Published in Life Sci on June 27, 2003
Bi- or multifunctional opioid peptide drugs. Life Sci (2009) 1.69
Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem (2006) 1.40
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. Bioorg Med Chem (2009) 1.28
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists. J Med Chem (2007) 1.21
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. J Med Chem (2008) 1.08
Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem (2007) 0.94
Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain. Brain Res (2011) 0.86
Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides. Tetrahedron Lett (2006) 0.86
Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization. J Med Chem (2010) 0.84
Investigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of pain. Expert Opin Investig Drugs (2013) 0.82
Opioid and melanocortin receptors: do they have overlapping pharmacophores? Biopolymers (2008) 0.82
Prediction of structural stability of short beta-hairpin peptides by molecular dynamics and knowledge-based potentials. BMC Struct Biol (2008) 0.77
Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain. Yale J Biol Med (2017) 0.75
BN-9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance-forming antinociception in mice. Br J Pharmacol (2016) 0.75
Adventures in peptides and science with students! the joys of research. Biopolymers (2013) 0.75
Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain. J Heterocycl Chem (2016) 0.75
Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin. Pain (2001) 2.05
Designing peptide receptor agonists and antagonists. Nat Rev Drug Discov (2002) 1.91
Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers. J Neurosci (2002) 1.58
Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and dynamic considerations. Biochem J (1990) 1.51
Conformational restrictions of biologically active peptides via amino acid side chain groups. Life Sci (1982) 1.32
Topographical requirements for delta-selective opioid peptides. Biopolymers (1991) 1.06
A three-dimensional model of the delta-opioid pharmacophore: comparative molecular modeling of peptide and nonpeptide ligands. Biopolymers (2000) 0.91
Opioid receptor binding properties of analgesic analogues of cholecystokinin octapeptide. Eur J Pharmacol (1991) 0.86
Models for the A- and B-receptor-bound conformations of CCK-8. Biochem Biophys Res Commun (1993) 0.80
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18. Nature (2001) 15.44
Genome sequence of Yersinia pestis, the causative agent of plague. Nature (2001) 14.36
The genome sequence of Schizosaccharomyces pombe. Nature (2002) 14.26
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491. Nature (2000) 9.86
The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18
A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat Biotechnol (2001) 6.50
High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R. J Biol Chem (2000) 5.18
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. N Engl J Med (2001) 3.77
Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev (2007) 3.42
Potent and nontoxic antisense oligonucleotides containing locked nucleic acids. Proc Natl Acad Sci U S A (2000) 3.04
PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science (1993) 2.80
Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature (2002) 2.59
Latent carcinoma of prostate at autopsy in seven areas. The International Agency for Research on Cancer, Lyons, France. Int J Cancer (1977) 2.56
CB2 cannabinoid receptor-mediated peripheral antinociception. Pain (2001) 2.38
Clinical outcome of 149 patients with polymyalgia rheumatica and giant cell arteritis. J Rheumatol (1998) 2.36
Community-based cancer screening for underserved women: design and baseline findings from the Breast and Cervical Cancer Intervention Study. Prev Med (2001) 2.35
Labile exocyclic amine protection of nucleosides in DNA, RNA and oligonucleotide analog synthesis facilitating N-deacylation, minimizing depurination and chain degradation. Biochimie (1993) 2.34
Effects of different ACE inhibitor combinations on albuminuria: results of the GUARD study. Kidney Int (2008) 2.26
Effect of nebulized ipratropium on the hospitalization rates of children with asthma. N Engl J Med (1998) 2.20
Comparison of physical chemical properties of llama VHH antibody fragments and mouse monoclonal antibodies. Biochim Biophys Acta (1999) 2.20
Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin. Pain (2001) 2.05
Behaviorism: Are reports of its death exaggerated? Behav Anal (1986) 2.04
Structure of Marek's disease virus DNA: detailed restriction enzyme map. J Virol (1984) 2.03
Pre-hospital notification reduced the door-to-needle time for iv t-PA in acute ischaemic stroke. Eur J Neurol (2009) 1.97
A cytoplasmic RNA vector derived from nontransmissible Sendai virus with efficient gene transfer and expression. J Virol (2000) 1.92
Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase. J Biol Chem (2001) 1.90
Distinct potassium channels on pain-sensing neurons. Proc Natl Acad Sci U S A (2001) 1.90
Characterization of symptoms in children with recurrent abdominal pain: resemblance to irritable bowel syndrome. J Pediatr Gastroenterol Nutr (1995) 1.89
Extremely long-lasting antagonistic actions of nor-binaltorphimine (nor-BNI) in the mouse tail-flick test. J Pharmacol Exp Ther (1992) 1.88
The epidemiology of acute appendicitis in California: racial, gender, and seasonal variation. Epidemiology (1991) 1.83
Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea. Hepatology (2000) 1.78
Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance. J Neurosci (2001) 1.76
Preclinical assessment of candidate analgesic drugs: recent advances and future challenges. J Pharmacol Exp Ther (2006) 1.75
Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor. J Neurosci (2001) 1.72
Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance. J Neurosci (2000) 1.71
Primary structure of rat cardiac beta-adrenergic and muscarinic cholinergic receptors obtained by automated DNA sequence analysis: further evidence for a multigene family. Proc Natl Acad Sci U S A (1987) 1.70
