PubRank

R E Tanzi

Author PubWeight™ 213.47‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A polymorphic DNA marker genetically linked to Huntington's disease. Nature 1984 16.71
2 Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995 13.80
3 Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 1987 8.29
4 Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat Genet 1998 7.26
5 Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 1994 5.34
6 Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 2001 4.42
7 Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology 2005 3.90
8 The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science 1987 3.59
9 Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science 2000 3.16
10 Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere. Cell 1987 3.11
11 DNA markers for nervous system diseases. Science 1984 3.02
12 Isolation of polymorphic DNA fragments from human chromosome 4. Nucleic Acids Res 1987 2.83
13 Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem 1998 2.78
14 The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry 1999 2.58
15 Genetics of aging. Science 1997 2.57
16 Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med 1996 2.43
17 Homozygotes for Huntington's disease. Nature 1987 2.40
18 LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell 1995 2.37
19 Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nat Med 2000 2.34
20 Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem 1999 2.30
21 Mapping, cloning and genetic characterization of the region containing the Wilson disease gene. Nat Genet 1993 2.29
22 Presenilin-mediated modulation of capacitative calcium entry. Neuron 2000 2.25
23 Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome. Nature 1985 2.19
24 Studies of a DNA marker (G8) genetically linked to Huntington disease in British families. Hum Genet 1986 2.18
25 Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J Biol Chem 2000 2.00
26 Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol 2001 1.96
27 Alzheimer's disease: genetic studies and transgenic models. Annu Rev Genet 1998 1.93
28 Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42. J Neurochem 2000 1.82
29 Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). J Biol Chem 1994 1.74
30 Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Hum Mol Genet 2001 1.74
31 Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nat Genet 1993 1.72
32 Huntington disease: no evidence for locus heterogeneity. Genomics 1989 1.70
33 Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 1997 1.66
34 Isolation of polymorphic DNA segments from human chromosome 21. Nucleic Acids Res 1985 1.66
35 Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease. J Neuropathol Exp Neurol 1992 1.61
36 The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene. Nature 1987 1.57
37 DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11. DNA 1987 1.56
38 Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proc Natl Acad Sci U S A 1992 1.52
39 Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. Science 1988 1.51
40 Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion. J Biol Chem 1999 1.48
41 Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. Proc Natl Acad Sci U S A 1996 1.46
42 Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. J Biol Chem 1997 1.40
43 Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system. J Neuropathol Exp Neurol 1996 1.35
44 The genetics of Alzheimer disease: current status and future prospects. Arch Neurol 1998 1.28
45 Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors. J Biol Chem 1997 1.24
46 Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein. Proc Natl Acad Sci U S A 1996 1.22
47 Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families. Neurobiol Dis 1998 1.18
48 Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex. Neurosci Lett 1991 1.18
49 Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative. Am J Med Genet 2000 1.13
50 Modulation of A beta adhesiveness and secretase site cleavage by zinc. J Biol Chem 1994 1.13
51 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction. Biochemistry 2000 1.13
52 A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes. Ann Neurol 1997 1.08
53 Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease. Neurology 1995 1.08
54 Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. J Biol Chem 2000 1.07
55 Metal chelation as a potential therapy for Alzheimer's disease. Ann N Y Acad Sci 2000 1.06
56 Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc Natl Acad Sci U S A 1997 1.04
57 Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. Brain Res Mol Brain Res 1995 1.03
58 The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element. Mol Psychiatry 2007 1.02
59 Amyloid, dementia and Alzheimer's disease. Curr Opin Neurol Neurosurg 1992 1.02
60 Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17. Proc Natl Acad Sci U S A 1988 1.00
61 Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease. Met Ions Biol Syst 1999 1.00
62 Presenilins and Alzheimer's disease. Curr Opin Neurobiol 1997 0.99
63 Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP. Brain Res Mol Brain Res 2001 0.99
64 Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease. Hum Mol Genet 1998 0.99
65 Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor. J Biol Chem 2000 0.98
66 Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain. J Biol Chem 1998 0.98
67 Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease. Science 1987 0.96
68 RFLPS at the D21S19 locus of human chromosome 21. Nucleic Acids Res 1985 0.95
69 Molecular genetic approaches to Alzheimer's disease. Trends Neurosci 1989 0.95
70 In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain. Proc Natl Acad Sci U S A 1996 0.94
71 The ETS genes on chromosome 21 are distal to the breakpoint of the acute myelogenous leukemia translocation (8;21). Genomics 1988 0.93
72 Apolipoprotein E4 allele and Alzheimer disease: examination of allelic association and effect on age at onset in both early- and late-onset cases. Genet Epidemiol 1995 0.92
73 The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. J Biol Chem 1994 0.92
74 Progress toward valid transgenic mouse models for Alzheimer's disease. Neurobiol Aging 1999 0.92
75 GSK3 beta forms a tetrameric complex with endogenous PS1-CTF/NTF and beta-catenin. Effects of the D257/D385A and FAD-linked mutations. Ann N Y Acad Sci 2000 0.92
