Published in Am J Respir Crit Care Med on June 05, 2003
Chronic Obstructive Pulmonary Disease Gene Localization | NCT00037739
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet (2005) 2.46
Alpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk. Thorax (2004) 1.55
Progress in chronic obstructive pulmonary disease genetics. Proc Am Thorac Soc (2006) 1.51
C21orf91 genotypes correlate with herpes simplex labialis (cold sore) frequency: description of a cold sore susceptibility gene. J Infect Dis (2011) 1.21
Genome-wide association study of lung function decline in adults with and without asthma. J Allergy Clin Immunol (2012) 1.20
Genomewide screen for pulmonary function in 200 families ascertained for asthma. Am J Respir Crit Care Med (2005) 1.12
National Emphysema Treatment Trial state of the art: genetics of emphysema. Proc Am Thorac Soc (2008) 0.92
Genetic associations with hypoxemia and pulmonary arterial pressure in COPD. Chest (2008) 0.91
Significant evidence for linkage to chromosome 5q13 in a genome-wide scan for asthma in an extended pedigree resource. Eur J Hum Genet (2008) 0.90
Genome-wide linkage analysis of pulmonary function in families of children with asthma in Costa Rica. Thorax (2006) 0.90
Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. Am J Respir Crit Care Med (2010) 0.89
Association of SERPINE2 with asthma. Chest (2011) 0.81
SERPINE2 polymorphisms and chronic obstructive pulmonary disease. J Korean Med Sci (2009) 0.80
CTLA-4 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease. Int J Clin Exp Pathol (2013) 0.75
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet (2006) 9.56
The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann Intern Med (2005) 8.86
Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17
A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation. N Engl J Med (2016) 3.99
Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet (2010) 3.91
A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet (2008) 3.25
Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome. J Allergy Clin Immunol (2008) 2.50
A role of SCN9A in human epilepsies, as a cause of febrile seizures and as a potential modifier of Dravet syndrome. PLoS Genet (2009) 2.12
KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum. Brain (2003) 1.92
Leukemia-associated minor histocompatibility antigen discovery using T-cell clones isolated by in vitro stimulation of naive CD8+ T cells. Blood (2010) 1.88
Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes. Nicotine Tob Res (2009) 1.84
Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study. Am J Nephrol (2009) 1.80
Genome scans for blood pressure and hypertension: the National Heart, Lung, and Blood Institute Family Heart Study. Hypertension (2002) 1.66
Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet (2013) 1.57
Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p. Hum Genet (2003) 1.50
Prognostic significance of p53 mutations in colon cancer at the population level. Int J Cancer (2002) 1.46
Mutation screening and association of human retinoid X receptor gamma variation with lipid levels in familial type 2 diabetes. Mol Genet Metab (2002) 1.44
AGT genetic variation, plasma AGT, and blood pressure: An analysis of the Utah Genetic Reference Project pedigrees. Am J Hypertens (2010) 1.43
Allogeneic hematopoietic cell transplantation for metastatic renal cell carcinoma after nonmyeloablative conditioning: toxicity, clinical response, and immunological response to minor histocompatibility antigens. Clin Cancer Res (2004) 1.42
Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. Am J Physiol Endocrinol Metab (2003) 1.38
Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. J Physiol (2008) 1.35
Genome-wide linkage and admixture mapping of type 2 diabetes in African American families from the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort. Diabetes (2008) 1.27
Associations between phenylthiocarbamide gene polymorphisms and cigarette smoking. Nicotine Tob Res (2005) 1.27
Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis. Gastroenterology (2004) 1.22
Linkage of serum creatinine and glomerular filtration rate to chromosome 2 in Utah pedigrees. Am J Hypertens (2004) 1.20
A genome-wide scan of pulmonary function measures in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Respir Crit Care Med (2003) 1.19
Alternating hemiplegia of childhood or familial hemiplegic migraine? A novel ATP1A2 mutation. Ann Neurol (2004) 1.18
Sodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressures. Hypertension (2005) 1.18
Toward targeting B cell cancers with CD4+ CTLs: identification of a CD19-encoded minor histocompatibility antigen using a novel genome-wide analysis. J Exp Med (2008) 1.14
Variability of spirometry in chronic obstructive pulmonary disease: results from two clinical trials. Am J Respir Crit Care Med (2006) 1.14
A genome-wide affected sibpair linkage analysis of hypertension: the HyperGEN network. Am J Hypertens (2003) 1.12
An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects. J Clin Endocrinol Metab (2011) 1.11
The effect of smoking intervention and an inhaled bronchodilator on airways reactivity in COPD: the Lung Health Study. Chest (2003) 1.11
American founder mutation for attenuated familial adenomatous polyposis. Clin Gastroenterol Hepatol (2007) 1.10
Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript. J Hum Genet (2002) 1.09
Meta-analysis of genome-wide linkage studies of quantitative lipid traits in families ascertained for type 2 diabetes. Diabetes (2007) 1.08