Antinuclear and antineutrophil cytoplasmic antibodies (ANCA) in the sera of patients with Felty's syndrome. Br J Rheumatol (1992) 1.69
Pronociceptive actions of dynorphin maintain chronic neuropathic pain. J Neurosci (2001) 1.67
A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain. Proc Natl Acad Sci U S A (1999) 1.66
Generation of a humanized, high affinity anti-tissue factor antibody for use as a novel antithrombotic therapeutic. Thromb Haemost (2001) 1.64
Integration of academic and clinical performance-based faculty compensation plans: a system and its impact on an anaesthesiology department. Br J Anaesth (2013) 1.63
Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds. J Korean Med Sci (2001) 1.62
A double-blind, placebo-controlled study of the use of amphetamine in the treatment of aphasia. Stroke (2001) 1.61
Inducible expression of claudin-1-myc but not occludin-VSV-G results in aberrant tight junction strand formation in MDCK cells. J Cell Sci (2000) 1.58
Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Mol Endocrinol (1999) 1.58
A Canadian faculty of medicine and dentistry's survey of career development needs. Med Educ (2001) 1.57
Dyspepsia in children and adolescents: a prospective study. J Pediatr Gastroenterol Nutr (2000) 1.56
Dicaffeoyl- or digalloyl pyrrolidine and furan derivatives as HIV integrase inhibitors. Bioorg Med Chem (2001) 1.56
HbA1c variability is associated with microalbuminuria development in type 2 diabetes: a 7-year prospective cohort study. Diabetologia (2012) 1.54
The Waikato Medical Care (WaiMedCa) Survey 1991-1992. N Z Med J (1994) 1.54
Referral and diagnosis of common rheumatic diseases by primary care physicians. Br J Rheumatol (1998) 1.54
Sarcoidosis of the small intestine. Am J Gastroenterol (1988) 1.53
A faster-acting and more potent form of tissue plasminogen activator. Proc Natl Acad Sci U S A (1994) 1.52
Immunological studies on the mechanism of gold hypersensitivity reactions. Br Med J (1973) 1.50
Dissection of a model for neuronal parabolic bursting. J Math Biol (1987) 1.49
The spondyloarthropathies in Zimbabwe: a clinical and immunogenetic profile. J Rheumatol (1990) 1.49
Non-Hodgkin's lymphoma of the pleural cavity developing from long-standing pyothorax. Cancer (1987) 1.48
Multimerization of phosphorylated and non-phosphorylated ArcA is necessary for the response regulator function of the Arc two-component signal transduction system. J Biol Chem (2001) 1.47
Phenylpropanolamine contained in cold remedies and risk of hemorrhagic stroke. Neurology (2007) 1.47
Left atrial ball thrombus in nonrheumatic atrial fibrillation diagnosed by transesophageal echocardiography. Am Heart J (1992) 1.46
Experimental immune synovitis in the rabbit. Relative roles of cell mediated and humoral immunity. Arthritis Rheum (1975) 1.46
Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse. J Pharmacol Exp Ther (1984) 1.45
Floor-pattern salt-split skin cannot distinguish bullous pemphigoid from epidermolysis bullosa acquisita. Use of toad skin. Arch Dermatol (1993) 1.45
A longitudinal study of in vitro tests for lymphocyte function in rheumatoid arthritis. Ann Rheum Dis (1978) 1.45
Opposing role of mitogen-activated protein kinase subtypes, erk-1/2 and p38, in the regulation of chondrogenesis of mesenchymes. J Biol Chem (2000) 1.45
Orphanin-FQ/nociceptin: lack of anti nociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats. Eur J Pain (1998) 1.44
Expression pattern of germ cell-specific genes in the testis of patients with nonobstructive azoospermia: usefulness as a molecular marker to predict the presence of testicular sperm. Fertil Steril (2000) 1.44
Isolation of Salmonella enterica serotype choleraesuis resistant to ceftriaxone and ciprofloxacin. Lancet (2004) 1.43
Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats. Pain (1999) 1.43
Statistical analysis of drug-drug and site-site interactions with isobolograms. Life Sci (1989) 1.43
Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells. Cell Growth Differ (1994) 1.42
HIV and arthritis--causal or casual acquaintances? J Rheumatol (1989) 1.42
Comparison of magnetic resonance imaging-fluorodeoxy- glucose positron emission tomography fusion with pathological staging in rectal cancer. Br J Surg (2010) 1.41
Snake wars. Br J Gen Pract (2000) 1.40
Phytoestrogen consumption and breast cancer risk in a multiethnic population: the Bay Area Breast Cancer Study. Am J Epidemiol (2001) 1.40
The impact of total antioxidant capacity on pulmonary function in asthma patients. Int J Tuberc Lung Dis (2012) 1.40
Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization. Neuroscience (2006) 1.39
Budd-Chiari syndrome treated successfully by percutaneous transluminal balloon angioplasty: two cases followed-up for 6 years. Cathet Cardiovasc Diagn (1992) 1.39
Opioid peptide receptor studies. 14. Stereochemistry determines agonist efficacy and intrinsic efficacy in the [(35)S]GTP-gamma-S functional binding assay. Synapse (2001) 1.39
Rheumatic diseases in African blacks. Semin Arthritis Rheum (1994) 1.38
Preterm infants 30-36 weeks' gestation in Victoria--where should they be delivered? Aust N Z J Obstet Gynaecol (1998) 1.38
An immunohistochemical study of ras oncoprotein expression in gastric carcinoma. Cancer (1993) 1.38
Proteinuria in passive Heymann nephritis is associated with lipid peroxidation and formation of adducts on type IV collagen. J Clin Invest (1994) 1.37
Rapid reduction of MDCK cell cholesterol by methyl-beta-cyclodextrin alters steady state transepithelial electrical resistance. Eur J Cell Biol (1999) 1.37
Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain. Neuroscience (2003) 1.35
Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin. Int J Oncol (2001) 1.35
Pseudomonas aeruginosa induction of apoptosis in respiratory epithelial cells: analysis of the effects of cystic fibrosis transmembrane conductance regulator dysfunction and bacterial virulence factors. Am J Respir Cell Mol Biol (2000) 1.35