Trends Mol Med (2008) 1.75

Effects of di(2-ethylhexyl) phthalate (DEHP) on female fertility and adipogenesis in C3H/N mice. Environ Health Perspect (2012) 1.70

Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. EMBO J (2003) 1.60

Functional characterization of p53beta and p53gamma, two isoforms of the tumor suppressor p53. Cell Cycle (2009) 1.59

Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design. Drug Discov Today (2003) 1.55

Thioredoxin in human and experimental sepsis. Crit Care Med (2009) 1.51

Targeting the EGFR pathway for cancer therapy. Curr Med Chem (2006) 1.48

Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis. J Cell Sci (2008) 1.46

Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity. Mol Cell Biol (2008) 1.44

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3. Cell Res (2009) 1.42

IκBζ is a transcriptional key regulator of CCL2/MCP-1. J Immunol (2013) 1.41

MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program. Blood (2006) 1.40

Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop. Oncogene (2003) 1.40

New approaches and therapeutics targeting apoptosis in disease. Pharmacol Rev (2005) 1.40

Apoptin, a tumor-selective killer. Biochim Biophys Acta (2009) 1.39

Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis. Fertil Steril (2013) 1.38

Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions. J Leukoc Biol (2004) 1.37

Multiple virulence factors are required for Staphylococcus aureus-induced apoptosis in endothelial cells. Cell Microbiol (2005) 1.35

SOX2 expression associates with stem cell state in human ovarian carcinoma. Cancer Res (2013) 1.34

Reactive oxygen species and sperm cells. Reprod Biol Endocrinol (2004) 1.32

Hereditary ovarian cancer in Poland. Int J Cancer (2003) 1.30

Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event. Cancer Res (2004) 1.30

Autologous skeletal myoblast transplantation for the treatment of postinfarction myocardial injury: phase I clinical study with 12 months of follow-up. Am Heart J (2004) 1.29

Guardians of cell death: the Bcl-2 family proteins. Essays Biochem (2003) 1.28

Non-apoptotic functions of caspases in cellular proliferation and differentiation. Biochem Pharmacol (2003) 1.27

Staphylococcus aureus alpha-toxin induces apoptosis in peripheral blood mononuclear cells: role of endogenous tumour necrosis factor-alpha and the mitochondrial death pathway. Cell Microbiol (2003) 1.26

p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation. Cancer Res (2006) 1.26

The multiple battles fought by anti-apoptotic p21. Cell Cycle (2007) 1.25

Caspases and cancer: mechanisms of inactivation and new treatment modalities. Exp Oncol (2004) 1.24

Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness. FASEB J (2002) 1.24

A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding. J Biol Chem (2006) 1.22

Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling. Anesthesiology (2007) 1.21

Caspase activation is associated with spontaneous recovery from acute liver failure. Hepatology (2008) 1.20

Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells. Eur J Pharmacol (2006) 1.19

S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2. Biochim Biophys Acta (2007) 1.19

The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. J Biol Chem (2007) 1.18

Expression, regulation and function of autotaxin in thyroid carcinomas. Int J Cancer (2004) 1.17

Serum cytochrome c indicates in vivo apoptosis and can serve as a prognostic marker during cancer therapy. Int J Cancer (2005) 1.17

Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B. J Invest Dermatol (2005) 1.16

Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis. J Biol Chem (2004) 1.16

Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene (2005) 1.15

Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1. FASEB J (2011) 1.14

Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells. J Invest Dermatol (2002) 1.12

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. J Biol Chem (2010) 1.12

CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function. J Exp Med (2004) 1.12

Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway. J Cell Sci (2005) 1.12

Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment. Blood (2007) 1.12

The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. Gene (2003) 1.11

Cell adhesion molecules and their relation to (cancer) cell stemness. Carcinogenesis (2014) 1.10

The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum. Hepatology (2005) 1.10

Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway. J Cell Mol Med (2008) 1.09

Impaired adrenal stress response in Toll-like receptor 2-deficient mice. Proc Natl Acad Sci U S A (2004) 1.09

Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc Natl Acad Sci U S A (2006) 1.08

Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis. J Biol Chem (2006) 1.08

Percutaneous trans-coronary-venous transplantation of autologous skeletal myoblasts in the treatment of post-infarction myocardial contractility impairment: the POZNAN trial. Eur Heart J (2005) 1.07

Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization. Mol Biol Cell (2006) 1.07

Impact of endocrine-disrupting compounds (EDCs) on female reproductive health. Mol Cell Endocrinol (2011) 1.06

Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. PLoS One (2011) 1.05

Bone marrow stromal cells produce nerve growth factor and glial cell line-derived neurotrophic factors. Biochem Biophys Res Commun (2004) 1.05

Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: differences between primary and cancer cells. Biochim Biophys Acta (2013) 1.05

Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta (2010) 1.04

Translational approaches targeting the p53 pathway for anti-cancer therapy. Br J Pharmacol (2012) 1.04

Switching Akt: from survival signaling to deadly response. Bioessays (2009) 1.03

Glycodelin-A as a paracrine regulator in early pregnancy. J Reprod Immunol (2011) 1.02

Apoptosis in liver diseases--detection and therapeutic applications. Med Sci Monit (2005) 1.02

BRCA2 mutations and androgen receptor expression as independent predictors of outcome of male breast cancer patients. Clin Cancer Res (2003) 1.01

MiRNA expression patterns predict survival in glioblastoma. Radiat Oncol (2011) 1.01

Zinc oxide nanoparticles induce necrosis and apoptosis in macrophages in a p47phox- and Nrf2-independent manner. PLoS One (2013) 0.99

Bacteria trigger oxygen radical release and sperm lipid peroxidation in in vitro model of semen inflammation. Fertil Steril (2007) 0.99

Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer Res (2009) 0.99

Caspase activation is required for antiviral treatment response in chronic hepatitis C virus infection. Hepatology (2006) 0.98

[Myoblast transplantation in the treatment of post-infarction heart failure]. Kardiol Pol (2002) 0.98

Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis. J Cell Sci (2009) 0.98

The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway. J Biol Chem (2006) 0.98

In vitro acute exposure to DEHP affects oocyte meiotic maturation, energy and oxidative stress parameters in a large animal model. PLoS One (2011) 0.98

Toxoplasma gondii inhibits Fas/CD95-triggered cell death by inducing aberrant processing and degradation of caspase 8. Cell Microbiol (2007) 0.97