Absence of TGFBR1 and TGFBR2 mutations in patients with bicuspid aortic valve and aortic dilation. Am J Cardiol (2008) 1.07
Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22. J Invest Dermatol (2008) 1.04
Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2). Am J Med Genet B Neuropsychiatr Genet (2005) 1.03
Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides. Hum Genet (2005) 1.02
Calsquestrin 1 (CASQ1) gene polymorphisms under chromosome 1q21 linkage peak are associated with type 2 diabetes in Northern European Caucasians. Diabetes (2004) 0.99
Dysregulation of the PDGFRA gene causes inflow tract anomalies including TAPVR: integrating evidence from human genetics and model organisms. Hum Mol Genet (2010) 0.99
Linkage and association mapping of a chromosome 1q21-q24 type 2 diabetes susceptibility locus in northern European Caucasians. Diabetes (2004) 0.98
Carriers of rare missense variants in IFIH1 are protected from psoriasis. J Invest Dermatol (2010) 0.97
Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. Diabetes (2006) 0.95
Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: the Hypertension Genetic Epidemiology Network (HyperGEN) Study. Am J Hypertens (2005) 0.94
Colonic adenoma risk in familial colorectal cancer--a study of six extended kindreds. Am J Gastroenterol (2008) 0.94
Evidence for linkage on chromosome 3q25-27 in a large autism extended pedigree. Hum Hered (2006) 0.94
Genome-wide multipoint parametric linkage analysis of pulse pressure in large, extended utah pedigrees. Hypertension (2003) 0.93
Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians. J Clin Endocrinol Metab (2002) 0.93
Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study. J Transl Med (2014) 0.93
Exome analysis of a family with pleiotropic congenital heart disease. Circ Cardiovasc Genet (2012) 0.92
A family-based paradigm to identify candidate chromosomal regions for isolated congenital diaphragmatic hernia. Am J Med Genet A (2012) 0.91
A genome-wide screen reveals evidence for a locus on chromosome 11 influencing variation in LDL cholesterol in the NHLBI Family Heart Study. Hum Genet (2002) 0.91
The 5q31 variants associated with psoriasis and Crohn's disease are distinct. Hum Mol Genet (2008) 0.91
(1)H nuclear magnetic resonance metabolomics analysis identifies novel urinary biomarkers for lung function. J Proteome Res (2010) 0.91
The PHQ-9 as a brief assessment of lifetime major depression. Psychol Assess (2007) 0.90
Loss of bone density with inhaled triamcinolone in Lung Health Study II. Am J Respir Crit Care Med (2004) 0.89
Linkage of creatinine clearance to chromosome 10 in Utah pedigrees replicates a locus for end-stage renal disease in humans and renal failure in the fawn-hooded rat. Kidney Int (2002) 0.89
Occupational exposures are associated with worse morbidity in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 0.87
Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects. Obesity (Silver Spring) (2011) 0.87
Evaluation of the gene-age interactions in HDL cholesterol, LDL cholesterol, and triglyceride levels: the impact of the SORT1 polymorphism on LDL cholesterol levels is age dependent. Atherosclerosis (2011) 0.87
Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study. J Hum Genet (2011) 0.87
Liver pyruvate kinase polymorphisms are associated with type 2 diabetes in northern European Caucasians. Diabetes (2002) 0.86
Electroconvulsive seizure thresholds and kindling acquisition rates are altered in mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions. Epilepsia (2009) 0.85
Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer. J Med Genet (2010) 0.83
Spirometry. Clin Rev Allergy Immunol (2009) 0.82
TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study. Atherosclerosis (2004) 0.82
Chronically inhaled salmeterol improves pulmonary function in heart failure. J Cardiovasc Pharmacol (2002) 0.81
Analysis of a Scottish founder effect narrows the TAPVR-1 gene interval to chromosome 4q12. Am J Med Genet A (2006) 0.80
Molecular screening and association studies of retinoid-related orphan receptor gamma (RORC): a positional and functional candidate for type 2 diabetes. Mol Genet Metab (2003) 0.79
Is combination therapy with inhaled anticholinergics and beta2-adrenoceptor agonists justified for chronic obstructive pulmonary disease? Drugs Aging (2007) 0.79
Lack of effect of Rhodiola or oxygenated water supplementation on hypoxemia and oxidative stress. Wilderness Environ Med (2003) 0.78
High-sensitivity nanoLC-MS/MS analysis of urinary desmosine and isodesmosine. Anal Chem (2009) 0.78
The role of gastroesophageal reflux in exercise-triggered asthma: a randomized controlled trial. Dig Dis Sci (2008) 0.77
Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol. Atherosclerosis (2012) 0.77
Rapid molecular analysis of the STAT3 gene in Job syndrome of hyper-IgE and recurrent infectious diseases. J Mol Diagn (2010) 0.76
Identification of distinct plasma biomarker signatures in patients with rapid and slow declining forms of COPD. COPD (2010) 0.76
The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities study. Am J Hypertens (2009) 0.75
Obesity Associated Modulation of miRNA and Co-Regulated Target Transcripts in Human Adipose Tissue of Non-Diabetic Subjects. Microrna (2016) 0.75
A novel form of juvenile recessive ALS maps to loci on 6p25 and 21q22. Neuromuscul Disord (2009) 0.75
The power to detect genetic linkage for quantitative traits in the Utah CEPH pedigrees. J Hum Genet (2005) 0.75
Measurement of lung volumes. Clin Rev Allergy Immunol (2009) 0.75