Published in Virology on June 05, 2003
Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models. Hepatology (2010) 2.28
Theory of lethal mutagenesis for viruses. J Virol (2007) 2.20
The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase. J Virol (2005) 1.91
Viral determinants of resistance to treatment in patients with hepatitis C. Clin Microbiol Rev (2007) 1.65
Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo. J Virol (2009) 1.58
Detection of anti-hepatitis C virus effects of interferon and ribavirin by a sensitive replicon system. J Clin Microbiol (2005) 1.53
Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cells. PLoS One (2011) 1.47
Ribavirin improves early responses to peginterferon through improved interferon signaling. Gastroenterology (2010) 1.43
Ribavirin resistance in hepatitis C virus replicon-containing cell lines conferred by changes in the cell line or mutations in the replicon RNA. J Virol (2005) 1.28
Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue. J Virol (2007) 1.16
Mechanisms of action of interferon and ribavirin in chronic hepatitis C: Summary of a workshop. Hepatology (2008) 1.11
Analysis of ribavirin mutagenicity in human hepatitis C virus infection. J Virol (2007) 1.10
Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461. PLoS One (2011) 1.08
Reduced ribavirin antiviral efficacy via nucleoside transporter-mediated drug resistance. J Virol (2009) 1.07
Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections. PLoS Pathog (2009) 1.05
Ribavirin can be mutagenic for arenaviruses. J Virol (2011) 1.03
Examining the theory of error catastrophe. J Virol (2006) 1.00
Therapeutically targeting RNA viruses via lethal mutagenesis. Future Virol (2008) 0.99
Biochemical characterization of the fidelity of poliovirus RNA-dependent RNA polymerase. Virol J (2007) 0.99
Ribavirin enhances IFN-α signalling and MxA expression: a novel immune modulation mechanism during treatment of HCV. PLoS One (2011) 0.99
Counteracting quasispecies adaptability: extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment. PLoS One (2009) 0.94
Coevolution of the hepatitis C virus polyprotein sites in patients on combined pegylated interferon and ribavirin therapy. J Virol (2011) 0.92
Mechanism of action of ribavirin in the treatment of chronic hepatitis C. Gastroenterol Hepatol (N Y) (2007) 0.89
Roles of ITPA and IL28B genotypes in chronic hepatitis C patients treated with peginterferon plus ribavirin. Viruses (2012) 0.89
Susceptibilities of Genotype 1a, 1b, and 3 Hepatitis C Virus Variants to the NS5A Inhibitor Elbasvir. Antimicrob Agents Chemother (2015) 0.85
Does mutational robustness inhibit extinction by lethal mutagenesis in viral populations? PLoS Comput Biol (2010) 0.83
Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation. PLoS One (2013) 0.82
Ribavirin modulates the conversion of human CD4(+) CD25(-) T cell to CD4(+) CD25(+) FOXP3(+) T cell via suppressing interleukin-10-producing regulatory T cell. Immunology (2012) 0.82
Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis. PLoS One (2013) 0.81
Ribavirin enhances the action of interferon-α against hepatitis C virus by promoting the p53 activity through the ERK1/2 pathway. PLoS One (2012) 0.81
Ribavirin Contributes to Hepatitis C Virus Suppression by Augmenting pDC Activation and Type 1 IFN Production. PLoS One (2015) 0.78
Ribavirin Inhibits Parrot Bornavirus 4 Replication in Cell Culture. PLoS One (2015) 0.76
Successful Re-treatment of Hepatitis C Virus in Patients Coinfected With HIV Who Relapsed After 12 Weeks of Ledipasvir/Sofosbuvir. Clin Infect Dis (2016) 0.76
Ribavirin contributes to eradicate hepatitis C virus through polarization of T helper 1/2 cell balance into T helper 1 dominance. World J Hepatol (2015) 0.75
Evaluation of anti-HIV-1 mutagenic nucleoside analogues. J Biol Chem (2014) 0.75
Ribavirin: Past, present and future. World J Hepatol (2016) 0.75
Establishment of hepatitis C virus RNA-replicating cell lines possessing ribavirin-resistant phenotype. PLoS One (2015) 0.75
Determining Ribavirin's mechanism of action against Lassa virus infection. Sci Rep (2017) 0.75
HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use. Proc Natl Acad Sci U S A (2002) 3.28
Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor. J Virol (2004) 2.80
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell (2013) 2.66
Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS Nano (2012) 2.35
Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc Natl Acad Sci U S A (2004) 2.23
Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034. Antiviral Res (2006) 2.21
Protein corona fingerprinting predicts the cellular interaction of gold and silver nanoparticles. ACS Nano (2014) 2.17
Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D). Virology (2005) 2.13
Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1. Antimicrob Agents Chemother (2005) 2.07
Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials. ACS Nano (2011) 1.68
Interaction of small molecule inhibitors of HIV-1 entry with CCR5. Virology (2006) 1.59
