Published in J Biol Chem on June 07, 2003
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proc Natl Acad Sci U S A (2004) 3.60
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development (2007) 3.28
Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res (2006) 3.12
Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci (2004) 3.12
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc Natl Acad Sci U S A (2005) 2.95
Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. PLoS Med (2007) 2.14
Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action. Mol Cell Biol (2008) 2.03
GSK-3: Functional Insights from Cell Biology and Animal Models. Front Mol Neurosci (2011) 1.99
Is glycogen synthase kinase-3 a central modulator in mood regulation? Neuropsychopharmacology (2010) 1.87
Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases. Pharmacol Ther (2014) 1.77
Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J (2009) 1.68
Combined treatment with the mood stabilizers lithium and valproate produces multiple beneficial effects in transgenic mouse models of Huntington's disease. Neuropsychopharmacology (2011) 1.66
Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease. Curr Med Chem (2008) 1.64
Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition. J Neurosci (2008) 1.58
Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder. Pharmacol Rev (2013) 1.52
Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3. Neuro Oncol (2008) 1.47
GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS. Front Mol Neurosci (2011) 1.47
Targeting protein kinases in central nervous system disorders. Nat Rev Drug Discov (2009) 1.45
The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis. EMBO J (2010) 1.41
Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders. Pharmacol Ther (2010) 1.39
GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder. Neurosci Biobehav Rev (2007) 1.36
Wnt signaling in ovarian tumorigenesis. Int J Gynecol Cancer (2007) 1.35
Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells. J Biol Chem (2009) 1.35
GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder. Front Mol Neurosci (2012) 1.34
Review of pharmacological treatment in mood disorders and future directions for drug development. Neuropsychopharmacology (2011) 1.28
Validating GSK3 as an in vivo target of lithium action. Biochem Soc Trans (2009) 1.27
Bipolar disorder: from genes to behavior pathways. J Clin Invest (2009) 1.24
JNK phosphorylates beta-catenin and regulates adherens junctions. FASEB J (2009) 1.21
Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice. J Clin Invest (2011) 1.20
Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia. Cell Death Dis (2010) 1.19
GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke. Front Mol Neurosci (2011) 1.14
Inhibition of GSK3 by lithium, from single molecules to signaling networks. Front Mol Neurosci (2012) 1.14
Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice. Mol Immunol (2008) 1.11
c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway. Carcinogenesis (2008) 1.07
Lithium regulates glycogen synthase kinase-3beta in human peripheral blood mononuclear cells: implication in the treatment of bipolar disorder. Biol Psychiatry (2006) 1.05
Phosphorylation of threonine-19 of PSD-95 by GSK-3β is required for PSD-95 mobilization and long-term depression. J Neurosci (2013) 1.04
Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice. EMBO J (2007) 1.04
Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease. Eur Arch Psychiatry Clin Neurosci (2008) 1.03
Cyanidin-3-glucoside reverses ethanol-induced inhibition of neurite outgrowth: role of glycogen synthase kinase 3 Beta. Neurotox Res (2009) 1.02
Lithium facilitates apoptotic signaling induced by activation of the Fas death domain-containing receptor. BMC Neurosci (2004) 1.02
Regulation of the interaction between glycogen synthase kinase 3 and the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen. J Virol (2005) 1.01
Upregulation of RGS4 expression by IL-1beta in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3beta pathway. Am J Physiol Cell Physiol (2009) 1.00
Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damage. Int J Neuropsychopharmacol (2009) 1.00
Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2. Mol Psychiatry (2013) 0.99
Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling. Mol Cell Neurosci (2007) 0.98
Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production. J Cell Mol Med (2008) 0.97
Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. J Biol Chem (2009) 0.96
Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome. PLoS One (2011) 0.95
GSK-3 and mitochondria in cancer cells. Front Oncol (2013) 0.95
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS One (2010) 0.94
Functional implications of glycogen synthase kinase-3-mediated tau phosphorylation. Int J Alzheimers Dis (2011) 0.94
Molecular actions and clinical pharmacogenetics of lithium therapy. Pharmacol Biochem Behav (2014) 0.94
Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice. J Biol Chem (2013) 0.94
Induction of canonical Wnt signaling by alsterpaullone is sufficient for oral tissue fate during regeneration and embryogenesis in Nematostella vectensis. Dev Dyn (2011) 0.93