76 Familial Alzheimer's disease: progress and problems. Neurobiol Aging 1989 0.92
77 hFE65L influences amyloid precursor protein maturation and secretion. J Neurochem 1999 0.91
78 Genetic linkage analysis of neurofibromatosis with DNA markers. Ann N Y Acad Sci 1986 0.91
79 Molecular genetics of human chromosome 21. J Med Genet 1987 0.90
80 Role of common and rare APP DNA sequence variants in Alzheimer disease. Neurology 2012 0.90
81 Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity. Eur Neurol 1998 0.90
82 Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells. J Neurochem 1999 0.90
83 Characterization of an unusual and complex chromosome 21 rearrangement using somatic cell genetics and cloned DNA probes. Am J Med Genet 1989 0.89
84 Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells. Neurosci Lett 1991 0.89
85 Response. Science 1995 0.88
86 Alzheimer's disease, beta-amyloid protein and zinc. J Nutr 2000 0.87
87 Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations. Biochemistry 1999 0.87
88 Copper catalyzed oxidation of Alzheimer Abeta. Cell Mol Biol (Noisy-le-grand) 2000 0.87
89 Molecular and cytogenetic characterization of a de novo t(5p;21q) in a patient previously diagnosed as monosomy 21. Am J Hum Genet 1988 0.87
90 Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site. Biochem Biophys Res Commun 2000 0.85
91 Changes in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction. Curr Alzheimer Res 2011 0.85
92 Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. J Struct Biol 2000 0.85
93 The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19. Genomics 1993 0.85
94 Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. Biochemistry 1997 0.84
95 Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation. J Biol Chem 1998 0.84
96 Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families. J Med Genet 2005 0.83
97 Developmental regulation of presenilin mRNA expression parallels notch expression. J Neuropathol Exp Neurol 1997 0.83
98 Molecular genetics of human chromosome 4. J Med Genet 1986 0.83
99 Alzheimer's mutation. Nature 1991 0.83
100 Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations. Cell Mol Life Sci 1998 0.82
101 Mounting evidence for the involvement of zinc and copper in Alzheimer's disease. Eur J Clin Invest 1999 0.81
102 Neuronal intranuclear inclusions in polyglutamine diseases: nuclear weapons or nuclear fallout? Neuron 1998 0.81
103 Negative regulation of the SAPK/JNK signaling pathway by presenilin 1. J Cell Biol 2001 0.81
104 Wilson's disease gene is homologous to hts causing abnormal copper transport in Long-Evans cinnamon rats. Gastroenterology 1994 0.80
105 Gene mutations in inherited amyloidopathies of the nervous system. Am J Hum Genet 1991 0.80
106 A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media. Biochem J 1995 0.80
107 Induction of HSP70 mRNA after transient ischemia in gerbil brain. Neurosci Lett 1991 0.79
108 Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21. Hum Genet 1994 0.79
109 Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains. Brain Res 1998 0.79
110 A linkage map of three anonymous human DNA fragments and SOD-1 on chromosome 21. EMBO J 1985 0.79
111 The beta amyloid protein precursor: mRNAs, membrane-associated forms, and soluble derivatives. Prog Clin Biol Res 1989 0.79
112 Molecular genetics of Huntington's disease. Cold Spring Harb Symp Quant Biol 1986 0.78
113 Of replications and refutations: the status of Alzheimer's disease genetic research. Curr Neurol Neurosci Rep 2001 0.78
114 Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex. Somat Cell Mol Genet 1994 0.78
115 Alzheimer disease-related abnormalities of amyloid beta precursor protein isoforms in the platelet: the brain's delegate in the periphery? Arch Neurol 1998 0.78
116 Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients. Neurosci Lett 2000 0.77
117 No association between a previously reported OLR1 3' UTR polymorphism and Alzheimer's disease in a large family sample. J Med Genet 2004 0.77
118 Alzheimer's disease and related dementias: the road to intervention. Exp Gerontol 2000 0.77
119 Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques. Brain Res Mol Brain Res 1993 0.77
120 The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene. Hum Mol Genet 1995 0.77
121 Caspases land on APP: one small step for apoptosis, one giant leap for amyloidosis? Nat Neurosci 1999 0.76
122 Linkage analysis in familial Alzheimer disease: description of the Duke and Boston data sets. Genet Epidemiol 1993 0.76
123 Natural Modulators of Amyloid-Beta Precursor Protein Processing. Curr Alzheimer Res 2012 0.76
124 Dancing in the dark? The status of late-onset Alzheimer's disease genetics. J Mol Neurosci 2001 0.76
125 Search for the genes responsible for familial Alzheimer's disease. Ann N Y Acad Sci 1993 0.76
126 Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products. Adv Neurol 1990 0.76
127 Cytoplasmic presenilin aggregates in proteasome inhibitor-treated cells. Ann N Y Acad Sci 2000 0.75
128 A genetic linkage map of the chromosome 4 short arm. Somat Cell Mol Genet 1993 0.75
129 Of calcium, caspases, and cognitive decline. Nat Med 1998 0.75
130 Two RFLPs detected by a cosmid at locus D16S144. Nucleic Acids Res 1990 0.75
131 ACAT1 is not associated with Alzheimer's disease in two independent family-based samples. Mol Psychiatry 2005 0.75
132 Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease. J Neurol Sci 1998 0.75
133 Alzheimer's disease risk and the interleukin-1 genes. Ann Neurol 2000 0.75
134 Molecular genetics of familial Alzheimer's disease. Eur Neurol 1989 0.75
135 Genetic linkage map for chromosome 21. Ann N Y Acad Sci 1985 0.75
136 Molecular genetics of familial Alzheimer's disease. Can J Neurol Sci 1989 0.75
137 PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample. Neurology 2004 0.75
138 Chromosome 21 genetic linkage data set based on the Venezuelan reference pedigree. Cytogenet Cell Genet 1992 0.75
139 Chromosomal localization of the mouse homolog of the Huntington's disease linked G8 (D4S10) marker. DNA 1987 0.75
140 Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease. Neurosci Lett 2000 0.75
141 Pseudogene of dihydrolipoyl succinyltransferase (E2k) found by PCR amplification and direct sequencing of rodent-human cell hybrid DNAs. Somat Cell Mol Genet 1994 0.75
142 No association between marker D10S1423 and Alzheimer's disease. Mol Psychiatry 2003 0.75