Single-port and multi-port laparoscopic left lateral liver sectionectomy for treating benign liver diseases: a prospective, randomized, controlled study. World J Surg (2014) 1.54
Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations. J Biol Chem (2005) 1.54
Establishment of a normal medakafish spermatogonial cell line capable of sperm production in vitro. Proc Natl Acad Sci U S A (2004) 1.51
Anti-human immunodeficiency virus interactions of SCH-C (SCH 351125), a CCR5 antagonist, with other antiretroviral agents in vitro. Antimicrob Agents Chemother (2002) 1.49
Expansile nanoparticles: synthesis, characterization, and in vivo efficacy of an acid-responsive polymeric drug delivery system. J Am Chem Soc (2009) 1.46
Single-port retroperitoneoscopic pancreatectomy: preliminary results from the first 3 patients. J Clin Gastroenterol (2014) 1.39
Early enhanced external counter pulsation improves neurological recovery after the return of spontaneous circulation in a mongrel dog cardiac arrest model*. Crit Care Med (2013) 1.39
Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis. Diabetes (2007) 1.34
Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line. Cell Res (2006) 1.28
Dynamic changes in genome-wide histone H3 lysine 4 methylation patterns in response to dehydration stress in Arabidopsis thaliana. BMC Plant Biol (2010) 1.28
Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity. J Med Chem (2002) 1.20
Two-stage polymerase chain reaction protocol allowing introduction of multiple mutations, deletions, and insertions, using QuikChange site-directed mutagenesis. Methods Mol Biol (2002) 1.15
Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction. Clinics (Sao Paulo) (2013) 1.14
Proteasome inhibition activates epidermal growth factor receptor (EGFR) and EGFR-independent mitogenic kinase signaling pathways in pancreatic cancer cells. Clin Cancer Res (2008) 1.14
Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activity. ChemMedChem (2013) 1.13
Toxicity mechanisms in Escherichia coli vary for silver nanoparticles and differ from ionic silver. ACS Nano (2013) 1.13
5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury. Am J Respir Crit Care Med (2005) 1.13
YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor. Am J Pathol (2012) 1.12
Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase. J Cell Physiol (2010) 1.12
The efficacy of TACE combined sorafenib in advanced stages hepatocellullar carcinoma. BMC Cancer (2012) 1.11
Self-organizing map analysis of toxicity-related cell signaling pathways for metal and metal oxide nanoparticles. Environ Sci Technol (2011) 1.11
Entry inhibitors SCH-C, RANTES, and T-20 block HIV type 1 replication in multiple cell types. AIDS Res Hum Retroviruses (2003) 1.10
NF- kappa B and chemoresistance: potentiation of cancer drugs via inhibition of NF- kappa B. Drug Resist Updat (1999) 1.10
In vivo characterization of murine myocardial perfusion with myocardial contrast echocardiography: validation and application in nitric oxide synthase 3 deficient mice. Circulation (2007) 1.10
High content screening in zebrafish speeds up hazard ranking of transition metal oxide nanoparticles. ACS Nano (2011) 1.08
Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of life. Epigenetics (2012) 1.08
Identification of pluripotency genes in the fish medaka. Int J Biol Sci (2011) 1.04
NPI-0052 enhances tumoricidal response to conventional cancer therapy in a colon cancer model. Clin Cancer Res (2006) 1.03
Intracisternal A particle genes: Distribution in the mouse genome, active subtypes, and potential roles as species-specific mediators of susceptibility to cancer. Mol Carcinog (2010) 1.03
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A. Neurobiol Dis (2008) 1.03
MEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons. J Neurosci (2012) 1.02
Maternal preconception body mass index and offspring cord blood DNA methylation: exploration of early life origins of disease. Environ Mol Mutagen (2013) 1.01
Increased expression of matrix metalloproteinases in mononuclear blood cells of normal-tension glaucoma patients. J Glaucoma (2004) 1.00
Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells. J Neurochem (2005) 0.99
Trans-complementation of HCV replication by non-structural protein 5A. Virus Res (2005) 0.99
Spectroscopic studies on the interaction between tetrandrine and two serum albumins by chemometrics methods. Spectrochim Acta A Mol Biomol Spectrosc (2013) 0.99
Prevention of in vivo lung tumor growth by prolonged local delivery of hydroxycamptothecin using poly(ester-carbonate)-collagen composites. J Control Release (2010) 0.99
A randomized clinical trial of laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy for the treatment of morbid obesity in China: a 5-year outcome. Obes Surg (2014) 0.97
Alteration of serum miR-206 and miR-133b is associated with lung carcinogenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Toxicol Appl Pharmacol (2013) 0.97
Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. Am J Respir Crit Care Med (2007) 0.96
Conserved C-terminal threonine of hepatitis C virus NS3 regulates autoproteolysis and prevents product inhibition. J Virol (2004) 0.96