The Wnt-dependent signaling pathways as target in oncology drug discovery. Invest New Drugs (2006) 0.93
Similar biological activities of two isostructural ruthenium and osmium complexes. Chemistry (2008) 0.92
NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. J Clin Invest (2010) 0.92
New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells. Am J Physiol Cell Physiol (2012) 0.92
Nek2 phosphorylates and stabilizes β-catenin at mitotic centrosomes downstream of Plk1. Mol Biol Cell (2014) 0.89
Glycogen synthase kinase-3 regulation of urinary concentrating ability. Curr Opin Nephrol Hypertens (2012) 0.89
Tau as a therapeutic target for Alzheimer's disease. Curr Alzheimer Res (2011) 0.89
The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels. Exp Cell Res (2006) 0.89
Regulation of serotonin 1B receptor by glycogen synthase kinase-3. Mol Pharmacol (2009) 0.89
Inhibitory phosphorylation of GSK-3β by AKT, PKA, and PI3K contributes to high NaCl-induced activation of the transcription factor NFAT5 (TonEBP/OREBP). Am J Physiol Renal Physiol (2013) 0.88
A new avenue for lithium: intervention in traumatic brain injury. ACS Chem Neurosci (2014) 0.88
Neuroprotective action of lithium in disorders of the central nervous system. Zhong Nan Da Xue Xue Bao Yi Xue Ban (2011) 0.87
Glycogen synthase kinase 3β inhibitors induce apoptosis in ovarian cancer cells and inhibit in-vivo tumor growth. Anticancer Drugs (2011) 0.86
Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II. Mol Neurobiol (2012) 0.86
Enhanced endothelial cell senescence by lithium-induced matrix metalloproteinase-1 expression. J Biol Chem (2009) 0.86
Overexpression screen in Drosophila identifies neuronal roles of GSK-3 beta/shaggy as a regulator of AP-1-dependent developmental plasticity. Genetics (2008) 0.86
A Rising Cancer Prevention Target of RSK2 in Human Skin Cancer. Front Oncol (2013) 0.85
Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons. Mol Biol Cell (2013) 0.85
The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function. PLoS One (2009) 0.85
Targeted disruption of glycogen synthase kinase 3A (GSK3A) in mice affects sperm motility resulting in male infertility. Biol Reprod (2015) 0.85
Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. J Cancer Res Clin Oncol (2011) 0.84
Pharmacogenetics in mood disorder. Curr Opin Psychiatry (2005) 0.84
SMO expression level correlates with overall survival in patients with malignant pleural mesothelioma. J Exp Clin Cancer Res (2013) 0.84
Folate rescues lithium-, homocysteine- and Wnt3A-induced vertebrate cardiac anomalies. Dis Model Mech (2009) 0.84
Lithium suppresses astrogliogenesis by neural stem and progenitor cells by inhibiting STAT3 pathway independently of glycogen synthase kinase 3 beta. PLoS One (2011) 0.83
Lithium: the pharmacodynamic actions of the amazing ion. Ther Adv Psychopharmacol (2013) 0.83
Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound. Mol Cancer Ther (2014) 0.83
Lithium ameliorates autistic-like behaviors induced by neonatal isolation in rats. Front Behav Neurosci (2014) 0.82
Effect of LiCl on phosphoenolpyruvate carboxylase kinase and the phosphorylation of phosphoenolpyruvate carboxylase in leaf disks and leaves of Sorghum vulgare. Planta (2007) 0.82
Regulation of glycogen synthase kinase-3 in patients with affective disorders. Biol Psychiatry (2007) 0.81
Inositol synthesis regulates the activation of GSK-3α in neuronal cells. J Neurochem (2014) 0.81
Glycogen synthase kinase 3α regulates urine concentrating mechanism in mice. Am J Physiol Renal Physiol (2015) 0.81
Anti-Bladder-Tumor Effect of Baicalein from Scutellaria baicalensis Georgi and Its Application In Vivo. Evid Based Complement Alternat Med (2013) 0.81
Behavioral stress-induced activation of FoxO3a in the cerebral cortex of mice. Biol Psychiatry (2011) 0.80
The wnt pathway in mood disorders. Curr Neuropharmacol (2012) 0.79
Lithium's role in neural plasticity and its implications for mood disorders. Acta Psychiatr Scand (2013) 0.78
Prolyl oligopeptidase, inositol phosphate signalling and lithium sensitivity. CNS Neurol Disord Drug Targets (2011) 0.78
Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus. J Neural Transm (Vienna) (2006) 0.78
Natural Functions of PLIN2 Mediating Wnt/LiCl Signaling and Glycogen Synthase Kinase 3 (GSK3)/GSK3 Substrate-Related Effects Are Modulated by Lipid. Mol Cell Biol (2015) 0.78
Valproate alters dopamine signaling in association with induction of Par-4 protein expression. PLoS One (2012) 0.77
GSK3-mediated instability of tubulin polymers is responsible for the failure of immature CD4+CD8+ thymocytes to polarize their MTOC in response to TCR stimulation. Int Immunol (2011) 0.77
Differential effects of glycogen synthase kinase 3 (GSK3) inhibition by lithium or selective inhibitors in the central nervous system. Naunyn Schmiedebergs Arch Pharmacol (2013) 0.77
High throughput transcriptome profiling of lithium stimulated human mesenchymal stem cells reveals priming towards osteoblastic lineage. PLoS One (2013) 0.77
Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice. Sci Rep (2016) 0.77
Lithium inhibits tumor lymphangiogenesis and metastasis through the inhibition of TGFBIp expression in cancer cells. Sci Rep (2016) 0.77
Polarized regulation of glycogen synthase kinase-3β is important for glioma cell invasion. PLoS One (2013) 0.77
GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature (2003) 4.97
Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci (2004) 3.12
Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock. Science (2006) 2.62
Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH. Blood (2011) 2.55
O2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol (2010) 2.45
beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. Dev Cell (2010) 2.44
Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability. Nat Cell Biol (2009) 2.42
Histone deacetylase is a target of valproic acid-mediated cellular differentiation. Cancer Res (2004) 2.17
Chromatin immunoprecipitation in early Xenopus laevis embryos. Dev Dyn (2009) 1.58
Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways. Nat Med (2012) 1.58
Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice. J Clin Invest (2009) 1.52
Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology (2007) 1.41
Beta-catenin/Tcf-regulated transcription prior to the midblastula transition. Development (2002) 1.40
The Frizzled family: receptors for multiple signal transduction pathways. Genome Biol (2004) 1.34
GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder. Front Mol Neurosci (2012) 1.34
Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo. FASEB J (2005) 1.31
Validating GSK3 as an in vivo target of lithium action. Biochem Soc Trans (2009) 1.27
Lithium and valproic acid: parallels and contrasts in diverse signaling contexts. Pharmacol Ther (2002) 1.23
Arginine methylation of vasa protein is conserved across phyla. J Biol Chem (2010) 1.21
PP2A:B56epsilon is required for Wnt/beta-catenin signaling during embryonic development. Development (2003) 1.21
Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice. J Clin Invest (2011) 1.20
Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin. ACS Med Chem Lett (2010) 1.11
SANE, a novel LEM domain protein, regulates bone morphogenetic protein signaling through interaction with Smad1. J Biol Chem (2002) 1.11
Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells. Cancer Res (2002) 1.10
Wnt-frizzled signaling in the induction and differentiation of the neural crest. Bioessays (2003) 1.06
An essential role for transcription before the MBT in Xenopus laevis. Dev Biol (2011) 1.06
Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity. J Biol Chem (2011) 1.05
Wnt-frizzled signaling in neural crest formation. Trends Neurosci (2003) 1.02
Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta elicit opposing effects on Rap1GAP stability. J Biol Chem (2003) 1.02
Switching on a signaling pathway with an organoruthenium complex. Angew Chem Int Ed Engl (2005) 1.02
Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J Biol Chem (2010) 1.00
Multiple roles for glycogen synthase kinase-3 as a drug target in Alzheimer's disease. Curr Drug Targets (2006) 1.00
Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS One (2009) 0.98
Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development. Development (2006) 0.98
Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1. Cancer Res (2011) 0.94
Neural crest induction by the canonical Wnt pathway can be dissociated from anterior-posterior neural patterning in Xenopus. Dev Biol (2005) 0.94
Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbα. Mol Endocrinol (2014) 0.92
Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera. Blood (2010) 0.92
Identifying an uptake mechanism for the antiepileptic and bipolar disorder treatment valproic acid using the simple biomedical model Dictyostelium. J Cell Sci (2011) 0.89
A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity. J Biol Chem (2010) 0.87
Mesodermal Wnt signaling organizes the neural plate via Meis3. Development (2010) 0.87
Gsk3β is required in the epithelium for palatal elevation in mice. Dev Dyn (2010) 0.87
A novel interaction between Glycogen Synthase Kinase-3α (GSK-3α) and the scaffold protein Receptor for Activated C-Kinase 1 (RACK1) regulates the circadian clock. Int J Biochem Mol Biol (2011) 0.86
SMIT1 haploinsufficiency causes brain inositol deficiency without affecting lithium-sensitive behavior. Mol Genet Metab (2006) 0.85
The mef/elf4 transcription factor fine tunes the DNA damage response. Cancer Res (2011) 0.85
Phosphorylation of frizzled-3. J Biol Chem (2006) 0.85
The role for oxidative stress in aberrant DNA methylation in Alzheimer's disease. Curr Alzheimer Res (2012) 0.84
Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish. Dis Model Mech (2013) 0.83
Regulation of glycogen synthase kinase-3 in patients with affective disorders. Biol Psychiatry (2007) 0.81
Interactions between BMP and Wnt signaling pathways in mammalian cancers. Cancer Biol Ther (2004) 0.80
The poly(rC)-binding protein alphaCP2 is a noncanonical factor in X. laevis cytoplasmic polyadenylation. RNA (2011) 0.80
The orphan nuclear receptor NR4A1 specifies a distinct subpopulation of quiescent myeloid-biased long-term HSCs. Stem Cells (2015) 0.78
Regulation of primitive hematopoiesis by class I histone deacetylases. Dev Dyn (2013) 0.77
Prepatterning embryonic development: tabula scripta? Dev Cell (2011) 0.75
CKAP4 is identified as a receptor for Dickkopf in cancer cells. J Clin Invest (2016) 0.75