SOX10 is a novel oncogene in hepatocellular carcinoma through Wnt/β-catenin/TCF4 cascade. Tumour Biol (2014) 0.95
The tree shrew provides a useful alternative model for the study of influenza H1N1 virus. Virol J (2013) 0.94
Impact of naturally occurring variants of HCV protease on the binding of different classes of protease inhibitors. Biochemistry (2006) 0.94
Transumbilical single-incision laparoscopic hepatectomy: an initial report. Chin Med J (Engl) (2011) 0.94
E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation. Cancer Res (2012) 0.94
Hepatocellular carcinoma invading the main portal vein: treatment with transcatheter arterial chemoembolization and portal vein stenting. Cardiovasc Intervent Radiol (2008) 0.93
NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound. Chem Commun (Camb) (2013) 0.93
Differences in fungicidal efficiency against Aspergillus flavus for neutralized and acidic electrolyzed oxidizing waters. Int J Food Microbiol (2009) 0.92
Expression of a novel murine type I IFN in the pancreatic islets induces diabetes in mice. J Immunol (2003) 0.92
Retroperitoneal laparoscopic hepatectomy: a novel approach. Surg Laparosc Endosc Percutan Tech (2011) 0.92
Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides. Bioorg Med Chem Lett (2003) 0.91
Prognostic analysis of pulmonary metastases from hepatocellular carcinoma. Hepatol Int (2008) 0.90
Laparoscopic surgery for pancreatic insulinomas: a single-institution experience of 29 cases. J Gastrointest Surg (2009) 0.89
Inhibition of phosphodiesterase 1 augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs with acute pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2005) 0.89
The performance of expansile nanoparticles in a murine model of peritoneal carcinomatosis. Biomaterials (2010) 0.89
Adiposity is inversely related to insulin sensitivity in relatively lean Chinese adolescents: a population-based twin study. Am J Clin Nutr (2010) 0.88
Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging (2012) 0.88
Fiber-based flexible all-solid-state asymmetric supercapacitors for integrated photodetecting system. Angew Chem Int Ed Engl (2014) 0.88
Expression of NLK and its potential effect in ovarian cancer chemotherapy. Int J Gynecol Cancer (2011) 0.88
RBRDetector: improved prediction of binding residues on RNA-binding protein structures using complementary feature- and template-based strategies. Proteins (2014) 0.88
Surface-enhanced Raman spectroscopy to probe reversibly photoswitchable azobenzene in controlled nanoscale environments. Nano Lett (2011) 0.88
Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice. J Clin Invest (2010) 0.88
Liver resection for benign hepatic lesions: a retrospective analysis of 827 consecutive cases. World J Gastroenterol (2008) 0.88
Expression and clinical role of TCTP in epithelial ovarian cancer. J Mol Histol (2015) 0.87
PdO doping tunes band-gap energy levels as well as oxidative stress responses to a Co₃O₄ p-type semiconductor in cells and the lung. J Am Chem Soc (2014) 0.87
The eye limits the brain's learning potential. Sci Rep (2012) 0.87
A novel indirubin derivative PHII-7 potentiates adriamycin cytotoxicity via inhibiting P-glycoprotein expression in human breast cancer MCF-7/ADR cells. Eur J Pharmacol (2011) 0.87
Prediabetes is not all about obesity: association between plasma leptin and prediabetes in lean rural Chinese adults. Eur J Endocrinol (2010) 0.87
Endoplasmic reticulum stress-related factors protect against diabetic retinopathy. Exp Diabetes Res (2011) 0.87
Prevalence of asthenopia and its risk factors in Chinese college students. Int J Ophthalmol (2013) 0.87
Laparoscopic versus open distal splenopancreatectomy for the treatment of pancreatic body and tail cancer: a retrospective, mid-term follow-up study at a single academic tertiary care institution. Surg Endosc (2014) 0.87
ARHGEF28 gene exon 6/intron 6 junction mutations in Chinese amyotrophic lateral sclerosis cohort. Amyotroph Lateral Scler Frontotemporal Degener (2014) 0.86
RNA interference of hypoxia-inducible factor-1 alpha improves the effects of transcatheter arterial embolization in rat liver tumors. Tumour Biol (2012) 0.86
Zebrafish high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1. Small (2012) 0.86
Adeno-associated virus-mediated gene delivery of the human ND4 complex I subunit in rabbit eyes. Clin Experiment Ophthalmol (2012) 0.86
Icariin inhibits neurotoxicity of beta-amyloid by upregulating cocaine-regulated and amphetamine-regulated transcripts. Neuroreport (2009) 0.86
In silico analysis of nanomaterials hazard and risk. Acc Chem Res (2012) 0.86
Functional characterization of 58-kilodalton inhibitor of protein kinase in protecting against diabetic retinopathy via the endoplasmic reticulum stress pathway. Mol Vis (2011) 0.86
TWEAK/Fn14 pathway is a novel mediator of retinal neovascularization. Invest Ophthalmol Vis Sci (2014) 0.86
Minimalist ensemble algorithms for genome-wide protein localization prediction. BMC Bioinformatics (2012) 0.85
High-throughput simultaneous analysis of RNA, protein, and lipid biomarkers in heterogeneous tissue samples. Clin Chem (2011) 0.85